Clinical trials: Otorhinolaryngologic Diseases
Otitis Media With Effusion
Clinical Study of the Tympanostomy Tube Delivery System
The objective of this investigational study is to evaluate the safety and performance of the Acclarent Tympanostomy Tube Delivery System (TTDS) for the placement of the Tympanostomy Tube [TT(s)] in patients indicated for such…
- Trial name
- inVENT (NCT00939796)
- Testing
- Acclarent Tympanostomy Tube Delivery System
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Integra LifeSciences Corporation
Nasopharyngeal Carcinoma
Penpulimab Combined With GP ± Anlotinib as Neoadjuvant Therapy in Locoregionally Advanced Nasopharyngeal Carcinoma
The purpose of this study is to explore the efficacy and safety of a combination of GP chemotherapy and Penpulimab ± Anlotinib in neoadjuvant therapy combined with Penpulimab in adjuvant therapy of locoregionally advanced…
- Trial name
- NCT05193617
- Testing
- GP+Penpulimab+Anlotinib, GP+Penpulimab
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Sun Yat-sen University
Sore Throat, Dexmedetomidine Analgesia
Effect of Preoprative Nebulized Dexmedetomidine Compared to Nebulized Lidocaine in Attenuating Sore Throat Following Tonsillectomy In Childern.
The aim of the study is to compare the effect of nebulized Dexmedetomidine compared to nebulized Lidocaine on postoperative sore throat in childern undergoing Tonsillectomy.
- Conditions
- Sore Throat, Dexmedetomidine Analgesia, Tonsillectomy
- Trial name
- NCT07780760
- Testing
- Group D (dexmedetomidine group), Group L (Lidocaine group)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Fayoum University Hospital
Mucositis, Solid Tumors
Palifermin for the Reduction of Oral Mucositis in Patients With Locally Advanced Head and Neck Cancer
The purpose of this research study is to test the safety and effectiveness of palifermin to determine if weekly doses can be safely administered to reduce the incidence (occurrence of), duration (length of time) and severity…
- Conditions
- Mucositis, Solid Tumors, Stomatitis, Head and Neck Cancer
- Trial name
- NCT00101582
- Testing
- palifermin, cisplatin chemotherapy, Radiotherapy
- Volunteers
- 188 people
- Sponsor
- Swedish Orphan Biovitrum
Nasopharyngeal Carcinoma
Molecular Genetics Study of Nasopharyngeal Carcinoma: Characterization of NCP Susceptibility Gene(s)
The objective of this study is to characterize genes associated either with susceptibility or resistance to the development nasopharyngeal carcinoma (NPC) in a Chinese population where the incidence of NPC is as high as 50 in…
- Trial name
- NCT00341146
- Where
- China
- Volunteers
- 6,490 people
- Sponsor
- National Cancer Institute (NCI)
Sinusitis, Nasal Polyps
Trial of Topical Verapamil in Chronic Rhinosinusitis With Nasal Polyps
Verapamil is an L-type calcium channel blocker(CCB) which has been shown to reduce inflammation in a variety of tissues. Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by eosinophilic inflammation as well as…
- Trial name
- NCT03102190
- Testing
- Verapamil Hydrochloride Intranasal
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Benjamin Bleier
Caregiver Burden, Alzheimer's Disease
WeCareToFeedDysphagia to Reduce Care-partner Burden Full-scale RCT
The goal of this clinical trial is to learn if a newly-created website tool, called WeCareToFeedDysphagia, helps to reduce feelings of burden in care partners of patients with Alzheimer's disease and related dementias (AD/ADRD)…
- Conditions
- Caregiver Burden, Alzheimer's Disease, Dementia, Oropharyngeal Dysphagia
- Trial name
- NCT07250113
- Testing
- WeCareToFeedDysphagia web tool
- Where
- United States
- Volunteers
- 802 people
- Sponsor
- Northwell Health
Perennial Allergic Rhinitis
A Study to Evaluate the Safety and Effectiveness of a Nasal Spray to Treat Perennial Allergies
The purpose of this study is to determine if two allergy medications are more effective than placebo.
- Trial name
- NCT00712920
- Testing
- 0.15% azelastine hydrochloride, 0.1% azelastine hydrochloride
- Where
- 43 sites in United States
- Volunteers
- 581 people
- Sponsor
- Meda Pharmaceuticals
Sensorineural Hearing Loss, Bilateral
Speech Perception of a Tonotopy-based Fitting for Cochlear Implant Recipients for 6 Months With Conventional Setting
Main objective: Compare speech recognition in noise with tonotopic fitting (FS4T) and with conventional non-tonotopic fitting (FS4noT) in adult patients implanted for 6 months with a MED-EL cochlear implant with FS4noT strategy.
- Trial name
- NCT06723262
- Testing
- Tonotopic cochlear implant fitting FS4T
- Where
- France
- Volunteers
- 25 people
- Sponsor
- MED-EL Elektromedizinische Geräte GmbH
Seasonal Allergic Rhinitis
Allergic Rhinitis Changes the Sinus Microbiome
The investigators hypothesize that treatment with QNASL will reduce nasal mucosal inflammation induced by the allergy season and prevent the changes in the microbiome caused by the allergy season.
- Trial name
- NCT01852513
- Testing
- QNASL
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Chicago
Vestibular Schwannoma
Vertigo Perception and Quality of Life in Patients After Surgical Treatment of Vestibular Schwannoma
Surgical removal of vestibular schwannoma causes acute vestibular symptoms, including postoperative vertigo and oscilopsia due to nystagmus. In general, the dominant symptom postoperatively is vertigo.
- Trial name
- ITG (NCT02963896)
- Testing
- gentamicin
- Volunteers
- 20 people
- Sponsor
- University Hospital, Motol
Recurrent Nasopharyngeal Carcinoma
Transnasal Endoscopic Surgery Combined With Adjuvant Immunotherapy for Recurrent NPC
A Prospective, Single-arm, Multicenter Clinical Study of Transnasal Endoscopic Surgery Combined With Adjuvant Immunotherapy for Recurrent Nasopharyngeal Carcinoma
- Trial name
- NCT05350891
- Testing
- endoscopic surgery
- Where
- 8 sites in China
- Volunteers
- 77 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Cisplatin, Ototoxicity
Intratympanic Steroid Treatment For The Prevention Of Inner Ear Toxicity Associated With Systemic Treatment With Cisplatin.
In this study we will aim to determine if cisplatin ototoxicity can be prevented by intratympanic administration of corticosteroids.
- Conditions
- Cisplatin, Ototoxicity, Intratympanic Steroids
- Trial name
- NCT01285674
- Testing
- Intra-tympanic Cisplatinum
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Ziv Hospital
Supraglottic Airway Efficiency, Airway Complication of Anesthesia
Wei Nasal Jet Tube vs Gastro Laryngeal Tube in Endoscopic Retrograde Cholangiopancreatography
The most common adverse event in endoscopic procedures is hypoxia. Different airway devices have been investigated in the literature to prevent hypoxia.
- Conditions
- Supraglottic Airway Efficiency, Airway Complication of Anesthesia, Airway Aspiration, Complication of Anesthesia
- Trial name
- NCT05360810
- Testing
- Wei Nasal Jet Tube, Gastro Laryngeal Tube
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people
- Sponsor
- Bezmialem Vakif University
Nasal Polyps, Nasal Diseases
Squamous Cell Carcinoma Antigen Analysis at the University Hospital Ostrava
This prospective study aimed to evaluate the usefulness of squamous cell carcinoma antigen (SCCA) as a clinical marker of sinonasal inverted papilloma (IP).
- Conditions
- Nasal Polyps, Nasal Diseases, Papilloma
- Trial name
- NCT01827423
- Testing
- Surgical removal of sinonasal papiloma
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- University Hospital Ostrava
Parkinson Disease, Dysphagia
Rehabilitation of Airway Protection in Parkinson's Disease
Airway protective disorders are a prevalent and progressive consequence of Parkinson's Disease (PD), and often result in aspiration pneumonia which is the leading cause of death in PD.
- Trial name
- NCT05700825
- Testing
- Expiratory Muscle Strength Training + Cough Skill Training
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Teachers College, Columbia University
Allergic Rhinitis
Observational Study of Allergic Rhinitis in Children
Observational, cross-sectional, prospective, multicentric study in France with private paediatricians to describe the management of allergic rhinitis in children.
- Trial name
- ORACLE (NCT05655858)
- Testing
- Management of allergic rhinitis
- Where
- France
- Volunteers
- 1,004 people
- Sponsor
- ALK-Abelló A/S
Bilateral Sensorineural Hearing Loss
Noise Reduction With Hearing Aids
The purpose of this study is to use an optimized version of the SEDA algorithm (SEDA-HA) for hearing aids to evaluate the benefit for listeners with varying degrees of hearing loss in realistic environments and evaluate its…
- Trial name
- NCT07700043
- Testing
- Speech Enhancement using Decomposition Approach-Hearing Aid (SEDA-HA) algorithm, Hearing aid (HA) prototype with SEDA-HA algorithm
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Benign Paroxysmal Positional Vertigo (Disorder)
Comparing Oral Lumbrokinase DLBS1033 and Betahistine Mesylate in Benign Paroxysmal Positional Vertigo
The goal of this clinical trial is to learn if oral lumbrokinase DLBS1033 works better than betahistine mesylate on inflammation, quality of life, and dizziness symptoms of adult benign paroxysmal positional vertigo (BPPV)…
- Trial name
- NCT07075289
- Testing
- DLBS1033, Betahistine Mesylate tablet
- Where
- Indonesia
- Volunteers
- 44 people
- Sponsor
- Universitas Sebelas Maret
Endolymphatic Hydrops
Comparison of 3 Methods to Diagnose Endolymphatic Hydrops in Meniere's Disease
The aim of this study is to compare 3 methods for the diagnosis of endolymphatic hydrops (EH) in patients with Meniere's disease: MRI 3 Tesla (to visualise EH directly), and functional explorations, namely electrocochleography…
- Trial name
- MRI Meniere (NCT03215420)
- Testing
- MRI 3T
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
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