Clinical trials: Other Disease/Injury
Diabetes, Prediabetes
Meta-Analyses of the Effect of Plant Protein Versus Animal Protein on Cardiometabolic Risk
Vegetarian diets have been associated with a reduced risk of preventable diseases such as type 2 diabetes and cardiovascular disease. These effects may be mediated through direct or indirect pathways.
- Conditions
- Diabetes, Prediabetes, Metabolic Syndrome, Dysglycemia
- Trial name
- NCT02037321
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- John Sievenpiper
Neurologic Diseases, Hemiparesis
NuroSleeve Powered Brace & Stimulation System to Restore Arm Function
The purpose of this study is to investigate if a person with weakness or paralysis in one or both arms, can use the NuroSleeve combined powered arm brace (orthosis) and muscle stimulation system to help restore movement in one…
- Conditions
- Neurologic Diseases, Hemiparesis, Quadriplegia, Muscular Dystrophies
- Trial name
- NCT04798378
- Testing
- Neurosleeve
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Intracranial Hypertension, Critical Illness
Mechanical Ventilation in Severe Brain Injury: The Effect of Positive End Expiratory Pressure on Intracranial Pressure
The purpose of this study is to collect physiologic data from patients with severe brain injury who require mechanical ventilation in order to describe the impact of ventilation, specifically positive end expiratory pressure…
- Conditions
- Intracranial Hypertension, Critical Illness, Brain Injuries, Lung Injury
- Trial name
- NCT02680704
- Testing
- PEEP titrated mechanical ventilation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Beth Israel Deaconess Medical Center
Dementia, Chronic Disease
Project to Improve Communication About Serious Illness--Hospital Study: Pragmatic Trial (Trial 1)
The objective of this protocol is to test the effectiveness of a Jumpstart intervention on patient-centered outcomes for patients with chronic illness by ensuring that they receive care that is concordant with their goals over…
- Conditions
- Dementia, Chronic Disease, Neoplasm Metastasis, Lung Neoplasm
- Trial name
- PICSI-H (NCT04281784)
- Testing
- EHR-based Clinician Jumpstart
- Where
- 3 sites in United States
- Volunteers
- 2,512 people
- Sponsor
- University of Washington
Sickle Cell Disease
TRF-1101 Assessment in Sickle Cell Disease
This study is designed to assess the safety, tolerability, and activity of TRF-1101 on microvascular blood flow, vascular endothelial injury, and vasoocclusive pain associated with sickle cell disease.
- Trial name
- NCT00773890
- Testing
- TRF-1101
- Where
- 6 sites in United States
- Volunteers
- 80 people
- Sponsor
- TRF Pharma, Inc
Ototoxicity, Drug-Induced
Sodium Thiosulfate Otoprotection During Salvage Cisplatin Therapy
This study will attempt to demonstrate the efficacy of Sodium Thiosulfate (STS) in preventing hearing loss in patients re-treated with cisplatin-based therapy according to regimens Cisplatin and STS (regimen CS) and Cisplatin…
- Trial name
- NCT05756660
- Testing
- Sodium Thiosulfate
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Chronic Kidney Disease
Simplified Rapid Hydration in Preventing CA-AKI Among Patients With Chronic Kidney Disease
No well-defined protocols exist to guide fluid administration for prevention of contrast-associated acute kidney injury in high risk patients.
- Trial name
- TIME (NCT02232997)
- Testing
- Standard Hydration, Simplified Hydration
- Where
- China
- Volunteers
- 1,002 people
- Sponsor
- Guangdong Provincial People's Hospital
Acute Kidney Injury
Combining CAF, L-FABP and NGAL as a Potentially Diagnostic Model for Acute Kidney Injury.
Acute kidney injury was a common clinical complication, and many diseases were associated with a high risk of occurrence of AKI.
- Trial name
- NCT04555382
- Testing
- Blood and Urine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
COVID-19
COVID-19 and Liver Injury in Patients With or Without Underlying Liver Disease: A Multi-centre Retrospective-prospective Observational Study
COVID-19 and liver injury in patients with or without underlying liver disease: A multi-centre retrospective-prospective observational study.
- Trial name
- NCT04422379
- Where
- India
- Volunteers
- 314 people
- Sponsor
- Max Healthcare Insititute Limited
Heart Failure, Cardiomyopathies
Multimodal Physiologic State Intelligence Study
The OMNIPHYS study will investigate whether multimodal ultrasound and other routinely collected clinical and physiologic data can be combined with artificial intelligence to characterize changes in a person's physiologic state…
- Conditions
- Heart Failure, Cardiomyopathies, Pulmonary Hypertension, Myocarditis; Acute or Subacute
- Trial name
- OMNIPHYS (NCT07814118)
- Testing
- OMNIPHYS Multimodal Ultrasound Imaging System
- Where
- United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Cardiac Allograft Vasculopathy, Endothelial Dysfunction
Determining the Association of Microvascular Disease as Assessed by PET and Graft Injury by Donor Derived Cell Free DNA
The goal of this research study is to understand if a blood test in people who have had heart transplants can detect and predict the following: Blockages in the small blood vessels of the heart.
- Conditions
- Cardiac Allograft Vasculopathy, Endothelial Dysfunction, Microvascular Coronary Artery Disease
- Trial name
- DEPICT (NCT05756088)
- Testing
- Blood draw to measure the levels of dd-cf DNA
- Where
- United States
- Sponsor
- Yale University
Acute Kidney Injury, Chronic Kidney Diseases
Impact on Mortality of Screening for Kidney Disease Associated With a Specialized Intervention During Hospitalization in a Territorial Hospital Trust
Kidney disease in its chronic or acute form shares many risk factors for initiation, progression and prognosis with an increase in morbidity and mortality, the length of hospitalization and the cost associated with stages of…
- Trial name
- WARNING KD (NCT05033652)
- Testing
- WARNING KD
- Where
- 3 sites in France
- Volunteers
- 1,179 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Prematurity; Extreme, Inflammation
Anakinra for Preterm Infants Pilot
Phase I/II study of anakinra to prevent the impact of perinatal inflammation in extremely premature infants.
- Trial name
- NCT05280340
- Testing
- Anakinra
- Where
- 2 sites in Australia, New Zealand
- Volunteers
- 25 people
- Sponsor
- Monash Medical Centre
Head Trauma, Traumatic Brain Injury
Does Discontinuation of Aspirin Treatment Following Head Trauma Decrease the Incidence of Chronic Subdural Hematoma?
Anti-aggregation therapy, including treatment with low-dose aspirin (LDA) is an established risk factor for intracranial hemorrhage, including chronic subdural hematoma (CSDH); however evidence guiding the decision to continue or…
- Conditions
- Head Trauma, Traumatic Brain Injury, Chronic Subdural Hematoma
- Trial name
- NCT01470040
- Testing
- discontinuation of aspirin therapy, continuation of aspirin therapy
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Coronavirus Disease 2019 (COVID-19), Acute Lung Injury
Dociparstat for the Treatment of Severe COVID-19 in Adults at High Risk of Respiratory Failure
This was a randomized, double-blind, placebo-controlled Phase 2/3 study to evaluate the safety and efficacy of dociparstat sodium in adult patients with acute lung injury (ALI) due to Coronavirus Disease 2019 (COVID-19).
- Conditions
- Coronavirus Disease 2019 (COVID-19), Acute Lung Injury, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
- Trial name
- NCT04389840
- Testing
- Dociparstat sodium
- Where
- 12 sites in United States
- Volunteers
- 27 people
- Sponsor
- Jazz Pharmaceuticals
Aging, Alzheimer Disease
The Nightlight Falls Prevention Study
This project will test the effectiveness of a novel intervention consisting of unobtrusive, low-intensity, horizontal and vertical lights that outline the bathroom or entry way doorframe in residents' rooms and provide visual…
- Conditions
- Aging, Alzheimer Disease, Dementia Alzheimers, Dementia of Alzheimer Type
- Trial name
- NCT05973448
- Testing
- Novel Lighting Condition, Control Lighting Condition
- Where
- United States
- Volunteers
- 335 people
- Sponsor
- University of North Carolina, Chapel Hill
Kidney Disease
Effects of Dexmedetomidine on Microcirculation of Kidney Transplant Recipient
The microcirculation is altered in acute kidney injury and chronic kidney disease. The microcirculation is poor in end-stage renal disease patients receiving hemodialysis.
- Trial name
- NCT02707809
- Testing
- Dexmedetomidine
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Critical Illness, Acute Kidney Injury
Development of a Web-based Multicenter Registry on the Use of oXiris Membrane for EBPTs in Critically Ill Patients
The use of extracorporeal blood purification therapies (EBPT) is becoming increasingly widespread worldwide in everyday clinical practice, particularly in the critical care setting.
- Conditions
- Critical Illness, Acute Kidney Injury, Sepsis, Systemic Inflammatory Response Syndrome
- Trial name
- NCT03807414
- Testing
- oXiris
- Where
- 12 sites in Italy
- Volunteers
- 270 people
- Sponsor
- Careggi Hospital
Lung Disease, Brain Injury
Genomics, Single Nucleotide Polymorphisms (SNPs), and Clinical Neonatology
This research seeks to establish a neonatal DNA Tissue Bank to find out if differences in small segments of DNA predispose babies to Chronic Lung Disease (CLD), Periventricular Brain Injury (PVI), Necrotizing Enterocolitis (NEC)…
- Conditions
- Lung Disease, Brain Injury, Necrotizing Enterocolitis, Respiratory Failure
- Trial name
- NCT00315263
- Where
- 2 sites in United States
- Volunteers
- 63 people
- Sponsor
- Children's Mercy Hospital Kansas City
Alzheimer Disease
A Clinical Trial for an Evaluation of Choline Alfoscerate and Donepezil for Cognitive Improvements of Patients With Cerebrovascular Injury in Alzheimer Patients
The purpose of this study is to evaluate efficacy and safety of Choline alfoscerate and Donepezil for cognitive improvements of patients with cerebrovascular injury in Alzheimer patients
- Trial name
- NCT02648906
- Testing
- Choline alfoscerate
- Where
- South Korea
- Volunteers
- 128 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.