Clinical trials: Ovarian Reserve
Infertility
Dehydroepiandrosterone (DHEA)Supplementation Pre-IVF(In Vitro Fertilization) Cycles
The purpose of this study is to compare the effect of pre-IVF cycles treatment with and without DHEA(Dehydroepiandrosterone) on the ovarian reserve markers, the number of oocytes obtained and IVF(in vitro fertilization) outcomes…
- Trial name
- IVF (NCT02866253)
- Testing
- DHEA
- Volunteers
- 78 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Ovarian Diseases, Fertility Issues
A Novel Ovarian Reserve Monitoring Algorithm for Patients at Risk of Ovarian Injury From Gonadotoxic Therapy
This is an observational cohort study to examine the use of a novel proposed ovarian reserve monitoring algorithm to (1) identify patients who are at risk of DOR and POI from gonadotoxic therapy, (2) minimize time from treatment…
- Conditions
- Ovarian Diseases, Fertility Issues, Gonadal Disorders
- Trial name
- MA (NCT05048654)
- Sponsor
- University of Colorado, Denver
Benign Uterine Disease
Impact of Opportunistic Salpingectomy on Ovarian Reserve in Patients Undergoing Laparoscopic Hysterectomy
Recently, many gynecologic oncologists proposed that surgeons should consider opportunistic salpingectomy to prevent ovarian cancer for all patients undergoing hysterectomy for benign disease.
- Trial name
- NCT01893086
- Testing
- LH alone, LH with opportunistic salpingectomy
- Where
- 3 sites in South Korea
- Volunteers
- 68 people
- Sponsor
- CHA University
Breast Cancer
A Pilot Observational Study to Assess Changes in Biochemical Parameters of Ovarian Reserve With Chemotherapy
Premenopausal women who are diagnosed with breast cancer are frequently treated with chemotherapy. Chemotherapy can affect the ovaries, and the effects can range from temporary loss of menstrual periods to permanent menopause.
- Trial name
- NCT00644683
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Lynn Henry
Diminished Ovarian Reserve (DOR)
Guishen Yijing Granules for Diminished Ovarian Reserve With Kidney Deficiency Syndrome: A Randomized Controlled Trial
This study is a multicenter, stratified block-randomized, double-blind, double-dummy clinical trial designed to evaluate the efficacy and safety of Guishen Yijing Granules in patients with diminished ovarian reserve (DOR) and…
- Trial name
- NCT07841548
- Testing
- Guishen Yijing Granules, Coenzyme Q10 (drug)
- Volunteers
- 120 people
- Sponsor
- Shi Yun
Endometriosis
Endometrioma Related Reduced Ovarian Reserve
Prior studies have shown surgical excision of endometriomas are associated with a decline in ovarian reserve as assessed by serum anti-Mullerian Hormone (AMH) levels.
- Trial name
- ERROR (NCT02438735)
- Testing
- laparoscopic endometrioma excision, Conservative follow up
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Uludag University
Amenorrhea Secondary
AMH and Functional Hypothalamic Amenorrhea
The purpose of this study is to analyze AMH levels in patients with prolonged FHA (more than 2 years). Based on previous studies, we can assume that prolonged FHA may mimic a condition of primary hypogonadotropic hypogonadism…
- Trial name
- AMELIA (NCT05921877)
- Testing
- venous sampling
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Benign Ovarian Cyst, Cystectomy
Benefit of Hemostatic Sealant in Preservation of Ovarian Reserve
Introduction : The most common technique used for ovarian cystectomy is the stripping technique. After stripping the cyst wall, the subsequent bleeding of the ovarian stromal wound is usually controlled by bipolar coagulation…
- Trial name
- FLOKIP (NCT05037552)
- Testing
- Bipolar coagulation, Coagulation by FLOSEAL haemostatic agent
- Where
- 2 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Ovarian Endometrioma, Ovary Cyst
The Impact of Electrocoagulation on Ovarian Reserve After Laparoscopic Excision of Ovarian Cysts.
The aim of the study is to evaluate the effect of bipolar electrocoagulation on ovarian reserve.
- Trial name
- NCT03585309
- Testing
- The impact of electrocoagulation on ovarian reserve after laparoscopic excision of ovarian cysts:
- Where
- Egypt
- Volunteers
- 96 people
- Sponsor
- Ain Shams University
FMR1 Gene Premutation
Assessment of Ovarian Reserve in Patients With Fragile X Premutation
Premature ovarian failure (POF) affects 1% of women under the age of 40 and is defined by the presence of a disorder of the cycle such as spaniomenorrhea or amenorrhea and an increase in FSH > 25 IU/l on two occasions a few weeks…
- Trial name
- ROFRA (NCT07039734)
- Testing
- collection of data from medical records
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
GH, Poor Ovarian Reserve Based on POSEIDON
To Explore the Effect of GH on Outcomes of IVF and Telomerase Activity of Granulosa Cells in Women With POR
It is still a big difficult clinical problem for patients with poor ovarian reserve undergoing in vitro fertilization. The decrease in both quality and quantity of egg are the main cause for poor clinical prognosis.
- Trial name
- NCT04384744
- Testing
- growth hormone
- Volunteers
- 40 people
- Sponsor
- Guangzhou First People's Hospital
Endometriosis Related Infertility
Surgery Before Embryo Transfer in ERROR (Endometrioma Related Reduction in Ovarian Reserve)
This prospective study evaluates the pregnancy results after laparoscopic endometriosis operation in infertile patients with ERROR (endometrioma related reduction in ovarian reserve)
- Trial name
- NCT04233983
- Testing
- Laparoscopic Endometriosis Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Uludag University
Decreased Ovarian Reserve
Real-world Evaluation of Qingxin Zishen Decoction on Ovarian Reserve Function Clinical Efficacy in Patients With Decreased
A prospective cohort study evaluated the clinical efficacy of Qingxin Zishen Decoction
- Trial name
- NCT06332742
- Where
- China
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Yun Chen
Ovarian Diseases, Ankylosing Spondylitis
Ovarian Reserve and Ankylosing Spondylitis
The aim of this study was to determine the status of ovarian reserve in patients with ankylosing spondylitis (AS) using anti-mullerian hormone (AMH) level and antral follicle count (AFC).
- Conditions
- Ovarian Diseases, Ankylosing Spondylitis, Anti-Mullerian Hormone Deficiency
- Trial name
- NCT04209881
- Testing
- ovarian reserve for Ankylosing spondylitis and control groups
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Ovarian Reserve
Ovarian Reserve Following Bilateral Salpingectomy Versus Tubal Ligation During Cesarean Section
The aforementioned study was designed to evaluate short term ovarian reserve as assessed by anti-Mullerian hormone(AMH) levels following bilateral salpingectomy versus tubal ligation, as part of cesarean sections performed in…
- Trial name
- NCT02377128
- Testing
- Bilateral salpingectomy, Tubal ligation
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Increased Oocyte Death, in Vitro Maturation
GREM1, HAS2 and PTGS2 Gene Expression Following the in Vitro Maturation (IVM)
Poor ovarian reserve (POR) is an adverse prognostic factor for In-Vitro Fertilization (IVF) success. Numerous established data showed low live birth rates per IVF cycle; 6 to 10%, including the usage of In-Vitro Maturation (IVM).
- Conditions
- Increased Oocyte Death, in Vitro Maturation, GREM1 Gene Mutation, Cumulus Cell
- Trial name
- NCT06315777
- Testing
- cumulus cell oocytes complex (COC) among women with poor ovarian reserve
- Where
- Malaysia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Infertility
Anti-Mullerian Hormone (AMH) and Antral Follicle Count as Markers of Ovarian Reserve- Prospective Followup of Young Cancer Patients
young female cancer patients have improving chances of survival. the main risk is a chronic damage to their ovarian reserve. This may lead to future infertility.
- Trial name
- Ovrescancer (NCT00930501)
- Testing
- blood tests
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
IVF
Platelet Rich Plasma on Ovarian Reserve Parameters and Intra Cytoplasmic Sperm Injection Outcomes in Patients With Diminished Ovarian Reserve
The aim of this study is to evaluate the efficacy of intra ovarian injection of autologous platelet rich plasma on ovarian reserve parameters and ICSI outcomes in poor ovarian reserve.
- Trial name
- NCT06048666
- Testing
- Intra ovarian by platelet rich plasma
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Beni-Suef University
Breast Cancer
Serum Biomarkers to Characterize the Effects of Therapy on Ovarian Reserve in Premenopausal Women With Early-stage Breast Cancer or BRCA Mutations
The purpose of this study is to learn more about the effects of your BRCA mutation on the ovaries. The BRCA gene can make it hard to conceive a child in the future. It may also bring on early menopause.
- Trial name
- NCT00823654
- Testing
- Blood draw and questionnaires
- Where
- 8 sites in United States
- Volunteers
- 609 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Poor Ovarian Reserve
Effect of Growth Hormone Injection on the IVF/ICSI Outcome of Patients With Poor Ovarian Reserve.
Declined fertility and ovarian reserve in older women are associated with lower density of Growth hormone (GH) receptors and dysregulation in GH secretion.
- Trial name
- NCT04588844
- Testing
- Polyethylene Glycol Recombinant Human Somatropin
- Volunteers
- 200 people
- Sponsor
- Shandong University