Clinical trials: Ovarian Aging, active
Perimenopausal
Effect of Rapamycin in Ovarian Aging
The investigators are proposing a prospective, randomized, double-blind, placebo-controlled pilot study assessing the ability of low-dose rapamycin to delay ovarian aging in women.
- Trial name
- Rapamycin (NCT05836025)
- Testing
- Rapamycin
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Columbia University
Ovarian Aging, In Vitro Fertilisation (IVF) Treatment
Follicular Fluid microRNAs in Ovarian Aging and Reproduction
The purpose of this study is to investigate the role of exosomal microRNAs (miRNAs) in follicular fluid (FF) as biomarkers of ovarian aging and predictors of in vitro fertilization (IVF) outcomes.
- Conditions
- Ovarian Aging, In Vitro Fertilisation (IVF) Treatment, InVitro Fertilization, In Vitro Fertilization Outcome
- Trial name
- NCT07214246
- Testing
- No Interventions
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Central Florida
Menopause, Estrogen Deficiency
Ovarian Hormone Regulation of Central and Cerebrovascular Hemodynamics (NoMEN Study)
This study will evaluate changes in blood vessels around the heart (e.g., aorta and carotid arteries) and in the brain with the loss of female sex hormones (e.g., estrogen) during the menopause transition.
- Conditions
- Menopause, Estrogen Deficiency, Women, Aging
- Trial name
- NCT05057546
- Testing
- GnRH antagonist
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diminished Ovarian Reserve, Diminished Ovarian Reserve Due to Advanced Maternal Age
Ovarian Function Following Intraovarian Injection of PRP
Consenting women with evidence of poor ovarian reserve will be randomly assigned to treatment with either Platelet Rich Plasma (PRP) or Platelet Poor Plasma (PPP).
- Trial name
- PRP4POA (NCT04278313)
- Testing
- PRP - Platelet Rich Plasma, PPP - Platelet Poor Plasma
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Infertility, Cardiovascular Risk Factor
The Longitudinal Evaluation of Ovarian Aging and Cardiovascular Risk
Despite significant improvements in prevention and treatment of cardiovascular disease (CVD), the growing aging population suggests CVD will continue to pose a significant public health burden.
- Trial name
- OVACV (NCT03825120)
- Where
- United States
- Volunteers
- 865 people
- Sponsor
- University of California, San Francisco
Menopause, Estrogen Deficiency
Cardiometabolic Consequences of the Loss of Ovarian Function
The menopause transition is associated with a decrease in artery health and an increased risk for weight gain in storing fat in the stomach area which may increase the risk for heart disease.
- Conditions
- Menopause, Estrogen Deficiency, Aging, Adiposity
- Trial name
- LILAC (NCT06264882)
- Testing
- Degarelix, Transdermal Estradiol Patch
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Premature Ovarian Insufficiency, Diminished Ovarian Reserve
The Correlation Between Ovarian Function and Serum Biomarkers
The goal of this observational study is to find differences in serum biomarkers between ovarian function and normal individuals.
- Conditions
- Premature Ovarian Insufficiency, Diminished Ovarian Reserve, Biomarker, Copper
- Trial name
- NCT06096766
- Testing
- blood test
- Where
- China
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Shi Yun
Menopause, Obesity, Abdominal
Bioenergetic Effects of Aging and Menopause (BEAM)
The menopause transition is associated with increased risk for weight gain and a shift toward storing fat in the belly region, which may increase risk for cardiovascular disease and diabetes.
- Conditions
- Menopause, Obesity, Abdominal, Aging, Weight Gain
- Trial name
- BEAM (NCT04043520)
- Testing
- GnRH antagonist, Estrogen Product
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Premature Ovarian Insufficiency, Ovarian Reserve Function
Therapeutic Effect of Vitamin C Supplementation in Patients With Ovarian Aging
The goal of this clinical trial is to learn if Vitamin C works to improve ovarian reserve in women with ovarian aging. It will also learn about the safety of Vitamin C.
- Trial name
- NCT06794060
- Testing
- Vitamin C (Ascorbic Acid)
- Volunteers
- 354 people
- Sponsor
- Peking University Third Hospital
Ovarian Aging, IVF Outcome
The ROAR Study: Reactive Oxygen Species and Reproduction
This is a prospective cohort study characterizing follicular fluid and serum levels of oxidative stress in women with various infertility diagnoses undergoing in vitro fertilization, and assessing the relationship of oxidative…
- Conditions
- Ovarian Aging, IVF Outcome, Oxidative Stress
- Trial name
- ROAR (NCT06831019)
- Testing
- Oxidative stress markers
- Where
- United States
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Ovarian Aging, Adverse Pregnancy Outcomes
The Bone and hEArt Health Consequences of Ovarian agiNg (BEACON) Study
Ovarian aging is a major driver of a woman's long-term health and disease risk. In particular, the rapid decline in the ovarian reserve that occurs with the menopause transition is linked to a striking increase in the risk for…
- Trial name
- BEACON (NCT07621965)
- Volunteers
- 655 people
- Sponsor
- Indiana University