Clinical trials: Ovarian Insufficiency, active
Early Menopause
Singapore Population Research on Integrated exposoMe & Early Menopause
Brief Summary The goal of this observational study is to learn how environmental factors, lifestyle choices, and social conditions affect the timing of menopause in Asian women aged 40-50 years living in Singapore.
- Trial name
- SG-PRIME (NCT07100639)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
POI
Safety and Efficacy of YB-1113 in Treatment of POI
This phase 1 study is to evaluate the safety and tolerability of YB-1113 administered via intravenous (IV) infusion in the treatment of premature ovarian insufficiency (POI).
- Trial name
- NCT05494723
- Testing
- YB-1113
- Volunteers
- 6 people
- Sponsor
- Bright Cell, Inc.
Premature Ovarian Insufficiency
Effect and Mechanism of Jiajian Guishen Optimized Formula on Premature Ovarian Insufficiency: Insights Into m6A Modification and Oxidative Stress
The goal of this clinical study is to evaluate the effectiveness of JiaJian GuiShen Optimized Formula (JJGS) and explore its mechanisms involving m6A modification and oxidative stress in women with premature ovarian insufficiency…
- Trial name
- JJGS ; POI (NCT07843030)
- Testing
- JJGS
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Shi Yun
Primary Ovarian Insufficiency (Poi)
Umbilical Cord Mesenchymal Stem Cells (UC-MSC) in the Treatment of Primary Ovarian Insufficiency
The goal of this clinical trial is to evaluate the safety, tolerability and efficacy of human umbilical cord mesenchymal stem cell injection (HS_SW01 cells injection) in patients with Primary Ovarian Insufficiency (POI).
- Trial name
- HS_SW01 (NCT07551895)
- Testing
- HS_SW01 cells injection
- Volunteers
- 21 people
- Sponsor
- Shenzhen Huishan Biotechnology Co., Ltd.
Primary Ovarian Insufficiency
Oral GDC-0077 in Premature Ovarian Insufficiency
This is a single-center, single-arm, exploratory clinical trial evaluating the safety and potential effect of oral GDC-0077 on ovarian function in women with premature ovarian insufficiency (POI).
- Trial name
- NCT07904208
- Testing
- GDC-0077
- Volunteers
- 12 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Perimenopause, Perimenopause-Related Depression
Intra Ovarian Muse Cell Injection for Perimenopause Symptom Relief and Ovarian Function Restoration (MUSE-OVARY)
This observational study examines the safety and effects of injecting Muse cells (a type of naturally occurring stem like cells found in adult tissues such as fat or bone marrow) directly into the ovaries of women aged 28 to 70…
- Conditions
- Perimenopause, Perimenopause-Related Depression, Premature Ovarian Insufficiency, Premature Ovarian Failure (POF)
- Trial name
- MUSE-OVARY (NCT07511660)
- Where
- Mexico
- Volunteers
- 12 people
- Sponsor
- Healing Hope International
Poor Response to Ovulation Induction, Infertility, Female
Autologous Platelet Rich Plasma Intraovarian Infusion for Poor Responders
Autologous platelet rich plasma (PRP) intraovarian infusion may improve ovarian response to controlled ovarian stimulation as well as the hormonal profile of poor ovarian response infertile women subjected to intracytoplasmic…
- Conditions
- Poor Response to Ovulation Induction, Infertility, Female, Ovarian Insufficiency, Ovarian Failure
- Trial name
- PRPPOR (NCT05181748)
- Testing
- Autologous platelet rich plasma
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Genesis Athens Clinic
Premature Ovarian Insufficiency
Clinical Study on the Safety and Efficacy of Human Amniotic Mesenchymal Stem Cells in the Treatment of Premature Ovarian Insufficiency
There is a high incidence of women suffering from Primary Ovarian Insufficiency (POI). So far, there was no treatment sufficient enough to cure POI.
- Trial name
- NCT07115082
- Testing
- Climen 21 Tablets, hA-MSCs
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Yan Hongli
Breast Carcinoma, Carcinoma of Unknown Primary
Veliparib, Paclitaxel, and Carboplatin in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery and Liver or Kidney Dysfunction
This phase I trial studies the side effects and the best dose of veliparib when given together with paclitaxel and carboplatin in treating patients with solid tumors that are metastatic or cannot be removed by surgery and liver…
- Conditions
- Breast Carcinoma, Carcinoma of Unknown Primary, Endometrial Carcinoma, Esophageal Carcinoma
- Trial name
- NCT01366144
- Testing
- Carboplatin, Laboratory Biomarker Analysis, Paclitaxel
- Where
- 17 sites in United States
- Volunteers
- 94 people
- Sponsor
- National Cancer Institute (NCI)
Infertility, Female, Premature Ovarian Failure
Is There A Role For Mechanical Stimulation In Ovarian Follicular Activation?
Premature ovarian failure (POI) is a loss of normal function before age 40, leading to infertility and hypoestrogenism. About 1% of women younger than 40 years old and 0.1% before 30 are affected.
- Conditions
- Infertility, Female, Premature Ovarian Failure, IVF
- Trial name
- NCT04390308
- Testing
- Ovarian puncture, Hormonal blood Test, Transvaginal ultrasound
- Where
- United Arab Emirates
- Volunteers
- 70 people
- Sponsor
- ART Fertility Clinics LLC
Anti-Müllerian Hormone, Polycystic Ovarian Syndrome
Clinical Application of Serum Anti-Müllerian Hormone (AMH) Measurements
This study aims to assess the association of Anti-Müllerian hormone (AMH) with polycystic ovarian syndrome, premature ovarian insufficiency and fertility. The main objectives include the following: 1.
- Conditions
- Anti-Müllerian Hormone, Polycystic Ovarian Syndrome, Premature Ovarian Insufficiency, Fertility Issues
- Trial name
- NCT05858307
- Where
- Hong Kong
- Volunteers
- 300 people
- Sponsor
- Chinese University of Hong Kong
Poor Ovarian Response
A RCT Study on Autologous Cell Injection Into the Ovaries of Patients With POR
Poor ovarian response (POR) is a pathological state where the ovaries do not respond well to the stimulation of gonadotropins. It is mainly characterized by a small number of developing follicles, a high cancellation rate of the…
- Trial name
- NCT07282288
- Testing
- PRP injection, SVF injection
- Volunteers
- 198 people
- Sponsor
- Peking University Third Hospital
Locally Advanced Cervical Carcinoma, Premature Ovarian Failure
Autologous Heterotopic Fresh Ovarian Graft in Woman With LACC Eligible for Pelvic Radiotherapy Treatment.
Pelvic chemoradiotherapy (CRT) is an effective treatment for Locally Advanced Cervical Cancer (LACC). However, CRT induces premature ovarian failure ceasing the production of ovarian hormones.
- Trial name
- NCT05462379
- Testing
- Ovarian graft
- Where
- Brazil
- Volunteers
- 22 people
- Sponsor
- MARILIA ALBANEZI BERTOLAZZI
Turner Syndrome, Primary Ovarian Insufficiency (Poi)
Bleeding Patterns in Sequential and Continuous Progesterone Supplementation in Adolescents With Turner Syndrome
This is a single-site open label non-randomized study comparing effects of sequential versus continuous use of progesterone supplementation amongst Turner Syndrome (TS) patients with primary ovarian insufficiency (POI) prescribed…
- Trial name
- BOOST (NCT06834594)
- Testing
- Micronized progesterone 200 MG, Micronized Progesterone 100 MG
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Mercy Hospital Kansas City
Fertility Preservation, Ovarian Tissue Cryopreservation
Preservation of Ovarian Cortex Tissue in Girls With Turner Syndrome
Rationale: Infertility due is a major concern for girls with Turner syndrome (TS) and their parents. Physicians are often asked about possible options to preserve their fertility.
- Conditions
- Fertility Preservation, Ovarian Tissue Cryopreservation, Turner Syndrome, Live Birth
- Trial name
- NCT03381300
- Testing
- Ovarian tissue cryopreservation
- Where
- Netherlands
- Volunteers
- 106 people
- Sponsor
- Radboud University Medical Center
Infertility, IVF
Will Autologous Platelet Rich Plasma Able To Restore Ovarian Function?
A-PRP (Autologous Platelet Rich Plasma) is becoming widely used in a variety of medical procedures seeking tissue remodeling and/or healing as an intervention.
- Conditions
- Infertility, IVF, Premature Ovarian Failure, Anti-Mullerian Hormone Deficiency
- Trial name
- NCT04381299
- Testing
- autologous platelet rich plasma, saline solution
- Where
- United Arab Emirates
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Poor Ovarian Response, PRP Injection
A RCT Study on Autologous PRP Injection in Patients With POR
Poor ovarian response (POR) is a pathological condition where the ovaries do not respond well to the stimulation of gonadotropins.
- Trial name
- NCT07282314
- Testing
- PRP injection
- Volunteers
- 142 people
- Sponsor
- Peking University Third Hospital
Cancer, Risk of Premature Ovarian Failure
Cryopreservation of Ovarian Tissue
The study hopes to contribute to the development of technologies of ovarian tissue freezing-thawing and in vitro maturation of immature eggs such that a person at risk for premature ovarian failure might be able to conceive a…
- Conditions
- Cancer, Risk of Premature Ovarian Failure, Fertility Preservation
- Trial name
- NCT01558544
- Testing
- surgery to remove ovaries or high dose chemotherapy
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Weill Medical College of Cornell University
Premature Ovarian Insufficiency
Efficacy and Safety of Huanjingjian Decoction in Women With Premature Ovarian Insufficiency
Study Summary This clinical trial aims to evaluate the efficacy and safety of the traditional Chinese herbal formula Huanjingjian decoction in women with premature ovarian insufficiency (POI).
- Trial name
- EAST-HOPE (NCT07020429)
- Testing
- Huanjingjian decoction, Hormone replacement therapy
- Where
- China
- Volunteers
- 276 people
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Premature Ovarian Insufficiency
Hormone Replacement Therapy in Adolescents With Premature Ovarian Insufficiency
Background: Premature ovarian insufficiency (POI) is a condition in which women under the age of 40 years have absent or irregular menstrual cycles. POI can cause infertility, signs of menopause, osteoporosis, and other symptoms.
- Trial name
- NCT06851754
- Testing
- Progesterone, Estrogen Patch
- Where
- United States
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)