Clinical trials: Other Disease
Tachycardia
VAST - Ventricular Arrhythmia Suppression Trial
The purpose of VAST is to determine whether the Rate Smoothing feature in Guidant's PRIZM/VITALITY-family ICDs has an effect on the incidence of ventricular tachyarrhythmias.
- Trial name
- NCT00158912
- Testing
- Implantable Cardioverter Defibrillator
- Volunteers
- 550 people
- Sponsor
- Boston Scientific Corporation
Coronary Heart Disease
Studies of Application of Combined General Anesthesia and Bilateral TPVB in OPCABG
This study intends to compare the combination of general anesthesia (GA) and single-shot bilateral thoracic paravertebral block (TPVB) by ropivacaine in the patients undergoing off-pump coronary artery bypass surgery ( OPCAB)…
- Trial name
- NCT02727712
- Testing
- bilateral thoracic paravertebral block, Transesophageal Echocardiography（TEE）, Lung protection measure during the surgery（Dräger Primus）
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xiangya Hospital of Central South University
Eosinophilic Esophagitis, Gastroesophageal Reflux Disease
The Role Of Gastroesophageal Reflux Disease (GERD) in Eosinophilic Esophagitis
The primary aim of this study was to determine the proportion of patients with esophageal eosinophilic infiltration that have objective (measurable) evidence of gastroesophageal reflux disease (GERD).
- Conditions
- Eosinophilic Esophagitis, Gastroesophageal Reflux Disease, EE, GERD
- Trial name
- NCT00728481
- Testing
- Esomeprazole, Budesonide
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Mayo Clinic
Liver Fibrosis, Liver Cirrhosis
Acoustic Radiation Force Impulse Imaging (ARFI) : a New Technique to Assess Liver Elasticity
Liver stiffness measurement (LSM) by non invasive methods is increasingly used to estimate liver fibrosis in patients with chronic liver diseases.
- Conditions
- Liver Fibrosis, Liver Cirrhosis, Viral Hepatitis, Liver Tumour
- Trial name
- NARFI (NCT01082419)
- Testing
- ARFI measurement
- Where
- France
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Blast Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive, Recurrent Acute Lymphoblastic Leukemia
Anti-CD19/20/22 Chimeric Antigen Receptor T Cells (TriCAR19.20.22 T Cells) for the Treatment of Relapsed or Refractory Non-Hodgkin Lymphoma, Acute Lymphoblastic Leukemia, and Chronic Lymphocytic Leukemia
This phase I trial tests the safety, side effects and best dose of anti-CD19/20/22 chimeric antigen receptor (CAR) T cells (TriCAR19.20.22 T cells) and how well they work in treating patients with non-Hodgkin lymphoma, acute…
- Conditions
- Blast Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive, Recurrent Acute Lymphoblastic Leukemia, Recurrent Chronic Lymphocytic Leukemia, Recurrent Chronic Myeloid Leukemia, BCR-ABL1 Positive
- Trial name
- NCT07166419
- Testing
- Autologous Anti-CD19/CD20/CD22 CAR T-cells, Biospecimen Collection, Bone Marrow Aspiration
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Liver Disease, Nutrition Disorders
Effects of Whey Protein Consumption by Patients Waiting for Liver Transplantation
Malnutrition is prevalent among chronic liver disease patients. Inadequate ingestion and/or metabolic alterations modify the body composition and biological functions.
- Trial name
- NCT02901119
- Testing
- Whey protein
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of Minas Gerais
Hallux Rigidus, Hallux Valgus
Return to Cross Country Skiing and Other Physical Activities After Arthrodesis of the First Metatarsophalangeal Joint
Patients who have undergone arthrodesis of the first metatarsophalangeal joint due to hallux valgus or hallux rigidus are invited to participate in this study, which aims to investigate how the foot functions after this…
- Trial name
- NCT07610330
- Testing
- Arthrodesis
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Psoriasis Arthritis, Psoriasis (PsO)
Exploratory Clinical Study on Fasting in Psoriasis and Psoriatic Arthritis (RiseFast)
The RiseFast pilot study will investigate the clinical, metabolic and immunological effects of fasting and plant-based diet (PBD) on patients with psoriasis (PsO) and psoriatic arthritis (PsA) on their gut microbiota.
- Trial name
- NCT06905028
- Testing
- Fasting and Plant-Based Diet
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Charite University, Berlin, Germany
Hypertension, Ischemic Heart Disease
A Morbidity-Mortality and Remodeling Study With Valsartan
The JIKEI HEART Study has been designed to investigate whether concomitant treatment with valsartan, an angiotensin II receptor blocker (ARB), in addition to conventional treatment, will improve the prognosis of 3000 Japanese…
- Conditions
- Hypertension, Ischemic Heart Disease, Congestive Heart Failure
- Trial name
- NCT00133328
- Testing
- valsartan
- Where
- Japan
- Volunteers
- 3,000 people
- Sponsor
- Jikei University School of Medicine
Deglutition Disorders in Children, Congenital Heart Disease
Speech Therapy Online Approach for Children With Congenital Heart Desease in Pre and Post Surgical Period
The goal of this clinical trial is to test the results of a protocoled speech therapy online intervention in children with congenital heart disease aged between 0 and 12 months old, who feeds tube only.
- Trial name
- NCT07481565
- Testing
- Oral motor intervention
- Where
- 2 sites in Brazil
- Volunteers
- 20 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Relapsing Remitting Multiple Sclerosis
Effectiveness and Safety of Generic Delayed-Release Dimethyl Fumarate (Sclera® or Marovarex ®, Hikma) in Routine Medical Practice in the Treatment of Relapsing-Remitting Multiple Sclerosis in MENA Region
The purpose of this observational study is to evaluate the effectiveness, safety and health related quality of life of Generic DMF (Sclera® or Marovarex ®, Hikma) in patients undergoing routine clinical care for RRMS in MENA…
- Trial name
- NCT04468165
- Testing
- Dimethyl Fumarate (DMF)
- Where
- 6 sites in Algeria, Egypt and 1 more
- Volunteers
- 160 people
- Sponsor
- Hikma Pharmaceuticals LLC
Parkinson Disease
Pharmacokinetics of Levodopa/Carbidopa Infusion With and Without Oral Catechol-O-methyl Transferase (COMT) Inhibitors
The purpose of this study is to determine whether oral intake of COMT inhibitors affects the smooth plasma levodopa levels achieved by intestinal levodopa/carbidopa infusion in advanced Parkinson's disease patients.
- Trial name
- DuoCOMT (NCT00906828)
- Testing
- levodopa/carbidopa, entacapone, tolcapone
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Uppsala University
Crohn Disease
Adalimumab for the Management of Post-operative Crohn's Disease (CD)
This study will be a prospective, open label, randomized, comparative study. Comparing the efficacy of adalimumab with immunomodulator therapy (i.e.
- Trial name
- POPART (NCT01629628)
- Testing
- Adalimumab, 6 Mercaptopurine
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Dementia, Alzheimer Disease
Coordinating Center for Enhancing ADRD Caregiving
Established in 1995, Resources for Enhancing Alzheimer's Caregiver Health (REACH) is a unique, multi-site research program sponsored by the National Institute on Aging (NIA) and the National Institute on Nursing Research (NINR).
- Trial name
- NCT00178165
- Testing
- Skill Training Condition - problem solving training, REACH for TLC (Telephone Linked Computer) system
- Where
- 5 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- University of Pittsburgh
Herpes Simplex Virus
A Safety and Dose-Determining Study of CMX001 In Infants With Neonatal Herpes Simplex Virus (HSV) Infection Involving the Central Nervous System (CNS Disease)
This study is to identify if a Novel Antiviral Drug could be used to treat babies with Herpes Simplex Virus (HSV) with central nervous system (CNS) disease.
- Trial name
- NCT01610765
- Testing
- Novel Antiviral Drug
- Where
- 18 sites in United States
- Sponsor
- University of Alabama at Birmingham
Inflammatory Bowel Diseases, Crohn Disease
Bowel Urgency in Inflammatory Bowel Disease
Bowel urgency is commonly defined as the sudden need to rush to the bathroom to empty one's bowel. In the field of inflammatory bowel disease (IBD) (including Crohn's disease (CD) and ulcerative colitis (UC)), bowel urgency is…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- URGENT-1 (NCT06069167)
- Testing
- Collection of data related to bowel urgency
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Paris IBD Center
Chronic Kidney Failure, Secondary Hyperparathyroidism
Follow-up Patients With End Stage Renal Disease Receiving Zemplar to Prevent and Treat Secondary Hyperparathyroidism
The aim of this post-marketing observational study is to obtain further data on the long term use, safety and efficacy of Zemplar as it is prescribed in the normal clinical setting and according to the approved Summary of Product…
- Trial name
- NCT01081665
- Where
- 19 sites in Greece
- Volunteers
- 237 people
- Sponsor
- Abbott
Cardiac Disease, Blood Transfusion
Predicting CSA-AKI With ACTA-PORT Score
In the scope of this study, it will be determined whether the ACTA-PORT (Association of Cardiothoracic Anesthetists perioperative risk of blood transfusion) scoring system can predict the incidence of events in other organ…
- Conditions
- Cardiac Disease, Blood Transfusion, Acute Kidney Injury
- Trial name
- NCT06484907
- Where
- Turkey (Türkiye)
- Volunteers
- 467 people
- Sponsor
- Ankara City Hospital Bilkent
Pompe Disease
Re-administration of Intramuscular AAV9 in Patients With Late-Onset Pompe Disease
A recombinant AAV vector has been generated to carry the codon-optimized acid alpha-glucosidase (coGAA) gene expressed from a human desmin enhancer/promoter (DES).
- Trial name
- AAV9-GAA_IM (NCT02240407)
- Testing
- Recombinant Adeno-Associated Virus Acid Alpha-Glucosidase, Rapamycin, saline
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Florida
Parkinson's Disease
A Phase 2b Study of Istradefylline (KW-6002) for the Treatment of Parkinson's Disease in Patients Taking Levodopa
The purpose of this study is to establish the efficacy of 20 mg/day and 40 mg/day doses of istradefylline for reducing the mean total hours of awake time per day spent in the OFF state in patients with advanced Parkinson's…
- Trial name
- NCT00455507
- Testing
- Istradefylline
- Where
- Japan
- Volunteers
- 363 people
- Sponsor
- Kyowa Kirin Co., Ltd.
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