Clinical trials: Otorhinolaryngologic Diseases
Perennial Allergic Rhinitis
To Evaluate the Efficacy and Safety of HL151 Versus Placebo in Perennial Allergic Rhinitis Patients
4week, a Multicenter, Randomized, Double-blinded, Parallel, Therapeutic confirmatory Clinical Trial
- Trial name
- NCT03655210
- Testing
- HL151
- Where
- South Korea
- Volunteers
- 272 people
- Sponsor
- Hanlim Pharm. Co., Ltd.
Hearing Loss, Deafness
Evaluation of Hearing Preservation in Adults With Partial Low-Frequency Hearing Implanted With the HiFocus™ Mid-Scala Electrode
The purpose of this study is to determine the feasibility of preserving low-frequency acoustic hearing in adults with a moderate degree of hearing loss in the low frequencies and severe-to-profound hearing loss in the mid-to-high…
- Conditions
- Hearing Loss, Deafness, Hearing Disorders, Ear Diseases
- Trial name
- NCT01959152
- Testing
- HiRes™ 90K Advantage implant with HiFocus™ Mid-Scala electrode
- Where
- 3 sites in Canada
- Volunteers
- 1 people
- Sponsor
- Advanced Bionics
Hearing Loss
Speech Perception for Children With Cochlear Implants
The purpose of this study is to determine whether speech recognition in noise can be improved by the addition of a special listening program to the sound processor.
- Trial name
- NCT01059838
- Testing
- sentence recognition
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Oculopharyngeal Muscular Dystrophy, Muscular Dystrophies
Expiratory Muscle Strength Training (EMST) in Neuromuscular Disorders
The purpose of this study is to investigate the impact of expiratory muscle strength training (EMST) on the swallowing, breathing, oral intake, quality of life and cough function of people with oculopharyngeal muscular dystrophy…
- Conditions
- Oculopharyngeal Muscular Dystrophy, Muscular Dystrophies, Myopathy; Hereditary
- Trial name
- NCT04009408
- Testing
- Expiratory muscle strength therapy (EMST150, Aspire LLC)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
General Anesthesia
Heated Circuit on Sore Throat
This investigation is planned to compare the incidence and severity of postoperative sore throat according to the use of heated breathing circuit in patients undergoing endotracheal intubation for general anesthesia.
- Trial name
- NCT03693417
- Testing
- Heated circuit on, Heated circuit off
- Volunteers
- 92 people
- Sponsor
- Keimyung University Dongsan Medical Center
Nasopharyngeal Carcinoma
Reduced-dose Versus Standard Dose Radiotherapy for Nasopharyngeal Carcinomain
To study the 2-year PFS (progression-free survival) of patients with stage II-III nasopharyngeal carcinoma treated with induction chemotherapy followed by two different doses of intensity modulated radiation therapy plus…
- Trial name
- NCT05304468
- Testing
- IMRT, induction chemotherapy, cisplatin concurrent chemotherapy
- Where
- China
- Volunteers
- 452 people
- Sponsor
- Sun Yat-sen University
Voice and Resonance Disorders, Vocal Fold Polyp
Efficacy of a Semi-occluded Mask in the Treatment of Patients With Voice Disorders
Current semi-occluded vocal tract therapies limit the type of vocalizations that can be produced to single vowels, which does not promote learning of the healthy voice behavior in connected speech or generalization to…
- Conditions
- Voice and Resonance Disorders, Vocal Fold Polyp, Vocal Cord Cyst, Vocal Cord Polyp
- Trial name
- NCT03410797
- Testing
- Inclusion of semi-occluded mask in voice therapy
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Jacqueline Gartner-Schmidt
Allergic Rhinitis
Sensitivity and Specificity of Nasal Provocation Test in Allergic Rhinitis to House Dust Mites
The diagnosis of allergic rhinitis to dust mites is difficult and based on three elements : suggestive symptoms of clinical sensitization to dust mites (rhinitis), the existence of an IgE sensitization defined by skin tests and /…
- Trial name
- NCT01485523
- Testing
- Nasal provocation test
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Scoliosis Idiopathic, Vestibular Function Disorder
Evaluation of Vestibular Dysfunction or Visuospatial Perception in Individuals With Idiopathic Scoliosis
This study was planned to investigate whether there is a visual-spatial perception disorder in individuals with idiopathic scoliosis and also to reveal its dependent/independent relationship with vestibular dysfunction.
- Conditions
- Scoliosis Idiopathic, Vestibular Function Disorder, Visuospatial/Perceptual Abilities
- Trial name
- NCT05045014
- Testing
- Balance assessment, Unterberger test, Corsi Block Tapping (mobıl app)
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Inonu University
Nasopharyngeal Carcinoma
A Retrospective Study Reveals the Relationship Between gp42-IgG Epitopes and EBV-associated NPC
Epstein-barr virus (EBV) infection is a necessary factor of nasopharyngeal carcinoma (NPC). The incidence of NPC in endemic regions reaches 24.60/100,000 people, far higher than that of the worldwide average.
- Trial name
- NCT05949749
- Testing
- Epitope exploration
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Cutaneous Squamous Cell Carcinoma of the Head and Neck
Remote Audiometry to Monitor for Treatment-Related Hearing Loss in Patients With H&N SCC Receiving Cisplatin and/or Radiation
This clinical trial tests the impact of offering hearing tests (audiometry) close to home and remotely on participation in monitoring for treatment-related hearing loss in patients with head and neck squamous cell cancer…
- Conditions
- Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Cutaneous Squamous Cell Carcinoma of the Head and Neck, Head and Neck Carcinoma of Unknown Primary, Head and Neck Squamous Cell Carcinoma
- Trial name
- NCT06662058
- Testing
- Audiometric Test, Interview
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- Emory University
Noise Exposure, Hearing Loss, Noise-Induced
A Multilevel Intervention to Prevent Noise Exposure in Farmworkers
This study will test a program to reduce noise exposure and prevent hearing loss among farmworkers. Farmworkers are often exposed to high levels of noise from machinery, which can lead to hearing loss over time.
- Conditions
- Noise Exposure, Hearing Loss, Noise-Induced, Occupational Exposure
- Trial name
- POP (NCT07554378)
- Testing
- Multilevel Hearing Protection Training
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Recurrent Nasopharyngeal Carcinoma
A Clinical Trial of Chemotherapy With Lobaplatin and 5-FU in Recurrent Local or Distant Advanced NPC.
The purpose of this study is to evaluate the efficacy and safety of chemotherapy with Lobaplatin and 5-FU, in Recurrent Local or Distant Advanced Nasopharyngeal Carcinoma.
- Trial name
- NCT03210389
- Testing
- Lobaplatin
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sun Yat-sen University
Allergic Rhinitis, Seasonal Allergic Rhinitis
Threshold Concentrations for Ragweed and Birch Pollen in Seasonal Allergic Rhinitis
The ragweed Ambrosia artemisiifolia is spreading in northern Europe due to climate change. The pollen are considered highly allergenic and might trigger allergy symptoms at much lower concentrations than e.g.
- Conditions
- Allergic Rhinitis, Seasonal Allergic Rhinitis, Ragweed Allergy, Birch Pollen Allergy
- Trial name
- UBAMBI (NCT05346718)
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Allergic Rhinitis Due to House Dust Mite, Allergic Asthma Due to Dermatophagoides Farinae
N.I.S of AIT in Adult Patients With House Dust Mite Allergy in Real Practice in France
Non-interventional study to investigate the safety and tolerability of allergy immunotherapy ACARIZAX® 12 SQ-HDM in real-life clinical practice in adults patients (>18 years) with house dust mite allergy over a period of 12…
- Conditions
- Allergic Rhinitis Due to House Dust Mite, Allergic Asthma Due to Dermatophagoides Farinae, Allergic Asthma Due to Dermatophagoides Pteronyssinus
- Trial name
- CARIOCA (NCT03746860)
- Testing
- Tablet, Dispersible
- Where
- France
- Volunteers
- 1,508 people
- Sponsor
- ALK-Abelló A/S
Allergic Rhinitis, Cough
Effects of Second-generation Antihistamine Bepotastine on Cough Outcomes in Cough Patients With Allergic Rhinitis
This is a phase 4 study to evaluate the the efficacy of second generation antihistamine on cough outcomes in cough patients with allergic rhinitis.
- Trial name
- NCT04877678
- Testing
- Bepotastine
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Asan Medical Center
Nasopharyngeal Carcinoma
Neoadjuvant and Adjuvant Tislelizumab for Nasopharyngeal Carcinoma
To estimate the efficacy and safety of tislelizumab for stage IVA locally advanced nasopharyngeal carcinoma combined with induction chemotherapy and concurrent chemoradiotherapy, followed by maintenance therapy
- Trial name
- NCT05448885
- Testing
- Tislelizumab
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Sensorineural Hearing Loss
Electrode Placement and Audiologic Outcomes With the Advanced Bionics HiFocus L23 Electrode
The goal of this study is to measure patient performance after cochlear implantation with the Food and Drug Administration (FDA) approved Advanced Bionics HiFocus L23 device. The specific aims of the project are as follows: 1.
- Trial name
- NCT03858647
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Vanderbilt University Medical Center
Preterm Birth, Tube Feeding
Maternal Role in Oral Feed Establishment in Preterm Neonates
Hypothesis Preterm babies who receive sensory motor stimulation from their mothers as compared to trained nurses will 1. Start taking oral feed at the same time as compared to control group 2.
- Conditions
- Preterm Birth, Tube Feeding, Swallowing Disorder, Maternal Care Patterns
- Trial name
- NCT05484726
- Testing
- perioral sensory motor stimulation
- Where
- Pakistan
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Fatima Memorial Hospital
Basaloid Squamous Cell Carcinoma, Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer
This phase II/III trial studies how well a reduced dose of radiation therapy works with nivolumab compared to cisplatin in treating patients with human papillomavirus (HPV)-positive oropharyngeal cancer that is early in its…
- Conditions
- Basaloid Squamous Cell Carcinoma, Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Oropharyngeal Squamous Cell Carcinoma
- Trial name
- NCT03952585
- Testing
- Biopsy Procedure, Biospecimen Collection, Cisplatin
- Where
- 494 sites in United States, Canada
- Volunteers
- 384 people
- Sponsor
- National Cancer Institute (NCI)
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