Clinical trials: Otorhinolaryngologic Diseases
Nasopharyngeal Carcinoma
Nedaplatin Versus Cisplatin and Capecitabine Versus Fluorouracil in IC + CCRT for Locoregionally Advanced NPC
This is a phase 3, multicentre, non-inferiority, randomised factorial trial. The purpose of this study is to study the efficacy and safety of nedaplatin versus cisplatin, and capecitabine versus fluorouracil in induction…
- Trial name
- NX-NPC (NCT03503136)
- Testing
- docetaxel, nedaplatin, and capecitabine, nedaplatin, docetaxel, cisplatin, and fluorouracil
- Where
- China
- Volunteers
- 632 people
- Sponsor
- Sun Yat-sen University
Hidden Hearing Loss, Cochlear Synaptopathy
Relationship Between LS Chirp ABR and Speech-in-Noise Skills in Hidden Hearing Loss
It is known that the underlying problem in Hidden Hearing Loss (HHL) is cochlear synaptopathy (CS) and that low-spontaneous-rate auditory nerve fibers play an important role in this pathology.
- Trial name
- NCT07230236
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Hodgkin Disease, Non-Hodgkin Lymphoma
Most Closely Matched 3rd Party Rapidly Generated LMP, BARF1 And EBNA1 Specific CTL, EBV-Positive Lymphoma (MABEL)
The subject has a type of cancer or lymph gland disease associated with a virus called Epstein Barr Virus (EBV), which has come back, is at risk of coming back, or has not gone away after standard treatments.
- Conditions
- Hodgkin Disease, Non-Hodgkin Lymphoma, Severe Chronic Active Epstein Barr Virus, T/NK-lymphoproliferative Disease
- Trial name
- MABEL (NCT02287311)
- Testing
- MABEL CTLs, Cyclophosphamide, Fludarabine
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Baylor College of Medicine
Nasal Bleeding
Epinephrine Nebulization Prior to Nasotracheal Intubation
This randomised, prospective study performed in Ain shams university hospitals over 126 Patients ASA I and ASA II, trauma patients who suffered isolated mandibular fractures and necessitated nasal intubation during general…
- Trial name
- NCT05738564
- Testing
- Epinephrine Inhalation Solution
- Where
- Egypt
- Volunteers
- 126 people
- Sponsor
- Ain Shams University
Hearing Loss - Conductive
Stability of the Cochlear Baha BI300/BA400 Implant System Loaded From 1 Week Post-surgery
Objectives To evaluate the safety of processor loading of the Cochlear BI300/BA400 implant system 1 week after implantation To evaluate the short term soft tissue healing and the long term skin reaction, with the new Cochlear…
- Trial name
- NCT02096809
- Testing
- One week loading of Bone Anchored Hearing Aid (BAHA), Cochlear Baha BI300/BA400 Implant System
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- Aarhus University Hospital
Hearing Loss, Bone Anchored Hearing Aids
Attitude Change Of Hearing Health Professionals On Bone-Anchored Hearing Devices Over Time In a Developing Country
This study aims to examine shifts in attitudes about bone-anchored hearing instruments (BAHIs) among hearing health professionals over a period of time.
- Trial name
- NCT06215599
- Testing
- Survey
- Where
- Turkey (Türkiye)
- Volunteers
- 243 people
- Sponsor
- Pamukkale University
Seasonal Allergic Rhinitis
A Study to Compare the Efficacy of QAV680 Against Placebo in Treating Seasonal Allergic Rhinitis in an Environmental Exposure Chamber
This study will compare the effectiveness of QAV680 against placebo in treating the symptoms of seasonal allergic rhinitis in an Environmental Exposure Chamber.
- Trial name
- NCT00784732
- Testing
- QAV680, Mometasone Furoate
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- Novartis
Acute Otitis Media
Bio-Kult Infantis® in AAD Prevention in Infants
Background: antibiotic-associated diarrhoea (AAD) is defined as an acute inflammation of the intestinal mucosa associated to the administration of antibiotics.
- Trial name
- NCT03516409
- Testing
- Biokult
- Where
- Italy
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- Probiotics International Ltd.
Pancreatic Cancer, Thyroid Cancer
Integrated Cancer Repository for Cancer Research
The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer…
- Conditions
- Pancreatic Cancer, Thyroid Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- iCaRe2 (NCT02012699)
- Where
- 42 sites in United States
- Volunteers
- 999,999 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Hearing Loss, Conductive, Hearing Loss, Mixed
Investigating Hearing With the Ponto 4, a Bone Anchored Hearing Aid
The study is a combined retrospective (fitting visit) and prospective (study visit), multi-center, single arm study The study is part of the Post Market Clinical Follow (PMCF) activity.
- Trial name
- NCT04761926
- Testing
- Audiometry
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Oticon Medical
Hearing Loss
Clinical Study of Cochlear Implants in Adults With Asymmetrical Hearing Loss
The objective of this study is to investigate benefits of binaural hearing for non-traditional cochlear implant candidates (with Asymmetric Hearing Loss).
- Trial name
- NCT02004535
- Testing
- Cochlear Implantation
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Washington University School of Medicine
Seasonal Allergic Rhinitis
A Study to Evaluate the Safety and Efficacy of Two Nasal Sprays to Treat Seasonal Allergies
The purpose of this study was to determine if two allergy medications are more effective than placebo.
- Trial name
- NCT00720278
- Testing
- 0.15% azelastine hydrochloride 1644 mcg daily, 0.1% azelastine hydrochloride 1096 mcg daily
- Where
- 29 sites in United States
- Volunteers
- 526 people
- Sponsor
- Meda Pharmaceuticals
Imaging Data Collection From Dynamic Swallowing MRI in Healthy Volunteers, Create Operating Algorithms
Transposition of Dynamic MRI Data From Healthy Subjects to an in Vitro Swallowing Simulator
Swallowing is a complex process, involving a very fine synchronization of the pharyngo-larynx, with respiration, under the control of the central nervous system and numerous peripheral effectors.
- Conditions
- Imaging Data Collection From Dynamic Swallowing MRI in Healthy Volunteers, Create Operating Algorithms, Apply the Imaging Data of MRI to a Swallowing Simulator
- Trial name
- SWALL-E (NCT05178108)
- Testing
- Real-time MRI of swallowing
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Hearing Loss, Fall
The Impact of Hearing Loss Severity on Balance Intervention Outcomes
The goal of this study is to learn about how hearing loss impacts balance intervention outcomes and risk of falling in older adults.
- Conditions
- Hearing Loss, Fall, Postural Balance
- Trial name
- NCT05681078
- Testing
- A Matter of Balance: Managing Concerns about Falls
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Allergic Rhinitis (w/w Asthma) Due to Alternaria Alternata
Sublingual Immunotherapy In Alternaria-Induced Rhinitis
Respiratory allergy due to Alternaria is a relevant clinical problem, and specific immunotherapy may represent a viable treatment option. Sublingual immunotherapy (SLIT) is safe and effective, but data for Alternaria are lacking.
- Trial name
- NCT01127035
- Testing
- sublingual immunotherapy
- Where
- Italy
- Volunteers
- 27 people
- Sponsor
- University of Genova
Cervical Cancer, Head and Neck Squamous Cell Carcinoma
HRYZ-T101 TCR-T Cell for HPV-18 Positive Advanced Solid Tumor
A single center, open, single arm dose escalation phase I study to evaluate the safety, tolerability, and efficacy of HRYZ-T101 TCR-T cell for HPV18 positive advanced solid tumor.
- Conditions
- Cervical Cancer, Head and Neck Squamous Cell Carcinoma, Oropharyngeal Cancer, Vagina Tumor
- Trial name
- NCT05787535
- Testing
- Fludarabine + Cyclophosphamide, HRYZ-T101 TCR-T Cell
- Where
- China
- Volunteers
- 17 people
- Sponsor
- HRYZ Biotech Co.
Dysphagia, Dysphonia
Dysphagia and Dysphonia Outcomes in SARS CoV-2 (COVID-19) Infection (DYADS Study)
This study examines the presence, severity and natural history of dysphagia and dysphonia in the post-extubation and severely unwell COVID-19 patient.
- Conditions
- Dysphagia, Dysphonia, Subglottic Stenosis, Voice Disorders
- Trial name
- DYADS (NCT04584658)
- Testing
- Fibreoptic Endoscopic Evaluation of Swallowing (FEES), Videofluoroscopy, Dysphagia Handicap Index (DHI)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Rhinitis, Allergic
A Study to Evaluate Changes in Nasal Airflow of Loratadine/Pseudoephedrine Tablet and Fluticasone Propionate Nasal Spray in Subjects Following Allergen Exposure
The purpose of the study is to evaluate changes in nasal airflow caused by loratadine 5 mg/pseudoephedrine sulfate 120 mg (Claritin D) tablet and fluticasone propionate 50 mcg per spray nasal spray (Flonase) in subjects suffering…
- Trial name
- NCT03443843
- Testing
- loratadine + pseudoephedrine sulfate (BAY818725/Claritin-D), Fluticasone Propionate
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- Bayer
Tinnitus, Temporomandibular Joint Disorders
CBCT and Audiological Analysis of the TMJ-Tinnitus Relationship
The aim of this study is to investigate the relationship between Temporomandibular Disorders (TMD) and subjective tinnitus at both morphological and functional levels.
- Conditions
- Tinnitus, Temporomandibular Joint Disorders, Somatosensory Tinnitus, Osteoarthritis, Temporomandibular Joint
- Trial name
- NCT07460193
- Testing
- Cone Beam Computed Tomography (CBCT), Audiological Assessment, Clinical TMJ Examination
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Kutahya Health Sciences University
Nasopharyngeal Carcinoma, CIPN - Chemotherapy-Induced Peripheral Neuropathy
Compression Therapy as a Prophylactic Method Against CIPN: a Prospective Self-controlled Trial
This is a single-center, self-controlled, evaluator-blinded prospective study, which applies pressurized gloves and foot caps to prevent paclitaxel-induced peripheral neuropathy in patients with nasopharyngeal carcinoma.
- Trial name
- CIPN (NCT05531916)
- Testing
- Pressurized gloves and foot caps
- Where
- China
- Volunteers
- 182 people
- Sponsor
- Sun Yat-sen University
The first 5,000 results can be paged through. Add a filter or change the sort order to reach the rest.