Clinical trials: Otorhinolaryngologic Neoplasms
Vestibular Schwannoma
Enhancing Facial Nerve Function With Omega-3 After Resection of Vestibular Schwannoma
The purpose of this research is to develop a therapeutic agent to help improve facial nerve outcomes and ultimately improve long-term quality-of-life following surgical resection of vestibular schwannomas.
- Trial name
- EFFORTS (NCT05116878)
- Testing
- Omega-3
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mayo Clinic
Otitis Media Effusion, Nasopharyngeal Carcinoma
Distribution of Bacteria in OME After Radiotherapy For NPC.
To observe the prognostic difference of tympanocentesis in different kinds of otitis media effusion.
- Trial name
- NCT06523933
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Nasopharyngeal Carcinoma, T2-3N0 or T1-2N1
PD-1 Combined With Intensity Modulated Radiation Therapy in the Treatment of Intermediate-risk Nasopharyngeal Carcinoma
To evaluate the safety and efficacy of PD-1 immune checkpoint inhibitor combined with intensity modulated radiation therapy in the treatment of intermediate-risk nasopharyngeal carcinoma (T2-3N0 or T1-2N1 stage and EBV-DNA≤4000…
- Conditions
- Nasopharyngeal Carcinoma, T2-3N0 or T1-2N1, EBV-DNA≤4000 Copy/ml
- Trial name
- NCT05229315
- Testing
- Toripalimab, Intensity modulated radiotherapy
- Where
- China
- Volunteers
- 45 people
- Sponsor
- XIANG YANQUN
Cancer Larynx, Total Laryngectomy
Effects of Propofol-dexmedetomidine on Immune Function in Patients With Cancer Larynx
The aim of this prospective, randomized clinical study is to compare between propofol and isoflurane on perioperative immune cell populations and function in patients undergoing total laryngectomy surgery.
- Trial name
- NCT02739958
- Testing
- Propofol group, Isoflurane group
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Mansoura University
Vestibular Schwannoma, Unilateral Vestibular Deficit
Early Rehabilitation Using Head Impulse Test for Acute Vestibular Deficit
The vestibulo-ocular reflex (VOR) induces a compensatory movement in the eye when the head is rotated, to maintain stable vision when we move. It originates in the peripheral vestibular system, which detects head movements.
- Trial name
- KINE HIT (NCT06660082)
- Testing
- Experimental treatment: Head movements
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Hospices Civils de Lyon
Nasopharyngeal Carcinoma
40.2Gy Versus 49.2Gy Radiotherapy in Low-Risk Target Volume for Chemosensitive Stage II Nasopharyngeal Carcinoma
This study aims to explore the efficacy and adverse events of reduced-dose radiotherapy (40.2Gy) versus conventional-dose radiotherapy (49.2Gy) to low-risk target volume for chemosensitive intermediate-stage nasopharyngeal…
- Trial name
- NCT07328854
- Testing
- Cisplatin-based induction chemotherapy, Full course of PD-1 monoclonal antibody, Reduced-dose radiotherapy to CTV2
- Where
- 15 sites in China
- Volunteers
- 346 people
- Sponsor
- Ming-Yuan Chen
Neurofibromatosis Type II, NF2
Study to Determine Optimal Dose, Evaluate the Efficacy and Safety of PRG-N-01 in Patients With Neurofibromatosis Type II
The goal of this clinical trial is to learn if Trineumin(Code name:PRG-N-01) works to treat Neurofibromatosis Type II(NF2) in adults. It will also learn about the safety and tolerability and toxicity of PRG-N-01.
- Trial name
- NCT07131722
- Testing
- Trineumin
- Volunteers
- 25 people
- Sponsor
- PRG Science & Technology Co., Ltd.
Solid Tumor, Non-Small Cell Lung Cancer
Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)
This is a Phase 1/2, open-label, non-randomized, 4-part trial to determine the safety profile and identify the maximum tolerated dose (MTD) and/or recommended Phase 2 dose (RP2D) of INBRX 106 administered as a single agent or in…
- Conditions
- Solid Tumor, Non-Small Cell Lung Cancer, Head and Neck Cancer, Melanoma
- Trial name
- NCT04198766
- Testing
- INBRX-106 - Hexavalent OX40 agonist antibody, pembrolizumab 200 mg, pembrolizumab 400 mg
- Where
- 42 sites in United States, Singapore and 2 more
- Volunteers
- 340 people
- Sponsor
- Inhibrx Biosciences, Inc
Vestibular Schwannoma, Unilateral Vestibular Deficit
Mapping of Vestibular Centers Activation Using fMRI in Patients With Vestibular Schwannoma
The goal of this clinical trial is to visualize the possible activation of vestibular centers in the brain using in patiens with unilateral vestibular damage, specifically in patients after vestibular schwannoma surgery.
- Conditions
- Vestibular Schwannoma, Unilateral Vestibular Deficit, Healthy
- Trial name
- NCT07130851
- Testing
- vestibular schwannoma resection
- Where
- Czechia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Marketa Bonaventurova
Target Volume Delineation, Early-stage Nasopharyngeal Carcinoma
Delineation of Reducing Clinical Target Volume for Early-stage Nasopharyngeal Carcinoma Patients
To analyze the long-term results and toxicities of the reducing clinical target volume (CTV) delineation method in early-stage nasopharyngeal carcinoma (NPC) patients treated with intensity modulated radiation therapy (IMRT).
- Conditions
- Target Volume Delineation, Early-stage Nasopharyngeal Carcinoma, Intensity Modulated Radiation Therapy
- Trial name
- NCT03839602
- Testing
- Reducing CTV
- Where
- China
- Volunteers
- 103 people
- Sponsor
- Sun Yat-sen University
Nasopharyngeal Carcinoma
Molecular Genetics Study of Nasopharyngeal Carcinoma: Characterization of NCP Susceptibility Gene(s)
The objective of this study is to characterize genes associated either with susceptibility or resistance to the development nasopharyngeal carcinoma (NPC) in a Chinese population where the incidence of NPC is as high as 50 in…
- Trial name
- NCT00341146
- Where
- China
- Volunteers
- 6,490 people
- Sponsor
- National Cancer Institute (NCI)
Nasopharyngeal Neoplasms
ADjuVant Apatinib in Nasopharyngeal Carcinoma Patients With Residual Epstein-Barr Virus (EBV) DNA Following Radiotherapy
This study will enroll patients with non-metastatic nasopharyngeal carcinoma (NPC) that have residual Epstein-Barr virus (EBV) DNA after curative radiotherapy or chemoradiotherapy.
- Trial name
- ADVANCE (NCT02874651)
- Testing
- Apatinib
- Where
- 3 sites in China
- Volunteers
- 25 people
- Sponsor
- Sun Yat-sen University
Squamous Cell Carcinoma, Oropharynx Cancer
PET-MRI Assessment of Early Tumor Response to Predict Outcomes of HPV-Positive Oropharynx Cancer Patients
This proposal explores the novel hypothesis that the variability in outcomes within the Intermediate Risk(IR) HPV-positive Oropharynx Squamous Cell Carcinoma(OPSCC) cohort can be exploited to identify a subpopulation that…
- Trial name
- NCT03342378
- Testing
- Intensity modulated radiotherapy (IMRT), PET-MRI
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Wisconsin, Madison
Head and Neck Cancer
Endoscopic Surgery or Radiation Therapy in Treating Patients With Stage 0, Stage I, or Stage II Laryngeal Cancer of the Glottis
RATIONALE: Endoscopic surgery is a less invasive type of surgery for laryngeal cancer and may have fewer side effects and improve recovery. Radiation therapy uses high-energy x-rays to kill tumor cells.
- Trial name
- NCT00334997
- Testing
- endoscopic surgery, laser surgery, radiation therapy
- Where
- 6 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- University College London Hospitals
Nasopharyngeal Carcinoma, Adverse Effect of Radiation Therapy
Treatment of Bevacizumab Followed by Steroid in RN
Treatment of bevacizumab followed by steroid may have a better effect on patients with radiation-induced brain injury.This randomized trial aims to investigate whether treatment of bevacizumab followed by steroid may alleviate…
- Conditions
- Nasopharyngeal Carcinoma, Adverse Effect of Radiation Therapy, Brain Injuries
- Trial name
- NCT04553510
- Testing
- Bevacizumab and steroid
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Recurrent Laryngeal Cancer
Nomograms to Precisely Predict Conditional Risk of Recurrence for Patients With Laryngeal Cancer
Advanced laryngeal squamous cell carcinoma (SCC) remains a highly morbid and fatal disease despite aggressive interventions. Mortality is high in this cohort: laryngeal cancer affects over 13 000 patients in the United States…
- Trial name
- NCT03595410
- Testing
- Recurrence laryngeal cancer
- Where
- China
- Volunteers
- 300 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Nasopharyngeal Carcinoma, Head and Neck Cancer
Exploratory Study of EBV DNA Titre Clearance Whilst on Proton Beam Therapy
How does plasma Epstein-Barr Virus (EBV) DNA level change during definitive radiation therapy for nasopharyngeal carcinoma (NPC) in the teenage and young adult cohort and does it correlate with outcomes?
- Conditions
- Nasopharyngeal Carcinoma, Head and Neck Cancer, Nasopharyngeal Cancer, Epstein-Barr Virus
- Trial name
- ClearED (NCT06480903)
- Volunteers
- 10 people
- Sponsor
- The Christie NHS Foundation Trust
Cancer Head Neck
Single and Combined Modality Trans-Oral Robotic Surgery in Early Oropharyngeal Cancer
Multi-centre retrospective observational cohort study with optional exploratory radiomic study (international) and prospective molecular analysis studies (UK only).
- Trial name
- SCORE (NCT05933889)
- Testing
- Molecular Analysis, Radiomic/ Morphological analysis
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Nasopharyngeal Carcinoma
Olfactory Change After Chemo-radiotherapy for Nasopharyngeal Carcinoma
This is an observational cohort study aimed to explore the changes of olfactory function at multiple time points from baseline to 1 year after radiotherapy among the local advanced nasopharyngeal carcinoma patients.
- Trial name
- NCT05146050
- Where
- China
- Volunteers
- 107 people
- Sponsor
- Sun Yat-sen University
Vestibular Schwannoma
Preoperative Vestibular Rehabilitation Effectiveness After Vestibular Schwannoma Surgery
Vestibular schwannoma (VS) is a benign tumour from Schwann cells surrounding the vestibular nerve, which slowly grows within the internal auditory canal and then into the cerebellopontine angle, leading to a gradual vestibular…
- Trial name
- ReveSTAN (NCT02275325)
- Testing
- Preoperative vestibular rehabilitation
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France
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