Clinical trials: Ovarian Cancer, completed
Ovarian Cancer, Cytoreductive Surgery
Esketamine for Prevention of Depression After Cytoreductive Surgery in Ovarian Cancer
The goal of this clinical trial is to learn if intraoperative administration of esketamine would prevent or mitigate postoperative depressive symptoms after cytoreductive surgery in ovarian cancer.
- Conditions
- Ovarian Cancer, Cytoreductive Surgery, Depressive Symptom
- Trial name
- NCT06624878
- Testing
- esketamine
- Where
- China
- Volunteers
- 568 people
- Sponsor
- Zhejiang Cancer Hospital
Ovarian Cancer
ASTRA Study: Circulating Tumor Cells in Blood of Patients With High-Grade Serous Ovarian Cancer
High-grade serous ovarian cancer is typically diagnosed at an advanced stage and remains associated with poor long-term survival. Reliable biomarkers for predicting disease course and treatment response are still limited.
- Trial name
- NCT07439328
- Testing
- Peripheral Blood Collection for CTC Isolation and Analysis
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- Institute of Oncology Ljubljana
Hereditary Breast and Ovarian Cancer
Cancer Genetics Hereditary Cancer Panel Testing
This study is about understanding the use of a genetic test (Myriad Genetics myRisk panel) that analyzes 25 genes related to different hereditary cancer conditions.
- Trial name
- HCP (NCT02324062)
- Testing
- Questionnaires, Blood Draw and Baseline Questionnaire
- Where
- 2 sites in United States
- Volunteers
- 1,511 people
- Sponsor
- University of Southern California
Ovarian Cancer Stage IV, Ovarian Cancer Stage IIIC
Retarded Surgery Following Neoadjuvant Chemotherapy in Advanced Ovarian Cancer
The aim of CHRONO trial is to compare the DFS when surgery is performed after 3 courses of NACT, or after 6 courses of NACT, in a prospective multi institutional randomized setting,considering only patients initially unsuitable…
- Conditions
- Ovarian Cancer Stage IV, Ovarian Cancer Stage IIIC, Ovarian Cancer Stage IIIb
- Trial name
- CHRONO (NCT03579394)
- Testing
- Retarded IDS (Interval Debulking Surgery), Standard IDS (Interval Debulking Surgery)
- Where
- 28 sites in France
- Volunteers
- 211 people
- Sponsor
- ARCAGY/ GINECO GROUP
Gynecologic Cancers
Assessing Whole-body Metabolism in Gynecologic Cancers in Response to a Single Chemotherapy Cycle and/ or Immunotherapy
It is well established that cancer cells have fundamentally altered metabolism, which contributes to tumorigenicity and malignancy.
- Trial name
- NCT07393633
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Tennessee Graduate School of Medicine
Recurrent Ovarian Cancer
Phase IB Trial of LDE225 and Paclitaxel in Recurrent Ovarian Cancer
The purpose of this study is to find out if a new drug, LDE225, is safe and has beneficial effects when combined with paclitaxel in women with platinum resistant ovarian cancer.
- Trial name
- NCT02195973
- Testing
- LDE225
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Alabama at Birmingham
Ovarian Neoplasms
Biobehavioral-Cytokine Interactions in Ovarian Cancer
The purpose of this study is to understand relationships between behavioral factors, hormones, and chemicals produced by the body that may help tumor growth in ovarian cancer.
- Trial name
- VEGF (NCT01113112)
- Where
- 2 sites in United States
- Volunteers
- 613 people
- Sponsor
- Susan Lutgendorf
Fatigue, Ovarian Cancer
Acupressure for Fatigue in Ovarian Cancer Survivors
The purpose of this study is to see if accupressure can help reduce the severity of fatigue experienced by ovarian cancer patients.
- Trial name
- NCT03763838
- Testing
- Acupressure, Standard of Care
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- University of Michigan Rogel Cancer Center
Advanced Malignant Neoplasm, Advanced Melanoma
Genetic Analysis of Blood and Tissue Samples From Patients With Advanced Cancer, Moonshot Study
This trial studies the genetic analysis of blood and tissue samples from patients with cancer that has spread to other anatomic sites (advanced) or is no longer responding to treatment.
- Conditions
- Advanced Malignant Neoplasm, Advanced Melanoma, Advanced Renal Cell Carcinoma, Anatomic Stage III Breast Cancer AJCC v8
- Trial name
- NCT03707574
- Testing
- Biospecimen Collection
- Where
- 144 sites in United States, Puerto Rico
- Volunteers
- 64 people
- Sponsor
- National Cancer Institute (NCI)
Recurrent Ovarian Cancer, Platinum-sensitive Ovarian Cancer
Statin Therapy to Reduce Progression in Women With Platinum Sensitive Ovarian Cancer
This is a single arm pilot trial to evaluate the feasibility of using a simvastatin intervention, and to evaluate its effects on cancer progression, among 20 patients with platinum-sensitive ovarian cancer, treated with…
- Trial name
- NCT04457089
- Testing
- Simvastatin 40mg
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Marc Goodman
Epithelial Ovarian Cancer
The Real World Efficacy and Safety of Niraparib in Korean Women With Primary and Recurrent Epithelial Ovarian Cancer
1. To evaluate the efficacy and safety of niraparib in Korean women with primary and recurrent epithelial ovarian cancer who underwent niraparib maintenance therapy 2.
- Trial name
- REFIRM (NCT06086665)
- Testing
- Niraparib
- Where
- South Korea
- Volunteers
- 850 people
- Sponsor
- Asan Medical Center
Adnexal Lesion, Ovarian Cancer
A Performance Study of (Opportunistic) Salpingectomy
The goal of this clinical trial is to test the quality of the performance of opportunistic salpingectomies in women scheduled for adnexectomy.
- Trial name
- QOS (NCT05646680)
- Testing
- two step adnexectomy
- Where
- Belgium
- Volunteers
- 115 people
- Sponsor
- University Hospital, Ghent
Ovarian Cancer
Study of IMP4297 in Patients With BRCA1/2 Mutation Ovarian Cancer
A phase II, multi-center, open-label, single-arm, non-randomized study to evaluate the efficacy, safety and tolerability of IMP4297 capsules in subjects with germline and/or somatic BRCA1/2 mutated advanced ovarian cancer in china
- Trial name
- SABRINA (NCT04089189)
- Testing
- IMP4297
- Where
- China
- Volunteers
- 93 people
- Sponsor
- Impact Therapeutics, Inc.
Colorectal Cancer, Breast Cancer
Dose-finding Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of SNB-101(SN-38) in Patients With Tumors
SNB-101 is a novel nano-particle formulation of SN-38, the active metabolite of irinotecan(CPT-11). Study SNB101P01 is a multicenter, open-label, dose escalation, phase 1 study of SNB 101 with its active ingredient SN-38, in…
- Conditions
- Colorectal Cancer, Breast Cancer, Pancreas Cancer, Ovarian Cancer
- Trial name
- NCT04640480
- Testing
- SNB-101
- Where
- 3 sites in South Korea
- Volunteers
- 21 people
- Sponsor
- SN BioScience
Epithelial Ovarian Cancer
Exploration of DNA Methylation as a Marker for Early Detection of High Grade Serous Epithelial Ovarian Cancer
The purpose of this study is to determine if there are markers in plasma that can be used to develop a diagnostic panel for early detection and diagnosis of high grade serous epithelial ovarian cancer.
- Trial name
- NCT03622385
- Testing
- DNA Methylation
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Colorectal Cancer, Gastric Cancer
A Phase 1 in Patients With HLA-A*0201+ and WT1+ Recurrent/Metastatic Cancers
This is a Phase 1, open-label, 2-part, multi-center study evaluating the safety, tolerability, PK, pharmacodynamics (PD), immunogenicity, and antitumor activity of CUE-102 intravenous (IV) monotherapy in HLA-A*0201 positive…
- Conditions
- Colorectal Cancer, Gastric Cancer, Pancreatic Cancer, Ovarian Cancer
- Trial name
- NCT05360680
- Testing
- CUE-102
- Where
- 15 sites in United States
- Volunteers
- 42 people
- Sponsor
- Cue Biopharma
Peritoneal Metastases
Feasibility of the LUM Imaging System for Peritoneal Surface Malignancies
The objective of this feasibility study is to assess the initial safety and efficacy of the LUM Imaging System for in vivo imaging of metastases to the peritoneum from primary gastrointestinal cancer, ovarian cancer and…
- Trial name
- NCT03834272
- Testing
- LUM Imaging System
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Lumicell, Inc.
Ovarian Cancer, Peritoneal Cancer
Mirvetuximab Soravtansine Monotherapy in Platinum-Sensitive Epithelial, Peritoneal, and Fallopian Tube Cancers
PICCOLO (IMGN853-0419) is a Phase 2 multicenter, open label study designed to evaluate the safety and efficacy of Mirvetuximab Soravtansine in participants with platinum-sensitive ovarian, primary peritoneal or fallopian tube…
- Conditions
- Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer
- Trial name
- PICCOLO (NCT05041257)
- Testing
- Mirvetuximab soravtansine
- Where
- 35 sites in United States, Australia and 5 more
- Volunteers
- 79 people
- Sponsor
- AbbVie
Primary Peritoneal Cancer, Fallopian Tube Cancer
RC88 in Platinum-Resistant Recurrent Epithelial Ovarian Cancer, Fallopian Tube Cancer, and Primary Peritoneal Cancer
The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of RC88 monotherapy in subjects with Platinum-Resistant Recurrent Epithelial Ovarian, Fallopian Tube and Primary Peritoneal Cancer.
- Conditions
- Primary Peritoneal Cancer, Fallopian Tube Cancer, Epithelial Ovarian Cancer
- Trial name
- NCT06173037
- Testing
- RC88
- Where
- 30 sites in China
- Volunteers
- 43 people
- Sponsor
- RemeGen Co., Ltd.
Debulking Surgery for Ovarian Cancer
Study of Nutritional Supplement Shakes in People About to Receive Their Debulking Surgery for Ovarian Cancer
The purpose of this study is to find out if it is possible to establish a nutritional support program for people who are scheduled to receive primary debulking surgery.
- Trial name
- NCT03956095
- Testing
- Ensure Surgery Immunonutrition Shake supplements, Daily Food Intake form
- Where
- 8 sites in United States
- Volunteers
- 23 people
- Sponsor
- Memorial Sloan Kettering Cancer Center