Clinical trials: Otorhinolaryngologic Diseases
Tinnitus
Exploration of Cortical Neural Network in Patients With Bothersome Tinnitus
This will be an experimental task-based functional MRI pilot study involving the neuroimaging assessment of patients with severely bothersome tinnitus, defined by a global bothersome scale.
- Trial name
- NCT01385540
- Testing
- Task-Based Functional Magnetic Resonance Imaging (fMRI)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Chronic Rhinosinusitis, Intraoperative Bleeding
Effect of Vitamin C Administration on Intraoperative Bleeding in Patients Undergoing Sinusoscopy
Functional endoscopic sinus surgery (FESS), or sinusoscopy, is a standard surgical procedure used to treat chronic rhinosinusitis and other conditions of the nasal sinuses.
- Conditions
- Chronic Rhinosinusitis, Intraoperative Bleeding, Blood Loss, Surgical
- Trial name
- NCT07866274
- Testing
- Ascorbic acid
- Volunteers
- 78 people
- Sponsor
- Assiut University
Nasopharyngeal Carcinoma
Phase II Trial of Neoadjuvant and Adjuvant Anti-PD-1 Antibody Toripalimab Combined With CCRT in NPC Patients
This is a randomized Phase II trial to study the effectiveness and toxicity of neoadjuvant and adjuvant PD-1 antibody Toripalimab combined with concurrent cisplatin chemoradiotherapy versus cisplatin concurrent chemoradiotherapy…
- Trial name
- NCT03925090
- Testing
- Cisplatin+Toripalimab
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Sun Yat-sen University
Pharyngitis, Respiratory Diseases
The Efficacy and Safety of Using the Novel Tyto Device
To investigate the efficacy and safety of using the novel Tyto device for remote physical examination by co-investigators as compared to a standard medical physical examination by physicians.
- Conditions
- Pharyngitis, Respiratory Diseases, Cardiac Diseases, Ear Infection
- Trial name
- NCT02723890
- Testing
- Tyto Device
- Where
- Israel
- Volunteers
- 136 people
- Sponsor
- Rabin Medical Center
Bronchial Asthma, Allergic Rhinitis
Assessment of Sublingual Immunotherapy in Children Allergic to House Dust Mites
The purpose of the trial is to asses the efficacy and safety of sublingual annual immunotherapy in children with bronchial asthma and/or allergic rhinitis allergic to house dust mites.
- Trial name
- NCT01052610
- Testing
- sublingual house dust mites allergen extract
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Lodz
Nasopharyngeal Neoplasms
Study of Pembrolizumab (MK-3475) in Platinum Pre-treated Recurrent/Metastatic Nasopharyngeal Cancer (MK-3475-122/KEYNOTE-122)
This is a study of pembrolizumab (MK-3475) versus standard treatment (capecitabine, gemcitabine, or docetaxel) for the treatment of recurrent or metastatic nasopharyngeal cancer (NPC).
- Trial name
- NCT02611960
- Testing
- Pembrolizumab, Capecitabine, Gemcitabine
- Volunteers
- 233 people
- Sponsor
- Merck Sharp & Dohme LLC
Acute Otitis Media, Otitis Media
A Pilot Study to Evaluate the Efficacy of Montelukast in the Treatment of Acute Otitis Media (AOM) in Children
The objective of this pilot study is to evaluate the efficacy of treatment with montelukast as compared to placebo in the prevention of recurrence of acute Otitis media (AOM)
- Conditions
- Acute Otitis Media, Otitis Media, Ear Infection
- Trial name
- NCT00189462
- Testing
- Montelukast
- Where
- 2 sites in United States
- Volunteers
- 99 people
- Sponsor
- Deborah Gentile
Extraesophageal Reflux, Laryngopharyngeal Reflux
Comprehensive Analysis of the Swallowing Mechanism Using High-resolution Manometry With Impedance
The aim of this project is to perform a detailed evaluation of upper esophageal sphincter function and the swallowing mechanism in patients with swallowing disorders or suspected extraesophageal reflux using high-resolution…
- Conditions
- Extraesophageal Reflux, Laryngopharyngeal Reflux, Dysphagia, Chronic Cough
- Trial name
- NCT07365046
- Testing
- High resolution oesophageal manometry with impedance, 24-hour pH metry
- Where
- Czechia
- Volunteers
- 160 people
- Sponsor
- University Hospital Ostrava
Nasal Sinus; Inflammation, Opioid Abuse
Pain Management Following Sinus Surgery
This Study evaluates the effect of adding Non-steroidal anti-inflammatories (NSAIDs) to the post-operative pain management of sinus surgery patients and wether or not this addition reduces or eliminates the need for narcotic pain…
- Conditions
- Nasal Sinus; Inflammation, Opioid Abuse, Pain, Postoperative
- Trial name
- NCT03822962
- Testing
- Ibuprofen 600Mg Tablet, Standard Regimen | Tylenol
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Oropharyngeal Cancers
Photon/Proton Radiation Therapy for Oropharyngeal Cancers
The purpose of this study is to collect information from the questionnaire and medical records to see what effects proton radiation has on cancer and collect and analyze morbidity outcomes: incidence of xerostomia (dry mouth) and…
- Trial name
- OP01 (NCT00797446)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Florida
Sensorineural Hearing Loss, Noise Induced Hearing Loss
ABR Characteristics and Salivary Cortisone Concentration in Noise-exposed Workers
The aim of the research: Investigate the association of auditory evoked brainstem response characteristics with salivary cortisone concentrations in noise-exposed workers. Purpose of the research: 1.
- Conditions
- Sensorineural Hearing Loss, Noise Induced Hearing Loss, Auditory Nerve; Lesion
- Trial name
- NCT04183361
- Testing
- ABR and salivary cortisone testing
- Where
- Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital Sestre Milosrdnice
Hearing Disorder
Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan
Objective: One objective of this study is to genetically map and identify mutated genes for human hereditary hearing loss. A second objective is to study the function of these genes in the auditory system using mouse models.
- Trial name
- NCT00341874
- Where
- Pakistan
- Volunteers
- 18,009 people
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Paradoxical Vocal Fold Motion, Vocal Cord Dysfunction
Biofeedback vs Laryngeal Control Therapy in Management of Paradoxical Vocal Fold Motion
Paradoxical Vocal Fold Motion (PVFM) is a condition where vocal cords adduct (move toward another) instead of abduct (move away from one another) during inspiration, thus causing shortness of breath.
- Trial name
- NCT05770518
- Testing
- Biofeedback, Laryngeal control therapy (LCT)
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Washington University School of Medicine
Oropharyngeal Cancer
Exosome Testing as a Screening Modality for Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma
Cancer of the oropharynx (middle, side and back walls of the throat; back of the tongue; soft palate, and tonsils), or oropharyngeal squamous cell carcinoma (OPSCC), has been on the rise in the United States.
- Trial name
- NCT02147418
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- New Mexico Cancer Research Alliance
Speech, Memory, Delayed
Effects of Clear Speech on Listening Effort and Memory in Sentence Processing
Sensorineural hearing loss (SNHL) is among the most prevalent chronic conditions in aging and has a profoundly negative effect on speech comprehension, leading to increased social isolation, reduced quality of life, and increased…
- Conditions
- Speech, Memory, Delayed, Sensorineural Hearing Loss
- Trial name
- NCT06053190
- Testing
- Sentence stimulus, Speaking style
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Utah
Intraocular Retinoblastoma, Hearing Loss
Determining Whether Intra-Arterial Carboplatin Causes Hearing Loss in Children
The purpose of this study is to find out how often hearing loss occurs in patients with retinoblastoma after receiving treatment with intra-arterial carboplatin.
- Trial name
- NCT03866460
- Testing
- Distortion product otoacoustic emission measurement (DPOAE)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Otitis Media
Open-Label Study of OTO-201 in Pediatric Subjects With a History of Otitis Media Requiring Tympanostomy Tubes
This is an 8-week, multicenter, open-label study in which eligible subjects with a history of otitis media requiring TT placement will receive 6 mg OTO-201 to each ear.
- Trial name
- NCT02600559
- Testing
- OTO-201 (ciprofloxacin)
- Where
- United States
- Volunteers
- 501 people
- Sponsor
- Otonomy, Inc.
Head and Neck Cancer, Infection
Oral HPV Infection in Young Men
RATIONALE: Gathering information about human papillomavirus infection of the mouth in young men may help doctors learn more about risk factors for oropharyngeal cancer.
- Conditions
- Head and Neck Cancer, Infection, Precancerous Condition
- Trial name
- NCT00897273
- Testing
- comparative genomic hybridization, gene expression analysis, study of socioeconomic and demographic variables
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Urinary Bladder Neoplasms, Microtia
Microbiota in Urine and Urothelium Can be a Factor for Induction of Urinary Bladder Cancer. The Study Will Examine Urine and Bladder Cancer Tissues From Male Patients and Urine of Controls Using Whole Genomic Sequencing Techniques and 16S rRNA. The Aim is to Elucidate Role of Microbiota in Bladder
Microbes inhabiting the urinary tract that are playing an important role in maintenance of health and the development of diseases and bladder cancer. There is correlation between initiation of bladder cancer and microbes.
- Trial name
- Cancer bladder (NCT06289283)
- Testing
- Urine samples and tissue samples: Samples will be collected in clean leak-proof containers without disinfectant or detergent residue and with tight-fitting leak-proof lids and preserved in a refrigera
- Where
- Egypt
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Theodor Bilharz Research Institute
Hearing Disorder
Evaluation of Cochlear (Promontory) Stimulation During Awake Ear Surgery (TONES Study)
The goal of this clinical trial is to learn if short electrical signals can be heard in adult subjects who are otherwise having surgery on their ear.
- Trial name
- NCT07402941
- Testing
- Electrical extracochlear stimulation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Auricle Health Inc.
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.