Clinical trials: Ovarian Diseases
Polycystic Ovary Syndrome
Novel Subtypes of Polycystic Ovary Syndrome
To classify subtypes of Polycystic Ovary Syndrome (PCOS) using machine-learning algorithms, and compare the reproductive and metabolic characteristics and IVF outcomes across these identified subtypes.
- Trial name
- NCT06124391
- Testing
- Long-term follow-up
- Where
- 11 sites in United States, Brazil and 4 more
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Shandong University
Neoplasm, Colorectal, Neoplasm, Breast
Development, Implementation and Evaluation of an Individual Decision Aid in Swedish Cancer Screening Programs
Background: Sweden has a long tradition of organized national population-based screening programs. Participation rates differ between programs and regions, are relatively high in some groups, but lower in other.
- Conditions
- Neoplasm, Colorectal, Neoplasm, Breast, Neoplasm, Ovarian
- Trial name
- BESTa (NCT05512260)
- Testing
- Individual decision aid (iDA)
- Where
- Sweden
- Volunteers
- healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Ovarian Cancer
Study of Clinical and Biological Prognostic Factors in Patients With Ovarian Cancer Receiving Carboplatin +Paclitaxel With Bevacizumab
The addition of bevacizumab to first-line chemotherapy has been shown to improve progression free survival for patients with ovarian cancer.
- Trial name
- MITO16/MANGO-2 (NCT01706120)
- Testing
- Bevacizumab, Paclitaxel, Carboplatin
- Where
- 47 sites in Italy
- Volunteers
- 400 people
- Sponsor
- National Cancer Institute, Naples
Infertility
FSH Doser for Controlled Ovarian Stimulation
The study aims to evaluate the effectiveness of an individualized FSH dosing model called IDoser in controlled ovarian stimulation (COS) for assisted reproduction.
- Trial name
- ALGO3 (NCT05948293)
- Testing
- Machine learning model called IDoser, Standard clinical practice
- Sponsor
- Clínica EUGIN
Anovulation
Predictors of Ovarian Response During Clomiphene Citrate Ovulation Induction in Patients With Polycystic Ovary Syndrome
The purpose of this study is to determine whether Visceral fat area and other criteria assessed during initial screening could predict the response to ovulation induction with clomiphene citrate (CC) in patients with polycystic…
- Trial name
- NCT02269306
- Testing
- clomiphen citrate
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Menoufia Obstetrics and Gynecology Group
Breast Cancer
Impact of Formulation Change on Ovarian Suppression in Young Breast Cancer Patients.
This is a multicenter, prospective, randomized controlled, phase II study. The primary objective is to evaluate the effect of endocrine therapy modification (switching from a 3-month to a 1-month GnRHa) versus continuation of the…
- Trial name
- IFOCOS (NCT07610733)
- Testing
- 1-month GnRH, 3-month GnRH
- Volunteers
- 100 people
- Sponsor
- Fudan University
Coronary Heart Disease, Stroke
Examining the Long-Term Risks of Oophorectomy
At the time of hysterectomy for benign disease, the overall health benefits of preserving ovarian function in a large population of women have not been established.
- Conditions
- Coronary Heart Disease, Stroke, Breast Cancer, Ovarian Cancer
- Trial name
- NCT00655447
- Where
- United States
- Volunteers
- 32,175 people, healthy volunteers welcome
- Sponsor
- Parker, William H., M.D.
Gestational Diabetes Mellitus (GDM), Pregnancy
Poi for Mama: a Pilot to Improve Maternal Microbiome and Gestational Diabetes Risk
This investigator-initiated, non-randomized pilot study evaluates the effect of daily consumption of fermented poi on the maternal microbiome and gestational diabetes risk during pregnancy.
- Trial name
- NCT07446205
- Testing
- Fermented Poi
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Hawaii
Quality of Life, Cervical Cancer
Comprehensive Study on the Quality of Life in Cervical Cancer Patients
This is prospective cohort study. All the patients with primary cervical cancer in the future three years in Peking Union Medical College Hospital will be included in this study.
- Conditions
- Quality of Life, Cervical Cancer, Urodynamics, Rectum Dynamics
- Trial name
- NCT03967457
- Testing
- questionnaires survey, Urodynamic testing, Rectum dynamics testing
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Lei Li
Ovarian Cancer
Maintenance Treatment With BGB-290 Versus Placebo in Participants With Platinum-sensitive Recurrent Ovarian Cancer
To evaluate the efficacy, safety and tolerability of maintenance therapy with BGB-290(Pamiparib) versus placebo in Chinese participants with recurrent ovarian cancer who achieved a complete response (CR) or partial response (PR)…
- Trial name
- NCT03519230
- Testing
- Pamiparib capsule
- Where
- 28 sites in China
- Volunteers
- 224 people
- Sponsor
- BeiGene
Fallopian Tube Carcinoma, Primary Peritoneal Carcinoma
Oregovomab With or Without Cyclophosphamide in Treating Patients With Stage III or Stage IV Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer That Responded to Second-Line Chemotherapy
This randomized clinical trial is studying the side effects of oregovomab and to see how well it works with or without cyclophosphamide in treating patients with stage III or stage IV ovarian epithelial cancer, fallopian tube…
- Conditions
- Fallopian Tube Carcinoma, Primary Peritoneal Carcinoma, Recurrent Ovarian Carcinoma, Stage III Ovarian Cancer
- Trial name
- NCT00551265
- Testing
- Cyclophosphamide, Laboratory Biomarker Analysis, Oregovomab
- Where
- United States
- Sponsor
- Gynecologic Oncology Group
Fallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Endometrioid Adenocarcinoma
Paclitaxel, Polyglutamate Paclitaxel, or Observation in Treating Patients With Stage III or Stage IV Ovarian Epithelial, Peritoneal Cancer, or Fallopian Tube Cancer
This randomized phase III trial studies paclitaxel to see how well it works compared to polyglutamate paclitaxel or observation only in treating patients with stage III or stage IV ovarian epithelial, peritoneal cancer, or…
- Conditions
- Fallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube Mucinous Adenocarcinoma, Fallopian Tube Serous Adenocarcinoma
- Trial name
- NCT00108745
- Testing
- Clinical Observation, Laboratory Biomarker Analysis, Paclitaxel
- Where
- 315 sites in United States
- Volunteers
- 1,157 people
- Sponsor
- GOG Foundation
Breast Cancer
Biological and Clinical Effects of Palbociclib With Ovarian Suppression and Letrozole in the Neoadjuvant Treatment of Breast Cancer
This study will look at the safety and effectiveness of the combination of palbociclib and letrozole and ovarian suppression for premenopausal patients who have ER-positive/HER2-negative breast cancer that has not yet been…
- Trial name
- NCT03628066
- Testing
- Letrozole, Palbociclib, Goserelin
- Where
- 15 sites in United States, Canada
- Volunteers
- 24 people
- Sponsor
- NSABP Foundation Inc
Breast Neoplasm Female, Early Detection of Cancer
The FYI on MRI: A Multilevel Decision Support Intervention for Screening Breast MRI
The purpose of this study is to test the impact of a multilevel decision support intervention on informed decisions about breast MRI among high-risk Black and Latina women.
- Conditions
- Breast Neoplasm Female, Early Detection of Cancer, Hereditary Breast and Ovarian Cancer Syndrome, Magnetic Resonance Imaging
- Trial name
- NCT06892275
- Testing
- Enhanced Usual Care, Decision Support
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Georgetown University
Renal Cell Carcinoma, Ovarian Cancer
A Clinical Research About CD70-targeted CAR-T in the Treatment of CD70-positive Advanced/Metastatic Solid Tumors
This is a single-center, double-arm, open-label study. this study plans to evaluate the safety and efficacy of CD70-targeting CAR-T cells in the treatment of CD70-positive advanced/metastatic solid tumors, and obtain recommended…
- Conditions
- Renal Cell Carcinoma, Ovarian Cancer, Cervix Cancer, Metastatic Cancer
- Trial name
- NCT06010875
- Testing
- CD70 CAR-T cells
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Chongqing Precision Biotech Co., Ltd
Primary Ovarian Insufficiency, Genetic Predisposition to Disease
Genetic Etiology in Premature Ovarian Insufficiency
Premature Ovarian Insufficiency (POI), first described by Albright in 1942, is defined as an increase in Follicle Stimulating Hormone (FSH), an insufficiency of the ovarian function leading to an early menopause (<40 years of…
- Trial name
- POI (NCT01973075)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- BEGUM AYDOGAN
Ovarian Cysts, Menstrual Cycle
Timing of LNG-IUD Insertion and Ovarian Cyst Formation
In this prospective observational study, the effect of timing of insertion (early/late follicular; early/late luteal) on ovarian cyst development in women receiving an LNG-IUD will be assessed ultrasonographically at months 0, 3…
- Conditions
- Ovarian Cysts, Menstrual Cycle, Intrauterine Device (IUD)
- Trial name
- LNG-IUD TIMING (NCT07248553)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Endometrial Cancer, Ovarian Cancer
Quality of Life in Survivors of Gynecologic Cancer
RATIONALE: Quality-of-life assessment in cancer survivors may help determine the long-term effects of having had gynecologic cancer and may help improve the quality of life for future cancer survivors.
- Trial name
- NCT00003795
- Testing
- quality-of-life assessment
- Where
- 44 sites in United States, Canada
- Volunteers
- 311 people
- Sponsor
- Gynecologic Oncology Group
Cancer
Early Intervention vs. Standard Palliative Care in Improving End-of-Life Care in Advanced Cancer Patients
RATIONALE: Palliative care may help patients with advanced cancer live more comfortably. PURPOSE: This randomized clinical trial is studying an early intervention palliative care program to see how well it works compared to a…
- Trial name
- NCT00253383
- Testing
- counseling intervention, educational intervention, psychosocial assessment and care
- Where
- 2 sites in United States
- Volunteers
- 329 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Ovarian Cancer
Study of Lenalidomide With Topotecan In Subjects With Advanced Ovarian and Primary Peritoneal Carcinoma
Phase I will determine the MTD and evaluated the safety profile of oral lenalidomide on days 1-14 when given with topotecan on days 1-5 of every 21 day cycle Phase II will commence once the MTD is established, additional subjects…
- Trial name
- NCT00179712
- Testing
- CC-5013, topotecan
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Celgene Corporation
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