Clinical trials: Osteonecrosis
Avascular Necrosis, Post-traumatic; Arthrosis
iAssist vs. Conventional Instrumentation in Total Knee Arthroplasty
The purpose of this prospective study is to evaluate Zimmer® iASSIST™ with respect to radiographic, clinical and economic outcomes and compared to conventional instrumentation in primary total knee arthroplasty (NexGen or Persona…
- Conditions
- Avascular Necrosis, Post-traumatic; Arthrosis, Knee Osteoarthritis
- Trial name
- NCT03111407
- Testing
- total knee arthroplasty
- Where
- 3 sites in Spain, Switzerland
- Volunteers
- 72 people
- Sponsor
- Zimmer, GmbH
Osteonecrosis Due to Drugs, Jaw
Antiresorptive Drug Continuation Compared With Drug Holiday in Cancer Patients Needing Tooth Extraction
The aim of this trial is to evaluate high-dose antiresorptive drug holiday related to tooth extraction with primary mucosal closure (surgical extraction) including how a drug holiday affects the health related quality of life.
- Trial name
- DrugHoliday (NCT04540601)
- Testing
- Continuation of antiresorptives in relation to tooth extraction (surgical tooth removal)
- Where
- 2 sites in Denmark
- Volunteers
- 30 people
- Sponsor
- University of Copenhagen
Non-inflammatory Degenerative Joint Disease, Osteoarthritis
A Clinical Investigation of the M2a- Taper™ Hip System
The purpose of this prospective clinical data collection is to document the performance and clinical outcomes of the M2a- Taper™ Hip System
- Conditions
- Non-inflammatory Degenerative Joint Disease, Osteoarthritis, Avascular Necrosis
- Trial name
- NCT00698633
- Volunteers
- 43 people
- Sponsor
- Biomet Orthopedics, LLC
Legg-Calve Perthes Disease
Intraarticular Corticosteroid Therapy in Perthes Disease.
Legg-Calve-Perthes disease (LCP) represents the loss of blood flow to the head of the femur, resulting in significant hip pain and potential long term disability.
- Trial name
- NCT01026909
- Testing
- Aristospan 20mg
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Seattle Children's Hospital
Osteoarthritis of the Shoulder
TITAN™ Reverse Shoulder System
The Integra® TITAN™ Reverse Shoulder System (TRS) is a semi-constrained total shoulder construct. When used under the conditions and purposes intended the TRS will relieve pain and restore some functional joint motion to the…
- Trial name
- NCT02204228
- Testing
- TITAN™ Reverse Shoulder System (TRS)
- Where
- 10 sites in United States, France and 2 more
- Volunteers
- 151 people
- Sponsor
- Smith & Nephew, Inc.
Patient With a History of Previous Radiotherapy
Deep Learning for Automatic Segmentation of Bone Sequestra on Orthopantomographs: A UNet-Based Approach
This study developed and evaluated a UNet-based deep learning model for automatic segmentation of bone sequestra on orthopantomographs (OPGs), with the goal of improving diagnostic efficiency and reducing inter-observer…
- Trial name
- Deep Learning (NCT07809048)
- Testing
- Radiographic Evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Izmir Katip Celebi University
Rheumatoid Arthritis, Osteoarthritis
A Multi-centre Study to Assess the Long-term Performance of the DePuy PROXIMA™ Hip in Primary Total Hip Replacement
The purpose of this study is to monitor the performance of the DePuy PROXIMA™ hip in the treatment of patients with hip joint disease requiring a total hip replacement.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Post-traumatic Arthritis, Avascular Necrosis
- Trial name
- NCT00208455
- Testing
- DePuy Proxima™ Hip
- Where
- 4 sites in Germany, Italy and 2 more
- Volunteers
- 184 people
- Sponsor
- DePuy International
Rheumatoid Arthritis, Osteoarthritis
An Electronic Data Capture Study to Assess the Long-term Performance of the DePuy PROXIMA™ Hip in Primary Total Hip Replacement
The purpose of this study is to monitor the performance of the DePuy PROXIMA™ hip in the treatment of patients with hip joint disease requiring a total hip replacement.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Post-traumatic Arthritis, Avascular Necrosis
- Trial name
- NCT01134445
- Testing
- DePuy Proxima™ Hip
- Where
- 4 sites in France, Portugal and 2 more
- Volunteers
- 42 people
- Sponsor
- DePuy International
Osteonecrosis, Acute Lymphoblastic Leukemia
Osteonecrosis in Children With Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia is the most common form of childhood cancer with current treatment survival rates approaching 80%. Improved outcomes show an increased number of survivors at risk for long-term treatment related side…
- Trial name
- NCT01104324
- Where
- 10 sites in Canada
- Volunteers
- 130 people
- Sponsor
- Halton, Jacqueline, M.D.
Legg Calve Perthes Disease
Perthes Disease in Norway
Calvé-Legg-Perthes disease (CLP) is a hip disease in children whose femoral head becomes completely or partially necrotic. The disease is most common in five-six years of age.
- Trial name
- NCT03885960
- Where
- Norway
- Volunteers
- 216 people
- Sponsor
- Oslo University Hospital
Rheumatoid Arthritis, Osteoarthritis
A Two Centre Study to Assess the Stability and Long-term Performance of the C-Stem™ AMT in a Total Primary Hip Replacement
The purpose of this study is to monitor the stability of the C-Stem™ AMT hip within the thigh bone when used in the treatment of patients with hip joint disease requiring a total hip replacement.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Post-traumatic Arthritis, Collagen Disorders
- Trial name
- NCT00872573
- Testing
- C-Stem™ AMT Femoral Component (standard and high off-set variants)
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- DePuy International
Osteoarthritis, Avascular Necrosis
A Clinical Evaluation of Metal Ion Release From Metal-on-Metal Cementless Total Hip Arthroplasty
A clinical Evaluation to determine metal ion release from 4th generation metal-on-metal hip articulating surfaces in cementless total hip arthroplasty.
- Conditions
- Osteoarthritis, Avascular Necrosis, Traumatic Arthritis, Rheumatoid Arthritis
- Trial name
- NCT00757354
- Testing
- Metal on Metal cementless hip
- Where
- United Kingdom
- Volunteers
- 77 people
- Sponsor
- Zimmer Biomet
Osteonecrosis, Osteonecrosis of the Femoral Head
A Phase II Trial of RAB001 (LLP2A-Alendronate) for Steroid-Induced Early-Stage Osteonecrosis of the Femoral Head
This is a multicenter, randomized (similar to drawing lots, where the treatment you receive is not chosen by you or the researchers), controlled, blinded (the three dose groups of the investigational drug are blinded, meaning…
- Trial name
- LLP2A-Ale (NCT07471880)
- Testing
- RAB001 high dose, RAB001 medium dose, RAB001 low dose
- Where
- China
- Volunteers
- 161 people
- Sponsor
- ZhongShan LaiBo RuiChen BioMedicine Co.,Ltd.
Avascular Necrosis
Atorvastatin to Prevent Avascular Necrosis of Bone in Steroid Treated Exacerbated Systemic Lupus Erythematosus
This study uses the cholesterol lowering drug atorvastatin, also known as lipitor, to show reduction of avascular necrosis in steroid treated lupus patients.
- Trial name
- NCT00412841
- Testing
- Atorvastatin, MRI, Venipuncture
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- NYU Langone Health
Bone Cancer, Chondrosarcoma
Differentiation of Bone Sarcomas and Osteomyelitis With Ferumoxytol-Enhanced MRI
This pilot trial studies the differentiation of bone sarcomas and osteomyelitis with ferumoxytol-enhanced magnetic resonance imaging (MRI).
- Conditions
- Bone Cancer, Chondrosarcoma, Ewing's Sarcoma, Osteosarcoma
- Trial name
- Osteosarcoma (NCT01336803)
- Testing
- Feraheme, Magnetic Resonance Imaging (MRI) scan
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Heike E Daldrup-Link
Osteoarthritis, Hip, Osteonecrosis
Effect of Cycle Ergometer in the Rehabilitation of Elderly Patients With Total Hip Arthroplasty
The aim of this study is to evaluate the effects of an exercise program with a cycle ergometer in functional outcome and related-health quality of life (RHQL) in elderly patients with total hip arthroplasty.
- Trial name
- NCT01622465
- Testing
- Ergometer cycling, Conventional exercises
- Where
- Brazil
- Volunteers
- 14 people
- Sponsor
- University of Campinas, Brazil
Osteolysis, Arthroplasty Complications
Plasmafit® Revision Structan® Hip Endoprosthesis Cup
The aim of this observational study is to collect clinical and radiological results of the new Plasmafit® Revision Structan® Hip Endoprosthesis Cup in a standard patient population and when used in routine clinical practice.
- Conditions
- Osteolysis, Arthroplasty Complications, Instability of Prosthetic Joint, Degenerative Osteoarthritis
- Trial name
- NCT04255966
- Testing
- Plasmafit® Revision Structan®
- Where
- 4 sites in Germany
- Volunteers
- 60 people
- Sponsor
- Aesculap AG
Healing Surgical Wounds, Infection
Surgical Management of Medication Related Osteonecrosis of the Jaws With Concentrated Growth Factor
The purpose of this present study was to evaluate the efficiency of the growth factors delivered by concentrated growth factor (CGF) on the healing process of osteoporotic patients with medication-related osteonecrosis of the…
- Trial name
- NCT04531800
- Testing
- Concentrated growth factor, Non-concentrated growth factor
- Volunteers
- 28 people
- Sponsor
- Ege University
Osteoarthritis, Rheumatoid Arthritis
Tritanium® Study in Japan
The purpose of this study is to evaluate early fixation and stability of the Tritanium cup. It is expected that the Tritanium® cup will be equal to or better than conventional cementless cups in early fixation/stability and meet…
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Avascular Necrosis of the Femoral Head
- Trial name
- NCT02552069
- Testing
- Tritanium® cup
- Where
- Japan
- Volunteers
- 50 people
- Sponsor
- Stryker Japan K.K.
Joint Disease
Microplasty Tibial Tray Data Collection
The purpose of this prospective clinical data-collection is to document the performance and clinical outcomes of the Microplasty Tibial Tray.
- Trial name
- MTT (NCT00754637)
- Where
- United States
- Sponsor
- Zimmer Biomet