Clinical trials: Osteoporosis Risk
Osteoporosis, Metabolic Syndrome
Body Composition and Risk for Development of Pre-diabetes in Post-menopausal Chinese Women in Singapore
This project aims to ascertain that novel imaging and metabolic markers can be used to identify as well as to validate and improve the detection of Singapore-Chinese women at increased risk of diabetes.
- Trial name
- NCT03503552
- Where
- Singapore
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- JeyaKumar Henry
Osteoporosis, Postmenopausal, Exercise Therapy
Effects of Whole-Body Vibration and High Impact Exercises in Postmenopausal Women
We investigated the effects of whole body vibration (WBV) and high-impact (HI) exercises in postmenopausal women with low bone mineral density.
- Trial name
- NCT03910348
- Testing
- Whole-body vibration exercise, High-impact exercise
- Volunteers
- 58 people
- Sponsor
- Istanbul University
Osteoporosis Risk
Prune Consumption and Bone Health in Young Women Using Hormonal Contraceptives
The primary objective of this study is to determine if 12 months of consuming 50 grams of dried plum daily will prevent bone loss or augment bone accrual of young adult oral contraceptive (OC) users.
- Trial name
- NCT04785131
- Testing
- Prune
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Postmenopausal
A Study to Evaluate the Efficacy and Safety of HLX14 vs. Denosumab Prolia® in Postmenopausal Women With Osteoporosis at High Risk of Fracture
This is a randomized, double-blind, international multicentre, parallel-controlled phase III clinical study. The study plans to enroll 478 postmenopausal women with osteoporosis at high risk of fracture, whom will be randomized…
- Trial name
- NCT05352516
- Testing
- HLX14, Prolia®
- Where
- 38 sites in China
- Volunteers
- 514 people
- Sponsor
- Shanghai Henlius Biotech
Osteoporosis
Longitudinal Study of Bone Mineral Density in Survivors of Solid Pediatric Cancers
Specific subgroups of children who survive treatment for childhood malignancies have been shown to develop relative osteopenia following chemotherapy and are felt to be at risk for developing osteoporosis later in life due to…
- Trial name
- NCT00615485
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- State University of New York - Upstate Medical University
Osteopenia, Osteoporosis
Exercise and Fall Prevention for Fracture Reduction
According to the current guideline of the German Osteology Association (DVO), pharmacological treatment is a cornerstone of osteoporosis-related fracture prevention, effectively increasing bone mineral density and reducing…
- Conditions
- Osteopenia, Osteoporosis, High Fall Risk
- Trial name
- OsteoApp (NCT07897929)
- Testing
- Guideline-based home exercise training
- Where
- Germany
- Volunteers
- 72 people
- Sponsor
- Wolfgang Kemmler, PhD
HIV Infections, Drug Interaction
Variation in Drug Interactions in People With HIV (PLWH) Aged 60 Years and Older.
Several cohort studies have recently shown a significant increase in the mean age of PLWH ( People Living With HIV) and in the prevalence of people in advanced age in the various cohorts, as a result of the marked increase in the…
- Conditions
- HIV Infections, Drug Interaction, Elderly Infection, Comorbidities and Coexisting Conditions
- Trial name
- NCT06717581
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Breast Cancer, Metastatic Breast Cancer (MBC)
A Study of Romosozumab in People With Breast Cancer and Osteoporosis
The researchers are doing this study to see if romosozumab is effective at helping with bone formation in people with metastatic breast cancer (MBC) that has spread to the bones. All participants will have osteoporosis.
- Trial name
- NCT07776613
- Testing
- Romosozumab
- Where
- 7 sites in United States
- Volunteers
- 25 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Osteoporosis, Osteopenia or Osteoporosis
Assessment of Cortical Bone Mechanics Technology (CBMT) Fracture Discrimination Capability
Osteoporosis is a disease characterized by low bone mass and structural deterioration of bone tissue leading to bone fragility (i.e., weakness) and an increased risk for fracture.
- Conditions
- Osteoporosis, Osteopenia or Osteoporosis, Osteoporosis, Postmenopausal, Osteoporosis Risk
- Trial name
- STRONGER (NCT05721898)
- Testing
- Cortical Bone Mechanics Technology
- Where
- 5 sites in United States
- Volunteers
- 394 people
- Sponsor
- Ohio University
Atypical Femur Fracture
Personalizing Osteoporosis Care: Clinical & Genetic Risk Factors for AFFs
The overall objective of this project is to identify clinical and genetic risk factors for Atypical Femur Fractures (AFFs) in Anti-resorptive therapy (ART) users by conducting a case control study of 330 cases of AFFs and 660…
- Trial name
- NCT04110795
- Testing
- No Intervention
- Where
- 3 sites in Canada
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Postmenopausal Women With Osteoporosis
A Phase II Clinical Trial of the Safety and Efficacy of SAL056 at Different Doses and Dosing Regimens
This is a multicenter, randomized, open-label, parallel-controlled Phase II study designed to evaluate the differences in safety among four different dosing regimens of SAL056.
- Trial name
- NCT07579936
- Testing
- SAL056 56.5μg, Intervention Group 1, Intervention Group 2
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shenzhen Salubris Pharmaceuticals Co., Ltd.
Osteoporosis
Aquatic Verses Land Exercise to Decrease Fall Risk
Compare the effect of aquatic,land and no exercise on fall risk factors in women diagnosed with osteoporosis
- Trial name
- NCT00227071
- Testing
- exercise
- Where
- Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Postmenopausal Osteoporosis
Effects of Sensorimotor Balance Training vs Digitally Augmented Core Stabilization in Women With Osteoporosis
This randomized controlled trial aims to compare the effects of sensorimotor-based balance training and digitally augmented core stabilization on postural control and fall risk in postmenopausal women with osteoporosis.
- Trial name
- NCT07875894
- Testing
- Sensorimotor-Based Balance Training, Digitally Augmented Core Stabilization
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Stress Fracture
Determining the Risk of Stress Fracture in IDF Soldiers Based on SNPs Identified for Osteoporosis
The study is a genetic historical cohort study in a military combat recruits - this study does not examine a specific treatment but rather examines a statistical link between medical history of traumatic fractures, clinical…
- Trial name
- NCT03197545
- Where
- Israel
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
Osteoporosis
Opportunistic Fragility Fracture Risk Estimates From Radiographs
The proposed study will predict a patients' risk of having osteoporosis by using a combination of the IBEX BH (Bone Health) software outputs and other clinical risk factors such as age, gender, medical history and lifestyle.
- Trial name
- OFFER2 (NCT06110442)
- Testing
- IbexBH Software
- Where
- United Kingdom
- Volunteers
- 497 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Osteoporosis, Osteoarthritis
Resistance Exercise Training to Improve Bone and Articular Cartilage Health in Women
Osteoarthritis (degenerative joint disease) and osteoporosis (weak and fragile bones) are common conditions, particularly in women after menopause, and become even more common as we get older.
- Trial name
- REPROOF (NCT05889598)
- Testing
- Ballistic Resistance Lower Body Strength Training, Conventional Resistance Lower Body Strength Training
- Where
- United Kingdom
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Osteoporosis, Postmenopausal, Osteoporotic Fractures
Evaluation of a Decision Analysis Model in the DASH-Osteo Decision Aid.
Fragility fractures, often caused by low bone mineral density, are a major health concern for postmenopausal women. One way to prevent these fractures is by taking medication, but deciding whether to start treatment can be…
- Conditions
- Osteoporosis, Postmenopausal, Osteoporotic Fractures, Diphosphonates, Fracture Risk Assessment
- Trial name
- DASH-Osteo (NCT07120854)
- Testing
- Decision aid with decision analysis model, Decision aid alone, Usual Care
- Where
- Spain
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Osteoporosis, Fracture Risk Assessment
Five-Year CT Follow-Up of Vertebral Fracture Risk Using Opportunistic Osteoporosis Screening
This study evaluates whether opportunistic osteoporosis screening using routinely acquired computed tomography (CT) scans improves fracture risk prediction compared with guideline-recommended FRAX-based screening from age 50.
- Conditions
- Osteoporosis, Fracture Risk Assessment, Osteoporotic Fracture of Vertebra
- Trial name
- NCT07487688
- Testing
- Opportunistic osteoporosis screening
- Where
- Germany
- Volunteers
- 2,799 people
- Sponsor
- Technical University of Munich
Osteoporosis, Osteoporotic Fracture of Vertebra
Development and Evaluation of an Exercise Intervention for Prevention of Vertebral Osteoporosis and Deformity in Postmenopausal Women
Osteoporotic fractures of the vertebrae (bones in the back) cause substantial pain and disability. Exercise could help to prevent these fractures by increasing bone strength and improving posture.
- Conditions
- Osteoporosis, Osteoporotic Fracture of Vertebra, Postural, Thoracic Kyphosis
- Trial name
- NCT04660825
- Testing
- A resistance band exercise programme, Control
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Health Belief Model-Based Osteoporosis Education Programme
OSTEOPOROSIS EDUCATION AND ITS IMPACT ON OSTEOPOROSIS HEALTH BELIEFS AND AWARENESS IN WOMEN AT RISK OF OSTEOPOROSIS
Osteoporosis is a significant public health problem characterized by low bone mass and deterioration in the microarchitecture of bone tissue, leading to an increased risk of fractures.
- Trial name
- HBM-osteo-edu (NCT07486076)
- Testing
- Osteoporosis Education Based on the Health Belief Model
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Bartın Unıversity