Clinical trials: Other Disease/Injury
Coronary Artery Disease, Angina, Unstable
Contrast-associated Acute Kidney Injury in Patients With Different Types of Coronary Artery Disease
The goal of the study is to assess the prevalence of contrast-associated acute kidney injury in patients with stable coronary artery disease, ST-elevation myocardial infarction and unstable angina/NSTEMI, assess the risk factors…
- Conditions
- Coronary Artery Disease, Angina, Unstable, Angina, Stable, STEMI - ST Elevation Myocardial Infarction
- Trial name
- NCT04163484
- Testing
- Iodinated contrast
- Where
- Russia
- Volunteers
- 156 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Chronic Traumatic Encephalopathy
The DIAGNOSE-CTE Research Project
This is a study to develop methods of diagnosing chronic traumatic encephalopathy (CTE) during life, as well as to examine possible risk factors for this neurodegenerative disease.
- Trial name
- DIAGNOSE-CTE (NCT02798185)
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Boston University
COVID-19
A Randomized, Double-Blind, Placebo-Controlled Phase 2/3 Study to Determine the Safety and Effectiveness of Azeliragon in the Treatment of Patients Hospitalized for Coronavirus Disease 2019 (COVID-19) or Pneumonia
A new drug called azeliragon could be used to treat patients with COVID-19 or other pneumonia infections but the researchers don't know.
- Trial name
- NCT05815485
- Testing
- Azeliragon
- Where
- 3 sites in United States
- Volunteers
- 144 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Cholestasis
Omegaven® as Parenteral Nutrition
The purpose of this study is to determine if a fat emulsion comprised of omega-3 fatty acids, Omegaven, would be beneficial in the management of steatotic liver injury in parenteral nutrition (PN) by its inhibition of de novo…
- Trial name
- NCT02334293
- Testing
- Omegaven
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Carle Foundation Hospital
Alcohol and Substance-Related Mental Disorders
Effectiveness of an Evidence-based Stepped Care System for Alcohol and Other Drug Use Problems Among Congolese Refugees in Zambia
This is a randomized controlled trial (RCT) evaluating the effectiveness of a screening, brief intervention, and referral to treatment (SBIRT) stepped-care system in reducing unhealthy AOD use among Congolese refugees and the…
- Trial name
- NCT05471921
- Testing
- SBIRT, Treatment as usual
- Where
- 2 sites in United States, Zambia
- Volunteers
- 400 people
- Sponsor
- Columbia University
Acute Kidney Injury in Critically Ill Children
Utility of NGAL to Diagnose AKI in Critically Ill Children
Acute Kidney Injury is common in critically ill children and is associated with high morbidity and mortality in pediatric intensive care unit.
- Trial name
- NCT03034876
- Volunteers
- 140 people
- Sponsor
- Aga Khan University
Cartilage Injury, Cartilage Disease
Long-term Outcome Evaluation of Patients Undergoing Autologous Chondrocyte Transplantation Delivered on Biomaterial
Chondro-Long study is prospective observational study for a long-term clinical evaluation (follow-up up to 25 years) in patients treated with autologous chondrocyte transplantation delivered on biomaterial for full-thickness…
- Trial name
- NCT06238947
- Volunteers
- 200 people
- Sponsor
- Istituto Ortopedico Rizzoli
Disorders of Consciousness, Acquired Brain Injury
Spontaneous Eye Blinking Evaluation for Cognitive Assessment of Individuals With Severe Acquired Brain Injury
Assessment of consciousness and attention in individuals with severe Acquired Brain Injury (sABI) is crucial for planning rehabilitation, but it is often hindered by coexisting sensory-motor and/or cognitive-behavioural…
- Trial name
- SEE-ABI (NCT06464549)
- Testing
- EEG-EOG recording at rest and during an auditory oddball paradigm
- Where
- 2 sites in Italy
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Alfonso Magliacano
Critical Illness, Acute Kidney Injury
Development of a Web-based Multicenter Registry on the Use of oXiris Membrane for EBPTs in Critically Ill Patients
The use of extracorporeal blood purification therapies (EBPT) is becoming increasingly widespread worldwide in everyday clinical practice, particularly in the critical care setting.
- Conditions
- Critical Illness, Acute Kidney Injury, Sepsis, Systemic Inflammatory Response Syndrome
- Trial name
- NCT03807414
- Testing
- oXiris
- Where
- 12 sites in Italy
- Volunteers
- 270 people
- Sponsor
- Careggi Hospital
Brain Injury, Chronic, Intellectual Disability, Mild to Moderate
The (Cost)Effectiveness of a Social Robot for Persons With Problems in Daily Structure and Planning in Disability Care
The goal of this multiple baseline single case study is to study the (cost)effectiveness of a social robot in reducing professional caregiver support and promoting independence for individuals in long-term disability care…
- Conditions
- Brain Injury, Chronic, Intellectual Disability, Mild to Moderate, Autism Spectrum Disorder, Down Syndrome
- Trial name
- NCT06592404
- Testing
- Robot Tessa
- Where
- 4 sites in Netherlands
- Volunteers
- 32 people
- Sponsor
- Academy Het Dorp
Diabetes Mellitus, Chronic Kidney Disease
Rosuvastatin Prevent Contrast Induced Acute Kidney Injury in Patients With Diabetes
The number of cardiac angiography and percutaneous coronary interventions (PCI) has increased steadily in recent years. This has resulted in the increasing incidence of contrast-induced acute kidney injury (CIAKI).
- Trial name
- TRACK-D (NCT00786136)
- Testing
- rosuvastatin
- Where
- 53 sites in China
- Volunteers
- 2,998 people
- Sponsor
- Shenyang Northern Hospital
Post Traumatic Stress Disorder, PTSD
Effectiveness of Trauma Therapy Using Prolonged Exposure for Patients With PTSD and a Comorbid Psychotic Disorder
Psychosis patients with comorbid PTSD will be treated with trauma therapy.
- Conditions
- Post Traumatic Stress Disorder, PTSD, Psychosis
- Trial name
- TEP (NCT06048172)
- Testing
- Prolonged Exposure
- Where
- Germany
- Volunteers
- 56 people
- Sponsor
- Medicalschool Hamburg
Silicosis
The SHIELD Study-silicosis
An observational cohort study to derive biomarkers which are able to more accurately diagnose silicosis, as well as predict disease progression, assess response to treatment, and hasten therapeutic discovery.
- Trial name
- NCT05546944
- Where
- Australia
- Volunteers
- 120 people
- Sponsor
- The University of Queensland
Diabetes Mellitus, Type 2, Coronary Artery Disease
POST-CABGDM: Empagliflozin in Perioperative CABG
Introduction: Diabetes Mellitus (DM) is a condition known to be associated with coronary artery disease (CAD) and its role as promoter of atherosclerosis is well stablished.
- Conditions
- Diabetes Mellitus, Type 2, Coronary Artery Disease, Coronary Artery Bypass Surgery, Acute Kidney Injury
- Trial name
- POST-CABGDM (NCT04523064)
- Testing
- Empagliflozin 25 MG
- Where
- Brazil
- Volunteers
- 155 people
- Sponsor
- University of Sao Paulo General Hospital
Critically Ill, Cancer
Spironolactone Administration to Prevent Ischemic Kidney Injury in Critically Ill Cancer Patients
Acute kidney injury frequently affects cancer patients. The main cause of acute kidney injury is ischemic damage caused by transient decrease in renal blood flow, followed by blood flow restoration and accompanying reperfusion…
- Trial name
- SPIROCAN (NCT02531412)
- Testing
- Spironolactone
- Where
- Mexico
- Volunteers
- 24 people
- Sponsor
- Instituto Nacional de Cancerologia de Mexico
Coronary Heart Disease, Coronary Artery Disease
Study of Sivelestat Sodium in OPCABG
The goal of this clinical trial is to learn if drug Sivelestat Sodium works to improve the prognosis of off-pump coronary artery bypass grafting (OPCABG) in adults. It will also learn about the safety of drug Sivelestat Sodium.
- Conditions
- Coronary Heart Disease, Coronary Artery Disease, Coronary Arterial Disease (CAD)
- Trial name
- NCT07118930
- Testing
- Sivelestat Sodium injection 2 h after OPCABG for 72 h, Saline (0.9% NaCl)
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Affiliated Hospital of Nantong University
Acute Kidney Injury, Kidney Failure Chronic
French AKI Registry (FAKIR): A Multicenter Study on the In-Hospital Management and Outcomes of Severe Acute Kidney Injury in Nephrology Units
Acute Kidney Injury (AKI) is a common and serious condition in hospitalized patients, especially when it reaches stages 2 or 3 according to the KDIGO classification.
- Conditions
- Acute Kidney Injury, Kidney Failure Chronic, Cardiorenal Syndrome, Renal Replacement Therapies
- Trial name
- FAKIR (NCT07123324)
- Volunteers
- 750 people
- Sponsor
- University Hospital, Strasbourg, France
Necrotizing Enterocolitis, Intraventricular Hemorrhage
PUFAs in Preterm Infants
The research endeavors to examine the critical composition of Polyunsaturated Fatty Acids (PUFAs) in premature infants across different gestational stages and under varying disease conditions, and delineate the metabolic…
- Conditions
- Necrotizing Enterocolitis, Intraventricular Hemorrhage, BPD - Bronchopulmonary Dysplasia, Sepsis
- Trial name
- PIPI (NCT06045130)
- Volunteers
- 600 people
- Sponsor
- The First Hospital of Jilin University
Acute Renal Failure
Phase I Study of Alpha-Melanocyte Stimulating Hormone in Patients With Acute Renal Failure
OBJECTIVES: I. Determine the maximum tolerated dose and safety of alpha-melanocyte stimulating hormone (alpha-MSH) in patients with acute renal failure. II.
- Trial name
- NCT00004496
- Testing
- alpha-melanocyte stimulating hormone
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- University of Texas
Opioid Use, Substance Use
Preventing Opioid Use Among Justice-involved Youth as They Transition to Adulthood Leveraging Safe Adults (LeSA)
Across the US, substance use is a significant public health concern, with juvenile justice (JJ)-involved youth representing a particularly vulnerable population.
- Trial name
- LeSA (NCT04678960)
- Testing
- Trust-based Relational Intervention Training, Trust-based Relational Intervention In-Home Structured Coaching, Trust-based Relational Intervention In-Home Responsive Coaching
- Where
- 11 sites in United States
- Volunteers
- 250 people
- Sponsor
- Texas Christian University
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