Clinical trials: Otorhinolaryngologic Diseases
Tinnitus, Noise Induced
TNF-α Treatment of Blast-Induced Tinnitus
The purpose of this multi-site research study is to determine if Etanercept, compared to a placebo, significantly reduces the severity of tinnitus (ringing in the ears) associated with history of blast and/or noise exposure or…
- Trial name
- NCT04066348
- Testing
- Etanercept, Saline
- Where
- 4 sites in United States
- Volunteers
- 88 people
- Sponsor
- Wayne State University
Nasopharyngeal Carcinoma
PD-1 Inhibitor Plus Anti-EGFR Therapy And Radiotherapy in Locally Advanced NPC Resistant to Induction Chemotherapy
Because nasopharyngeal carcinoma （NPC）is very sensitive to radiation and the specificity of the anatomical structure, radiotherapy has become the core treatment for NPC.
- Trial name
- NCT06156878
- Testing
- Anti-EGFR and PD-1 inhibitor arm
- Where
- China
- Volunteers
- 41 people
- Sponsor
- Fudan University
Nasopharyngeal Cancer
A Study of Gemcitabine and Cisplatin/Carboplatin Plus Erlotinib in Patients With Nasopharyngeal Cancer
Cisplatin or Carboplatin will be given on day 1 every 21 days for 6 cycles; Gemcitabine will be given on day 1 and day 8 every 21 days for 6 cycles.
- Trial name
- NCT00603915
- Testing
- Gemcitabine, Carboplatin/Cisplatin, erlotinib
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Sensorineural Hearing Loss, Bilateral Hearing Loss
Comparative Analysis of Hearing Outcomes: Robotic vs. Manual Insertion of Cochlear Implants
This research study is evaluating two different methods of cochlear implant (CI) insertion - robotic-assisted insertion and manual insertion - to better understand how they affect hearing outcomes.
- Conditions
- Sensorineural Hearing Loss, Bilateral Hearing Loss, Cochlear Implantation, Hearing Disorders
- Trial name
- NCT07081542
- Testing
- IotaSoft Robotic Insertion System, Manual Cochlear Implant Insertion
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- AdventHealth
Chronic Rhinitis, Chronic Sinus Congestion
Proof-of-Concept Interventional Study With a Nasal Spray of JT-1 in Patients With Chronic Rhinitis or Chronic Sinusitis
Proof-of-concept study with a novel nasal spray in chronic rhinitis or chronic sinusitis. The study will involve 25 patients completing the study for a per protocol analysis.
- Trial name
- NCT05331222
- Testing
- JT-1
- Where
- Switzerland
- Volunteers
- 3 people
- Sponsor
- Jantar GmbH
Neuropsychological Tests, Memory
Adaptation and Normalization of a Verbal Episodic Memory Test in French Sign Language
To date, neuropsychological assessment of deaf signing persons is complicated by a lack of resources, especially the absence of tools available in French Sign Language (LSF).
- Conditions
- Neuropsychological Tests, Memory, Alzheimer Disease, Deafness
- Trial name
- RL-RI-LSF (NCT06902753)
- Testing
- Questionnaire and Physical Exam
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Respiratory Failure
Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU Patients
The COSMIC trial will be a multicentred, national, parallel-group, pragmatic vanguard pilot trial.
- Trial name
- COSMIC (NCT05456542)
- Testing
- Cuff Leak Test, Dexamethasone 4mg
- Where
- 5 sites in United States, Canada and 1 more
- Volunteers
- 100 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Benign Paroxysmal Positional Vertigo
Effects of Myofascial Release on Postural Balance and Cervical Muscle Function in Benign Paroxysmal Positional Vertigo
This completed, two-arm randomized controlled trial investigated the effects of therapist-administered myofascial release added to a progressive home-based balance exercise program in individuals diagnosed with benign paroxysmal…
- Trial name
- NCT07884786
- Testing
- Home-Based Balance Exercise Program, Myofascial Release Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Karabuk University
Myotonic Dystrophy 1, Dysphagia, Oropharyngeal
Profile of Dysphagia in Myotonic Dystrophy Type 1 (DM1)
The goal of this observational study is to learn about swallowing difficulties (dysphagia) in patients living with myotonic dystrophy type 1 (DM1).
- Trial name
- SwallowDM1 (NCT05865483)
- Where
- United Kingdom
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- University College, London
Vestibular Schwannoma
Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Vestibular Schwannoma
A recent study by Plotkin et al. showed that bevacizumab (Avastin) treatment was followed by clinically meaningful hearing improvement, tumor-volume reduction, or both in some, but not all, patients with Vestibular Schwannoma…
- Trial name
- NCT01083966
- Testing
- Bevacizumab (Avastin)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwell Health
Allergic Rhinitis, Allergic Rhinoconjunctivitis
Study With High Dose PURETHAL Mites in Allergic Rhinitis/Rhinoconjunctivitis Patients
The aim of the study is to establish the maximum tolerated dose of PURETHAL Mites that is achieved by 90% of the patients with less than 20% of the injections giving rise to a swelling of > 5 cm and the optimal regimen to reach…
- Trial name
- NCT00973453
- Testing
- PURETHAL Mites 20,000 AUeq/ml
- Where
- 6 sites in Germany
- Volunteers
- 48 people
- Sponsor
- HAL Allergy
Vestibular Disorder
Activity and Participation in Vestibular Disorders
This study will examine whether impairments and personal factors are associated with activity and participation in people with vestibulopathy.
- Trial name
- APV (NCT06271694)
- Testing
- Vestibular Rehabilitation
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Pittsburgh
Otitis Externa
OTO-201 for the Treatment of Otitis Externa
This is a 1-month, multicenter, open-label study in subjects with unilateral otitis externa. Eligible subjects will receive a single dose of 6 mg OTO-201 to the affected ear.
- Trial name
- NCT02511561
- Testing
- OTO-201 (ciprofloxacin)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Otonomy, Inc.
Vestibular Function Disorder
Combined Effects of Vestibular Rehabilitation With Dual Task Training in Vestibular Disorders
Patients with vestibular disorders often experience cognitive-motor interference which can adversely affect their motor performance, significantly impair daily functioning, increase instability, reducing quality of life and…
- Trial name
- NCT06797141
- Testing
- Vestibular Rehabilitation and Dual task Training and Traditional Physical Therapy, Vestibular Rehabilitation and Traditional Physical Therapy
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Dysphagia, Critical Illness
Optimizing Dysphagia Treatment Delivery in Acute Care: A Hybrid Efficacy Implementation Trial
This research study is investigating the efficacy and implementation of expiratory muscle strength training (EMST), standard of care dysphagia treatment, and intensive dysphagia treatment in critically ill adults in the acute…
- Trial name
- NCT07736105
- Testing
- Expiratory muscle strength training (EMST), Standard of Care Dysphagia Treatment, Intensive Dysphagia Treatment
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Vanderbilt University Medical Center
Paranasal Sinus Neoplasms
Chemoradiotherapy Followed by Surgery for Advanced Paranasal Sinus Cancer
The purpose of this study is to determine the efficacy of concurrent chemotherapy and radiotherapy pre-operatively in patients with advanced paranasal sinus cancer.
- Trial name
- NCT00347256
- Testing
- cisplatin, targeted radiation therapy, tumor resection
- Volunteers
- 60 people
- Sponsor
- University of Tennessee
Benign Paroxysmal Positional Vertigo
Canalith Repositioning Procedure for BPPV in Primary Care
The purpose of this study is to see whether family doctors can treat benign paroxysmal positional vertigo (BPPV), or dizziness, using a procedure in the office.
- Trial name
- NCT00182273
- Testing
- Canalith repositioning maneuver (CRM)
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- McMaster University
Tympanic Membrane Perforation
Comparison Tympanoplasty With Membrane Amniotic and Autologous Fascia
The tympanic membrane separates the middle and the outer ear from each other and consists of three layers. The outer layer is covered with squamous epithelium, a thick basement membrane in the middle and an inner Mucosal layer.
- Trial name
- NCT03569969
- Testing
- device: Tympanoplasty with Membrane Amniotic, Tympanoplasty With Autologous Fascia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mohammad Sadegh Bagheri Baghdasht
Recurrent or Metastatic Nasopharyngeal Cancer, Patients Who Have Experienced Treatment Failure at Least Second-line Chemotherapy
JMT101 Combined With Mitoxantrone Liposome for Nasopharyngeal Cancer
This study is a randomized, open-label, multicenter Phase II clinical study, with the objective to assess the efficacy and safety of JMT101 Injection combined with Mitoxantrone Hydrochloride Liposome Injection in patients with…
- Trial name
- NCT06892431
- Testing
- Mitoxantrone Hydrochloride Liposome, JMT101 injection, Capecitabine
- Volunteers
- 150 people
- Sponsor
- Shanghai JMT-Bio Inc.
Chronic Rhinosinusitis With Nasal Polyps
Evaluation of Patient Satisfaction During Treatment With Dupilumab in Severe and Recurrent Nasosinusal Polyposis Despite Appropriate Medical and Surgical Treatment.
Chronic rhinosinusitis with nasal polyps (CRSwNP) or nasal polyposis is a frequent disease leading to a decreased quality of life.
- Trial name
- Dupi-PNS (NCT06017427)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 32 people
- Sponsor
- IHU Strasbourg
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