Clinical trials: Ovarian Disease
Epithelial Ovarian Cancer
Intraperitoneal (IP) Cisplatin Given With Paclitaxel to Treat Epithelial Ovarian Cancer
The purpose of this study is to determine whether intraperitoneal (IP) Cisplatin combined with intravenous (IV) Paclitaxel is well tolerated in women with epithelial ovarian cancer who have had neoadjuvant chemotherapy followed…
- Trial name
- OVHM-01 (NCT00889733)
- Testing
- Intraperitoneal (IP) Cisplatin
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- University Health Network, Toronto
PCOS (Polycystic Ovary Syndrome)
Health-Related Quality of Life and Metabolic Outcomes in PCOS
The primary outcome of interest is change in PCOS health-related quality of life, while the secondary outcome of interest is change in adiposity, cardiometabolic, and inflammation biomarkers.
- Trial name
- NCT07571915
- Testing
- Intervention Group
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Polycystic Ovary Syndrome
Treating Inflammation in Polycystic Ovary Syndrome to Ameliorate Ovarian Dysfunction
Polycystic Ovary Syndrome (PCOS) is characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovaries. Insulin resistance (IR) is a common feature of PCOS, and the resultant hyperinsulinemia is theorized to promote…
- Trial name
- TIN-PCOS-AOD (NCT03229408)
- Testing
- Salsalate
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Fallopian Tubes Cancer, Ovarian Cancer
Polyvalent Vaccine-KLH Conjugate + Opt-821 Given in Combination With Bevacizumab
The immune system of the body has the ability to fight and eliminate infections and cancers. Immune treatments, such as in this study, seek to teach the immune system to find and destroy cancer cells.
- Conditions
- Fallopian Tubes Cancer, Ovarian Cancer, Peritoneal Cancer
- Trial name
- NCT01223235
- Testing
- bevacizumab and the polyvalent vaccine-KLH conjugate + OPT-821
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Solid Tumor, Hepatocellular Carcinoma
Intravenous T3011 Given as a Single Agent and in Combination With Other Therapy in Subjects With Advanced Solid Tumors
A Phase 1/2a Open-Label Dose Escalation and Dose Expansion Study of T3011 when Administered Intravenously as a Single Agent and in Combination with Other Therapy in Subjects with Advanced Solid Tumors
- Conditions
- Solid Tumor, Hepatocellular Carcinoma, Colorectal Cancer, NSCLC
- Trial name
- NCT04780217
- Testing
- T3011
- Where
- 6 sites in United States
- Volunteers
- 42 people
- Sponsor
- ImmVira Pharma Co. Ltd
Ovarian Cancer, HIPEC
HIPEC in Ovarian Cancer, Case-Controls Study With 10-years Follow up
Objectives: Compare overall survival (OS) and progression-free survival (PFS) among ovarian cancer patients who underwent into cytoreduction and HIPEC procedure vs patients who only received systemic chemotherapy in a 10-years…
- Trial name
- NCT04234243
- Testing
- cytoreduction and HIPEC
- Volunteers
- 144 people
- Sponsor
- Instituto de Seguridad Social del Estado de Mexico y Municipios
Poly Cystic Ovary Syndrome
The Effect Of Polycystic Ovarian Syndrome Treatment On Ocular Surface.
This is a Descriptive prospective cohort study conducted at the Ophthalmology Department in Kasr-Alaini Hospital. A total of 90 subjects, 30 control females with no relevant medical, gynecological or ophthalmic history, and 60…
- Trial name
- NCT07419776
- Testing
- dry eye diagnostic system of Mediworks, Optical coherence tomography angiography, Contraceptives, Oral, Combined
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cairo University
Stage III Ovarian Cancer, Stage IV Ovarian Cancer
Phase Ib Study of Olaparib Plus Weekly Carboplatin and Paclitaxel in Relapsed Ovarian Cancer
The purpose of this study is to determine the maximum tolerated dose (MTD) of the investigational agent, olaparib, to give in combination with carboplatin and paclitaxel in patients with relapsed ovarian cancer or uterine cancer.
- Conditions
- Stage III Ovarian Cancer, Stage IV Ovarian Cancer, Uterine Cancer
- Trial name
- NCT01650376
- Testing
- Olaparib, Carboplatin, Paclitaxel
- Where
- 5 sites in United States
- Volunteers
- 52 people
- Sponsor
- Swedish Medical Center
Female Reproductive System Neoplasm, Malignant Female Reproductive System Neoplasm
EHealth Mindful Movement and Breathing in Improving Outcomes in Participants Undergoing Gynecologic Surgery
This trial determines how well eHealth mindful movement and breathing works to improve outcomes in participants undergoing gynecologic surgery.
- Conditions
- Female Reproductive System Neoplasm, Malignant Female Reproductive System Neoplasm, Malignant Uterine Neoplasm, Ovarian Carcinoma
- Trial name
- NCT03379376
- Testing
- Questionnaire Administration, Supportive Care
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University Health Sciences
brca1 Mutation Carrier, brca2 Mutation Carrier
Lysophosphatidic Acid Assay in Patients With Ovarian Cancer or Who Are at Risk for Ovarian Cancer
RATIONALE: Screening tests, such as the lysophosphatidic acid assay, may help doctors find cancer cells early and plan better treatment for ovarian cancer.
- Conditions
- brca1 Mutation Carrier, brca2 Mutation Carrier, Ovarian Cancer
- Trial name
- NCT00986206
- Testing
- Biomarker LPA and HE4
- Where
- United States
- Volunteers
- 525 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Cancer
Aprepitant in Preventing Nausea and Vomiting in Patients Who Are Undergoing a Stem Cell Transplant
RATIONALE: Antiemetic drugs, such as aprepitant, ondansetron, and dexamethasone, may help lessen or prevent nausea and vomiting in patients undergoing a stem cell transplant.
- Trial name
- NCT00248547
- Testing
- aprepitant, dexamethasone, ondansetron
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- OHSU Knight Cancer Institute
Polycystic Ovary Syndrome, Vitamin D Deficiency
Association of Vitamin D Status With Metabolic Markers in Adolescents With Polycystic Ovary Syndrome
This prospective cross-sectional case-control study aims to investigate the relationship between serum vitamin D levels, visceral adipose tissue (VAT) thickness, and metabolic parameters in adolescents diagnosed with polycystic…
- Conditions
- Polycystic Ovary Syndrome, Vitamin D Deficiency, Insulin Resistance
- Trial name
- NCT06970821
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Bagcilar Training and Research Hospital
Infertility, Female
One-shot Ovarian Stimulation Protocol (One-shot)
The current prospective observational pilot study aims to evaluate the endocrine profile of a single-injection protocol (single CFA + daily oral administration of CC).
- Trial name
- One-shot (NCT06635538)
- Testing
- Corifollitropin alfa (CFA) 150 mcg + Clomiphene Citrate (CC) 100 mg/day from D1, Clomiphene Citrate (CC) 100 mg/day from D1, Monitoring cycle
- Where
- 3 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Fundación Santiago Dexeus Font
Fallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Endometrioid Adenocarcinoma
Carboplatin and Paclitaxel With or Without Bevacizumab in Treating Patients With Stage III or Stage IV Ovarian Epithelial, Primary Peritoneal, or Fallopian Tube Cancer
This randomized phase III trial studies carboplatin, paclitaxel, and bevacizumab to see how well they work compared to carboplatin, paclitaxel, and placebo in treating patients with stage III or stage IV ovarian epithelial…
- Conditions
- Fallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube Mucinous Adenocarcinoma, Fallopian Tube Serous Adenocarcinoma
- Trial name
- NCT00262847
- Testing
- Bevacizumab, Carboplatin, Laboratory Biomarker Analysis
- Where
- 632 sites in United States, Canada and 2 more
- Volunteers
- 1,873 people
- Sponsor
- National Cancer Institute (NCI)
Reproductive Disorder, PCOS
Dampening the Reproductive Axis With Continuous Kisspeptin
The goal of this study is to assess response to kisspeptin as well as the baseline patterns of luteinizing hormone (LH) secretion in individuals with polycystic ovarian syndrome (PCOS).
- Conditions
- Reproductive Disorder, PCOS, Polycystic Ovary Syndrome
- Trial name
- NCT05971849
- Testing
- kisspeptin 112-121
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Stephanie B. Seminara, MD
Cervical Cancer, Endometrial Cancer
HER2 Expression in Gynecological Malignant Tumors in Chongqing Area of China
This study aims to retrospectively analyze the HER2 expression of gynecological malignant tumors in Chongqing by immunohistochemical detection, and explore the correlation between HER2 level, therapy response and prognosis based…
- Conditions
- Cervical Cancer, Endometrial Cancer, Ovarian Cancer, HER2 Expression
- Trial name
- NCT06238284
- Testing
- no intervention
- Volunteers
- 300 people
- Sponsor
- Chongqing University Cancer Hospital
Ovarian Cancer, Fallopian Tube Cancer
Personalized Timing of Interval Debulking Surgery in Advanced Ovarian Cancer
About 70% of epithelial ovarian cancer patients are diagnosed at advanced stage. When primary optimal surgery is not possible, neoadjuvant chemotherapy will followed by interval debulking surgery is one treatment option.
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Carcinoma
- Trial name
- Preselect-1 (NCT07023484)
- Testing
- KELIM, Carboplatin plus Paclitaxel, Interval debulking surgery
- Where
- 6 sites in China, Hong Kong
- Volunteers
- 126 people
- Sponsor
- The University of Hong Kong
Ovarian Hyperstimulation Syndrome
Luteal Phase Supplementation With Recombinant LH After GnRh Agonist Oocytes Triggering in Women at Risk of OHSS
The purpose of this study is to prove that luteal phase supplementation with recombinant LH can solve the luteal phase deficiency after Gnrh agonist oocytes triggering in women at risk of OHSS
- Trial name
- NCT02200952
- Testing
- recombinant LH
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- San Carlo Public Hospital, Potenza, Italy
Ovarian Cancer, Fallopian Tube Cancer
Tivozanib As Maintenance Therapy In GYN
This research study is evaluating a drug called tivozanib as a possible treatment for ovarian, fallopian tube or primary peritoneal cancer. Angiogenesis is the formation of new blood vessels.
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Carcinoma
- Trial name
- NCT01972516
- Testing
- Tivozanib
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Dana-Farber Cancer Institute
Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor
Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Rare Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Bone marrow transplantation may allow doctors to give higher doses of chemotherapy and kill more tumor cells.
- Conditions
- Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Head and Neck Cancer, Kidney Cancer
- Trial name
- NCT00002515
- Testing
- filgrastim, carboplatin, thiotepa
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
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