Clinical trials: Ovarian Hyperstimulation Syndrome
Infertility and at High Risk of OHSS
Dual Trigger to Reduce Ovarian Hyperstimulation Syndrome
Gonadotropin releasing hormone (GnRH) agonist is sufficient for triggering final oocyte maturation in GnRH antagonist protocol and can significantly reduce incidence of ovarian hyperstimulation syndrome (OHSS) in high-risk…
- Trial name
- NCT02022228
- Testing
- triptorelin, hCG
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chenshiling
In Vitro Fertilization
Corifollitropin Alfa Application in PCOS Patients
Corifollitropin alfa, single dose administered sustains multiple follicular development for 7 days. However, It may induce ovarian hyperstimulation syndrome (OHSS), especially in high responder women such as patients of…
- Trial name
- NCT02215135
- Testing
- Corifollitropin alfa
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Ovarian Hyper Stimulation Syndrome (OHSS)
Albumin and Furosemide for Preventing Ovarian Hyperstimulation Syndrome in ICSI Patients
This study aims to evaluate whether the combination of Albumin and Furosemide can reduce the risk of Ovarian Hyperstimulation Syndrome in women undergoing intracytoplasmic sperm injection (ICSI) who are at high risk of developing…
- Trial name
- ALFURO-OHSS (NCT07568886)
- Testing
- Albumin (Human) 20%, Furosemide, Standard luteal phase support
- Where
- Iraq
- Volunteers
- 200 people
- Sponsor
- Al-Nahrain University
Infertility, Ovarian Hyperstimulation Syndrome
Monitoring the Early Follicular Phase With Androstenedione in Low-dose Step-up Ovulation Induction in High Responders
This study aims to predefine the threshold FSH doses during the early follicular phases in low- dose step-up ovulation induction cycles used to treat anticipated high responders by monitoring total testosterone and…
- Trial name
- NCT02329483
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bagcilar Training and Research Hospital
Ovarian Hyperstimulation Syndrome, Cardiovascular Diseases
Medical Assistance for the Procreation and Risk of Thrombosis.
This study aims at evaluating clincal practice regarding prevention of arterial and venous thrombosis following ovarian stimulation.
- Conditions
- Ovarian Hyperstimulation Syndrome, Cardiovascular Diseases, Embolism and Thrombosis
- Trial name
- AMPERT (NCT02610608)
- Testing
- ovarian stimulation
- Where
- 9 sites in France
- Volunteers
- 129 people
- Sponsor
- University Hospital, Brest
Ovarian Hyperstimulation Syndrome
Can GnRH Agonist Trigger Prevent Ovarian Hyperstimulation Syndrome?
Ovarian hyperstimulation syndrome (OHSS) is a major complication of ovarian stimulation for IVF if hCG is used to trigger final oocyte maturation.
- Trial name
- NCT01714648
- Testing
- Triptorelin 0.2 mg
- Where
- Israel
- Volunteers
- 6 people
- Sponsor
- Elisha Hospital
Polycystic Ovary Syndrome, Ovarian Hyperstimulation Syndrome
Comparison Between GnRH Agonist and GnRH Antagonist Protocols of Ovarian Stimulation in PCOS Patients
The purpose of this study is to compare pregnancy rates and the occurrence of OHSS in PCOS patients who were treated with GnRH agonist and GnRH antagonist protocols ovarian stimulation during an IVF cycle.
- Trial name
- NCT00417144
- Testing
- Arvekap 0.1mg (Triptorelin, Ipsen, France), Ganirelix 0.25mg (Orgalutran, Organon, The Netherlands)
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Eugonia
Ovulation Induction
A Prospective, Multi-centric Observational Study to Determine the Mono-bifollicular Development in Infertile Women Subjected to Ovulation Induction With Follitropin α
This is a prospective and multicentric observational study to determine the real mono-bifollicular development rate that is obtained under normal care conditions following ovulation induction (OI) treatment with follitropin-alpha…
- Trial name
- P450 (NCT01111084)
- Testing
- Follitropin alpha (r-FSH)
- Where
- Spain
- Volunteers
- 410 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Ovarian Hyperstimulation Syndrome
The Letrozole Administration During Luteal Phase
To investigate the effect of letrozole in patients who have high risk of ovarian hyperstimulation syndrome (OHSS) after oocyte retrieval, the incidence of OHSS were calculated between letrozole group and supporting treatment…
- Trial name
- NCT02686151
- Testing
- Letrozole, Polygeline, Sodium Chloride
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The Affiliated Hospital of Inner Mongolia Medical University
Infertility
Aspiration of Limited Number of Follicles to Prevent Severe Ovarian Hyperstimulation Syndrome
The purpose of this study is to evaluate the effect of single ovarian puncture to retrieve 7eggs only in prevention of severe ovarian hyperstimulation syndrome.
- Trial name
- NCT02635425
- Testing
- 7 eggs collection, Full eggs collection
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ahmad Hussieny Salama
Ovarian Hyperstimulation Syndrome
Ovarian Hyperstimulation Syndrome (OHSS) Prevention With Agonist
The aim of the study is to explore the concept of GnRH-agonist triggering in combination with elective cryopreservation of all 2PN oocytes at larger scale in a pragmatic clinical setting.
- Trial name
- NCT00835523
- Where
- 10 sites in Germany
- Volunteers
- 51 people
- Sponsor
- University Hospital Schleswig-Holstein
Gynecologic Disease
Clinical Study to Evaluate Efficacy of Cabergoline to Coasting in Reducing the Incidence of Ovarian Hyperstimulation Syndrome
Ovarian hyperstimulation syndrome (OHSS) is a serious iatrogenic complication of controlled ovarian stimulation of gonadotrophin-Stimulated ovarian cycles.
- Trial name
- NCT07043322
- Testing
- Coasting, Cabergoline
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Tanta University
Polycystic Ovary Syndrome
Myo-Inositol for Ovarian Stimulation and ICSI Outcomes in Women With PCOS
Polycystic ovary syndrome (PCOS) is a common endocrine disorder that may affect ovarian function, insulin sensitivity, and fertility.
- Trial name
- NCT07779850
- Testing
- Myo-Inositol, Folic Acid
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Kafrelsheikh University
Ovarian Hyperstimulation Syndrome
Comparative Study Between Calcium Gluconate With Diosmin, Cabergoline and Cabergoline With Diosmin
Ovarian hyperstimulation syndrome is a potentially fatal iatrogenic condition. This syndrome is characterized by a sudden increase of the vascular permeability which results in the development of a massive extravascular exudate…
- Trial name
- NCT06333691
- Testing
- Calcium Gluconate
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Minia University
Ovarian Hyperstimulation Syndrome
Luteal Antagonist Versus Conventional Treatment in Women With Severe Early Ovarian Hyperstimulation Syndrome (OHSS)
The study aims to compare the novel method of GnRH antagonist administration in the luteal phase versus conventional treatment in IVF patients who develop severe early ovarian hyperstimulation syndrome and have all their embryos…
- Trial name
- NCT02392520
- Testing
- cetrorelix (cetrotide)
- Where
- Greece
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Eugonia
Endometrial Receptivity, Ovarian Hyperstimulation Syndrome
Gene Expression Profile After Gonadotropin Releasing Hormone (GnRH) Agonist Trigger of Oocyte Maturation
The purpose of this study is to compare gene expression profiles in endometrial biopsies during the window of implantation after triggers of oocyte maturation using GnRH agonist or hCG and compared with their natural cycles in…
- Trial name
- NCT01606709
- Testing
- GnRH agonist, hCG
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- UConn Health
OHSS
Cabergoline Versus GnRH Antagonist Rescue and Cabergoline in the Prevention of Ovarian Hyperstimulation Syndrome
The aim of study is to compare the efficacy of GnRH antagonist rescue combined with cabergoline with cabergoline in the prevention of ovarian hyperstimulation syndrome in high risk patients undergoing ovarian stimulation for…
- Trial name
- NCT02461875
- Testing
- Cabergoline, GnRH antagonist rescue & cabergoline
- Where
- Egypt
- Volunteers
- 236 people
- Sponsor
- Aljazeera Hospital
Ovarian Hyperstimulation Syndrome, GnRH Antagonist
Preventive Application of GnRH Antagonist on Early OHSS
Ovarian hyperstimulation syndrome is an iatrogenic complication of controlled ovarian stimulation. Ovarian hyperstimulation syndrome prevention is a multistage process and more important than treatment.Preventive administration…
- Conditions
- Ovarian Hyperstimulation Syndrome, GnRH Antagonist, Aspirin, Vascular Endothelial Growth Factor
- Trial name
- NCT03188471
- Testing
- GnRH antagonist, aspirin
- Where
- China
- Volunteers
- 175 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Ovarian Hyperstimulation Syndrome
Preventive Application of Letrozole Decrease Incidence of Early Onset of OHSS
Letrozole is one kind of aromatase inhibitors which may have effect on decrease estrogen in luteal phase and inhibit the luteal function of ovary.
- Trial name
- NCT02670304
- Testing
- letrozole, Aspirin
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Ovarian Hyperstimulation Syndrome
Clinical Study of Recombinant Human Follitropin for Injection Assisted in COH Assisted IVF-ET
The aim of this study was to evaluate the efficacy and safety of domestic recombinant human follicle stimulating hormone (rhFSH) stimulating ovarian to promote follicular development before assisted reproductive technology, which…
- Trial name
- NCT03071172
- Testing
- Triptorelin for Injection, Recombinant Human Choriogonadotropin alfa Solution for Injection, Progesterone Soft Capsules
- Where
- 7 sites in China
- Volunteers
- 252 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.