Clinical trials: Ovarian Diseases
Ovarian Cancer
A Study of Niraparib in Combination With Abemaciclib for Late Line Treatment of Ovarian Cancer (NICHOL TRIAL)
This is an interventional trial. The goal of this clinical trial is dose finding. There are two phases: phase Ib to determine the MTD and recommended phase II dose of niraparib in combination with abemaciclib in patients with…
- Trial name
- NICHOL (NCT06594679)
- Testing
- Niraparib Tosylate Monohydrate
- Where
- Italy
- Volunteers
- 73 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Polycystic Ovary Syndrome
IVM With Low Cost Priming, Enhanced Oocyte Recovery, and Delayed Transfer
A protocol was developed to improve pregnancy results after IVM compared to results from studies in the literature. Differences from most published protocols include the use of the Steiner-Tan needle to optimize oocyte…
- Trial name
- IVMprt (NCT04149496)
- Testing
- in vitro maturation of oocytes
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Bruce Rose, MD
Platinum-sensitive Recurrent BRCA Wild Type Ovarian Cancer
Olaparib Maintenance With Pembrolizumab & Bevacizumab in BRCA Non-mutated Patients With Platinum-sensitive Recurrent Ovarian Cancer
This study is phase II, open label, clinical trial to determine the efficacy of Olaparib maintenance with Bevacizumab and Pembrolizumab by assessment progression-free survival(6 months PFS rate) in BRCA non-mutated patients with…
- Trial name
- OPEB-01 (NCT04361370)
- Testing
- Olaparib-Pembrolizumab-Bevacizumab
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Yonsei University
Paralytic Ileus
Effects of Gum Chewing on Recovery of Bowel Function Following Abdominal Surgery for Endometrial and Ovarian Cancer
Following extensive abdominal surgery for the treatment of endometrial or ovarian cancer, paralytic ileus frequently develops. Gum chewing can promotes the return of bowel function through the cephalic-vagal reflex and increased…
- Trial name
- NCT01389986
- Testing
- Gum chewing
- Where
- Thailand
- Sponsor
- Chiang Mai University
Epithelial Ovarian Cancer, Homologous Recombination Deficiency
HRD and Resistance to PAPPi in EOC Patients
The association between homologous recombination (HR) gene mutations and homologous recombination deficiency (HRD) status in Chinese epithelial ovarian cancer (EOC) patients has been investigated in previous studies (NCT04190667…
- Conditions
- Epithelial Ovarian Cancer, Homologous Recombination Deficiency, Homologous Recombination Repair Gene Mutation, Poly(ADP-ribose) Polymerase Inhibitor
- Trial name
- NCT05310370
- Testing
- Testing of homologous recombination deficiency
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Lei Li
Polycystic Ovary Syndrome
High Versus Normal Protein Diet in Polycystic Ovary Syndrome (PCOS)
The objective of this study is to assess the effects of a high protein (HP) and a normal protein diet (NP) on patients with polycystic ovary syndrome (PCOS) and body mass index (BMI)-matched controls in a sample of southern…
- Trial name
- NCT01184963
- Testing
- High protein diet, Normal protein diet
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Polycystic Ovary Syndrome
A Study to Explore Correlation Between Symptoms and Signs of Polycystic Ovarian Syndrome (PCOS) and Risk of Over-response to Ovarian Stimulation
This is a Phase IV, prospective, observational, single arm, multicenter trial to identify the population at high risk of overstimulation associated with signs and symptoms of PCOS and examines the utility of 12.5 international…
- Trial name
- ARTIST (NCT02607293)
- Testing
- Gonal-f®, Long GnRH agonist, GnRH antagonist
- Where
- Germany
- Volunteers
- 1,064 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Ovary Cancer
An Exploratory Study on NK Cell-assisted Prevention of Bone Marrow Suppression During Chemotherapy for Ovarian Cancer
To evaluate the remission effect and safety of intravenous injection of METR-NK cells as adjuvant therapy on bone marrow suppression in patients with ovarian cancer after chemotherapy
- Trial name
- NCT07096583
- Testing
- METR-NK cell（metabolic remodeling nature killer cells）
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Anhui Provincial Cancer Hospital
Advanced Solid Tumors
A Dose Escalation and Cohort Expansion Study of Subcutaneously-Administered Cytokine ALKS 4230 (Nemvaleukin Alfa) as a Single Agent and in Combination With Anti-PD-1 Antibody (Pembrolizumab) in Subjects With Select Advanced or Metastatic Solid Tumors (ARTISTRY-2)
This study will characterize the safety and tolerability and identify the recommended Phase 2 dose (RP2D) of subcutaneous (SC) ALKS 4230 as monotherapy and in combination with pembrolizumab.
- Trial name
- NCT03861793
- Testing
- ALKS 4230, Pembrolizumab
- Where
- 48 sites in United States, Canada and 4 more
- Volunteers
- 116 people
- Sponsor
- Mural Oncology, Inc
BRCA Mutation, Estrogen Deficiency
A 3D Bioprinted Hormone-producing Model for BRCA Mutated Patients After Risk Reducing Surgery: the DISC-OVARY Trial
Selecting theca and granulosa cells from removed ovaries of BRCA1/2mut patients undergoing Risk-reducing salpingo-oophorectomy (RRSO) and developing a 3D bioprinted hormone-producing bioprosthetic model.
- Conditions
- BRCA Mutation, Estrogen Deficiency, Surgical Menopause, Menopause Related Conditions
- Trial name
- DISC-OVARY (NCT06497270)
- Testing
- Theca and Granulosa Cell Isolation
- Where
- Italy
- Volunteers
- 3 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Ovarian Cancer
Vaccine Therapy in Treating Patients With Stage III or Stage IV Ovarian Epithelial Cancer
RATIONALE: Vaccines made from tumor tissue may make the body build an immune response and kill tumor cells. PURPOSE: Phase II trial to study the effectiveness of vaccine therapy in treating patients who have stage III or stage IV…
- Trial name
- NCT00003386
- Testing
- BCG vaccine, autologous tumor cell vaccine, carboplatin
- Where
- 60 sites in United States, Canada
- Sponsor
- Gynecologic Oncology Group
Gynecologic Cancer
PSMA PET and MRI in Gynecological Cancers
The goal of this research is to determine the accuracy of PSMA positron emission tomography (PET) and multi-parametric magnetic resonance (MR) imaging to detect the presence of gynecological cancer cells in the body.
- Trial name
- NCT03302156
- Testing
- PSMA-based 18F-DCFPyL PET tracer
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Breast Cancer, Ovarian Cancer
A Phase 1 Study to Evaluate MEDI4736 in Combination With Tremelimumab
This was a Phase 1, open-label, nonrandomized, multicenter study of durvalumab and tremelimumab in subjects with advanced cancers who were not eligible for, declined, or failed standard treatment.
- Conditions
- Breast Cancer, Ovarian Cancer, Colorectal Cancer, Cervical Cancer
- Trial name
- NCT01975831
- Testing
- Durvalumab, Tremelimumab
- Where
- 6 sites in United States
- Volunteers
- 104 people
- Sponsor
- Ludwig Institute for Cancer Research
Ovarian Cancer
(GI-RADS) in Preoperative Evaluation of Adnexal Masses
prospective study was conducted and performed on 100 women with pelvic pain due to accidently discovered adnexal mass
- Trial name
- NCT06403072
- Testing
- The Gynecologic Imaging-Reporting and Data System (GI-RADS)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Beni-Suef University
Breast Cancer, Ovarian Cancer
A Study Of TeleGenetics Versus Usual Care To Increase Access To Cancer Genetic Services
The goal of this research is to evaluate the relative advantage of remote counseling over usual care in community health practices without access to genetic services.
- Conditions
- Breast Cancer, Ovarian Cancer, Colorectal Cancer
- Trial name
- NCT02517554
- Testing
- Penn genetic counselors provides counseling and test results disclosure by videoconferene to patient at community site, Penn genetic counselor provides counseling and test results disclosure by telephone to patient at community site, Patient receives written information on how to find genetic services in their area
- Where
- 7 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Major Depressive Disorder
Ovarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual Exacerbations of Depression
The goal of this clinical trial is to learn how hormonal changes over the menstrual cycle affect mood symptoms in reproductive-aged women with depression that worsens during the premenstrual period.
- Trial name
- PEAR (NCT06610305)
- Testing
- Transdermal estradiol, Progesterone
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of North Carolina, Chapel Hill
Infertility
Corifollitropin Alfa Versus Recombinant Follicle Stimulating Hormone (FSH) in Ovarian Stimulation of Women Undergoing in Vitro Fertilisation
The use of corifollitropin alfa is superior in terms of pregnancy outcome parameters as compared to recombinant follicle stimulating hormone (FSH) during ovarian stimulation protocols in women undergoing in vitro fertilisation.
- Trial name
- NCT01319695
- Testing
- corifollitropin alfa, recombinant follicle stimulating hormone (FSH)
- Where
- 2 sites in Greece
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Healthy, Premature Ovarian Failure
Feasibility Study for Development of an Early Test for Ovarian Failure
This purpose of this study is to gain information about normal ovarian function that will be useful in developing a test for early detection of ovarian failure.
- Trial name
- NCT00006156
- Testing
- Control, Drug: FSH
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Ovarian Cancer, Ovarian Tumor
AI Analysis of CT Scans to Classify Ovarian Tumours as Benign, Borderline or Malignant Before Surgery
The goal of this observational study is to learn if a computer program can tell what type of ovarian tumour a person has from a CT scan taken before surgery. The program uses artificial intelligence (AI).
- Conditions
- Ovarian Cancer, Ovarian Tumor, Borderline Ovarian Tumor
- Trial name
- OvaClass (NCT07883551)
- Where
- 7 sites in Belgium, Netherlands
- Volunteers
- 1,300 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Ovarian Cancer
Pilot Study of Rosuvastatin and Enoxaparin Thromboprophylaxis Following Ovarian Cancer Surgery (O-STAT Study)
This research study is studying a combination of two drug interventions called rosuvastatin and enoxaparin as a possible preventative measure against developing venous blood clots (such deep vein thrombosis or pulmonary…
- Trial name
- NCT03532139
- Testing
- Enoxaparin, Enoxaparin + Rosuvastatin, Thromboprophylaxis
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Beth Israel Deaconess Medical Center
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