Clinical trials: Other Metabolic Diseases
Multiple Myeloma, Amyloidosis
Combined Bone Marrow and Renal Transplantation for Hematologic Disorders With End Stage Renal Disease
This pilot trial offers the unique opportunity for both the treatment of multiple myeloma or systemic AL amyloidosis for which hematopoietic stem cell transplantation would be ordinarily indicated and the reversal of end-stage…
- Trial name
- NCT02158052
- Testing
- Tacrolimus, Equine Anti-thymocyte globulin, Kidney transplant from a related donor
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Massachusetts General Hospital
Schizophrenia, Alzheimer's Disease
Side Effects of Newer Antipsychotics in Older Adults
This study will compare four atypical antipsychotic medications in terms of the risk of specific side effects each of them presents in middle-aged and elderly individuals.
- Conditions
- Schizophrenia, Alzheimer's Disease, Dementia
- Trial name
- NCT00245206
- Testing
- Aripiprazole, Olanzapine, Risperidone
- Where
- United States
- Volunteers
- 406 people, healthy volunteers welcome
- Sponsor
- Veterans Medical Research Foundation
Lynch Syndrome, Neoplasms
The GEOLynch Cohort Study
The GEOLynch cohort study has been established to investigate the influence of genetic, environmental and other factors on tumour risk in persons with Lynch syndrome.
- Conditions
- Lynch Syndrome, Neoplasms, Hereditary Nonpolyposis Colorectal Cancer, Colorectal Neoplasms
- Trial name
- GEOLynch (NCT03303833)
- Testing
- No intervention, observational study.
- Where
- Netherlands
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Insulin Resistance, Diabetes Mellitus Type 2
Insulin Sensitivity, Irisin and Adipokines as Outcome Parameters in Patients Undergoing Cardiac Surgery
BACKGROUND: Surgical injury and inflammation provoke a stereotypical stress response. Insulin resistance plays an intriguing role in these metabolic alterations and depends on the intensity of injury.
- Conditions
- Insulin Resistance, Diabetes Mellitus Type 2, Other Functional Disturbances Following Cardiac Surgery
- Trial name
- NCT02258698
- Testing
- Cardiac surgery
- Where
- Switzerland
- Volunteers
- 348 people
- Sponsor
- University Hospital, Basel, Switzerland
Type 2 Diabetes
High Protein Breakfast on Appetite, Postprandial Glycemia and Weight Loss in T2D
The investigators hypothesis is that eating whey protein in the breakfast versus other proteins will results in higher satiety, reduced overall postprandial glycemia and more weight loss in obese diabetic individuals
- Trial name
- HPB (NCT01623648)
- Testing
- Arm 1 Whey Breakfast, Arm 2 No Whey Breakfast, Arm 3 Low Protein Breakfast
- Where
- 2 sites in Israel, Venezuela
- Volunteers
- 58 people
- Sponsor
- Hospital de Clinicas Caracas
Overweight, Obesity and Other Hyperalimentation
Taking Action to Thrive - A Healthy Lifestyle Intervention Pilot Study
There have been some preliminary studies, primarily in animals, that suggest that exposure to some of the chemicals in our everyday environment, such as the chemicals found in plastics, may cause weight gain.
- Trial name
- THRIVE (NCT03478345)
- Testing
- endocrine disruptor chemical reduction intervention
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- George Washington University
Psychotic Disorders
Fitforlife- Exercise in Care of Psychosis
Persons affected by psychosis have a shorter life expectancy mainly due to metabolic disorders. This is partly due to the drugs but also to a sedentary life style.
- Trial name
- NCT04239612
- Testing
- Physical exercise
- Where
- Sweden
- Volunteers
- 156 people
- Sponsor
- Karolinska Institutet
Diabetes Mellitus, Type 2
Relationship Between HbA1c, Fasting Plasma Glucose, Post-prandial Glucose and Other Measures of Glycemic Control
This study aims to evaluate relative contributions of fasting plasma glucose and postprandial glucose at various HbA1c levels using 6-day CGM.
- Trial name
- NCT02117154
- Testing
- 6-day Continuous Glucose Monitoring System
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- University of Malaya
Hypercholesterolemia
Study of Alirocumab (REGN727/SAR236553) added-on to Rosuvastatin Versus Other Lipid Modifying Treatments (LMT) (ODYSSEY OPTIONS II)
To evaluate the reduction of low-density lipoprotein cholesterol (LDL-C) by alirocumab (REGN727/SAR236553) as an add-on therapy to other LMT in patients with hypercholesterolemia at high cardiovascular (CV) risk.
- Trial name
- NCT01730053
- Testing
- Alirocumab, Rosuvastatin, Ezetimibe
- Where
- 93 sites in United States, Australia and 7 more
- Volunteers
- 305 people
- Sponsor
- Regeneron Pharmaceuticals
Anemia, Hemosiderosis
Extension Study of Iron Chelation Therapy With Deferasirox in β-thalassemia and Rare Chronic Anemia Patients
A 1-year randomized Phase II core trial was conducted to investigate the efficacy of deferasirox in regularly transfused patients with β-thalassemia and other rare chronic anemia 2 years of age and older.
- Trial name
- NCT00303329
- Testing
- Deferasirox
- Where
- 28 sites in United States, Belgium and 5 more
- Volunteers
- 184 people
- Sponsor
- Novartis Pharmaceuticals
Obesity
Family & Friends - the Significance of a Significant Other in Treatment
This study focuses on the difficulties to maintain a weight loss and behavioural change after having been in a institutional intermittent weight loss programme.
- Trial name
- NCT01238354
- Testing
- With friend, Without friend
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Norwegian University of Science and Technology
Diabetes Mellitus Type 2, Sensory Neuropathy
Evaluation of Pressure Distribution of Kyboot Shoes in Comparison to Other Foot Wear
Comparison and evaluation of pressure distribution, gait pattern, changes in the movement of the center of pressure, shock absorbing capabilities and comfort of wear using KyBoot shoes versus normal foot wear in diabetic and…
- Conditions
- Diabetes Mellitus Type 2, Sensory Neuropathy, Foot Ulcer, Diabetic
- Trial name
- Kyboot (NCT02451722)
- Testing
- Kyboot shoes
- Where
- Israel
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Schizophrenia, Bipolar Disorder
Targeting a Genetic Mutation in Glycine Metabolism With D-cycloserine
The purpose of this study is to assess the efficacy of d-cycloserine (DCS) as an augmentation strategy in two psychotic patients with a triplication (4 copies) of the glycine decarboxylase (GLDC) gene.
- Trial name
- DCS (NCT02304432)
- Testing
- D-cycloserine
- Volunteers
- 2 people
- Sponsor
- Mclean Hospital
Schizophrenia
Creatine Treatment in Psychiatric Disorders
Creatine plays a pivotal role in brain energy homeostasis. Creatine supplementation is widely used in enhancing sports performance, and has been tried in the treatment of neurological, neuromuscular and atherosclerotic disease…
- Trial name
- NCT00140192
- Testing
- creatine
- Where
- Israel
- Volunteers
- 12 people
- Sponsor
- Beersheva Mental Health Center
Obesity, Schizophrenia
Bariatric Surgery in Patients With Schizophrenia
It is known that schizophrenia is associated with obesity in a significant number of patients and it implies a poor prognostic factor, with weight loss being important in this population.
- Trial name
- SCHIZOBAR (NCT06043206)
- Testing
- Bariatric Surgery
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Schizophrenia and Related Disorders, Diet Habit
Efficacy of Prebiotic and Probiotic Dietary Modulation in Schizophrenic Disorders
The microbiota plays a vital role in the two-way communication between the gastrointestinal tract and the central nervous system (CNS), articulated as the microbiota-intestine-brain axis.
- Trial name
- NCT04366401
- Testing
- Conventional Dietary Advice, Prebiotic/Probiotic Dietary Modulation
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Universidad de Córdoba
Organic, Including Symptomatic, Mental Disorders, Substance Use
Exploring the Comorbidity Between Mental Disorders and General Medical Conditions
Mental disorders have been shown to be associated with a number of general medical conditions (also referred to as somatic or physical conditions).
- Conditions
- Organic, Including Symptomatic, Mental Disorders, Substance Use, Schizophrenia, Mood [Affective] Disorders
- Trial name
- COMO-GMC (NCT03847753)
- Testing
- Organic Disorders, Substance Use Disorders, Schizophrenia Disorders
- Volunteers
- 5,940,299 people
- Sponsor
- University of Aarhus
Schizophrenia
A Placebo-Controlled, Cross-Over Trial of Aripiprazole
This study is a ten-week, placebo-controlled, double-blind, cross-over, randomized trial of the novel antipsychotic agent, aripiprazole, added to 20 obese stable olanzapine-treated patients with schizophrenia or schizoaffective…
- Trial name
- NCT00351936
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- North Suffolk Mental Health Association
Transfusional Iron Overload
A Protocol to Allow Treatment With ICL670 for Patients With or at Risk of Life-threatening Complications of Transfusional Iron Overload Who Are Unable to Tolerate Other Iron Chelators Because of Documented Severe Toxicity
The purpose of this open-label, non-comparative, multi-center protocol was to further evaluate safety and to provide treatment with ICL670 to patients who had or were at risk of life threatening complications due to transfusional…
- Trial name
- NCT01044186
- Testing
- ICL670
- Where
- 18 sites in United States, Greece and 1 more
- Volunteers
- 30 people
- Sponsor
- Novartis Pharmaceuticals
Obesity, Morbid, Hypertension
Comparison of Extremely Obese Patients Undergoing Gastric Sleeve Surgery
By the comparison of the preoperative and postoperative data of approximately 160 patients undergoing gastric sleeve surgery, we try to draw conclusions about the effectiveness of gastric sleeve surgery, expected complication…
- Conditions
- Obesity, Morbid, Hypertension, Diabetes Mellitus, Type 2
- Trial name
- NCT05929170
- Where
- Hungary
- Volunteers
- 160 people
- Sponsor
- University of Pecs