Clinical trials: Osteoporosis
Osteoporosis
Frequency of Zoledronic Acid to Prevent Further Bone Loss in Osteoporotic Patients Requiring Androgen Deprivation Therapy for Prostate Cancer
The aim of this study is to determine if 3 monthly infusions of zoledronic acid, given over one year, improves the bone mineral density in osteoporotic patients undergoing androgen deprivation therapy for prostate cancer
- Trial name
- NCT00520052
- Testing
- zoledronic acid
- Where
- United Kingdom
- Volunteers
- 58 people
- Sponsor
- Wirral University Teaching Hospital NHS Trust
Asthma, Osteoporosis, Osteopenia
Long-term Effect of Steroid on Metabolic Diseases in Asthmatics
The goal of this retrospective/observational study is to compare the clinical outcomes between the high-cumulative-dose group and the low- cumulative-dose group of oral/inhaled corticosteroid in the long-term management of asthma…
- Conditions
- Asthma, Osteoporosis, Osteopenia, Osteoporosis Risk, Osteoporotic Fractures
- Trial name
- NCT06279078
- Testing
- Corticosteroid
- Where
- South Korea
- Volunteers
- 19,968 people
- Sponsor
- Ajou University School of Medicine
Osteoporosis
Effect of Bone on Vibration-Induced Muscle Electrical Activity
The aim of this study is to investigate effects of femur exposed to vibration on the rest muscle electrical activity of hip adductors in cases with postmenopausal osteoporosis.
- Trial name
- PMO-WBV-sEMG (NCT01367041)
- Testing
- vibration
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bagcilar Training and Research Hospital
Osteoporosis
A Study That Will Compare the Effect of Two Drugs on Participants With Low Bone Mass and a Recent Hip Fracture
This study will evaluate whether teriparatide is superior to the active comparator in the change from baseline of lumbar spine BMD (bone mineral density) in men and postmenopausal women with low bone mass and a recent…
- Trial name
- MOVE (NCT00887354)
- Testing
- Teriparatide, Risedronate, Calcium
- Where
- 28 sites in United States, Canada and 10 more
- Volunteers
- 224 people
- Sponsor
- Eli Lilly and Company
Postmenopausal Women With Osteoporosis
Study to Determine the Efficacy and Safety of Romosozumab in the Treatment of Postmenopausal Women With Osteoporosis
The purpose of this study is to determine if treatment is effective in preventing fractures in women with postmenopausal osteoporosis.
- Trial name
- ARCH (NCT01631214)
- Testing
- Romosozumab, Alendronate
- Where
- 316 sites in United States, Argentina and 40 more
- Volunteers
- 4,093 people
- Sponsor
- Amgen
Breast Cancer, Menopausal Symptoms
Raloxifene With or Without Exercise Compared With Exercise Alone in Women Who Have Been Previously Treated for Breast Cancer
RATIONALE: Raloxifene and exercise may improve bone health and quality of life in breast cancer survivors. Assessing bone health and quality of life may improve the ability to plan treatment.
- Conditions
- Breast Cancer, Menopausal Symptoms, Osteoporosis
- Trial name
- NCT00031811
- Testing
- raloxifene, quality-of-life assessment
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- OHSU Knight Cancer Institute
Cortical Bone Erosion
Age Influence on Cortical Bone Measured by Ultrasound
The study of this study is to evaluate the age influence on cortical bone strength properties by two methods:HR-pQCT (HighResolution-peripheral quantitativeComputedTomography) and ultrasound.
- Trial name
- OCO-US (NCT03453242)
- Testing
- Bone measurement by HR-pQCT and ultrasound
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteoporosis Fracture, Spinal Cord Injuries
Evaluation of Romosozumab vs. Zoledronic Acid Effect in Patients With Spinal Cord Injury and Low Bone Mineral Density
This is a randomized study to determine the effects of monthly romosozumab for one year or one-time zoledronic acid on bone mineral density (BMD) and biochemical markers of bone formation and resorption, in patients with spinal…
- Trial name
- NCT04597931
- Testing
- Romosozumab, Zoledronic Acid
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Osteoporosis, Osteopenia
Texture Analysis for Postmenopausal Osteoporosis
The purpose of this study is to determine if a new test for osteoporosis can be useful in monitoring treatment. We are studying a new method for examining the quality of bone by an experimental method of computerized analysis of…
- Trial name
- NCT00145977
- Testing
- Alendronate, Calcium Citrate, Vitamin D
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Chicago
Aging, Frailty
Testosterone Effects on Bone and Frailty
The purpose of this study is to assess the effects of testosterone replacement on bone density, muscle strength, physical performance, quality of life and prostate symptoms in men selected for low bone mineral density or fracture…
- Conditions
- Aging, Frailty, Osteoporosis
- Trial name
- NCT00182871
- Testing
- testosterone
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- National Institute on Aging (NIA)
Osteoporosis, Post-Traumatic, Calcium Supplementation
Study of the Adequacy Between Calcium Supplementation and Dietary Intake in Treatment-naive Patients After a Fracture
Osteoporosis is a disease that causes many fractures. However, treatments exist such as anti-osteoporotic treatments, vitamin D supplementation and an adaptation of calcium intake.
- Conditions
- Osteoporosis, Post-Traumatic, Calcium Supplementation, Osteoporosis, Management Care, Fracture
- Trial name
- MONTE-CRIST'OS (NCT06847087)
- Testing
- Self-questionnaire
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Centre Hospitalier de Colmar
Osteoporosis
Clinical Study of AK159 in Healthy Postmenopausal Women
The objective of this study is to investigate the pharmacokinetics, safety, and tolerability of AK159 administered to healthy postmenopausal women.
- Trial name
- NCT01551602
- Testing
- AK159, MN-10-T
- Where
- 3 sites in Japan
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Asahi Kasei Therapeutics Corporation
Osteoporosis, Sarcopenia
Bone Microstructure by Using HR-pQCT in Long Courses After Gastrectomy
Osteoporosis after gastrectomy, which is characterized by both the loss of bone mass and the deterioration of bone architecture, is a serious complication in the long course after gastrectomy.
- Conditions
- Osteoporosis, Sarcopenia, Gastric Cancer
- Trial name
- NCT03251430
- Testing
- gastrectomy
- Where
- Japan
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Kobayashi Shinichiro
Osteoporosis, Accidental Falls
The Effect of Digital Education for Osteoporosis Patients on Fracture Risk and Related Health Outcomes.
A digital education for osteoporosis patients (DEOP) has been developed and tested on patients in Region Vastra Gotaland, Sweden.
- Conditions
- Osteoporosis, Accidental Falls, Fractures, Bone, Patient Reported Outcome Measures
- Trial name
- NCT06603545
- Testing
- Digital education for osteoporosis patients
- Volunteers
- 2,640 people
- Sponsor
- Sahlgrenska University Hospital
Osteoporosis
Nitrates and Bone Turnover; Nitrates and Bone Turnover Bisphosphonate Sub-Study
Purpose: NABT: To compare five widely available nitrate formulations: (1) 15 of nitroglycerin (NTG) ointment, (2) 0.3 mg and (3) 0.6 mg of sublingual NTG, (4) 20 mg of isosorbide mononitrate (an oral tablet), and (5) 160 mg of…
- Trial name
- NABT;NABT-B (NCT01387672)
- Testing
- Nitrates (NABT Main trial)
- Where
- Canada
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Postmenopausal Osteoporosis
Post-Marketing Drug Intensive Monitoring Surveillance of EDIROL in Patients With Postmenopausal Osteoporosis
This is a post-marketing drug intensive monitoring surveillance with an observational, non-interventional design. The objectives are to compare the incidence of hypercalcemia in patients with and without calcium intake (including…
- Trial name
- NCT05433207
- Testing
- Eldecalcitol soft capsules
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Chugai Pharmaceutical
Osteoporosis
Teriparatide (PTH) and Bone Strength in Postmenopausal Women
This study will investigate the effects on bone quality of a medication (Teriparatide) used to treat people with severe osteoporosis.
- Trial name
- NCT01155245
- Testing
- Forteo
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Osteoporosis
FORCE (Falls, Fracture, and Osteoporosis Risk Control Evaluation) Study
Falls and osteoporosis-related fractures cause substantial morbidity and mortality in the elderly, and are an increasingly important public health concern.
- Trial name
- NCT00465387
- Testing
- Falls, Fractures & Osteoporosis Risk Assessment & Management
- Volunteers
- 400 people
- Sponsor
- Group Health Centre
Postmenopausal Osteoporosis, Multiple Sites
Safety Study of an Oral Vitamin D Analog in Postmenopausal Women
Determine the safety of 2MD, a vitamin D analog, when administered orally once daily for 28 days in healthy normal postmenopausal women.
- Trial name
- NCT01969656
- Testing
- 2MD, Calcitriol
- Sponsor
- Deltanoid Pharmaceuticals
Osteoporosis
Carnitine Supplementation and Bone Mineral Density
The primary aim of the current research project is to explore whether carnitine supplementation and resistance training may prevent decrements in bone mineral density of aged women.
- Trial name
- NCT05120011
- Testing
- L-carnitine, L-leucine
- Where
- Poland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education