Clinical trials: Ovarian Disease
Infertility
Elonva in Combination With Hp-FSH Versus Elonva With Low Dose hCG
The study compares in a randomized controlled way two stimulation methods. One of these stimulation methods implements a new insight in ovarian follicular growth.
- Trial name
- NCT03208972
- Testing
- low dose hCG, hp-FSH, Corifollitropin Alfa
- Where
- Belgium
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- AZ Jan Palfijn Gent
Solid Tumors
Azacitidine and Valproic Acid Plus Carboplatin in Patients With Ovarian Cancer
The goal of this clinical research study is to find out if giving azacitidine with valproic acid plus carboplatin can help control advanced cancer. The safety of this treatment will be studied as well.
- Trial name
- NCT00529022
- Testing
- Azacitidine, Valproic Acid, Carboplatin
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer, Lung Cancer
HER-2/Neu Vaccine Plus GM-CSF in Treating Patients With Stage III or Stage IV Breast, Ovarian, or Non-small Cell Lung Cancer
RATIONALE: Vaccines made from the HER2/neu antigen may make the body build an immune response and kill tumor cells. Colony-stimulating factors such as GM-CSF increase the number of immune cells found in bone marrow or peripheral…
- Conditions
- Breast Cancer, Lung Cancer, Ovarian Cancer
- Trial name
- NCT00003002
- Testing
- HER-2/neu peptide vaccine, sargramostim
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Washington
PCOS
IVM Versus Standard IVF in Infertile Patients Diagnosed With PCOS
A single center, prospective, open-label, non-inferiority randomized controlled clinical trials (1:1 treatment ratio) regarding pregnancy outcomes between IVM and standard IVF among infertility couples with PCOS in China.
- Trial name
- NCT03463772
- Testing
- standard IVF, In vitro maturation
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Jie Qiao
Ovarian Cancer
Olaparib, Durvalumab and UV1 in Relapsed Ovarian Cancer
This prospective, multicenter, open-label, randomized phase II maintenance study is evaluating the efficacy of UV1-olaparib-durvalumab combination as maintenance therapy after platinum combination therapy for BRCAwt patients with…
- Trial name
- DOVACC (NCT04742075)
- Testing
- Olaparib + durvalumab + UV1
- Where
- Denmark
- Volunteers
- 188 people
- Sponsor
- Nordic Society of Gynaecological Oncology - Clinical Trials Unit
Polycystic Ovary Syndrome, Infertility
Therapy for Infertile PCOS Patients Ovulating Under Clomiphene Citrate or Metformin
Several data demonstrated that both clomiphene citrate (CC) and metformin are two safe and valid first-step options to induce ovulation in infertile anovulatory PCOS patients.
- Trial name
- NCT00502229
- Testing
- Clomiphene citrate, metformin, highly purified urinary FSH
- Where
- Italy
- Sponsor
- University Magna Graecia
Early Menopause, Menopause
Influence of Early Menopause on Sympathetic Activation and Cardiovascular Function in Older Women
Women who enter menopause early are at a greater risk for developing cardiovascular disease later in life as compared to women with normal onset of menopause.
- Trial name
- NCT03692572
- Testing
- Nitrate supplementation
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Ovarian Cancer, Primary PERITONEUM
Intravenous and Intraperitoneal Paclitaxel, Intraperitoneal Cisplatin, and Intravenous Bevacizumab for the Initial Treatment of Optimal Stage II or III Ovarian, Primary Peritoneal, and Fallopian Tube Cancer
The purpose of this study is to test whether it is safe to treat your cancer with 3 drugs instead of 2 drugs. After surgery, your cancer is typically treated with 2 drugs called cisplatin and paclitaxel (also known as Taxol).
- Conditions
- Ovarian Cancer, Primary PERITONEUM, Fallopian Tube Cancer
- Trial name
- NCT00588237
- Testing
- Paclitaxel,Cisplatin, Bevacizumab
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Infertility, Female
Clinical Measures of Ovarian Reserve in Predicting IVF Success
The purpose of this study is to find out more about tests used to estimate the number of eggs a woman has remaining in her ovaries (her 'ovarian reserve').
- Trial name
- NCT01756872
- Testing
- Measurements of ovarian reserve
- Where
- United Kingdom
- Volunteers
- 204 people
- Sponsor
- University of Oxford
Advanced Solid Tumor
M9466 Alone or in Combination in Advanced Solid Tumors (DDriver 501)
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetic, pharmacodynamic profile of M9466 with and without tuvusertib or an ARPi and early signs of clinical activity of M9466 with tuvusertib in…
- Trial name
- NCT06421935
- Testing
- M9466, Tuvusertib, Abiraterone acetate
- Where
- 20 sites in United States, Australia and 3 more
- Volunteers
- 60 people
- Sponsor
- EMD Serono Research & Development Institute, Inc.
Granulosa Cell Tumour of the Ovary
Ketoconazole as Inhibitor of the Enzyme CYP17 in Locally Advanced or Disseminated Granulosa Cell Tumour of Ovary
Our proposal is to conduct an open phase II clinical trial that allows us to explore the activity of ketoconazole, an inhibitor of the enzyme CYP17, in ovarian granulosa tumors similar to what has been done in prostate cancer.
- Trial name
- GreKo (NCT01584297)
- Testing
- Ketoconazole
- Where
- 10 sites in Spain
- Volunteers
- 6 people
- Sponsor
- Grupo Español de Tumores Huérfanos e Infrecuentes
Polycystic Ovary
Serum Ghrelin in Polycystic Ovary Syndrome
measuring serum gherlin in polycystic ovary syndrome patients and compare it to healthy levels
- Trial name
- NCT02087410
- Where
- Egypt
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- amr hesham el etreby
Ovarian Cancer, Fallopian Tube Cancer
Determinants of Age-Related Treatment Effectiveness in Ovarian Cancer
While significant progress has been made in the treatment and prognosis of ovarian cancer, this progress has mostly shown benefits for younger women.
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer, Ovarian Diseases
- Trial name
- NCT02973750
- Testing
- Baseline Biopsy, Tissue Collection, Blood Draws
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Advanced Solid Tumors, Solid Tumors
A Bioequivalence Study Between the Proposed and Current Talazoparib Capsule Formulation and Food Effect Study for the Proposed Talazoparib Capsule Formulation in Participants With Advanced Solid Tumors
This will be a Phase 1, open label, 2-sequence, crossover study to establish the BE of the current commercial formulation (Generation 3.1 talazoparib capsules) to the proposed talazoparib liquid-filled soft gelatin capsule (soft…
- Conditions
- Advanced Solid Tumors, Solid Tumors, Ovarian Cancer, Breast Cancer
- Trial name
- NCT04672460
- Testing
- TALZENNA capsule, Talazoparib soft gel capsule
- Where
- 31 sites in United States, Australia
- Volunteers
- 73 people
- Sponsor
- Pfizer
Polycystic Ovary Syndrome, in Vitro Fertilization
Vitamin D and Pregnancy Outcome in PCOS Patients
This multicenter double-blinded placebo-controlled randomised trial aims to evaluate the effectiveness of vitamin D supplementation prior to IVF on the live birth rate in women with PCOS.
- Trial name
- NCT04082650
- Testing
- vitamin D
- Where
- 2 sites in China
- Volunteers
- 876 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Polycystic Ovarian Syndrome
Efficacy Study of Raloxifene to Induce Ovulation in Polycystic Ovarian Syndrome
This study examines Raloxifene versus Clomiphene to induce ovulation in women with polycystic ovarian syndrome (PCOS).
- Trial name
- PCOS (NCT01607320)
- Testing
- Raloxifene, Clomiphene
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Bruce Lessey
Polycystic Ovary Syndrome
The Effect of Dihydroartemisinin in PCOS
Artemisinin has been widely used as a first-line antimalarial drug in routine clinical practice. In recent years, it has been reported that Artemisinin also has some significant anti-inflammatory, anti-tumor and immune-modulating…
- Trial name
- NCT05465135
- Testing
- Dihydroartemisinin
- Where
- China
- Volunteers
- 19 people
- Sponsor
- Shanghai Zhongshan Hospital
Carcinoma, Ovarian Epithelial, Ovarian Neoplasms
Oregovomab Plus Chemo in Newly Diagnosed Patients With Advanced Epithelial Ovarian Cancer Following Optimal Debulking Surgery
Study to compare the safety and efficacy of oregovomab versus placebo, administered in combination with specific cycles of a standard six-cycle chemotherapy regimen (paclitaxel and carboplatin), for the treatment of subjects with…
- Conditions
- Carcinoma, Ovarian Epithelial, Ovarian Neoplasms, Ovarian Cancer, Ovarian Serous Adenocarcinoma
- Trial name
- FLORA-5 (NCT04498117)
- Testing
- Oregovomab, Paclitaxel, Carboplatin
- Where
- 148 sites in United States, Argentina and 12 more
- Volunteers
- 615 people
- Sponsor
- CanariaBio Inc.
Ovarian Cancer, Pancreas Cancer
Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple Myeloma
Study QXL138AM-001 is a Phase 1a/1b study to investigate the safety, pharmacokinetics, and preliminary activity of QXL138AM in subjects with locally advanced un-resectable and/or metastatic solid tumors and multiple myeloma.
- Conditions
- Ovarian Cancer, Pancreas Cancer, Urothelial Carcinoma, Renal Cell Carcinoma
- Trial name
- NCT06582017
- Testing
- QXL138AM Injection every 2 weeks by IV Infusion
- Where
- 11 sites in United States
- Volunteers
- 100 people
- Sponsor
- Nammi Therapeutics Inc
Ovarian Cancer
Study of XL999 in Patients With Previously Treated Ovarian Cancer
This clinical trial is being conducted at multiple sites to evaluate the activity, safety, and tolerability of XL999 when given weekly to patients with ovarian cancer that has previously been treated with platinum-based…
- Trial name
- NCT00277290
- Testing
- XL999
- Where
- 9 sites in United States
- Volunteers
- 24 people
- Sponsor
- Symphony Evolution, Inc.
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