Clinical trials: Osteolysis
Hip Arthroplasty, Knee Arthroplasty
CT for Diagnosis of Implant Stability in Revision Arthroplasty
All patients over 18 who undergo a revision of hip or knee arthroplasty will be included. Patients undergo a CT of the hip joint. A radiologist will mark the presence of cysts and bone loss and will assess implant stability.
- Conditions
- Hip Arthroplasty, Knee Arthroplasty, Osteolysis
- Trial name
- NCT00367289
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Osteoarthritis
Do We Need High-Flexing Total Knee Arthroplasty to Improve the Survivorship and to Decrease the Incidence of Osteolysis?
The purpose of this study is to determine if there are any clinical or ROM differences in total knee arthroplasty with standard NexGen LPS prosthesis and NexGen LPS-Flex prosthesis.
- Trial name
- NCT01422642
- Testing
- legacy posterior stabilized high-flexion (NexGen LPS-Flex), legacy posterior stabilized standard (NexGen LPS)
- Where
- South Korea
- Volunteers
- 111 people
- Sponsor
- Ewha Womans University
Aseptic Loosening of the Hip Prosthesis
Bisphosphonates and Impaction Grafting in Hip Revision
The primary focus of this study is to investigate whether increased bone density of the graft in revision arthroplasty of the hip can cause a decreased micromotion of the implant relative to the femur.
- Trial name
- NCT00658268
- Testing
- Clodronate
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Region Skane
Metastatic Cancer
A Study of ARRY-382 in Patients With Selected Advanced or Metastatic Cancers
This is a Phase 1 study during which patients with advanced cancer will receive investigational study drug ARRY-382. Patients will receive increasing doses of study drug in order to achieve the highest dose of the study drug…
- Trial name
- NCT01316822
- Testing
- ARRY-382, cFMS inhibitor; oral
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Array Biopharma, now a wholly owned subsidiary of Pfizer
Flatfoot, Bone Resorption
Bio-Integrative Versus Metallic Screws for Calcaneus Osteotomies
The use of bio-integrative implants in orthopedic surgery is growing exponentially. As many biomechanical and histological studies were able to sustain its structural and biological properties, few clinical studies are available…
- Conditions
- Flatfoot, Bone Resorption, Cavus Deformity, Osteolysis
- Trial name
- NCT05018130
- Testing
- Calcaneus Osteotomy (Metallic), Calcaneus Osteotomy (Bio-integrative)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Iowa
Breast Neoplasms, Prostatic Neoplasms
Study to Investigate Adherence of Patients to Clodronate (Bonefos) Treatment
Adherence (or compliance with) a medication regimen is generally defined as the extent to which patients take medication as prescribed by their health care providers.
- Conditions
- Breast Neoplasms, Prostatic Neoplasms, Multiple Myeloma, Osteolysis
- Trial name
- BONA (NCT01198457)
- Testing
- Clodronate (Bonefos, BAY94-8393)
- Where
- Czechia
- Volunteers
- 147 people
- Sponsor
- Bayer
Knee Osteoarthritis
Total Knee Arthroplasty With Vitamin E Polyethylene
The aim of this observational study is to investigate if there is any difference in survival rate, clinical and radiological results after total knee replacement with vitamin E-blended polyethylene in comparison to conventional…
- Trial name
- NCT05810285
- Testing
- GKS Prime Flex Mobile knee
- Where
- Italy
- Volunteers
- 186 people
- Sponsor
- Permedica spa
Lymphatic Diseases, Lymphatic Abnormalities
A Prospective Natural History Study of Lymphatic Anomalies
Background: The lymphatic system is a network of vessels that carry a clear fluid called lymph through the body. Problems in the lymphatic system can cause pain, fluid buildup, and issues with immunity.
- Trial name
- NCT05731141
- Where
- 2 sites in United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Refractory Multiple Myeloma
Tivantinib in Treating Patients With Relapsed, or Relapsed and Refractory Multiple Myeloma
This phase II trial studies the side effects and how well tivantinib works in treating patients with relapsed, or relapsed and refractory multiple myeloma.
- Trial name
- NCT01447914
- Testing
- Tivantinib, Diagnostic laboratory biomarker analysis, Questionnaire administration
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Cancer Institute (NCI)
Hip Replacement, Hip Implant
Investigation of Systemic Metal Ion Concentration Following a Ceramic-on-metal Total Hip Arthroplasty
This is a pilot study to compare systemic concentrations of cobalt and chromium in patients that have previously undergone total hip arthroplasties with ceramic on metal and metal on metal bearing surfaces.
- Conditions
- Hip Replacement, Hip Implant, Total Hip Arthroplasty, Orthopaedic Surgery
- Trial name
- NCT00883805
- Testing
- Blood draw, X-Ray of Hip
- Where
- United States
- Sponsor
- Northwell Health
Aseptic Loosening, Osteolysis
Post-Market Study of the Modular Revision Hip System
The purpose of this study is to examine the short term efficacy of the MRH system as well as determine if operating room time is decreased using this simple, two-tray system.
- Conditions
- Aseptic Loosening, Osteolysis, Traumatic Fracture, Failed Total Hip Implant
- Trial name
- MRHS (NCT01464645)
- Testing
- Modular Revision Hip System
- Where
- 6 sites in United States
- Volunteers
- 16 people
- Sponsor
- Encore Medical, L.P.
Osteoarthritis, Hip, Arthritis
Longterm-Evaluation of Vitelene® Against Standard
The purpose of this randomised prospective multicenter longterm study is to evaluate the survival rate of the implant, wear and periprosthetic osteolysis of highly cross-linked polyethylene with and without addition of Vitamin E…
- Trial name
- VITAS (NCT01713062)
- Testing
- Vitelene, XLPE
- Where
- 6 sites in Germany
- Volunteers
- 400 people
- Sponsor
- Aesculap AG
Multiple Myeloma
Prolonged Protection From Bone Disease in Multiple Myeloma
Main hypothesis: Patients who continue zoledronic acid after year 2 have longer time until progression in bone disease compared to patients who stop treatment after two years? Secondary hypothesis: Serum will bone markers…
- Trial name
- Magnolia (NCT02286830)
- Testing
- Zoledronic acid
- Where
- Denmark
- Volunteers
- 158 people
- Sponsor
- Thomas Lund
Osteolysis
Incidence & Clinical Significance of Osteolysis Following PEEK Suture Anchor Use in Hand & Wrist Surgery
This prospective observational study evaluates the incidence \& clinical significance of osteolysis following polyetheretherketone (PEEK) suture anchor use in hand \& wrist surgery.
- Trial name
- NCT06824545
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Colorado, Denver
Periprosthetic Osteolysis
Assessment of Periprosthetic Bone Mineral Density in Patients Undergoing Total Knee Prosthesis of Different Design
compare changes in BMD via DXA at the level of the femoral and tibial periprosthetic bone between two groups of patients undergoing cemented TKA of different design (posterior stabilization vs posterior cruciate preservation)…
- Trial name
- DXA-TKA (NCT06309433)
- Testing
- dual energy x-ray absorptiometry
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Istituto Ortopedico Rizzoli