Clinical trials: Out-of Hospital Cardiac Arrest
Out-Of-Hospital Cardiac Arrest, Hypothermia
Prehospital Resuscitation Intranasal Cooling Effectiveness Survival Study 2
The aim of this clinical trial is to study the impact of ultra-early transnasal evaporative cooling after cardiac arrest and subsequent hypothermia at hospital, on survival with complete neurologic recovery, compared to currently…
- Conditions
- Out-Of-Hospital Cardiac Arrest, Hypothermia, Ventricular Fibrillation
- Trial name
- PRINCESS2 (NCT06025123)
- Testing
- Early transnasal evaporative cooling with the RhinoChill device
- Where
- 17 sites in Austria, Belgium and 6 more
- Volunteers
- 1,022 people
- Sponsor
- Karolinska Institutet
Cardiac Arrest, Out-Of-Hospital, Hypotension
Cardiac Arrest - Ultrasound Detection of Occult Perfusion
The goal of this study is to describe the population of patients presenting after out of hospital cardiac arrest with occult perfusion, defined as a patient without a palpable pulse but with some evidence of pulsatile arterial…
- Trial name
- NCT07897370
- Where
- 8 sites in United States
- Volunteers
- 1,400 people
- Sponsor
- University of Massachusetts, Worcester
Out-Of-Hospital Cardiac Arrest
Neuroprotective Effect of Remote Ischemic Post-conditioning in Out-of-hospital Cardiac Arrest
Patients admitted to intensive care unit (ICU) following an out-of-hospital cardiac arrest (OHCA) have a high morbidity and mortality rate, primarily due to ischemia-reperfusion (I/R) syndrome leading to anoxic-ischemic brain…
- Trial name
- RIPOST-CA (NCT06473207)
- Testing
- Remote ischemic post conditioning sessions
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Out-of-Hospital Cardiac Arrest, Hypothermia
Early Coronary Angiography Versus Delayed Coronary Angiography
This study is a pilot, multi-centered, randomized, clinical trial to evaluate the safety and efficacy of performing early Coronary Angiography (CAG) versus no early CAG in post-cardiac arrest patients without ST segment…
- Conditions
- Out-of-Hospital Cardiac Arrest, Hypothermia, Cardiac Arrest
- Trial name
- PEARL (NCT02387398)
- Testing
- Early Angiography
- Where
- 6 sites in United States, Australia and 1 more
- Volunteers
- 99 people
- Sponsor
- University of Arizona
Resuscitation
Incidence of the Out- and in Hospital Cardiac Arrest at a Tertiary Hospital in Germany
Incidence of the background information, incidence and special characteristics of out- and in-hospital cardiac arrest at a tertiary hospital in Germany.
- Trial name
- ProseCPR (NCT05709665)
- Testing
- Time to Decision for eCPR
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Johannes Gutenberg University Mainz
COVID-19
The RAPID COVID-19 TRIAGE Algorithm
This study is being conducted to study the use and application of a point-of-care (POC) Covid-19 test developed by Spartan BioSciences and recently approved for clinical use by Health Canada.
- Trial name
- NCT04353154
- Testing
- Spartan Cube Point-of Care Covid-19 test
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Bystander, Chest Compression
REsuscitation Survey of Police Officers in New Taipei City for Duty
Out-of-hospital cardiac arrest (OHCA) remains a time-critical emergency where early cardiopulmonary resuscitation (CPR) and timely defibrillation using an automated external defibrillator (AED) are key to improving survival and…
- Conditions
- Bystander, Chest Compression, Out of Hospital Cardiac Arrest, AED
- Trial name
- RESPOND (NCT06955351)
- Testing
- Survey by Questionnaire
- Where
- Taiwan
- Volunteers
- 4,867 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Post-Cardiac Arrest Syndrome, Post Cardiac Arrest Brain Injury
Cerebral Oximetry in Management of Post Cardiac Arrest
Resuscitation from a cardiac arrest is a common reason for admission to an intensive care unit (ICU). Because the brain is highly vulnerable to oxygen deprivation, severe brain damage often occurs during a cardiac arrest.
- Conditions
- Post-Cardiac Arrest Syndrome, Post Cardiac Arrest Brain Injury, Hypoxic-Ischemic Brain Injury
- Trial name
- COMPACT (NCT07829887)
- Testing
- Cerebral oximetry-guided treatment
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- University of Calgary
Resuscitation, Emergency Department
The Association Between Post-resuscitation Time Series Management in the Emergency Department and Short-term Outcomes for Out-of-hospital Cardiac Arrest Patients
This study examines the impact of emergency department (ED) management on short-term outcomes of nontraumatic adult out-of-hospital cardiac arrest (OHCA) patients.
- Conditions
- Resuscitation, Emergency Department, Outcome
- Trial name
- NCT06165081
- Where
- Taiwan
- Volunteers
- 6,000 people
- Sponsor
- National Taiwan University Hospital
Out of Hospital Cardiac Arrest
I-Gel in Out-of-hospital Cardiac Arrest in Norway
The main objective of this trial is to compare the effectiveness of a newer supraglottic airway method (the i-Gel), compared to current airway management practice in out-of-hospital cardiac arrests treated by Norwegian ambulance…
- Trial name
- I-CAN (NCT02090218)
- Testing
- I-Gel, LTS, ETI or current airway management practice
- Where
- 4 sites in Norway
- Volunteers
- 550 people
- Sponsor
- Haukeland University Hospital
Out-Of-Hospital Cardiac Arrest
Dispatcher-Assisted CPR: Low-Dose, High-Frequency Simulation-Based Training
Clear, concise, yes, and no answers can be challenging to achieve in the assessment of consciousness and breathing in out-of-hospital cardiac arrest (OHCA) calls.
- Trial name
- NCT04085692
- Testing
- Low-Dose, High-Frequency Simulation-Based Training
- Where
- Denmark
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Emergency Medical Services, Capital Region, Denmark
Cardiac Arrest
Microcirculatory Perfusion in Patients With Coma After Out-of-hospital Cardiac Arrest
The hypothesis is: In patients after an out of hospital cardiac arrest, treated with therapeutic hypothermia (33°C) will be found significantly more microcirculatory abnormalities, compared to the same group of patients treated…
- Trial name
- NCT01850485
- Testing
- microcirculation by SDF and NIRS, in 33 and 36 degrees
- Where
- Netherlands
- Volunteers
- 22 people
- Sponsor
- Frisius Medisch Centrum
Out-Of-Hospital Cardiac Arrest
Out-of-hospital Cardiac Arrest Epidemiology and Outcomes in Kaunas 2016-2021
Out-of-hospital cardiac arrest rate is common problem, because of high mortality rate. It is not clear incidence rate, epidemiology and outcomes in Lithuania and Kaunas city included.
- Trial name
- NCT04784117
- Testing
- Dispatcher protocol change
- Where
- 2 sites in Lithuania
- Volunteers
- 1,500 people
- Sponsor
- Lithuanian University of Health Sciences
Out-Of-Hospital Cardiac Arrest
Effect of Remote Ischemic Post-conditioning on Out-of-hospital Cardiac Arrest
Ischemia-reperfusion leads to mitochondrial injury, ion-pump injury, cell membrane damage, cytotoxic edema, and excessive oxygen free radical formation, and eventually destroys cells.
- Trial name
- NCT03093948
- Testing
- Remote ischemic post-conditioning
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Chonnam National University Hospital
Cardiac Arrest, Brain Injuries
A Combined Microdialysis and FDG-PET Study for Detection of Brain Injury After Cardiac Arrest
Brain injury remains the leading cause of death in comatose patients resuscitated from OHCA. One of the most challenging aspects in the treatment of a post-cardiac arrest patient is the assessment of the extent of brain damage.
- Trial name
- COMA-PROTECT (NCT04774055)
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Odense University Hospital
Ventilation Therapy, PEEP, Occult
PEEP vs. ZEEP in Out-of-Hospital-Cardiac-Arrest
Out-of-hospital cardiac arrest (OHCA) remains a major cause of mortality, with low survival probabilities to hospital discharge.
- Conditions
- Ventilation Therapy, PEEP, Occult, CPR, Cardiac Arrest (CA)
- Trial name
- PerAVent (NCT06836830)
- Testing
- PEEP 5 mbar, ZEEP 0 mbar
- Where
- 3 sites in Germany
- Volunteers
- 600 people
- Sponsor
- Muehlenkreiskliniken, MKK
Out-Of-Hospital Cardiac Arrest, Emergencies
Livestreaming From Smartphones as a Supplement to Emergency Calls
The aim of the study is to analyse if live video as a supplement to emergency calls can improve medical dispatchers' situation awareness and enhance the assistance they provide including provision of pre-hospital resources.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Emergencies, Unconscious
- Trial name
- NCT04061187
- Where
- Denmark
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Emergency Medical Services, Capital Region, Denmark
Cardiac Arrest, Out-Of-Hospital Cardiac Arrest
AutoPulse Compared With Manual Technique for OHCA Patients on Outcome and CPR Process.
The AutoPulse Resuscitation System Model 100 (ZOLL Medical Corporation, Chelmsford, MA, US) ZOLL has been used as a standard treatment for a number of subjects in this trial and granted CE marking for Europe in November of 2003.
- Trial name
- NCT04663009
- Testing
- AutoPulse
- Where
- Norway
- Volunteers
- 3,250 people
- Sponsor
- Lars Wik
Out-of-Hospital Cardiac Arrest
Early-onset Pneumonia After Out-of-hospital Cardiac Arrest
Early-onset pneumonia after out-of-hospital cardiac arrest is frequent. An association between early-onset pneumonia and an increase in morbidity has been reported in this population.
- Trial name
- PP-ACR (NCT03355885)
- Where
- France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Brest
Out-Of-Hospital Cardiac Arrest
AMSA and Amiodarone Study in Cardiac Arrest
Investigators' aim is to assess whether the administration of amiodarone during resuscitation could cause a reduction of the values of the amplitude spectral area (AMSA).
- Trial name
- MOSAIC (NCT04997980)
- Testing
- Amiodarone Injection
- Where
- 4 sites in Italy, Norway and 1 more
- Volunteers
- 629 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia