Clinical trials: Osteoprotegerin
Osteopenia, Bone Metabolism Disorders
Effects of Aerobic Versus Resistance Training on Bone Metabolism in Stage 3-4 Chronic Kidney Disease
This randomized controlled trial investigates the comparative effects of aerobic versus resistance training on bone mineral density (BMD) and bone metabolism markers in patients with stage 3 or 4 chronic kidney disease (CKD).
- Conditions
- Osteopenia, Bone Metabolism Disorders, Chronic Kidney Disease (Stage 3-4), Mineral and Bone Disorder (CKD-MBD)
- Trial name
- CKD-BONE-EX (NCT07133256)
- Testing
- Resistance Exercise, Aerobic Training
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sinai University
Chronic Apical Periodontitis
Comparison of the Effects of N-acetylcysteine, Calcium Hydroxide, and Double Antibiotic Paste
This study aimed to evaluate the efficacy of N-acetylcysteine (NAC) used as an intracanal medicament on antibacterial activity, periapical RANKL/OPG ratio, and postoperative pain levels.
- Trial name
- NCT07340944
- Testing
- N Acetyl Cysteine, Calcium Hydroxide (Ca(OH)2), Double Antibiotic Paste
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Peri-Implantitis
Er,Cr:YSGG Laser Application in Peri-implantitis
In the present study, investigators, aimed to evaluate the effect of erbium, chromium:yttrium-scandium-gallium-garnet (Er,Cr:YSGG) laser application combined with mechanical debridement (MD) on clinical parameters and biochemical…
- Trial name
- NCT06031467
- Testing
- Er, Cr: YSGG laser-assisted non-surgical mechanical therapy, Non-surgical mechanical therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Adrenal Hyperplasia, Congenital
Role of the Protein Osteoprotegerin in the Bone Health of Women With Congenital Adrenal Hyperplasia
21-hydroxylase deficiency (21-OHD) is an inherited disorder that results from a mutation on the CYP21A2 gene. It affects the adrenal glands and is the most common cause of congenital adrenal hyperplasia (CAH).
- Trial name
- NCT00694525
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Office of Rare Diseases (ORD)
Periodontitis
Gingival Crevicular Fluid Levels of Sclerostin, Osteoprotegerin (OPG) and RANKL in Health, Disease and After Treatment
The primary objective of this case-control intervention study to explore the effectiveness of non surgical periodontal therapy on the gingival crevicular fluid (GCF) levels of sclerostin in patients with chronic periodontitis…
- Trial name
- NCT02390479
- Testing
- non surgical periodontal treatment
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Umut BALLI
Dental Implants, Osteoprotegerin
The Effect of Local Melatonin Application Around Immediately Placed Implants in the Maxillary Premolar
Background: Immediate implants provide ideal three-dimensional positioning compared to conventional implants. There may be a gap between the surface of the implant and the bone walls of the socket when it is inserted into a…
- Conditions
- Dental Implants, Osteoprotegerin, Melatonin
- Trial name
- NCT07103564
- Testing
- Immediately placed implant in maxillary premolars with local melatonin application, Immediately placed implant in maxillary premolars without local melatonin application
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Hams Hamed Abdelrahman
Osteoporosis
The Effects of Therapy With Teriparatide on Vascular Compliance and Osteoprotegerin/RANKL
The purpose of this study is to determine what effect teriparatide will have on vascular (blood vessel) compliance and osteoprotegerin (bone fluid)and RANKL levels (bone cells).
- Trial name
- NCT00347737
- Testing
- teriparatide
- Where
- United States
- Sponsor
- Leland Graves III, MD
Chronic Renal Failure
Effect of Omega 3 Fatty Acids on the Vascular Calcification Biomarkers Fetuin A and Osteoprotegerin in Patients With CRF
study the effect of omega 3fatty acids on the vascular calcification biomarkers Fetuin -A and Osteoprotegerin (OPG) in dialysis patients.
- Trial name
- CRF (NCT03982966)
- Testing
- Omega 3 fatty acids (fish oil) 1000 mg/day oral
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Damanhour University
Osteoporosis, Lupus Erythematosus, Systemic
Determination of the RANKL/Osteoprotegerin Ratio in Patients With Systemic Lupus Erythematosus. Role in Osteoporosis and Cardiovascular Calcification
Patients with Systemic lupus erythematosus (SLE) are known to present an increased risk of osteoporosis and cardiovascular calcification.
- Trial name
- CALCILUP (NCT02799173)
- Testing
- RANKL/OPG ratio, bone densitometry, fan beam CT scan
- Where
- 2 sites in France
- Volunteers
- 74 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Primary Hyperparathyroidism
OPG/Soluble RANKL (sRANKL) and Bone Mineral Density in Primary Hyperparathyroidism
The purpose of this study is to determine whether osteoprotegerin and RANKL (receptor activator of nuclear factor-κB ligand) are involved in bone remodeling in patients with primary hyperparathyroidism (PHPT), and whether…
- Trial name
- NCT01889134
- Testing
- Sedron (alendronate), Parathyroidectomy
- Where
- Poland
- Volunteers
- 112 people
- Sponsor
- Wroclaw Medical University
Prevalent OPG and RANKL Excession in Patients With CAD
Graz Osteoprotegerin as a Risk Factor (GORF) Study
Osteoprotegerin (OPG) is membrane bound in the immune system but can also be produced and secreted almost everywhere in the organism, so that it is mainly available in soluble form.
- Trial name
- NCT01574963
- Where
- Austria
- Volunteers
- 150 people
- Sponsor
- Medical University of Graz
Influence of 8 Months of Increased Physical Activity Workload on Osteoprotegerin and Endocan Levels
IPHAAB-study Influence of Physical Activity on Atherosclerosis Biomarkers
This study investigates the influence of an increased physical activity and sports workload in formerly nonsporting healthy individuals on current promising biomarkers of atherosclerosis research.
- Trial name
- NCT02097199
- Testing
- Increased sports workload
- Where
- Austria
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Hypogonadotropic Hypogonadism, Endothelial Dysfunction
Bone Mineral Markers in Hypogonadism
The aim of this study is to investigate the markers of bone mineral metabolism in an unconfounded group of patients with hypogonadism and to search for a relationship between endothelial dysfunction and insulin resistance.
- Conditions
- Hypogonadotropic Hypogonadism, Endothelial Dysfunction, Insulin Resistance
- Trial name
- NCT02062307
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Gulhane School of Medicine
Acute Charcot Neuroarthropathy
Clinico-Radiological Characterisation for Remission of Acute Charcot-Neuroarthropathy of Foot.
Charcot's neuro-arthropathy is a condition which is generally prevalent among the diabetic patients. Acute charcot's neuro-arthropathy is characterized by signs of inflammation, hot, red swelling around the involved joint along…
- Trial name
- NCT06017011
- Testing
- Total contact cast
- Where
- India
- Volunteers
- 25 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Periodontitis, Gingivitis
Evaluation of PTHrP, RANKL, and OPG Levels in Periodontal Health and Diseases
This observational study aims to evaluate the levels of specific biological markers-Parathyroid Hormone-Related Protein (PTHrP), RANKL, and Osteoprotegerin (OPG)-in the gingival crevicular fluid of individuals with different gum…
- Conditions
- Periodontitis, Gingivitis, Periodontal Disease
- Trial name
- NCT07793370
- Testing
- Routine periodontal clinical examination and GCF collection
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Preeclampsia, Gestational Hypertension
Evaluation of sFlt-1/PlGF Ratio ,OPG and sEng as Predictive Biomarkers in the Diagnosis and Treatment Evaluation of Preeclampsia
his study investigates the effectiveness of three specific biological markers (biomarkers) in the blood-the sFlt-1/PlGF ratio, soluble endoglin (sEng), and osteoprotegerin (OPG)-to better diagnose and monitor preeclampsia.
- Conditions
- Preeclampsia, Gestational Hypertension, Hypertensive Disorders of Pregnancy
- Trial name
- PE-POSS (NCT07349277)
- Where
- Iraq
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ammar Jassim Abed