Clinical trials: Otorhinolaryngologic Diseases
Atopy, Rhinitis
Study to Compare the Effect of a Combination of Cetirizine With Pseudoephedrine Versus Placebo on Symptoms in Patients With Allergic Rhinitis Within/Out of Season
A previous study has shown very clearly that the treatment with the combination of cetirizine and pseudoephedrine is superior to the treatment with the single agents regarding the reduction of symptoms in patients with allergic…
- Trial name
- NCT00474890
- Testing
- cetericine and pseudoephedrine
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Seasonal Allergic Rhinitis
Clinical Trial of TQC2938 Injection in Patients With Seasonal Allergic Rhinitis
To evaluate TQC2938 injection in all patients receiving background treatment with azelastine fluticasone nasal spray. The efficacy, safety and immunogenicity of the injection in patients with seasonal allergic rhinitis compared…
- Trial name
- NCT07052097
- Testing
- TQC2938 injection
- Where
- 30 sites in China
- Volunteers
- 136 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.
Allergic Rhinitis
Cellulose Powder Against Grass Pollen Allergic Rhinitis
Background: A nasally applied cellulose powder is increasingly used in many countries as a remedy for allergic rhinitis. In 2009, a 4-week study in birch pollen-allergic children showed a reduction in nasal symptoms.
- Trial name
- CPARGPDBPC (NCT03039816)
- Testing
- Nasaleze
- Where
- 3 sites in Sweden, Ukraine
- Volunteers
- 108 people
- Sponsor
- Nasaleze International Ltd
Chronic Rhinosinusitis With Nasal Polyps, Asthma
Comparison of Immune Profiles in Chronic Rhinosinusitis Patients After Mepolizumab Treatment
This study aims to analyze the immune profiles of patients with Chronic Rhinosinusitis with Nasal polyps (CRSwNP) with and without asthma before and after Mepolizumab.
- Conditions
- Chronic Rhinosinusitis With Nasal Polyps, Asthma, Chronic Rhinosinusitis Without Nasal Polyps
- Trial name
- NCT05642806
- Testing
- Mepolizumab
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- St. Paul's Sinus Centre
Pharyngitis
Best Assessment of Sore Throat and Antibiotic Prescribing
This project aims to investigate if an organisational change of patient flow away from medical practitioners can reduce unnecessary antibiotic prescribing in patients attending with a sore throat as the main complaint.
- Trial name
- BASTA (NCT06114706)
- Testing
- Physicians assess patients, Nurses assess patients, Pharmacists assess patients
- Where
- 4 sites in Sweden
- Volunteers
- 450 people
- Sponsor
- Vastra Gotaland Region
Otitis Media With Effusion
Adenoidectomy for Otitis Media in 2-3 Year Old Children
The purpose of this study is to evaluate the efficacy of three different surgical treatments (1. Bilateral myringotomy and tube insertion (M\&T); 2. Adenoidectomy and bilateral myringotomy (A\&T); 3.
- Trial name
- NCT00016497
- Testing
- bilateral myringotomy, bilateral myringotomy and tubes, adenoidectomy
- Where
- United States
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Acute Pharyngitis
Yanlishuang Buccal Dropping Pills for Acute Pharyngitis
Acute pharyngitis commonly causes sore throat and pain on swallowing. This multicenter trial will compare Yanlishuang Buccal Dropping Pills with a matching placebo in 400 adults aged 18 to 65 years whose acute pharyngitis began…
- Trial name
- YLS-AP-RCT (NCT07761013)
- Testing
- Yanlishuang Buccal Dropping Pills
- Where
- 10 sites in China
- Volunteers
- 400 people
- Sponsor
- Beijing University of Chinese Medicine
Hearing Loss, Sensorineural
A Study Of The Effects Of PF-04958242 In Subjects With Age-Related Hearing Loss
The objective of this study is to examine the safety, tolerability, and effects on hearing thresholds of two single doses of PF-04958242 and placebo in subjects with age-related hearing loss.
- Trial name
- NCT01518920
- Testing
- PF-04958242
- Where
- 11 sites in United States
- Volunteers
- 44 people
- Sponsor
- Biogen
Larynx Stenosis, Larynx Disease
Laryngeal Allograft Transplantation
The purpose of this proposed study is to obtain safety and efficacy data on human laryngeal allograft transplantation in an effort to safely use these procedures as a viable reconstructive option for patients with severe…
- Conditions
- Larynx Stenosis, Larynx Disease, Laryngectomy, Larynx
- Trial name
- NCT03269396
- Testing
- Larynx Allograft Transplantation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Sinusitis
Rates of Middle Meatus Synechiae Formation Post ESS
The study is designed to evaluate if addition of the steroid to the spacer / stent will improve healing after endoscopic sinus surgery (ESS) compared to spacer without drug.
- Trial name
- NCT03036735
- Testing
- steroid eluting spacer
- Volunteers
- 10 people
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Nasopharyngeal Carcinoma
TPC vs PF as Induction Chemotherapy Combined With CCRT for Stage IVa-b Nasopharyngeal Carcinoma
The purpose of this study is to compare the survival and toxicity of TPC (TAXOL, DDP AND CAPECITABINE ) VS PF (cisplatin and 5-Fluorouracil) as induction chemotherapy combined with concurrent chemoradiotherapy (CCRT) for stage…
- Trial name
- NCT02940925
- Testing
- Drug: Taxol,cisplatin and capecitabine, Drug: Cisplatin and 5-Fluorouracil
- Where
- China
- Volunteers
- 241 people
- Sponsor
- Sun Yat-sen University
Esophageal Neoplasm, Laryngeal Neoplasms
Feasibility Study CORPPS
The incidence of cancer in France has increased by +135% to reach nearly 400,000 new cases in 2018. The ten-year cancer control strategy 2021-2030 and the health innovation plan have defined strategic axes.
- Trial name
- FAISA-CORPPS (NCT05406024)
- Testing
- Digital platform
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Vestibular Diseases
Computerized Vestibular Rehabilitation
Disorders of vestibular function and balance are an important component of many conditions that commonly affect veterans, such as inner ear diseases, diabetes, and traumatic brain injury.
- Trial name
- NCT03589859
- Testing
- VOR Test, Computer Game, Nausea Scale
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Hereditary Haemorrhagic Telangiectasia
Iron Deficiency and Hereditary Haemorrhagic Telangiectasia
Managing iron deficiency is important for more than 1 billion individuals worldwide, to avoid blood transfusions, or excessive strain on vital organs that depend on iron-containing haemoglobin to deliver oxygen to the tissues.
- Trial name
- NCT01908543
- Testing
- Ferrous sulphate 200mg oral tablet
- Where
- United Kingdom
- Volunteers
- 3 people
- Sponsor
- Imperial College London
Otitis Media With Effusion (OME)
Short-term Application of Lactoferrin Ventilation Tubes
This study aims to evaluate the feasibility and preliminary biocompatibility of a novel lactoferrin-based ventilation tube and its manufacturing process for use in implantable medical materials.
- Trial name
- ST-LVT (NCT07913490)
- Testing
- Ventilation tube insertion
- Volunteers
- 20 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Usher Syndromes
Natural History Study of Usher Syndrome ( Light4Deaf )
Clinical centres in the LIGHT4DEAF consortium have developed and will continue to improve a reliable, early molecular diagnosis and protocols for full clinical characterisation of Usher syndrome, which will be valuable for the…
- Trial name
- Light4Deaf (NCT04665726)
- Where
- 4 sites in France
- Volunteers
- 400 people
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Anxiety, Fear Anxiety
Effect of AI(Artificial Intelligence)-Based Storytelling Video on Anxiety and Fear During Skin Prick Test in Children
This study evaluates the effectiveness of an AI-generated therapeutic storytelling video on pre-procedural anxiety and fear levels in children aged 4 to 10 years undergoing their first Skin Prick Test (SPT).
- Conditions
- Anxiety, Fear Anxiety, Allergic Rhinitis, Asthma (Diagnosis)
- Trial name
- NCT07453615
- Testing
- AI-Generated Storytelling Video, Standard Clinic Care
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Antalya Training and Research Hospital
Laryngeal Dystonia, Focal Dystonia
Effects of Neuromodulation in Laryngeal Dystonia
Laryngeal dystonia (LD) causes excessive vocal fold abduction (opening) or adduction (closing) leading to decreased voice quality, job prospects, self-worth and quality of life.
- Trial name
- NCT05095740
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- MGH Institute of Health Professions
Oropharyngeal Neoplasms, Robotic Surgery and/or Radiotherapy
Phase II Randomized-registry Embedded Study of Lymphoscintigraphy for Oropharyngeal Neoplasms to Enable Risk-adapted Nodal Guidance for Robotic Surgery and/or Radiotherapy (LONE-RANGR2)
To test a new radiation treatment design based on where your cancer is located. Most participants with oropharyngeal cancer are treated with radiation to both sides of the neck.
- Conditions
- Oropharyngeal Neoplasms, Robotic Surgery and/or Radiotherapy, Lymphoscintigraphy
- Trial name
- NCT06167291
- Testing
- Arm 1- Ipsilateral
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- M.D. Anderson Cancer Center
Systemic Sclerosis, Deglutition Disorders
Swallowing Difficulties With Medication Intake and Coping Strategies in Patients With Systemic Sclerosis
The purpose of this study is the validation of a newly developed self-report questionnaire which aims at determining the prevalence, location and intensity of SWAllowing difficulties with drug intake, and describing the impact on…
- Conditions
- Systemic Sclerosis, Deglutition Disorders, Adherence to Medication Regime, Coping Behaviour
- Trial name
- SWAMECO (NCT02105818)
- Where
- Switzerland
- Volunteers
- 64 people
- Sponsor
- Kurt Hersberger
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