Clinical trials: Out-of Hospital Cardiac Arrest
Out-Of-Hospital Cardiac Arrest, Healthy
Dose-Finding Study of Intranasal Insulin in Healthy Participants Insulin in Healthy Participants
This study is to determine the safety and tolerability of regular insulin (Humulin R) when given intranasally (as drops in nostrils).
- Trial name
- NCT05062785
- Testing
- Intranasal insulin
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Robert Silbergleit
Out-of-hospital Cardiac Arrest (OHCA)
Resuscitation Enhancement to Avoid Rearrest Through Evidence-based Strategies in Prehospital Post-resuscitation Care
Out-of-hospital cardiac arrest (OHCA) remains a leading global emergency condition with low survival to hospital discharge despite advances in cardiopulmonary resuscitation.
- Trial name
- RE-ARREST (NCT07239908)
- Testing
- Prehospital post cardiac arrest care protocol
- Where
- Thailand
- Volunteers
- 318 people
- Sponsor
- Siriraj Hospital
Hypothermia, Heart Arrest
Clinical and Economical Interest of Endovascular Cooling in the Management of Cardiac Arrest (ICEREA Study)
According to international guidelines, mild therapeutic hypothermia is recommended for resuscitated patients after cardiac arrest due to ventricular fibrillation.
- Trial name
- NCT00392639
- Testing
- Comparison of 2 cooling procedures
- Where
- France
- Volunteers
- 389 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Out-of-Hospital Cardiac Arrest
Predicting Long-term Outcomes After Cardiac Arrest by Using Serum NGAL
This study was performed to determine the prognosis of patients after cardiac arrest using serum markers called NGAL. The initial NGAL values of patients with post-cardiac arrest syndrome are checked by blood tests, and the…
- Trial name
- NCT03615300
- Testing
- serum NGAL
- Where
- South Korea
- Volunteers
- 73 people
- Sponsor
- Uijeongbu St. Mary Hospital
Sudden Cardiac Death, Acute Myocardial Infarction
Thrombus and Inflammation Study in Sudden Cardiac DEath
Sudden death is a natural death occurring within one hour after the onset of symptoms. It remains a major public health problem and accounts for 5 to 10 % of the annual total mortality ie about 300.000 in the United States.
- Trial name
- TIDE (NCT00748111)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 380 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Out-Of-Hospital Cardiac Arrest, BIS
Frontal EEG in OHCA Feasibility Study
This study aims to optimize the treatment of out-of-hospital cardiac arrest (OHCA) by focusing on neurological outcomes through Bispectral Index (BIS) monitoring.
- Trial name
- FEICA (NCT06072092)
- Testing
- BIS Monitor
- Where
- Austria
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Out-Of-Hospital Cardiac Arrest
Differential Diagnosis and Cause-specific Treatment During OHCA
Differential diagnosis: ultrasound, blood gas analyse combined with examination of the patient and environment is used during Out Of Hospital Cardiac Arrest (OHCA) to screen possible underlying cause of cardiac arrest.
- Trial name
- NCT04670354
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Helsinki University Central Hospital
Cardiac Arrest
Antioxidant and NMDA Receptor Blocker Wins Anoxic Brain Damage of KorEa OHCA Patients
This study aims to investigate the efficacy and safety of Neu2000KWL, a neuroprotectant, in patients resuscitated from out-of-hospital cardiac arrest and receiving therapeutic hypothermia.
- Trial name
- AWAKE (NCT03651557)
- Testing
- Neu2000KWL High-dose group, Neu2000KWL Low-dose group
- Where
- 6 sites in South Korea
- Volunteers
- 150 people
- Sponsor
- GNT Pharma
Out-Of-Hospital Cardiac Arrest
Feedback Intervention and Treatment Trial in Patients With Out-of-Hospital Cardiac Arrest
The trial collects and analyzes data from Cardiac Arrest Centres in patients with out-of-hospital cardiac arrest (OHCA).
- Trial name
- FITT-OHCA (NCT06299969)
- Where
- Germany
- Volunteers
- 3,000 people
- Sponsor
- St.Bernward Hospital
Out-Of-Hospital Cardiac Arrest, Ventricular Fibrillation
DOuble SEquential External Defibrillation for Refractory VF
Despite significant advances in resuscitation efforts, there are some patients who remain in refractory ventricular fibrillation (VF) during out-of-hospital cardiac arrest.
- Trial name
- DOSEVF (NCT04080986)
- Testing
- Double Sequential Defibrillation, Vector Change Defibrillation
- Where
- 6 sites in Canada
- Volunteers
- 405 people
- Sponsor
- Sunnybrook Health Sciences Centre
Cardiac Arrest (CA)
The Impact of First Responder Intervention on Survival in Out-of-Hospital Cardiac Arrest in Emilia-Romagna Region
Out-of-hospital cardiac arrest (OHCA) is a life-threatening emergency and one of the leading causes of death worldwide. Survival depends critically on how quickly help arrives and whether cardiopulmonary resuscitation (CPR) and…
- Trial name
- FIRSST-RER (NCT07589504)
- Where
- Italy
- Volunteers
- 5,200 people
- Sponsor
- Azienda Usl di Bologna
Out-Of-Hospital Cardiac Arrest, Cardiac Arrest
Technological and Patient-tailored Innovations for Maximizing Effectiveness of Cardiac Arrest Resuscitation
Out-of-hospital cardiac arrest (OHCA) affects 275,000 people in Europe every year. In Italy alone, 50,000 people experience OHCA annually, with only 9% surviving. Half of the survivors suffer severe brain damage.
- Trial name
- TIME-CARE (NCT06538155)
- Testing
- Wearable device, Cardiopulmonary resuscitation, CT scan, TEE exam, or chest X ray
- Where
- 3 sites in Italy
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Università Vita-Salute San Raffaele
Ventricular Arrhythmias and Cardiac Arrest
Prophylactic Anti-aRrhythmic Therapy With Amiodarone in Critically Ill Patients Admitted for an Out-of-hospital Cardiac Arrest With Initial Shockable Rhythm
To determine if prophylactic administration of amiodarone for 72 hours in critically ill patients admitted after an OHCA with shockable rhythm, with a confirmed or a presumed cardiac cause, decreases the incidence of a composite…
- Trial name
- PARACA (NCT06835491)
- Testing
- Amiodarone
- Where
- 29 sites in France
- Volunteers
- 674 people
- Sponsor
- Versailles Hospital
Cardiac Arrest, Out-Of-Hospital
Drone Delivered Defibrillators (The 3D Project).
The goal of this observational study is to explore the optimisation and integration of a drone-delivered Automated External Defibrillator (AED) system into the pre-hospital response to out-of-hospital cardiac arrest.
- Trial name
- NCT06334718
- Testing
- Interviews and simulation
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Warwick
Cardiac Arrest, Out-Of-Hospital, Hypotension and Shock
BCG Biosensor and Non- and Invasive Monitoring During Emergency Medicine Cases, a Prospective Feasibility Study
In a out of hospital emergency medicine study the investigators will measure hemodynamic effects of implemented treatments for patients with cardiac arrest, hypotension, and intensive care transports.
- Trial name
- NCT04891380
- Testing
- LUCAS 2 Active Decompression 2, Hypotension, Intensive care transport
- Where
- Norway
- Volunteers
- 183 people
- Sponsor
- Oslo University Hospital
Cardiac Arrest (CA), Cardiogenic Shock
On Scene ECPR in Ostrava
On-scene extracorporeal pulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest (OHCA) seems to speed up the start of extracorporeal membrane oxygenation (ECMO) and shorten low flow during cardiopulmonary resuscitation…
- Trial name
- NCT07374289
- Testing
- Prehospital ECMO cannulation on scene of cardiac arrest, Transfer with ongoing mechanical chest compression to hospital followed by hospital ECMO cannulation
- Where
- 2 sites in Czechia
- Volunteers
- 90 people
- Sponsor
- University Hospital Ostrava
Out-of-hospital Cardiac Arrest (OHCA)
Ketamine Sedation As Neuroprotective Agent Following Out-of-hospital Cardiac Arrest
OHCA is a critical medical emergency with significant mortality and morbidity primarily due to hypoxic-ischemic brain injury (HIBI).
- Trial name
- KETOHCA (NCT06744361)
- Testing
- esketamine hydrochloride, propofol
- Where
- 2 sites in Denmark
- Volunteers
- 282 people
- Sponsor
- Christian Hassager
Cardiac Arrest
Effect of Pre-imaging on Cardiopulmonary Resuscitation (CPR) Pause
Patients presenting following out of hospital cardiac arrest will undergo bedside ultrasound as per the hospital clinical practice.
- Trial name
- NCT04248985
- Testing
- Pre-Imaging - an ultrasound technique of acquiring images
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Massachusetts, Worcester
Out of Hospital Cardiac Arrest
Continuous Chest Compressions vs AHA Standard CPR of 30:2
The primary aim of the trial is to compare survival to hospital discharge after continuous chest compressions (CCC) versus standard American Heart Association (AHA) recommended cardiopulmonary resuscitation (CPR) with interrupted…
- Trial name
- CCC (NCT01372748)
- Testing
- Standard CPR, Continuous chest compressions
- Where
- 7 sites in United States, Canada
- Volunteers
- 23,711 people
- Sponsor
- University of Washington
Cardiac Arrest, Out-of-hospital Cardiac Arrest (OHCA)
Mean Arterial Pressure After Out-of-hospital Cardiac Arrest
Out-of-hospital cardiac arrest is a public health problem for which overall survival is below 10%. Post-cardiac arrest syndrome is the principal cause of death in intensive care units (ICU), due to refractory shock or brain…
- Trial name
- METAPHORE (NCT05486884)
- Testing
- Maintain MAP ≥ 90 mmHg, Maintain MAP ≥ 65 mmHg
- Where
- 31 sites in France
- Volunteers
- 1,380 people
- Sponsor
- Centre Hospitalier le Mans