Clinical trials: Otorhinolaryngologic Diseases
Rhinitis
Phenylephrine Pediatric Pharmacokinetic Study
To characterize the pharmacokinetics of phenylephrine in two pediatric populations: children, ages 2 to <12 years, and adolescents, ages 12 to <18 years.
- Trial name
- NCT00762567
- Testing
- phenylephrine HCl
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Microtia
Tissue Engineering Microtia Auricular Reconstruction: in Vitro and in Vivo Studies
Platelet-rich plasma (PRP) has mixed growth factors such as TGF-ß1 and TGF-ß2, vascular epithelial growth factor (VEGF), platelet-derived growth factor (PDGF), and insulin-like growth factor (IGF).
- Trial name
- NCT00958802
- Testing
- Platelet-rich plasma (PRP), Chondrocyte culture with FBS medium
- Where
- Taiwan
- Volunteers
- 6 people
- Sponsor
- Taipei Medical University WanFang Hospital
Severe Stroke, Acute Stroke
Optimizing Early Nutrition Support in Severe Stroke-2
Post stroke pneumonia (PSP) is one of the common early complications of stroke. Post-stroke infections, in general, are associated with less favorable neurologic outcomes.
- Conditions
- Severe Stroke, Acute Stroke, Dysphagia
- Trial name
- NCT05998902
- Testing
- Trophic enteral feeding combined with supplemental parenteral nutrition, Full enteral feeding
- Where
- 30 sites in China
- Volunteers
- 546 people
- Sponsor
- Wen Jiang-3
Hearing Loss
Psychiatric and Cognitive Assessment of Adult Patients With Hearing Impairment
1. Assess the impact of hearing impairment on cognition 2. Evaluate the impact of hearing impairment on mental health 3. Evaluate the impact of hearing impairment on quality of life 4.
- Trial name
- NCT06238102
- Testing
- pure tone audiometry
- Volunteers
- 132 people
- Sponsor
- Assiut University
Dementia, Hearing Loss
Evaluation of the Impact of Cochlear Implants on Cognition in Older Adults
The subjects will be age 65 years and older, with no upper limit of age range with hearing loss that are candidates for standard-of-care cochlear implant.
- Conditions
- Dementia, Hearing Loss, Presbycusis
- Trial name
- NCT02729402
- Testing
- Cognitive Testing
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Utah
Recurrent Acute Otitis Media, Acute Otitis Media
Efficacy of the EarPopper Device in Children With Recurrent Otitis Media
This is a randomized controlled clinical trial evaluating the efficacy of the EarPopper device (EP) in the reduction of episodes of acute otitis media (AOM) in children with recurrent otitis media.
- Trial name
- NCT03534219
- Testing
- EarPopper
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwell Health
Hearing Loss
Relationship Between Auto NRT and Behavioural T & C Levels With the Nucleus Freedom Cochlear Implant
Cochlear implants require programming on an individual basis to provide appropriate levels of electrical stimulation. This program, or "map", is placed in the speech processor of the cochlear implant.
- Trial name
- NCT00331539
- Testing
- Cochlear Implant
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bnai Zion Medical Center
Cochlear Hearing Loss
Safety and Performance of HiRes Ultra/Ultra 3D Cl Mid-Scala Electrodes in Adults With Severe-to-profound Hearing Loss
This is a prospective study designed to evaluate the safety and performance of the HiRes Ultra Cl HiFocus MS Electrode and HiRes Ultra 3D Cl HiFocus MS Electrode (Ultra X) under normal conditions of use as it is approved for this…
- Trial name
- NCT04610112
- Testing
- Cochlear implantation
- Where
- 3 sites in Germany
- Volunteers
- 30 people
- Sponsor
- Advanced Bionics AG
Allergic Rhinitis
Impact Of Montelukast On Allergic Rhinitis And Its Inflammatory Makers
To examine the efficacy of Montelukast as an adjunct to INCS in patients with allergic rhinitis.
- Trial name
- NCT05381207
- Testing
- Montelukast Oral Tablet
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Acoustic Trauma
Study of Diagnostic Biomarkers of Acute Acoustic Trauma
Every year, more than two thousand acute acoustic trauma occur in France, equally between the military and the civilian environment.
- Trial name
- BIOTSA (NCT04832230)
- Testing
- Hearing test, Questionnaire about previous noise exposure, Otoacoustic emission measurement
- Where
- 14 sites in France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Carcinoma, Squamous Cell of Head and Neck, Oropharynx Squamous Cell Carcinoma
Adjuvant De-Escalated Radiation + Adjuvant Nivolumab for Intermediate-High Risk P16+ Oropharynx Cancer
This clinical trial will evaluate a new combination of treatments for Oropharyngeal Squamous Cell cancers (OPSCC), and compare it to the current standard of care (concurrent, platinum-based chemoradiotherapy).
- Trial name
- NCT03715946
- Testing
- Nivolumab Injection, Radiotherapy (RT)
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Robert L. Ferris, MD, PhD
Dysphagia, OSA
Obstructive Sleep Apnea (OSA), Oral Frailty, Dysphagia, Continuous Positive Airway Pressure (CPAP)
The purpose of this study is to evaluate the effects of the CPAP treatment on oral frailty and dysphagia among OSA patients.
- Conditions
- Dysphagia, OSA, CPAP
- Trial name
- NCT05977296
- Testing
- CPAP
- Where
- Taiwan
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Age Related Hearing Loss, Deafness
A Clinical Trial of the Safety and Efficacy of TJ0113 Capsules in the Treatment of Patients With Age-related Hearing Loss
The purpose of this study is to explore the safety and efficacy of TJ0113 capsules in patients with age-related hearing loss.
- Trial name
- NCT07012746
- Testing
- TJ0113 capsules
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Yilai Shu
Rhinitis, Allergic, Seasonal, Hay Fever
Study Using the Environmental Exposure Unit (EEU) to Assess the Onset of Action of Ciclesonide, Applied as a Nasal Spray in the Treatment of Seasonal Allergic Rhinitis (BY9010/M1-407)
The primary objective of this placebo-controlled EEU study is to determine the time to onset of action of ciclesonide, applied as a nasal spray (200 mg, once daily) in patients with SAR.
- Trial name
- NCT00659503
- Testing
- Ciclesonide
- Where
- Canada
- Volunteers
- 420 people
- Sponsor
- AstraZeneca
Oropharyngeal Squamous Cell Cancer
Phase II Treatment Stratification Trial Using Neck Dissection-Driven Selection to Improve Quality of Life for Low Risk Patients With HPV+ Oropharyngeal Squamous Cell Cancer
Investigators will determine whether a treatment paradigm of up-front neck dissection, to more accurately pathologically stage patients, minimizing the number of treatment modalities in patients with low risk oropharyngeal…
- Trial name
- NCT02784288
- Testing
- Neck Dissection, Standard-of-Care (SOC) Transoral Surgery of Primary Site, SOC Radiation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan Rogel Cancer Center
Nasal Obstruction, Deviated Nasal Septum
Diagnosis of Respiratory Disorders by the Numerical Modeling.
Chronic Nasal obstruction (CNO) is not currently measurable objectively because clinicians use validated declarative self-questionnaires whose results are linked to the level of understanding, the acute or chronic clinical…
- Trial name
- JUNE (NCT06670261)
- Testing
- Data collection
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Hearing Loss, Sensorineural
Autoimmunity in Inner Ear Disease
The purpose of this study is to determine whether prednisone, methotrexate, and cyclophosphamide are effective in the treatment of rapidly progressive sensorineural hearing loss in both ears.
- Trial name
- NCT00000361
- Testing
- Corticosteroids, Methotrexate
- Where
- 9 sites in United States
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Hearing Loss,Conductive
Half-thickness Tragal Cartilage Graft vs Temporalis Fascia Graft Tympanoplasty Type I
The rationale of this study is to find out the surgical outcome and success rates of tragal cartilage and temporalis fascia, subsequently to develop guide line in light of the results of this study for our department as our…
- Trial name
- PTA (NCT03817242)
- Testing
- Tympanoplasty using tragal cartilage graft, Tympanoplasty using temporalis fascia graft
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Lady Reading Hospital, Pakistan
Sleep Apnea, Obstructive Sleep Apnea
Effect on Sleep of Surgical Treatment of Severe Nasal Obstruction
The aim of the study is to evaluate the effect of nasal desobstruction surgery (septoplasty, septorhinoplasty or total ethmoidectomy) on sleep quality, assessed by the variation of the Wake after sleep onset (WASO), in patients…
- Conditions
- Sleep Apnea, Obstructive Sleep Apnea, Nasal Obstruction
- Trial name
- SOMNOSE (NCT05582070)
- Testing
- actigraphy
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Bordeaux
Tinnitus, Trigger Point Pain, Myofascial
Dry Needling on the Treatment of Chronic Somatosensory Tinnitus: An Open Pilot Study
Self paring study, double blind placebo controlled with chronic tinnitus patients attended at the Tinnitus Research Group HC- FMUSP, complaining of neck and/or cervical pain and with myofascial trigger point in the head, neck…
- Conditions
- Tinnitus, Trigger Point Pain, Myofascial, Somatosensory Disorders
- Trial name
- NCT03295890
- Testing
- Dry Needing
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo General Hospital
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