Clinical trials: Osteoporosis Fracture
Osteoporosis, Fragility Fracture
Image-guided Computational and Experimental Analyses of Fractured Patient's Bone (GAP)
Due to the increase in the average age of the population, the projections on the number of age-dependent bone fractures appear to be constantly increasing. They are mainly due to bone pathologies, including osteoporosis.
- Trial name
- GAP (NCT04787679)
- Testing
- Hip replacement surgery
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Laura Maria Vergani
Osteoporosis, Bladder Disease
Osteoporosis, Trabecular Bone Score and Fracture Risk Assessment in Male Patients After Radical Cystectomy
Radical cystectomy (RC) with ileal urinary diversion (UD) is a standard treatment for muscle-invasive bladder cancer. However, emerging evidence indicates that this procedure may significantly impact bone health.
- Trial name
- NCT04153227
- Testing
- Bone mineral density (BMD), Trabecular bone score (TBS), Fracture risk Assessment Tool (FRAX)
- Where
- Spain
- Volunteers
- 112 people
- Sponsor
- Corporacion Parc Tauli
Osteoporosis
Teriparatide Use in Hip Replaced Subjects
A pilot study on the use of Teriparatide in severe osteoporotic women with hip fracture and submitted to hip replacement The primary objective of this study is to obtain preliminary data, in a pilot group of postmenopausal women…
- Trial name
- NCT00191321
- Testing
- Teriparatide
- Where
- 11 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Eli Lilly and Company
Post-menopausal Osteoporosis
Vitamin K as Additive Treatment in Osteoporosis
Vitamin K is thought to be important for bone health because it activates several proteins involved in bone formation. Poor dietary intake of vitamin K (mainly found in dark green leafy vegetables) is associated with bone loss…
- Trial name
- VITKANDOP (NCT01232647)
- Testing
- Phylloquinone, Menatetrenone (MK4)
- Where
- 2 sites in United Kingdom
- Volunteers
- 105 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Osteoporosis, Fractures in the Elderly
Fractures in the Elderly Population of El Salvador at Hospital Zacamil: Exploring Knowledge, Causes, Risk Factors, and Outcomes
As the population's life expectancy increases, fractures among the elderly in El Salvador are also increasing. There is currently limited data specific to the incidence and cause of fractures in the elderly within developing…
- Trial name
- NCT00625599
- Testing
- Osteoporosis Prevention Information
- Where
- 2 sites in El Salvador
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Edward Via Virginia College of Osteopathic Medicine
Osteoporosis, Frailty
The iCARE Study: Education Modules for Fracture Prevention
A large proportion of older adults living in long term care homes are frail and have osteoporosis. With age, there is a gradual and progressive decline in bone quality and quantity and an increase in frailty, which is associated…
- Conditions
- Osteoporosis, Frailty, Chronic Conditions, Multiple, Fracture
- Trial name
- iCARE (NCT05445336)
- Testing
- PREVENT Program
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McMaster University
Breast Cancer, Osteoporosis
Do Aromatase Inhibitors (AIs) Decrease Intestinal Calcium Absorption?
Research Question: Do Aromatase Inhibitors Decrease Intestinal Calcium Absorption? Study Design: Postmenopausal women with early stage breast cancer initiating aromatase inhibitor adjuvant therapy will participate in this…
- Conditions
- Breast Cancer, Osteoporosis, Osteopenia, Fracture
- Trial name
- NCT00766532
- Testing
- Aromatase Inhibitor
- Volunteers
- 12 people
- Sponsor
- University of Wisconsin, Madison
Osteoporosis, Postmenopausal, Osteoporosis
Early Effects of Abaloparatide on Tissue-Based Indices of Bone Formation and Resorption
The objective of this study is to measure the early effects of abaloparatide on tissue-based bone formation using samples obtained by transiliac crest bone biopsy after quadruple fluorochrome labeling.
- Conditions
- Osteoporosis, Postmenopausal, Osteoporosis, Osteoporosis Vertebral, Osteoporosis Risk
- Trial name
- NCT03710889
- Testing
- Abaloparatide
- Where
- 4 sites in United States
- Volunteers
- 23 people
- Sponsor
- Radius Health, Inc.
Osteoporosis, Osteopenia
µMRI of Therapeutic Intervention in Postmenopausal Osteoporosis
The purpose of this study is to apply a novel advanced magnetic resonance imaging methodology to evaluate the response to drug intervention involving two treatment arms of postmenopausal participants with osteoporosis, randomized…
- Trial name
- TERIZOL (NCT01153425)
- Testing
- Virtual Bone Biopsy, Teriparatide, Zoledronic Acid
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Pennsylvania
Osteoporosis, Bone Fracture
PATHophysiology of OSteoporosis: Role of Hidden Cortisol Excess and Its Predictors in Bone Fragility
Osteoporosis is a chronic skeletal disease which leads to a decrease in bone strength which increases the risk of fractures. Clinically overt hypercortisolism leads to hypertension, central obesity, diabetes and osteoporosis.
- Conditions
- Osteoporosis, Bone Fracture, Cortisol Excess
- Trial name
- PATHOS (NCT06324084)
- Where
- 5 sites in Italy
- Volunteers
- 1,500 people
- Sponsor
- Istituto Auxologico Italiano
Osteoporosis, Vertebral Fracture
Treatment With a Spinal Orthosis Compared to Equipment Group Training and a Control Group
Background: Back pain and osteoporosis with vertebral fractures are common conditions in elderly women and significantly affect their quality of life. A common complication of osteoporosis are vertebral fractures.
- Conditions
- Osteoporosis, Vertebral Fracture, Back Pain, Elderly Women
- Trial name
- NCT03263585
- Testing
- Spinal orthosis Spinomed, Equipment training
- Where
- 2 sites in Sweden
- Volunteers
- 113 people
- Sponsor
- Helena Salminen
Osteoporotic Fractures
Optimisation of Falls Prevention After Low-energy Osteoporotic Fractures: Feasibility Study
Within the Groupe Hospitalier Paris Saint-Joseph (GHPSJ), a reinforced medical care of osteoporosis ('Fracture Liaison service') was organized for osteoporotic fractured patients.
- Trial name
- OPTICHUTE (NCT03642808)
- Testing
- rehabilitation program
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Osteoporosis, Osteoarthritis, Hip
Metabolic Profiling of Hematopoietic Stem Cells in Clonal Hematopoiesis (CHIP)
Bone marrow samples will be collected from patients undergoing hip arthroplasty surgery. Blood and bone marrow samples will be used for metabolic profiling and analysis of relevant CHIP mutations.
- Conditions
- Osteoporosis, Osteoarthritis, Hip, Hip Fractures, Clonal Hematopoiesis of Indeterminate Potential
- Trial name
- NCT05246813
- Testing
- Blood and bone marrow cell collection
- Where
- Belgium
- Volunteers
- 24 people
- Sponsor
- Imelda Hospital, Bonheiden
Fragility Fracture
Hip Fracture Prevention Follow-up of Elderly Women in Primary Health Care
Researchers plan a 2022 follow-up of medical records data to investigate fracture incidence and survival for 1248 women, born 1902-1931, in a comparative fracture prevention study with 435 participants from an intervention area…
- Trial name
- HIP22 (NCT05269979)
- Testing
- Prevention of hip fractures
- Volunteers
- 1,248 people, healthy volunteers welcome
- Sponsor
- Kronoberg County Council
Postmenopausal Women With Osteoporosis
To Evaluate the Efficacy and Safety of Abaloparatide Injection (QLG2128) in the Treatment of Postmenopausal Women With Osteoporosis and at High Risk of Fracture
The purpose of this study is to evaluate the efficacy and safety of QLG2128 in the treatment of postmenopausal women with osteoporosis and at high risk of fracture.
- Trial name
- NCT06898060
- Testing
- QLG2128, Teriparatide Injection
- Volunteers
- 282 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Accidental Falls, Osteoporosis
Prevention of Falls and Its Consequences in Elderly People
Falls are an important risk factor for fragility fractures. Both are associated with the ageing process and as they rise also increase the risk of mortality, disability and dependency.
- Trial name
- PRECIOSA (NCT02617303)
- Testing
- OTAGO's exercises, COMMON PRACTICE
- Where
- 11 sites in Spain
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Osteoporosis Risk, Fracture of Femur
Prediction Model of Hip Fragility Fracture Realistic Data From a Traumatology Department and Orthogeriatric Ward.
The aim of the project is to build a prediction model of hip fragility fracture using hospital data routinely collected in the traumatology department from the last 12 years and up to date Explainable Artificial Intelligence…
- Conditions
- Osteoporosis Risk, Fracture of Femur, Fragility
- Trial name
- NCT06545487
- Testing
- BLOOD SAMPLE
- Where
- Chile
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad de Valparaiso
Spinal Cord Injury, Bone Loss
Effect of Alendronate on Bone in People With Chronic Spinal Cord Injury (SCI) Previously Treated With Teriparatide
The purpose of this study is to determine if a year of alendronate treatment will maintain or increase bone mass density (BMD) compared to baseline BMD values in people with chronic spinal cord injury (SCI).
- Conditions
- Spinal Cord Injury, Bone Loss, Osteoporosis
- Trial name
- NCT02195895
- Testing
- Alendronate, Calcium, Vitamin D
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Northwestern University
Metabolic Bone Disease, Transplant-Related Disorder
Assessment of Vertebral Fracture Risk for First Time Liver Transplant Candidates
The researchers are trying to compare the effectiveness of Vertebral Fracture Assessment (VFA) in addition to the current standard of care spine x-ray in evaluation pre-liver transplant patients.
- Conditions
- Metabolic Bone Disease, Transplant-Related Disorder, Secondary Osteoporosis
- Trial name
- VFA (NCT03811873)
- Testing
- Dual x-ray absorptiometry, Vertebral Fracture Assessment
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Osteoporosis, Post-Traumatic, Calcium Supplementation
Study of the Adequacy Between Calcium Supplementation and Dietary Intake in Treatment-naive Patients After a Fracture
Osteoporosis is a disease that causes many fractures. However, treatments exist such as anti-osteoporotic treatments, vitamin D supplementation and an adaptation of calcium intake.
- Conditions
- Osteoporosis, Post-Traumatic, Calcium Supplementation, Osteoporosis, Management Care, Fracture
- Trial name
- MONTE-CRIST'OS (NCT06847087)
- Testing
- Self-questionnaire
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Centre Hospitalier de Colmar