Clinical trials: Ovarian Disease
FIGO Stage IIC-IV Ovarian Carcinoma, Fallopian Tube Carcinoma
Heated Carboplatin in Treating Patients With Stage II-IV Ovarian, Fallopian Tube, or Peritoneal Cancer
This phase I trial studies the side effects and best dose of heated carboplatin given into the abdomen at the time of surgery in treating patients with stage II-IV ovarian, fallopian tube, or peritoneal cancer.
- Conditions
- FIGO Stage IIC-IV Ovarian Carcinoma, Fallopian Tube Carcinoma, Peritoneal Carcinoma
- Trial name
- NCT02199171
- Testing
- carboplatin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Irvine
Infertility
Circadian Variation in Serum-progesterone Levels Following Controlled Ovarian Hyperstimulation.
The aim of the study is to investigate the circadian variation in serum-progesterone in women undergoing controlled ovarian stimulation.
- Trial name
- NCT02673034
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Regionshospitalet Viborg, Skive
Recurrent Ovarian Cancer
An Exploratory, Multi-cohort Phase II Study of Combination Therapy With AK104 and AK112 for Recurrent Ovarian Cancer
An Exploratory, Multi-cohort Phase II Study of Combination Therapy With AK104 and AK112 for Recurrent Ovarian Cancer
- Trial name
- NCT06560112
- Testing
- AK104, AK112, Chemotherapy
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Akeso
Ovarian Cancer
BELOVA Data Collection: Safety and Efficacy of Frontline Bevacizumab Treatment in Participants With Ovarian Cancer 70 Years and Older
The purpose of this study is to evaluate the safety and efficacy in the frontline treatment of ovarian cancer in participants 70 years of age and older in routine clinical practice in Belgium.
- Trial name
- NCT02393898
- Testing
- Bevacizumab, Carboplatin, Paclitaxel
- Where
- 26 sites in Belgium
- Volunteers
- 76 people
- Sponsor
- Hoffmann-La Roche
Premature Ovarian Insufficiency, Reproductive Health
Microbiome and Premature Ovarian Insufficiency
This study investigates the differences in gut and vaginal microbiota between women with premature ovarian insufficiency (POI) and healthy volunteers.
- Trial name
- NCT07275671
- Where
- 2 sites in China
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Westlake University
Ovarian Neoplasms, Fallopian Tube Neoplasms
Efficacy and Safety of Niraparib Combined With Bevacizumab in Platinum Refractory/Resistant Recurrent Ovarian Cancer
Niraparib is an oral, potent and highly selective PARP1/2 inhibitor. It can be used as a single drug in HRD positive ovarian cancer patients for multi-line therapy.
- Conditions
- Ovarian Neoplasms, Fallopian Tube Neoplasms, Endocrine Gland Neoplasms, Neoplasms by Site
- Trial name
- AVANIRA3 (NCT04556071)
- Testing
- Niraparib, Bevacizumab
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Xiaoxiang Chen
Planned RRSO
E2 and LDX for the Treatment of Cognitive Complaints After Oophorectomy
This project seeks to address cognitive disturbance, which is a frequent adverse sequelae of riskreducing bilateral salpingo-oophorectomy (RRSO) with or without post-procedure chemotherapy and adjunctive treatments.
- Trial name
- E2LDX (NCT01986764)
- Testing
- Lisdexamfetamine, Estradiol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Ovarian Cancer
A Study of Second Look Laparoscopy (SLL) in People With Ovarian Cancer Who Have Completed Their First Course of Chemotherapy
The researchers are doing this study to look at the health outcomes of people with advanced ovarian cancer who have a second look laparoscopy (SLL) after they complete their first course of chemotherapy.
- Trial name
- NCT06240598
- Testing
- Second Look Laparoscopy
- Where
- 7 sites in United States
- Volunteers
- 10 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Ascites, Ovarian Epithelial Cancer
Preoperative Ascites Drainage Versus Standard Care for Patients With Advanced Ovarian Cancer
Patients with significant ascites and advanced ovarian cancer (AOC), undergoing complex, cytoreductive surgery are at risk of malnutrition, poor quality of life and the risk of hypo- or hypervolemia in a perioperative period.
- Conditions
- Ascites, Ovarian Epithelial Cancer, Malnutrition
- Trial name
- NCT02742428
- Testing
- Systematic ascites evacuation, Acute paracentesis., Interview.
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Gdynia Oncology Center
Ovarian Cancer
A Phase I/II, First-in-Human Study to Evaluate TJ102 in Participants With Advanced or Metastatic Ovarian Cancer and Other Solid Tumors.
The goal of this clinical trial is to evaluate whether TJ102, an investigational antibody-drug conjugate (ADC), can safely and effectively treat patients with advanced ovarian or other solid tumors.
- Trial name
- NCT07778498
- Testing
- TJ102
- Where
- 9 sites in United States, China
- Volunteers
- 150 people
- Sponsor
- Phrontline Biopharma
Ovarian Cancer
A Study of Fluzoparib（SHR-3162）in BRCA1/2-mutant Relapsed Ovarian Cancer
This is a multicenter， open-label study to evluate the efficacy and safety of a novel PARP 1/2 inhibitor fluzoparib （SHR-3162）in BRCA1/2-mutant Relapsed Ovarian Cancer.
- Trial name
- NCT03509636
- Testing
- Fluzoparib
- Where
- China
- Volunteers
- 113 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Cancer, Hematologic Disorder
Fertility Preservation With Ovarian Tissue Freezing
The purpose of this study is to obtain ovarian tissue from female patients undergoing gonadotoxic treatments or gonadal ablating surgery, and that in consequence may see their future fertility impaired.
- Conditions
- Cancer, Hematologic Disorder, Infertility, Ovarian Failure
- Trial name
- PTO (NCT03674164)
- Testing
- Ovarian Cryopreservation
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- St. Justine's Hospital
Polycystic Ovary Syndrome
Treatment of Hyperandrogenism Versus Insulin Resistance in Infertile Polycystic Ovary Syndrome (PCOS) Women
The goal of this three-armed randomized controlled trial is to establish the relative roles of treatment of hyperandrogenism versus obesity (as the largest modifiable factor contributing to insulin resistance) in treating…
- Trial name
- OWL-PCOS (NCT00704912)
- Testing
- Orlistat/Meal Replacement/Lifestyle Modification, Loestrin 1/20, Combination of treatments
- Where
- 2 sites in United States
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Polycystic Ovary Syndrome
The Psychological and Social Impact of PCOS
The aim of the study is to assess the association between the quality of life of patients with PCOS and various factors (age, BMI, socio-professional category, delay in diagnostic of PCOS, infertility, hyperandrogenism, parity…
- Trial name
- SPICE (NCT05982236)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Lille
Prostate Cancer, Hepatocellular Carcinoma
68Ga-FAPI-PSMA PET Imaging for the Diagnosis of Solid Tumors
This study aims to evaluate a novel dual-targeted PET imaging tracer, 68Ga-FAPI-PSMA, for the detection and evaluation of solid tumors.
- Conditions
- Prostate Cancer, Hepatocellular Carcinoma, Ovarian Cancer, Solid Tumors
- Trial name
- NCT07639801
- Testing
- 68Ga-FAPI-PSMA, 68Ga-PSMA-617, 68Ga-FAPI-04
- Volunteers
- 20 people
- Sponsor
- Peking University Cancer Hospital & Institute
Infertility
Improved Medically Assisted Procreation Monitoring
Patient care in Medically Assisted Procreation (MAP) requires a close and regular monitoring of the evolution of the estradiol rate.
- Trial name
- NGAMP (NCT03274765)
- Testing
- Dosage of oestradiol
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Rennes University Hospital
Infertility
Pharmacogenetic Algorithm for Individualized Controlled Ovarian Stimulation
In this study, the investigators will evaluate genetic variation or polymorphisms between individuals submitted to IVF/ICSI cycles, and how these variations influence response to COS and pregnancy outcomes.
- Trial name
- NCT03149536
- Testing
- Pharmacogenetic test
- Volunteers
- 1,350 people
- Sponsor
- Clínica Origen
Ovarian Carcinoma, Relapse
A Trial Evaluating Efficacy and Safety of Oxaliplatin With 5-Fluorouracil in Patients With Recurrent Ovarian Carcinoma
This is a Phase II study for recurrent ovarian carcinoma platinum-sensitive and resistant tumors Folfox regimen.
- Trial name
- NCT01481701
- Testing
- Oxaliplatin
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- Jules Bordet Institute
Visceral Adiposity Index, Polycystic Ovary Syndrome
Visceral Adiposity Index Differences Between Subtypes of Polycystic Ovary Syndrome
We aimed to investigate visceral adiposity index (VAI) in patients with different phenotype of policystic ovary syndrome (PCOS) and to compare healthy controls.
- Trial name
- NCT06358300
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Uşak University
Ovarian Cancer
Influences of Propofol and Sevoflurane Anesthesia in Ovarian Cancer (Anesthetics)
Ⅶ. Study procedures (summary) 1. Written informed consent must be obtained before any study specific procedures are undertaken. Qualified participants were identified at the pre-anesthesia evaluation clinic or ward.
- Trial name
- anesthetics (NCT05606692)
- Testing
- Propofol 1%, Sevoflurane/Ultane
- Where
- Taiwan
- Volunteers
- 416 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
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