Clinical trials: Other Disease
Crohn Disease
Prospective Observational Study on Ustekinumab (Stelara) Assessing Efficacy and Healthcare Resource Utilization in Crohn's Disease
The main purpose of this study is to assess ustekinumab's ability to induce clinical response and remission ("effectiveness") at Week 16 and remission at Week 52 and Week 104 in participants with Crohn's disease (CD).
- Trial name
- PROSE (NCT03495973)
- Testing
- Ustekinumab
- Where
- Sweden
- Volunteers
- 114 people
- Sponsor
- Janssen-Cilag Ltd.
Fabry Disease
Treatment Protocol of Replagal for Patients With Fabry Disease
The study will evaluate the safety and efficacy of Replagal® (agalsidase alfa) at a dose of 0.2 mg/kg infused intravenously (IV) over 40 minutes, every other week.
- Trial name
- NCT01031173
- Testing
- agalsidase alfa
- Where
- 25 sites in United States
- Sponsor
- Shire
Alzheimer Disease
SAGE-LEAF: Reducing Burden in Alzheimer's Disease Caregivers Through Positive Emotion Regulation and Virtual Support
The goal of the proposed study, is to adapt a positive emotion intervention for Alzheimer's Disease (AD) caregivers into a self-guided online format that incorporates social connection components and adaptive system feedback…
- Trial name
- SAGE-LEAF (NCT05562583)
- Testing
- SAGE LEAF
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- BrightOutcome
Prolonged QT Interval in EKG and Sudden Death
Influence of Progesterone Administration on Drug-Induced QT Interval Lengthening
Female sex is an independent risk factor for the potentially fatal drug-induced arrhythmia (irregular heartbeat) known as torsades de pointes (TdP), which is associated with prolongation of the corrected QT (QTc) interval on the…
- Trial name
- NCT01929083
- Testing
- Progesterone, Ibutilide
- Where
- 2 sites in United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Indiana University
Atherosclerosis
Natural History of Atherosclerosis
20 patients will be recruited. The aim of the study is to determine the natural progression of atherosclerotic disease.
- Trial name
- NCT00918541
- Where
- 3 sites in Switzerland
- Volunteers
- 30 people
- Sponsor
- University of Zurich
Clozapine, Parkinson's Disease (PD)
Clozapine-related Immunodeficiency in Parkinsons Disease
Clozapine is a second generation antipsychotic drug used in psychiatry to treat schizophrenia, affective disorders or certain symptoms of dementia.
- Conditions
- Clozapine, Parkinson's Disease (PD), Immunodeficiency, Psychosis
- Trial name
- CLOZIDPD (NCT06634641)
- Testing
- blood test
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Knee Osteoarthritis, Metabolic Disease
Bracing for Patellofemoral Osteoarthritis
BACKGROUND: Despite the prevalence of patellofemoral ostearthritis (OA), this joint has received relatively little attention in the OA literature and there are few treatment options for individuals with patellofemoral OA.
- Trial name
- NCT02984254
- Testing
- Womac, Lequesne, Timed-up-and-go (TUG)
- Volunteers
- 52 people
- Sponsor
- University of Sao Paulo General Hospital
Mucopolysaccharidosis II
Phase I/II Study of Retroviral-Mediated Transfer of Iduronate-2-Sulfatase Gene Into Lymphocytes of Patients With Mucopolysaccharidosis II (Mild Hunter Syndrome)
OBJECTIVES: I. Evaluate the safety and feasibility of treating mucopolysaccharidosis II (mild Hunter syndrome) by lymphocyte gene therapy. II.
- Trial name
- NCT00004454
- Testing
- lymphocyte gene therapy
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
COPD
A Dose Ranging Study of Arformoterol Given Once Daily Compared to Arformoterol Given Twice Daily in Subjects With Chronic Obstructive Pulmonary Disease (COPD)
A dose ranging study to evaluate the safety, tolerability and efficacy of arformoterol (given once or twice a day) in subjects with COPD.
- Trial name
- NCT00691405
- Testing
- Arformoterol tartrate inhalation solution
- Where
- 31 sites in United States
- Volunteers
- 215 people
- Sponsor
- Sumitomo Pharma America, Inc.
Dialysis, Chronic Kidney Disease
Next Generation Advanced Insulin Delivery System in Adults With Diabetes and Advanced Renal Disease
The goal of this this randomized, clinical trial is to test an automated insulin delivery system (AID) in people with type 1 or type 2 diabetes who are on hemodialysis, peritoneal dialysis, or have advanced chronic kidney disease…
- Conditions
- Dialysis, Chronic Kidney Disease, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
- Trial name
- NCT06330194
- Testing
- 2nd Generation Automated Insulin Delivery (AID) system
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Steno Diabetes Center Copenhagen
Respiratory Tract Diseases, Respiratory Hypersensitivity
Effects Of Ciclesonide And Beclomethasone On Lens Opacification In Adult Subjects With Moderate To Severe Persistent Asthma
The primary objective is to demonstrate the non-inferiority of ciclesonide compared to beclomethasone-HFA in the occurrence of Class 1 lens event for nuclear (NO), cortical (C), or posterior subcapsular (P) lens opacification…
- Conditions
- Respiratory Tract Diseases, Respiratory Hypersensitivity, Asthma
- Trial name
- NCT00254956
- Testing
- ciclesonide (XRP1526)
- Where
- France
- Volunteers
- 1,568 people
- Sponsor
- Sanofi
Schizophrenia
The Efficacy and Safety of a Selective Estrogen Receptor Beta Agonist (LY500307) for Negative Symptoms and Cognitive Impairment Associated With Schizophrenia
The primary objectives of this application are to determine if the selective ERβ agonist LY500307, when added to antipsychotic medications, improves negative and/or cognitive symptoms in patients with schizophrenia.
- Trial name
- Beta (NCT01874756)
- Testing
- LY500307 150mg, LY500307 75mg, LY500307 25mg
- Where
- 4 sites in United States
- Volunteers
- 95 people
- Sponsor
- Indiana University
End-stage Renal Disease, Kidney Failure, Chronic
Safety and Efficacy of a Vascular Prosthesis for Hemodialysis Access in Patients With End-Stage Renal Disease
The purpose of this study is to assess the safety and efficacy of a novel, tissue-engineered vascular prosthesis, the Human Acellular Vascular Graft, HAVG.
- Trial name
- NCT01840956
- Testing
- HAVG
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Humacyte, Inc.
Cardiac Sarcoidosis, Infective Endocarditis
A Prospective Diagnostic Trial of Al[¹⁸F]F-NOTA-folate PET in Patients With Suspected Cardiac Sarcoidosis and Infective Endocarditis
The goal of this prospective diagnostic study is to evaluate the imaging characteristics, diagnostic performance, radiation dosimetry, and safety of Al[¹⁸F]F-NOTA-folate PET imaging in patients with suspected cardiac sarcoidosis…
- Trial name
- FOL-CARD (NCT07814222)
- Testing
- Al[¹⁸F]F-NOTA-folate PET imaging, [15O]water PET imaging, Echocardiography
- Where
- Finland
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Chronic Lymphocytic Leukemia
Protocol to Obtain Blood Samples for Leukemia Research
The purpose of this study is to collect a blood sample in patients with Chronic Lymphocytic Leukemia (CLL).
- Trial name
- NCT00889031
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 187 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Critical Illness, Hyperglycemia
Early Glucose States and 72-Hour Care-Metabolic Clusters in Critically Ill Patients
Blood glucose patterns during critical illness may change together with treatment, nutritional support, organ support, and the frequency of glucose monitoring.
- Trial name
- NCT07851545
- Testing
- Early glucose state, 72-hour integrated care-metabolic cluster
- Where
- China
- Volunteers
- 5,109 people
- Sponsor
- Shanghai Zhongshan Hospital
Ventilator-associated Pneumonia
Comparison of the Frequency of Ventilator-Associated Pneumonia in Intubated Patients Followed Up With Automatic Cuff Pressure Controller and Manual Cuff Pressure Controller in Pediatric Intensive Care
This study was designed to compare manual (intermittent) versus automatic (continuous) endotracheal cuff pressure monitoring for the prevention of ventilator-associated pneumonia (VAP) in mechanically ventilated pediatric…
- Trial name
- NCT05918172
- Testing
- endotracheal cuff pressure manual measurement, endotracheal cuff pressure automatic measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 241 people
- Sponsor
- Istanbul Medeniyet University
Pancreatic Ductal Adenocarcinoma, Colorectal Adenocarcinoma
A Vaccine (Ad5.F35-hGCC-PADRE) for the Treatment of Gastrointestinal Adenocarcinoma
The goal of this clinical trial is to learn whether the Ad5.F35-hGCC-PADRE vaccine is safe and can stimulate an immune response against gastrointestinal (GI) cancers in patients with pancreatic, colorectal, esophageal, gastric…
- Conditions
- Pancreatic Ductal Adenocarcinoma, Colorectal Adenocarcinoma, Gastric Adenocarcinoma, Clinical Stage II Gastric Cancer AJCC v8
- Trial name
- NCT04111172
- Testing
- Adenovirus 5/F35-Human Guanylyl Cyclase C-PADRE
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Thomas Jefferson University
Leukemia, Lymphoma
Total-Body Irradiation, Tacrolimus, and Mycophenolate Mofetil Plus Bone Marrow Transplantation in Treating Patients With Hematologic Cancers
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Bone marrow transplantation may be able to replace immune cells that have been destroyed by radiation therapy used to kill tumor cells.
- Conditions
- Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes
- Trial name
- NCT00003572
- Testing
- peripheral blood lymphocyte therapy, mycophenolate mofetil, tacrolimus
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Parkinson Disease, Nutritional and Metabolic Diseases
Influence of Glucose on Metabolism and Clinical Symptoms of Patients With Parkinson's Disease
Many patients with Parkinson's Disease (PD) report an increased consumption of fast-acting sugars. This tendency to consume sweet, high-sugar foods occurs in some patients even before the onset of cardinal motor symptoms.
- Conditions
- Parkinson Disease, Nutritional and Metabolic Diseases, Sugar Intake
- Trial name
- PaGlu (NCT05998772)
- Testing
- Oral Glucose Tolerance Test
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Schleswig-Holstein
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