Clinical trials: Other Disease
Coronavirus, Inflammation
Treatment of Patients With Mild Coronavirus-19 (COVID-19) Disease With Methotrexate Associated to LDL Like Nanoparticles (Nano-COVID19)
The investigators propose a prospective, randomized, double-blind, placebo-controlled study, conducted in two phases. The purpose of the study is to evaluate the safety and efficacy of methotrexate in a cholesterol-rich…
- Conditions
- Coronavirus, Inflammation, Covid19
- Trial name
- Nano-COVID19 (NCT04610567)
- Testing
- Methotrexate-LDE phase 1, Methotrexate-LDE phase 2
- Where
- 3 sites in Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo General Hospital
Atherosclerosis, Cardiovascular Diseases
Mediators of Atherosclerosis in South Asians Living in America
South Asian (Indian, Pakistani, Bangladeshi, Nepali, and Sri Lankan) individuals have high rates of cardiovascular disease that is not explained by traditional cardiovascular risk factors.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Coronary Artery Disease
- Trial name
- MASALA (NCT01207167)
- Where
- 3 sites in United States
- Volunteers
- 2,314 people
- Sponsor
- University of California, San Francisco
Ventricular Tachyarrhythmia
Change in Heart Rate Variability Prior to Tachyarrhythmia in ICD Implanted Patients
To investigate changes in HRV during the time before a spontaneous episode of ventricular tachyarrhythmia.
- Trial name
- HRV (NCT00701467)
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
Anxiety Disorder, Panic Disorder
Vestibular Dysfunction In Adult Patients With Panic Disorder With or Without Agoraphobia
OBJECTIVES: I. Determine whether the prevalence of abnormalities on clinical vestibular (balance) tests is higher in panic disorder with agoraphobia than in uncomplicated panic disorder and nonpanic anxiety disorder. II.
- Trial name
- NCT00004367
- Testing
- Clinical vestibular tests
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Breast Cancer, Autoimmune Disease
Continuation of Follow-up of DES-Exposed Cohorts
Diethylstilbestrol (DES), a drug first synthesized in 1938, was administered to several million pregnant women in the U.S. and Europe for the prevention of spontaneous abortion and premature delivery.
- Conditions
- Breast Cancer, Autoimmune Disease, Prostate Cancer, Ovarian Cancer
- Trial name
- NCT00340600
- Where
- United States
- Volunteers
- 10,805 people
- Sponsor
- National Cancer Institute (NCI)
Congestive Heart Failure, Chronic Obstructive Pulmonary Disease
Evaluation of Remote Patient Monitoring.
Nottingham Primary Care Trust has launched telemonitoring to support: independent living and self-management ability of people with congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD) and co-morbidities…
- Trial name
- NCT00789100
- Where
- United Kingdom
- Sponsor
- Brunel University
Pulmonary Disease, Chronic Obstructive
Safety And Efficacy Of UK-432,097 In Chronic Obstructive Pulmonary Disease.
Safety and efficacy (measured by spirometry) of UK-432,097 administration will be tested in patients with chronic obstructive pulmonary disease.
- Trial name
- NCT00430300
- Testing
- UK-432,097
- Where
- 22 sites in Australia, Canada and 3 more
- Volunteers
- 87 people
- Sponsor
- Pfizer
Dry Eye Disease
A Study Designed to Evaluate Tear Production
The purpose of this study is to evaluate tear production following acute administration of AR-15512 ophthalmic solution 0.003% (0.003% AR-15512) in subjects with dry eye disease (DED).
- Trial name
- NCT06544707
- Testing
- 0.003% AR-15512 ophthalmic solution
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Alcon Research
Extensive Disease Small Cell Lung Cancer
Sintilimab Combined With Anlotinib as Second or Further-line Therapy for ED-SCLC
Small cell lung cancer (SCLC) accounts for 10-15% of lung cancer. More than 70% of SCLC patients are diagnosed with advanced stage (ED-SCLC) at diagnosis.
- Trial name
- NCT04055792
- Testing
- Sintilimab
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Henan Cancer Hospital
Schizophrenia
A Follow-on Study of the Long-Term Safety of Aripiprazole in Patients With Chronic Schizophrenia
The primary objective of the study was to determine the safety of aripiprazole administered long-term in doses ranging from 10 to 30 mg per day as a maintenance therapy in subjects with chronic or first episode of schizophrenia.
- Trial name
- NCT02435836
- Testing
- Aripiprazole
- Volunteers
- 631 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Paroxysmal Supraventricular Tachycardia
Study on Left Atrial Function of Paroxysmal Supraventricular Tachycardia After Radiofrequency Ablation
This study to investigate the effects of RF ablation on left atrial systolic function in patients with atrioventricular nodal reentrant tachycardia (AVNRT) and atrioventricular tachycardia (AVRT).
- Trial name
- NCT03348436
- Testing
- radiofrequency ablation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Ruiqin xie
Obesity
Rural Engagement in Primary Care for Optimizing Weight Reduction
The purpose of this study is to compare three methods for managing obesity in rural patients, to see which method will result in patients being able to attain their weight loss goal and maintain that weight loss.
- Trial name
- RE-POWER (NCT02456636)
- Testing
- Fee-for-Service Model (FFS, In clinic individual visits), Patient Centered Medical Home (PCMH, In clinic group visits), Disease Management (DM, Phone group visits)
- Where
- United States
- Volunteers
- 1,432 people
- Sponsor
- University of Kansas Medical Center
Atopic Dermatitis
A Study to Assess Disease Activity in Adolescent and Adult Participants With Atopic Dermatitis Who Receive Oral Upadacitinib Tablets in a Real-World Setting
Atopic dermatitis (AD) is a skin condition that may cause a rash and itching due to inflammation of the skin. Therapies spread over the skin may not be enough to control the AD in trial participants who require systemic…
- Trial name
- UP-TAINED (NCT05139836)
- Where
- 125 sites in Germany
- Volunteers
- 634 people
- Sponsor
- AbbVie
Schizophrenia Spectrum
Target Engagement for Oxytocin: Dose Ranging Study
This study will evaluate the effect of 8 doses of intranasal oxytocin or placebo on two proposed measures of target engagement in brain.
- Trial name
- R21Dose (NCT02498236)
- Testing
- Intranasal Oxytocin
- Volunteers
- 51 people
- Sponsor
- University of California, Los Angeles
Parkinson's Disease
Striatal and Extra-striatal Mechanisms of Falling in Parkinson's Disease
This research study will evaluate functions of memory, thinking, eye movements and walking and how these relate to the measurement of certain chemicals (acetylcholine and dopamine) in the brain using an imaging procedure called…
- Trial name
- NCT00736671
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Hepatitis B, Chronic, Acute-On-Chronic Liver Failure
Combination of DPMAS and Low Volume PE for Patients With HBV Related ACLF
This study is to investigate investigate the safety and efficacy of Double plasma molecular adsorption system with sequential low-dose plasma exchange in treating hepatitis B virus-related acute-on-chronic liver failure.
- Trial name
- NCT04597164
- Testing
- Artificial liver support system
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Essential Tremor, Parkinson's Disease (PD)
Closed-loop TMS for Tremor
This study investigates the potential of phase-locked transcranial magnetic stimulation (TMS) as a non-invasive intervention for tremor in patients with Essential Tremor (ET) and Parkinson's Disease (PD).
- Trial name
- NCT07574164
- Testing
- TMS
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Oxford
Asthma, Reactive Airway Disease
Comparison of Asthma Programs for Schools
The purpose was to evaluate effectiveness and impact of an academic and counseling asthma health education program (SHARP) for fourth- and fifth-grade students diagnosed with asthma.
- Trial name
- CAPS (NCT01625364)
- Testing
- SHARP program, Open Airways for Schools
- Where
- United States
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Cardiovascular Diseases, Hyperlipidemia
Home-based Exercise for Management of HIV-associated Cardiovascular Disease Risk
Because of advances in drug treatment, people living with HIV/AIDS (PLWHA) are living longer, but are also at greater risk for cardiovascular disease (CVD) and diabetes.
- Conditions
- Cardiovascular Diseases, Hyperlipidemia, Obesity
- Trial name
- NCT01377064
- Testing
- Physical Activity Group, Standard Care Group
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of South Carolina
Crohn Disease
Phase 2b/3 Study of ABX464 in Moderate to Severe Active Crohn's Disease Patients
This is a multicenter, randomized, placebo controlled study to evaluate the efficacy and safety of ABX464, administered once daily (QD), in inducing clinical remission and endoscopic response in patients with moderate to severe…
- Trial name
- NCT03905109
- Testing
- ABX464
- Where
- Belgium
- Sponsor
- Abivax S.A.
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