Clinical trials: Otitis Media Chronic
Chronic Otitis Media, Tympanic Membrane Perforation
A Prospective Comparative Study of Dry vs Wet Temporalis Fascia Graft in Tympanoplasty
This study was conducted to compare two methods of using temporalis fascia graft in tympanoplasty, namely wet temporalis fascia graft and dry temporalis fascia graft.
- Trial name
- NCT07595484
- Testing
- Wet Temporalis Fascia Graft Tympanoplasty, Dry Temporalis Fascia Graft Tympanoplasty
- Where
- Pakistan
- Volunteers
- 92 people
- Sponsor
- Shaikh Zayed Hospital, Lahore
Otitis Media With Effusion, Healthy
The URT and Middle Ear Microbiota in Health and During Chronic OME
This study analyses which bacteria are present in the middle ear space and adjacent upper respiratory tract niches in healthy people and in patients suffering from chronic otitis media with effusion (OME; glue ear).
- Trial name
- NCT03109496
- Testing
- Collection of body fluids/swabs
- Where
- Belgium
- Volunteers
- 82 people
- Sponsor
- University Hospital, Antwerp
Chronic Suppurative Otitis Media
Mastoid Obliteration Using S53P4 Bioactive Glass Versus Mastoidectomy Alone for Chronic Suppurative Otitis Media
Chronic suppurative otitis media (CSOM) is characterized by intermittent or continuous otorrhea lasting for longer than 6 weeks. Most cases can be treated conservatively using antibiotic drops and oral antibiotics.
- Trial name
- NCT06160505
- Testing
- S53P4 Bioactive glass
- Where
- Netherlands
- Volunteers
- 250 people
- Sponsor
- Diakonessenhuis, Utrecht
Chronic Eustachian Tube Dysfunction, Chronic Recurrent Otitis Media
Balloon Eustachian Tuboplasty in Treatment of Chronic Eustachian Tube Dysfunction
The prevalence of Eustachian tube (ET) dysfunction in adults reaches 1%. It causes a feeling of fullness in the ear, otalgia and hearing loss and can lead to recurrent acute otitis media, development of chronic otitis media with…
- Conditions
- Chronic Eustachian Tube Dysfunction, Chronic Recurrent Otitis Media, Effusion After Tympanostomy
- Trial name
- NCT03556215
- Testing
- Eustachian tube dilatation device, Myringotomy
- Where
- 2 sites in Czechia
- Volunteers
- 55 people
- Sponsor
- University Hospital Ostrava
Otitis Media
The Effects of Ventilation Tubes - The SIUTIT Trial
The prevalence of otitis media among Greenlandic children is one of the highest in the world and twenty per cent of schoolchildren have impaired hearing in the frequencies for normal speech.
- Trial name
- SIUTIT (NCT02490332)
- Testing
- Ventilation tube treatment
- Where
- 6 sites in Greenland
- Volunteers
- 31 people
- Sponsor
- Zealand University Hospital
Otitis Media
Eustachian Tube Growth and Development
This study is to measure over time (from 3 years until 13 years of age) Eustachian tube function (the way the Eustachian tube works) and facial growth in groups of children with two types of middle-ear disease and with little…
- Trial name
- NCT00422929
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Otitis Media, Otitis Media Chronic
CLIKX® Tympanostomy Tube Delivery System for the Placement of Tympanostomy Tubes
This study looks at the safety and performance of the CLiKX device. The device is used to place ear tubes (also called ventilation tubes) in children and adults.
- Conditions
- Otitis Media, Otitis Media Chronic, Otitis Media Effusion, Otitis Media Recurrent
- Trial name
- NCT07625657
- Testing
- CLiKX® Tympanostomy Tube Delivery System
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- ClinQure, Inc.
Otitis Media, Otorrhea
N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media
Chronic suppurative otitis media (CSOM) can be particularly difficult to treat as a number of patients do not respond to routine antibiotic or surgical treatments.
- Trial name
- NCT00956748
- Testing
- Ciprodex, Ciprodex and 2% NAC
- Where
- Canada
- Sponsor
- St. Paul's Hospital, Canada
Chronic Otitis Media Tympanic Membrane Perforation
Effect of Platelet-Rich Plasma on Eardrum Healing and Hearing After Tympanoplasty in Adults
This single-center controlled trial evaluated whether intraoperative application of autologous platelet-rich plasma (PRP)-impregnated absorbable gelatin sponge improves graft take rates and audiological outcomes in adults…
- Trial name
- NCT07664319
- Testing
- Autologous platelet-rich plasma (PRP)-impregnated Spongostan, Dry Spongostan (absorbable gelatin sponge)
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ebubekir Toprak
Chronic Suppurative Otitis Media, Hearing Impairment
Prevalence and Associations of Paediatric Chronic Suppurative Otitis Media and Hearing Impairment in Rural Malawi
This community-based cross-sectional survey will estimate the frequency and risk factors of Chronic Suppurative Otitis Media and Hearing Impairment in Children ages 4-6 years in the Chikwawa District.
- Trial name
- NCT02779907
- Testing
- No Intervention
- Where
- Malawi
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Otitis Media, Suppurative, Tympanic Membrane Perforation
Effects of 100% Medical Grade Manuka Honey on Tympanic Membrane Reconstruction Healing.
Throughout history, honey has been recognized for its healing properties. The use of honey for its medicinal properties dates back to 2200 BCE.
- Trial name
- NCT05605262
- Testing
- Manukamed - Manukapli 100% sterile honey wound dressing - Premium medical grade 16+ Leptospermum Scoparium New Zealand honey
- Where
- Indonesia
- Volunteers
- 64 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Chronic Serous Otitis Media, Simple or Unspecified
Prevalence of Mucosal Biofilm Formations in Adenoidectomy Specimens
Rationale: Bacterial biofilms are defined as an assemblage of bacterial cells enclosed in a self-produced glycocalyx matrix. Adherence on surfaces, and resistance to both antibiotic treatments and host defenses are ones of the…
- Trial name
- BOLERO (NCT01022944)
- Testing
- With chronic middle ear effusion, Without chronic middle ear effusion
- Where
- France
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Otitis Media Chronic
Acetic Acid Ear Drops Versus 0.3 % Ciprofloxacin for Chronic Suppurative Otitis Media.
This randomized controlled trial aims to compare the effectiveness of 2% acetic acid ear drops with 0.3% ciprofloxacin ear drops in the medical management of chronic suppurative otitis media (CSOM).
- Trial name
- NCT07835425
- Testing
- Acetic Acid 2% Ear Drops, Ciprofloxacin 0.3% Otic Solution
- Where
- Pakistan
- Volunteers
- 146 people
- Sponsor
- Dow University of Health Sciences
Chronic Otitis Media, Tubotympanic Disease
A Comparative Study of the Outcomes of 2 Surgical Procedures for Safe Type of Chronic Otitis Media
Mastoidotympanoplasty is a recognised surgery that is performed for chronic otitis media. But whether mastoidectomy in addition to tympanoplasty is really necessary in each and every case of quiescent chronic otitis media still…
- Trial name
- NCT00271778
- Testing
- mastoidotympanoplasty and tympanoplasty
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Karnataka Institute of Medical Sciences
Vertigo Labyrinthine
Evaluation of Vestibular Function in Patients With C.S.O.M: Safe Type
To evaluate the function of vestibular system in patients with chronic suppurative otitis media safe type.
- Trial name
- NCT04791930
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hearing
Bone Anchored Hearing Implants in Chronic Otitis Media
The aim of this study is to investigate the cost, functional benefits, and impact on the quality of life of using bone-anchored hearing devices in chronic otitis media patients
- Trial name
- NCT06047639
- Testing
- Bone-anchored hearing implants
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Pamukkale University
Chronic Otitis Media, Tympanic Membrane Perforation
Comparison of Postoperative Outcomes of Interlay vs Underlay Graft in Tympanoplasty
Chronic otitis media is a long-term ear infection that may cause a hole in the eardrum, leading to repeated ear discharge and hearing loss.
- Conditions
- Chronic Otitis Media, Tympanic Membrane Perforation, Conductive Hearing Loss
- Trial name
- NCT07149480
- Testing
- Underlay Tympanoplasty, Interlay Tympanoplasty
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Shaikh Zayed Hospital, Lahore
Chronic Suppurative Otitis Media, Tympanic Membrane; Wound
Safety Profile of Applied 100% Manuka Honey in Tympanoplasty
Throughout history, honey has been recognized for its healing properties. The use of honey for its medicinal properties dates back to 2200 BCE.
- Trial name
- NCT05657717
- Testing
- Manukamed - Manukapli 100% sterile honey wound dressing - Premium medical grade 16+ Leptospermum Scoparium New Zealand honey
- Where
- Indonesia
- Volunteers
- 64 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Chronic Suppurative Otitis Media
Comparison of Topical Use of Platelet-rich Plasma Versus Hyaluronic Acid During Endoscopic Fat Graft Myringoplasty: a Randomized Clinical Study
This study aimed to compare the effect of adding HA versus PRP to endoscopic FGM in cases of small or medium-sized central TM perforation in the form of: 1. Evaluation of the graft uptake rate. 2.
- Trial name
- NCT06505252
- Testing
- enoscopic Myringoplasty
- Volunteers
- 60 people
- Sponsor
- Assiut University
Tympanic Membrane Perforation, Otitis Media
Does Adding a Fascial Layer to the Cartilage in Tympanoplasty for Large Tympanic Membrane Perforation Affect the Overall Results?
Large tympanic membrane (eardrum) perforations present a surgical challenge and are historically associated with lower graft take rates compared to smaller perforations.
- Conditions
- Tympanic Membrane Perforation, Otitis Media, Suppurative Otitis Media, Chronic Suppurative Otitis Media
- Trial name
- NCT07834892
- Testing
- Conchal Cartilage and Perichondrium Tympanoplasty, Conchal Cartilage, Perichondrium, and Temporalis Fascia Tympanoplasty
- Volunteers
- 50 people
- Sponsor
- Assiut University