Clinical trials: Other Disease
Mitral Valve Insufficiency, Mitral Valve Regurgitation
Feasibility Study of a Percutaneous Mitral Valve Repair System.
Prospective, multi-center, Phase I study of the Evalve Cardiovascular Valve Repair System (CVRS) in the treatment of mitral valve regurgitation. Patients will undergo 30-day, 6 month, 12 month, and 5 year clinical follow-up.
- Conditions
- Mitral Valve Insufficiency, Mitral Valve Regurgitation, Mitral Valve Incompetence, Mitral Regurgitation
- Trial name
- EVEREST(I) (NCT00209339)
- Testing
- Percutaneous mitral valve repair (MitraClip Implant)
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Abbott Medical Devices
Traumatic Brain Injury
Autologous Adipose-Derived Mesenchymal Stem Cells for Chronic Traumatic Brain Injury
The global objective of this study is to establish the safety and investigate the potential treatment effect of an intravenous infusion of HB-adMSCs (Hope Biosciences adipose-derived mesenchymal stem cells) on brain structure…
- Trial name
- NCT05951777
- Testing
- Autologous HB-adMSCs, Normal Saline
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Hope Biosciences LLC
Chronic Ischemic Cardiomyopathy, Coronary Artery Bypass Surgery
Human Umbilical Cord Stroma MSC in Myocardial Infarction
The purpose of this phase 1/2 clinical trial is to evaluate the efficacy and safety of allogeneic human umbilical cordstroma derived multipotent stem cells (hUCS-MSCs) in myocardial infarction (MI).
- Trial name
- HUC-HEART (NCT02323477)
- Testing
- stem cell transplantation
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Ankara University
Vitamin D Deficiency, Covid19
The Relationship Between Vitamin D Levels, Inflammatory Parameters and Disease Severity of COVID-19 Infection
Vitamin D deficiency increases the susceptibility to respiratory virus infections and the severity of infections. Inflammation plays a key role in pathogenesis in COVID19 while identifying clinical course and prognosis…
- Trial name
- NCT04945577
- Testing
- Inflammatory Parameters, 25 OH Vitamin D Level
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Colon Disease
Continuous Infusion of Remidazolam for Colonoscopic Polypectomy in Elderly Patients
To observe the sedative effect of continuous infusion of remidazolam in elderly patients undergoing colonoscopic polypectomy.
- Trial name
- NCT05801757
- Testing
- Remimazolam, Propofol
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Tongji Hospital
Cerebrovascular Disorders, Cognition Disorders
Renji Cerebral Small Vessel Disease Corhort Study
We aim to make clear the impact with the mechanisms of variant pathological injuries on the outcomes of CSVD, to find independent imaging markers and establish prediction model of it.
- Trial name
- RCCS (NCT03544801)
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Peripheral Arterial Disease, Critical Limb-Threatening Ischaemia
Shockwave ®S4 Catheter IVL to Treat Infrapopliteal Calcified Stenoses and/or Occlusions in CLTI Patients (LEGACY)
The study will evaluate the safety and efficacy of Peripheral Intravascular Lithotripsy system with Shockwave S4 catheter® for the treatment of de novo, re-stenosis or re-occlusive,calcified chronic total occlusion (CTOs) lesions…
- Trial name
- LEGACY (NCT05755412)
- Where
- 6 sites in Italy
- Volunteers
- 9 people
- Sponsor
- EndoCore Lab s.r.l.
Ocular Disease Requiring Surgery
INtravitreal and Aqueous Dexamethasone Levels After DEXtenza
A prospective, open-label, interventional study to determine intraocular concentration levels of dexamethasone following use of the DEXTENZA® implant.
- Trial name
- INDEX (NCT04529512)
- Testing
- DEXTENZA®
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Nathan Steinle
Kidney Failure, Chronic
Clinical Study of Asahi ViE Dialyzer in Canada
The purpose of the study is to obtain performance data on the Asahi ViE-21 dialyzer (ViE-21) .
- Trial name
- AVID (NCT02292212)
- Testing
- ViE-21
- Volunteers
- 17 people
- Sponsor
- Asahi Kasei Medical Co., Ltd.
Cognitive Impairment, Mild, Cognitive Dysfunction
MCLENA-2: A Phase II Clinical Trial for the Assessment of Lenalidomide in Patients With Mild Cognitive Impairment
This is a randomized, double-blind, placebo-controlled, parallel group study. The use of placebo is appropriate to minimize bias related to treatment expectations of the subject, study partner, and site investigator, as well as…
- Conditions
- Cognitive Impairment, Mild, Cognitive Dysfunction, Amyloid Plaque, Neurodegenerative Disease, Hereditary
- Trial name
- NCT06177028
- Testing
- Lenalidomide 10 mg
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Amyotrophic Lateral Sclerosis, ALS
An Efficacy and Safety Study of Ravulizumab in ALS Participants
The purpose of the study is to assess the efficacy and safety of ravulizumab for the treatment of adult participants with ALS.
- Trial name
- NCT04248465
- Testing
- Ravulizumab
- Where
- 95 sites in United States, Australia and 15 more
- Volunteers
- 382 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
IBD (Inflammatory Bowel Disease)
Efficacy of Melatonin Treatment on Sleep Quality Improvement in Inflammatory Bowel Disease Patients With Clinical Remission
Sleep disturbances are common in patients with inflammatory bowel disease (IBD) and are associated with increased disease activity and reduced quality of life.
- Trial name
- Melatonin IBD (NCT07737665)
- Testing
- Melatonin ("Circadin")
- Where
- Thailand
- Volunteers
- 90 people
- Sponsor
- Mahidol University
Covid19
Povidone-Iodine Rinses in the Management of COVID-19
The aim of this study is to determine if Povidone iodine (PVP-I) rinses and throat gargles or a PVP-I gel forming nasal spray compared to a placebo (a treatment that has no physical effect to a person) is an effective treatment…
- Trial name
- NCT04449965
- Testing
- Povidone-iodine
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- St. Paul's Hospital, Canada
Other Instability of Joint, Shoulder Region, Strain of Shoulder Muscle (Disorder)
The Effects of Muscle Characteristics on the Control of Shoulder Complex During Functional Movements
The movement control of shoulder joint relies not only on the glenohumeral joint, but also the critical contributions from scapulothoracic joint.
- Conditions
- Other Instability of Joint, Shoulder Region, Strain of Shoulder Muscle (Disorder), Movement Disorders
- Trial name
- NCT04176692
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tzu Chi University
Parkinson's Disease
Effect of Osteopathic Manipulative Medicine (OMM) on Pulmonary Function and Speech in Parkinson's Disease
The purpose of this study is to investigate the effect of selected Osteopathic Manipulative Medicine (OMM) techniques on the respiratory system of people with Parkinson's Disease (PD) in comparison to light touch.
- Trial name
- NCT01636011
- Testing
- Osteopathic Manipulative Medicine Treatment
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- New York Institute of Technology
Heart Failure, End Stage Renal Disease
Soluble Neprilysin, NT-proBNP, and Growth-Differentiation-Factor-15 as Biomarkers for Heart Failure in Dialysis Patients
Objectives: The aim of this study is to determine whether growth differentiation factor-15 (GDF15) and circulating neprilysin (cNEP) improve the diagnosis of congestive heart failure (HF) in patients on dialysis.
- Trial name
- SONGBIRD (NCT04061811)
- Testing
- Diagnostic biomarker study
- Where
- 2 sites in France, Germany
- Volunteers
- 153 people
- Sponsor
- Hannover Medical School
Primary Disease Facioscapulohumeral Dystrophy (FSHD)
Effects of NMES on Muscle Function of Patients With FSHD: a Double-blind Randomized Controled Clinical Trial
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant disease characterized by progressive weakness and atrophy of specific skeletal muscles.
- Trial name
- NEMS and FSHD (NCT02861911)
- Testing
- Current flow between sensory and motor threshold, Current intensity upper of motor threshold by Kneehab XP technology
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Montpellier
Schizophrenia, Cognition Disorders
The Effect of Nicotine on Arousal, Cognition and Social Cognition in Schizophrenic Patients
This study in patients with stable schizophrenia will investigate the effect of nicotine on arousal, cognitive task and social cognition after acute dose administration.
- Trial name
- NCT01186471
- Testing
- A643 (nicotine)
- Volunteers
- 32 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Senile Osteoporosis With Current Pathological Fracture Lower Leg (Diagnosis)
Rare Variation and Remote Gene Regulation of Osteoporosis Related Phenotypes in Han Chinesse
Bone density is recognized as the most important factor to measure osteoporosis, and the prevalence of osteoporosis increases with age.
- Trial name
- NCT04129671
- Testing
- No intervention was applied
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Schizophrenia, Schizoaffective Disorder
Neural Oscillations as Genetic and Functional Biomarkers in Normal and Disease States
The principle aim of the project is to analyze brain electrical activity and genetic information that will help identify the nature and cause of the disease schizophrenia.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder
- Trial name
- NCT01425671
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
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