Clinical trials: Ovarian Disease
Recurrent Ovarian Epithelial Cancer, Recurrent Ovarian Germ Cell Tumor
Phase I Stereotactic Body Radiation for Metastatic or Recurrent Platinum-Resistant Ovarian Cancer
This phase I trial studies the side effects and the best dose of stereotactic body radiation therapy (SBRT) in treating patients with metastatic or recurrent ovarian cancer or primary peritoneal cancer.
- Conditions
- Recurrent Ovarian Epithelial Cancer, Recurrent Ovarian Germ Cell Tumor, Malignant Tumor of Peritoneum, Stage IV Ovarian Epithelial Cancer
- Trial name
- NCT01494012
- Testing
- stereotactic body radiation therapy, positron emission tomography, computed tomography
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Stanford University
Polycystic Ovary Syndrome
Combination of D-chiro-inositol With Ketogenic Diet
The study aims to evaluate whether the combination of a product based on D-chiro-inositol and the ketogenic diet can improve the metabolic/endocrine picture of overweight/obese women with PCOS, with insulin resistance, in a…
- Trial name
- NCT05348967
- Testing
- TECADRIOL
- Where
- Italy
- Sponsor
- Lo.Li.Pharma s.r.l
Polycystic Ovary Syndrome
Polycystic Ovary Syndrome (PCOS): Effect Of Letrozole and Berberine
Polycystic ovary syndrome (PCOS) is a heterogeneous disorder affecting almost4%-7% of the female population of reproductive age.
- Trial name
- NCT01116167
- Testing
- Letrozole -Berberine, Letrozole, Berberine
- Where
- 18 sites in China
- Volunteers
- 660 people
- Sponsor
- Heilongjiang University of Chinese Medicine
Colorectal Cancer, Bladder Cancer
Feasibility Testing of Patient Reported Outcomes - Informed Symptom Management System (PRISMS)
This is a proof-of-concept pilot randomized clinical trial to test the feasibility of the innovative Patient-Reported Outcomes-Informed Symptom Management System (PRISMS) to enhance personalized supportive care for cancer…
- Conditions
- Colorectal Cancer, Bladder Cancer, Ovarian Cancer, Cervical Cancer
- Trial name
- PRISMS (NCT04492007)
- Testing
- Patient-Reported Outcomes-Informed Symptom Management System (PRISMS)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Endometriosis
Ovarian Blockade During Fertility Preservation in Patients With Endometriosis
The aim of the study is to demonstrate the non-inferiority of dienogest on the number of mature oocytes collected compared with "conventional" ovarian stimulation protocols (using a GnRH agonist or antagonist), in patients with…
- Trial name
- PFENDO (NCT06106919)
- Testing
- surveys (Fertiqol and WHOQOL-BREF)
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Ovarian Cancer
A Study of SHR-A1811 in Subjects With Ovarian Cancer
This is an open-label study to evaluate the safety and efficacy of SHR-A1811 for injection in subjects with ovarian cancer.
- Trial name
- NCT06828354
- Testing
- SHR-A1811, Paclitaxel Injection, Doxorubicin Hydrochloride Liposome Injection
- Where
- 2 sites in China
- Volunteers
- 300 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Ovarian Cancer
A Study With Intraperitoneal Cisplatin and Doxorubicin in Recurrent Ovarian Cancer and Peritoneal Carcinomatosis
Fifteen women with recurrent ovarian cancer will be treated by an intraperitoneal chemotherapy with cisplatin and doxorubicin in three escalating dosage schedules.
- Trial name
- NCT02475772
- Testing
- Cisplatin and doxorubicin
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Clemens Tempfer
Breast Cancer, Colon Cancer
CT-011 and p53 Genetic Vaccine for Advanced Solid Tumors
Background: The p53 gene normally helps to stop cancer cells from growing. However, when the p53 gene is mutated or damaged, cancer cells may grow unchecked.
- Conditions
- Breast Cancer, Colon Cancer, Pancreatic Cancer, Sarcoma
- Trial name
- NCT01386502
- Testing
- p53: 264-272 peptide, CT-011
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Ovarian Diseases
Added Value of O-RADS in Evaluation of Ovarian Lesions
To detect added value of O-RADS in evaluation of ovarian lesions and compare O-RADS with GI-RADS regarding malignancy rate, the validity and reliability through pathological results and other modalities
- Trial name
- NCT04579575
- Testing
- Trans-abdominal Ultrasound
- Volunteers
- 30 people
- Sponsor
- Assiut University
Ovarian Cancer, Peritoneal Cancer
Study of Prolanta™ in Recurrent or Persistent Epithelial Ovarian Cancer
This trial is a Phase I open-label safety study of Prolanta™, a recombinant analog of the human prolactin protein with a single amino acid substitution to create an antagonist of the prolactin receptor.
- Conditions
- Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer
- Trial name
- ProlantaOC (NCT02534922)
- Testing
- Prolanta, a human prolactin receptor antagonist
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Oncolix, Inc.
Recurrent Platinum-sensitive Ovarian Cancer
Evaluation of Optimal Treatment With Bevacizumab in Patients With Platinum-sensitive Recurrent Ovarian Cancer
Evaluation of the best therapeutic index for patients with platinum-sensitive ovarian cancer when treatment with bevacizumab and gemcitabine/carboplatin or with bevacizumab and PLD/carboplatin.
- Trial name
- NCT01837251
- Testing
- Carboplatin, PLD, Bevacizumab
- Where
- 193 sites in Australia, Austria and 4 more
- Volunteers
- 682 people
- Sponsor
- AGO Research GmbH
Female Infertility
Hormone Evaluation in Artificial Reproductive Technology
The aim is to be able to predict the hormonal response according to gonadotropin receptor genotype and hormone type used for treatment of women undergoing in vitro fertilization or egg donation.
- Trial name
- HEART (NCT03737253)
- Testing
- Follitropin alpha, Menotropin
- Where
- 2 sites in Poland, Sweden
- Volunteers
- 810 people
- Sponsor
- Lund University
Ovarian Cancer Recurrent
Trial of M4344 and Niraparib in Patients With Poly (ADP-ribose) Polymerase (PARP) Resistant Recurrent Ovarian Cancer
The purpose of this study is to find out if a new drug, M4344, is safe and has beneficial effects when given in combination with the PARP inhibitor, Niraparib, in women with recurrent ovarian cancer that has progressed while on a…
- Trial name
- PARP (NCT04149145)
- Testing
- M4344+Niraparib
- Sponsor
- University of Alabama at Birmingham
Ovarian Hyperstimulation Syndrome
Clinical Study of Recombinant Human Follitropin for Injection Assisted in COH Assisted IVF-ET
The aim of this study was to evaluate the efficacy and safety of domestic recombinant human follicle stimulating hormone (rhFSH) stimulating ovarian to promote follicular development before assisted reproductive technology, which…
- Trial name
- NCT03071172
- Testing
- Triptorelin for Injection, Recombinant Human Choriogonadotropin alfa Solution for Injection, Progesterone Soft Capsules
- Where
- 7 sites in China
- Volunteers
- 252 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Ovarian Cancer, Peritoneal Cancer
PH I SRC Kinase, Dasatinib Combo Paclitaxel & Carboplatin in Pts w Ovarian, Peritoneal, & Tubal Cancer
Primary objective to determine the maximal tolerated (MTD) of dasatinib in combination with paclitaxel and carboplatin during the first cycle of treatment.
- Conditions
- Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer
- Trial name
- NCT00672295
- Testing
- Dasatinib, Paclitaxel, and Carboplatin
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- AA Secord
Ovarian Cancer
Study to Evaluate INCB123667 Versus Investigator's Choice of Chemotherapy in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
The purpose of this study is to evaluate INCB123667 versus investigator's choice of chemotherapy in participants with platinum-resistant ovarian cancer with cyclin E1 overexpression.
- Trial name
- MAESTRA 2 (NCT07214779)
- Testing
- INCB123667, Investigator's choice of chemotherapy
- Where
- 198 sites in United States, Australia and 14 more
- Volunteers
- 466 people
- Sponsor
- Incyte Corporation
Obesity
Metformin Versus Orlistat in Obese Polycystic Ovary Syndrome (PCOS) Patients
The purpose of this study is to compare the influence of Orlistat and Metformin on obesity treatment in obese PCOS women.
- Trial name
- NCT01003483
- Testing
- orlistat
- Where
- Iran
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yazd Research & Clinical Center for Infertility
Polycystic Ovary Syndrome
Effect of High Intensity Interval Training on Insulin Resistance in Polycystic Ovarian Syndrome
This study will be conducted to investigate the effect of high- intensity interval training on insulin resistance in polycystic ovarian syndrome.
- Trial name
- NCT07708766
- Testing
- Intermittent fasting diet group, High intensity interval training
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Infertility, Female, Ovarian Stimulation
Double Ovarian Stimulation as Accumulation Strategy for Older Infertile Patients With Suboptimal Ovarian Response
Patients with infertility of the older age group of 37-42 years - a large cohort of patients of reproductive medicine. Two possible causes reduce their probability of pregnancy - an increasing age and a decrease of the ovarian…
- Conditions
- Infertility, Female, Ovarian Stimulation, In Vitro Fertilisation
- Trial name
- NCT03400722
- Testing
- Pergoveris, Clomiphene
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- Nova Clinic, Russia
Cancer
PV701 in Treating Patients With Advanced or Recurrent Peritoneal Cancer
RATIONALE: PV701 may be able to kill tumor cells while leaving normal cells undamaged. PURPOSE: Phase I trial to study the effectiveness of PV701 in treating patients who have advanced or recurrent ovarian epithelial, fallopian…
- Trial name
- NCT00055705
- Testing
- PV701
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
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