Clinical trials: Osteoporosis Fracture
Osteoporosis, With or Without Treatment, Bisphosphonate Treatment
Biomarker Identification in Orthopaedic & Oral Maxillofacial Surgery Subjects to Identify Risks of Bisphosphonate Use
Bisphosphonates are drugs that prevent bone loss by blocking the activity of cells that normally resorb bone. The most common examples of these drugs are Boniva and Fosamax.
- Conditions
- Osteoporosis, With or Without Treatment, Bisphosphonate Treatment, Atypical Femur Fracture, Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ)
- Trial name
- NCT01875458
- Where
- United States
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Osteoporosis
Randomized, Open, Parallel, Active Controlled Study on Fracture Prevention in Antiosteoporosis Treatment (OF Study)
To investigate a new incidence and preventive effect of menatetrenone on vertebral fracture in patients with osteoporosis who were randomly assigned to either treatment arm receiving daily dose of calcium supplement as a…
- Trial name
- NCT00165607
- Testing
- MENATETRANONE
- Where
- Japan
- Sponsor
- Eisai Limited
Osteoporosis
Does Bone Structure Explain the Increased Fracture Risk in Type II Diabetes Patients? A Pilot Study
For this cross-sectional case control pilot study 30 women, 55-75 years old with type II diabetes will be recruited. Diabetes will be defined as self-report of diabetes previously diagnosed by a physician, use of hypoglycemic…
- Trial name
- NCT00703417
- Testing
- magnetic Resonance Imaging, Computed Tomography, High resolution peripheral quantitative computed tomography
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Osteoporotic Fractures
Training of Orthopedic Residents in OP Treatment
Objective: To assess whether residents (R1, R2 or R3 according to the year of residency) of an orthopedic tertiary service, investigate, treat and / or refer the patient with an osteoporotic fracture to treat osteoporosis (OP)…
- Trial name
- NCT04911946
- Testing
- Questionnaire
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Osteoporosis, Osteopenia
µMRI of Therapeutic Intervention in Postmenopausal Osteoporosis
The purpose of this study is to apply a novel advanced magnetic resonance imaging methodology to evaluate the response to drug intervention involving two treatment arms of postmenopausal participants with osteoporosis, randomized…
- Trial name
- TERIZOL (NCT01153425)
- Testing
- Virtual Bone Biopsy, Teriparatide, Zoledronic Acid
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Pennsylvania
Femoral Fractures, Hip Fractures
Influence of Bone Strength Measured by DensiProbe on Bone Related Fixation Failure
Hip fractures mostly occur in elderly people with low bone strength. Bone strength is determined by bone mineral density (BMD), bone turnover, microarchitectural and geometrical properties of the bone.
- Conditions
- Femoral Fractures, Hip Fractures, Osteoporosis, Bone Density
- Trial name
- Densiprobe (NCT00822159)
- Testing
- DensiProbe Hip
- Where
- 8 sites in Austria, Germany and 2 more
- Volunteers
- 198 people
- Sponsor
- AO Clinical Investigation and Publishing Documentation
Osteoporosis in Post-menopausal Women
Bone Health in Postmenopausal Women: The Effect of Exercise With or Without Medication for Osteoporosis
Osteoporosis is a systemic bone disorder characterised by a reduced bone mass and structural deterioration, increasing the risk of fragility fractures, particularly in women post-menopause.
- Trial name
- BEAT-OP (NCT07267325)
- Testing
- EXERCISE TRAINING, Antiresorptive medication (routine clinical care)
- Where
- United Kingdom
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Osteoporotic Fractures, Femoral Neck Fracture
Short-term Functional Recovery Between Early- and Late Bisphosphonate Treatment Following Hemiarthroplasty
Femoral neck fracture in the elderly is one indication for initiating osteoporosis treatment. Bisphosphonates remain the first line therapy; however, many orthopaedic surgeons concern regarding their effects on fracture healing…
- Trial name
- NCT02148848
- Testing
- Risedronate
- Where
- Thailand
- Volunteers
- 86 people
- Sponsor
- Mahidol University
Osteoporosis, Fractures, Spinal
Virtual Intervention for Vertebral frActure: a Pilot, Feasibility Study for a Multicentre Randomized Controlled Trial
Spine fractures are the most common fracture due to osteoporosis. They happen during falls or activities of daily life, like bending to tie shoes.
- Trial name
- VIVA (NCT06650410)
- Testing
- Virtual Intervention for Vertebral Fractures (VIVA)
- Where
- 4 sites in Canada
- Volunteers
- 34 people
- Sponsor
- University of Waterloo
Osteoporosis, Rheumatoid Arthritis
Performance of CT Parameters Compared to Bone Mineral Density to Detect Bone Fragility in Rheumatoid Arthritis
Objective: To evaluate the performance of CT parameters (SBAC-L1 and fractal analysis) compared to BMD (gold standard) to detect vertebral fractures in rheumatoid arthritis
- Conditions
- Osteoporosis, Rheumatoid Arthritis, Vertebral Fracture
- Trial name
- NCT04413448
- Where
- France
- Volunteers
- 260 people
- Sponsor
- Central Hospital, Nancy, France
Osteoporosis Fracture
Evaluating Fracture Risk Assessment Tools (FRAX) From Different Regions in Central South Chinese Postmenopausal Women
We evaluated fracture risk assessment tools (FRAXs) from different regions in Chinese postmenopausal women.
- Trial name
- NCT04960033
- Testing
- FRAX
- Where
- China
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Central South University
Osteoporosis
Secondary Prevention of Osteoporotic Fractures: a Multiple Center Fracture Liaison Service in Greece
This is multiple center, prospective study aiming to investigate the tracking and outcome of patients attending Greek General hospitals with low-trauma fractures.
- Trial name
- NCT02637180
- Testing
- anti-osteoporotic medication
- Where
- 4 sites in Greece
- Volunteers
- 397 people
- Sponsor
- Hellenic Society for the Study of Bone Metabolism
Vertebral Fracture, Osteoporosis
Effectiveness of Implementation of Opportunistic AI-screening for Vertebral Fractures in Clinical Practice
The aim of this study is to evaluate clinical effectiveness and cost-effectiveness after implementing a medically approved and commercially available AI support system for opportunistic vertebral fracture screening in CT…
- Trial name
- vertAIdo (NCT07100756)
- Testing
- AI vertebral fracture diagnostics (Flamingo)
- Where
- Sweden
- Volunteers
- 10,500 people
- Sponsor
- University Hospital, Linkoeping
Osteopenia, Osteoporosis
Extension Study to Evaluate the Long Term Safety and Efficacy of Denosumab in the Treatment of Osteoporosis
The primary objective was to describe the safety and tolerability of up to 10 years or 7 years denosumab administration as measured by adverse event monitoring, immunogenicity and safety laboratory parameters in participants who…
- Trial name
- NCT00523341
- Testing
- Denosumab
- Volunteers
- 4,550 people
- Sponsor
- Amgen
Osteoporosis, Diagnoses Disease
Normative Database for HR-pQCT-Based Radius and Tibia Strength
A novel methodology was recently developed and validated by the applicants to compute bone strength at the distal radius and tibia using second-generation HR-pQCT reconstructions.
- Conditions
- Osteoporosis, Diagnoses Disease, Fracture, Bone Strength
- Trial name
- NODARATIS (NCT03219099)
- Where
- Switzerland
- Volunteers
- 576 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Osteoporosis, Osteoporosis Fracture
Post-fracture Medication and Mortality
Osteoporotic fracture is a common public-health problem in the whole world. Although postfracture usage of anti-osteoporosis medications, may reduce mortality, recent results have been inconsistent.
- Conditions
- Osteoporosis, Osteoporosis Fracture, Drug Therapy, Mortality
- Trial name
- NCT05366621
- Testing
- Anti-osteoporosis medications
- Where
- Taiwan
- Volunteers
- 216,155 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Non-union or Delayed Healing Fractures
Evaluation of the Risk for Radiographic and Clinical Nonunion in Patients With Previous Bisphosphonates Therapy.
Dose and duration of bisphosphonate therapy will increase the likelihood that patients experience delayed healing of non-union fractures.
- Trial name
- NCT01731535
- Where
- United States
- Sponsor
- University of Wisconsin, Madison
Osteoporosis
Education for Osteoporosis in Persons With Existing Fractures
We wish to investigate whether a weekly, 2½ hour group-based osteoporosis education intervention (the Osteoporosis Prevention and Self-Management Course), is different to one session course (1x 2½ hours) on osteoporosis…
- Trial name
- NCT00575250
- Testing
- Osteoporosis Prevention and Self-Management Course, Introductory education session on osteoporosis
- Where
- Australia
- Volunteers
- 152 people
- Sponsor
- University of Adelaide
Cancer of Thyroid, Vertebral Fracture
Study of the Prevalence of Osteo-metabolic Complications in Patients With Thyroid Cancer
This is a multicenter retrospective observational study aimed to evaluate the prevalence of osteo-metabolic complications in patients with thyroid cancer.
- Conditions
- Cancer of Thyroid, Vertebral Fracture, Osteoporosis
- Trial name
- NCT06627998
- Testing
- Diagnostic (chest x-ray /DXA)and clinical data collected for clinical practice
- Where
- Italy
- Volunteers
- 82 people
- Sponsor
- IRCCS San Raffaele
Osteoporotic Fractures
Osteoporosis Associated Vertebral Fractures - Medical and Socio-economic Aspects in Austria
The purposes of this study were to analyse demographic, medical, gender and socio-economic aspects of osteoporosis associated vertebral fractures.
- Trial name
- NCT02403726
- Testing
- Operation, Non-operative treatment
- Volunteers
- 694 people
- Sponsor
- Medical University of Vienna