Clinical trials: Other Disease
Ischemic Stroke
hsCRP in Japan Statin Treatment Against Recurrent Stroke (J-STARS hsCRP)
Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A(HMG-CoA) reductase can play a role in preventing recurrent vascular events from ischemic heart disease patients, whose mechanism consists in not only the reduction of serum…
- Trial name
- NCT00361699
- Testing
- Statin
- Where
- 2 sites in Japan
- Volunteers
- 1,095 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Post-COVID-19 Syndrome
Physiotherapy in Post COVID-19 Syndrome Patients
Patients who have undergone COVID-19 infection often have long-term sequelae. One of the most prevalent sequelae is pain. The main objective of this research is to investigate the efficacy of a cognitive behavioral…
- Trial name
- NCT05477199
- Testing
- Cognitive behavioral principles-based treatment program, Control intervention
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Universidad de Granada
Severe Aortic Valve Stenosis, Transcatheter Aortic Valve Implantation
Platelet Reactivity After TAVI: A Multicenter Pilot Study
A high platelet reactivity in patients with severe symptomatic Aortic Stenosis (AS) selected for TAVI (Transcatheter aortic valve implantation) procedure has been demonstrated previously, and the use of double antiaggregation…
- Conditions
- Severe Aortic Valve Stenosis, Transcatheter Aortic Valve Implantation, Transcatheter Aortic Valve Replacement
- Trial name
- REAC-TAVI (NCT02224066)
- Testing
- Ticagrelor 90 mg twice per day during three months following TAVI, Aspirin 100 mg plus Clopidogrel 75 mg daily during three months following TAVI
- Where
- 7 sites in Spain
- Volunteers
- 65 people
- Sponsor
- Hospital de Meixoeiro
COPD, Chronic Obstructive Pulmonary Disease
GOLD 0 - DLCO 1: A Look Beyond the Obstruction. Is Spirometry Enough for COPD (Chronic Obstructive Pulmonary Disease) Screening?
This is a multicenter observational prospective study in smokers or ex-smokers with cumulative exposure ≥ 10 a / p (years / pack) with respiratory symptoms and presenting a normal spirometry.
- Trial name
- NCT05016466
- Testing
- Standard Care, Standard Care plus oxidative stress study plus inflammation biomarkers study
- Where
- Spain
- Volunteers
- 236 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Interstitial Lung Disease, Lung Cancer
Assessment of Exhaled Breath Condensate Hydrogen Peroxide (EBC H2O2) as Measured Using a New Device (Inflammacheck™) in Patients With Interstitial Lung Disease, Lung Cancer and Healthy Volunteers.
A cross-sectional study of EBC H2O2 levels, as measured by a novel device, 'Inflammacheck™', and other markers of disease severity in patients with ILD and Lung Cancer.
- Trial name
- EXHALE 1B (NCT04061356)
- Where
- United Kingdom
- Volunteers
- 37 people
- Sponsor
- Portsmouth Hospitals NHS Trust
Disease Associated Underweight
Effects of Oral Nutrition Supplements in Children With Disease Associated Underweight
The purpose of this study is to test whether the provision of ONS to malnourished children across Europe, in addition to standard counselling, will improve weight gain and other outcomes.
- Trial name
- MIntS (NCT02383329)
- Testing
- The ONS provided to the children intervention group will be a ready to drink age adapted oral nutrition supplement providing 1,5 kcal/ml
- Where
- 19 sites in Belgium, Croatia and 7 more
- Volunteers
- 224 people
- Sponsor
- Dr. Michael Chourdakis
Educational Problems, Respiratory Muscle
Educational Programme in Diaphragm Ultrasonographic Assessment
Diaphragm ultrasound non-invasively explores the diaphragm function and it can be useful in several clinical situations. Diaphragm ultrasound is able to evaluate the cranio-caudal displacement of the diaphragm and its thickening…
- Conditions
- Educational Problems, Respiratory Muscle, Diaphragm Disease
- Trial name
- NCT03704129
- Testing
- Tutor
- Where
- Italy
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Paolo Navalesi
Cirrhosis, Cirrhosis, Liver
Liver Cirrhosis Network Rosuvastatin Efficacy and Safety for Cirrhosis in the United States
This is a double-blind, phase 2 study to evaluate safety and efficacy of rosuvastatin in comparison to placebo after 2 years in patients with compensated cirrhosis.
- Conditions
- Cirrhosis, Cirrhosis, Liver, Cirrhosis Early, Cirrhosis Due to Hepatitis B
- Trial name
- LCN RESCU (NCT05832229)
- Testing
- Rosuvastatin
- Where
- 13 sites in United States
- Volunteers
- 260 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Aortic Valve Regurgitation, Mitral Valve Regurgitation
Left Ventricular Reverse Remodeling Evaluation After Surgical Correction of Aortic Regurgitation
Investigators assume that surgical correction approach to functional mitral regurgitation during intervention for chronic aortic regurgitation in patients with severe enlargement of the left heart chambers influences reverse…
- Conditions
- Aortic Valve Regurgitation, Mitral Valve Regurgitation, Left Ventricle Dilated, Left Atrium Dilated
- Trial name
- ORMIX (NCT06805253)
- Testing
- Not applicable - observational study
- Where
- 2 sites in Russia
- Volunteers
- 120 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Crohn Disease Haemorrhagic Rectocolitis
Study of the Impact of a Physical Activity Programme on the Quality of Life of Patients With Inflammatory Bowel Disease
Regular physical activity at a mild to moderate intensity can control inflammation in general and intestinal inflammation in particular during IBD.
- Trial name
- APMICI (NCT05099653)
- Testing
- physical activity
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Raincy Montfermeil Hospital Group
Coronary Artery Disease (Left Main)
Clinical Study to Evaluate the STENTYS Xposition S for Treatment of Unprotected Left Main Coronary Artery Disease
Prospective, non-randomized, multi-center study assessing the long term safety and efficacy of the self expandable sirolimus eluting Xposition S stent in the treatment of unprotected left main coronary artery disease.
- Trial name
- TRUNC (NCT02800837)
- Where
- 4 sites in Italy, Switzerland and 1 more
- Volunteers
- 200 people
- Sponsor
- Stentys
Critical Illness, Critically Ill
Intensive Nutrition in Critically Ill Adults
Despite the widespread use of nutrition therapy, no large scale randomized controlled trials (RCTs) have demonstrated positive outcomes with delivery of nutrition therapy early in critical illness, with some showing no effect…
- Trial name
- INTENT (NCT03292237)
- Testing
- Supplemental parenteral nutrition
- Where
- 23 sites in Australia, New Zealand
- Volunteers
- 240 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Appointments and Schedules, Outpatient Clinics, Hospital/Economics
Non Attendance at Scheduled Appointments as a Marker of Mortality and Hospital Admission
To evaluate the association of non attendance at scheduled appointments with visits in the emergency department, hospitalizations and mortality during one year follow up.
- Conditions
- Appointments and Schedules, Outpatient Clinics, Hospital/Economics, Emergency Department, Hospitalization
- Trial name
- NCT02210637
- Where
- Argentina
- Volunteers
- 177,083 people, healthy volunteers welcome
- Sponsor
- Hospital Italiano de Buenos Aires
Keloids
Efficacy 2 Part Study of Identification of Keloid Biomarkers and Effect of QAX576 on Keloid Recurrence
This is a 2-part study. In the first part (Part I, 8 subjects), biopsies will be obtained from the resection site after keloid shaving and two weeks following resection to assess and select biomarkers to determine the biologic…
- Trial name
- NCT00987545
- Testing
- QAX576
- Where
- 4 sites in United States
- Volunteers
- 3 people
- Sponsor
- Novartis Pharmaceuticals
West Nile Fever
An Exploratory Study of AVI-4020 in Patients With Possible Acute Neuroinvasive West Nile Virus (WNV) Disease
Although the serious form of West Nile Virus (WNV) disease, referred to as neuroinvasive disease, is rare, it can result in permanent disabilities and occasionally death.
- Trial name
- NCT00091845
- Testing
- AVI-4020 Injection
- Volunteers
- 50 people
- Sponsor
- Sarepta Therapeutics, Inc.
COVID-19 Infection
Long Covid (Individuals with Ongoing COVID-19 Symptoms) Ongoing Effects
Persistent Covid-19 symptoms, known as long Covid, can impact healthcare provision. This study aimed to assess how symptoms persisting six months after Covid-19 affect quality of life and functional capacity.
- Trial name
- COVID-19 (NCT06528145)
- Testing
- Evalation
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Ziya Yildiz
Kidney Diseases, Dialysis; Complications
PRevEnting FracturEs in REnal Disease - 1
PREFERRED-1 is a pilot study designed to determine the feasibility of a large randomized, pragmatic, open-label, comparative-effectiveness trial of denosumab for the prevention of fragility fractures in people receiving…
- Conditions
- Kidney Diseases, Dialysis; Complications, Fragility Fracture, Chronic Kidney Disease-Mineral and Bone Disorder
- Trial name
- PREFERRED-1 (NCT05096195)
- Testing
- Denosumab 60 mg/ml, Calcium and vitamin D prophylaxis, Monitoring of post-injection calcium and phosphate
- Where
- 6 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Western University, Canada
Chronic Kidney Disease
Exercise to Prevent Muscle Mass and Functional Loss in Elderly Dialysis Patients
The majority of individuals with advanced ESRD have reduced exercise capacity in part due to decreased muscle mass. This leads to a reduced ability to perform daily activities, a greater incidence of falls, and a reduced quality…
- Trial name
- PERFECT (NCT01990495)
- Testing
- Exercise training, Usual Care
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- VA Office of Research and Development
Benign Prostatic Hyperplasia
Assessment of Efficacy of Vardenafil in the Treatment of Subjects With Symptomatic Benign Prostatic Hyperplasia
Assessment of efficacy of vardenafil in the treatment of subjects with symptomatic Benign Prostatic Hyperplasia.The purpose of this study is to find out whether vardenafil can improve the lower urinary tract symptoms of benign…
- Trial name
- NCT00657839
- Testing
- Levitra (Vardenafil, BAY38-9456)
- Where
- 15 sites in Germany
- Volunteers
- 222 people
- Sponsor
- Bayer
Huntington's Disease
Child to Adult Neurodevelopment in Gene Expanded Huntington's Disease
Huntington's Disease (HD) is an autosomal dominant disease manifested in a triad of cognitive, psychiatric, and motor signs and symptoms. HD is caused by a triplet repeat (CAG)expansion in the gene Huntingtin (HTT).
- Trial name
- ChANGE HD (NCT01860339)
- Where
- 6 sites in United States
- Volunteers
- 488 people, healthy volunteers welcome
- Sponsor
- Peggy C Nopoulos
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