Clinical trials: Ovarian Stimulation
Infertility
Does Letrozole Improve the Outcomes and/or Reduce the Cost of IVF-ET Cycles?
This research is being done to determine whether the success rate of in vitro fertilization treatment can be improved, while lowering the cost incurred from infertility medications using a pill called letrozole.
- Trial name
- Cost-Less (NCT00804960)
- Testing
- Letrozole, Std IVF Protocol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Infertility
The Effect of LH-Priming During Early Follicular Phase in IVF Treatment.
To evaluate the effect of LH-activity supplementation during the early follicular phase in GnRHa down-regulated women undergoing IVF in terms of S-Estradiol levels on hCG day by comparing different combinations with HP-HMG and…
- Trial name
- NCT00334425
- Testing
- MENOPUR; GONAL-F
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Central Jutland Regional Hospital
Fertility Disorders
Menopur And Rekovelle Combination Study
This study proposes to evaluate the effect of adding HP-hMG (Menopur) to follitropin delta in a "mixed protocol" regimen, using an individualized, fixed dose of follitropin delta based on the established algorithm, combined with…
- Trial name
- MARCS (NCT03483545)
- Testing
- Follitropin delta and HP-hMG
- Where
- 4 sites in Canada
- Volunteers
- 160 people
- Sponsor
- Dr François Bissonnette
Infertility
Luteal Phase-start Ovarian Stimulation With Corifollitropin Alfa
To evaluate the effect of random-start of ovarian stimulation initiated in the early follicular or luteal phase on the pharmacokinetics and follicular dynamics and embryo euploidy rates in oocyte donors treated with identical…
- Trial name
- NCT03555942
- Testing
- Follicular phase corifollitropin alfa, Luteal phase corifollitropin alfa
- Where
- 2 sites in Spain
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Fundacion Dexeus
Ovulation Induction, Infertility
An Open Label, Canadian Phase IIIb Study With Ovidrel in Ovulation Induction (OI) and Assisted Reproductive Technique (ART)
With the development of the recombinant gonadotrophins, the use of human source proteins for the production of hormones has become unnecessary.
- Trial name
- NCT01152866
- Testing
- Choriogonadotropin alpha (r-hCG)
- Volunteers
- 3 people
- Sponsor
- EMD Serono
Infertility, Female, Ovarian Follicular Cyst
Convolutional Neural Network in Ovarian Follicle Identification
A prospective cohort trial studying patients with infertility undergoing an ovarian stimulation with exogenous gonadotropins. Ovarian monitoring will be performed with a combination of transvaginal ultrasound and 2 dimensional…
- Trial name
- NCT04545918
- Testing
- Follicle Clarity
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Cycle Clarity
Infertility, Premature Ovarian Failure
Single Follicular Dexarelix for LH Suppression During Ovarian Stimulation in Oocyte Donors.
A randomized prospective study in the evaluation of the long acting GnRH antagonist Degarelix against the classical multidose regime with Ganirelix for LH suppression during the follicular phase of an ovarian stimulation cycle in…
- Trial name
- NCT03861715
- Testing
- live birth rate
- Where
- Greece
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Assisting Nature
antimüllerian Hormone and Gonadotrophin Receptor Polymorphism as Predictors of Ovarian Response
Impact of Gonadotrophin REceptor Polimorphisms on the Relationship Between Serum AMH and Ovarian Response
Aim of study: To compare the relationship between serum AMH and ovarian response for IVF with the GnRH antagonist protocol in patients who are carriers of FSH and/or LH receptor polymorphisms with those that are not.
- Trial name
- GREPAMOR (NCT03388099)
- Where
- Spain
- Volunteers
- 296 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Infertility
Estrogen Pretreatment Prior to GnRH Antagonist Protocol
The purpose of this study is to assess whether estrogen pre-treatment can allow retrieval of 2 additional oocytes in GnRH antagonist protocol.
- Trial name
- NCT01489852
- Testing
- 17beta-estradiol
- Where
- France
- Volunteers
- 472 people
- Sponsor
- Gemer
Infertility
Dydrogesterone Versus GnRH Antagonist in Poor Responders Undergoing Double Ovarian Stimulation
The aim of this randomized controlled trial is to compare the efficacy and cost-effectiveness of using progestin with GnRH antagonist to prevent premature LH surge in poor responders undergoing double stimulation protocol.
- Trial name
- NCT06212102
- Testing
- Progestin primed ovarian stimulation, GnRH antagonist
- Where
- 2 sites in Egypt
- Volunteers
- 120 people
- Sponsor
- Bedaya Hospital
Infertility
Biosimilar Versus Urinary Gonadotropins
Biosimilar drug marketing of recombinant FSH for the treatment of infertility is another step in simplifying fertility treatments, making them easier to manage and more accessible to patients.
- Trial name
- BEMDON (NCT02503605)
- Testing
- Biosimilar recombinant FSH, Urinary FSH
- Where
- Spain
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
Controlled Ovarian Hyperstimulation, Polycystic Ovarian Syndrome
Progesterone Primed Ovarian Stimulation Versus GnRH Antagonist Protocols in Women With Polycystic Ovarian Syndrome
The purpose of this study is to compare the use of the progesterone-primed ovarian stimulation protocol versus GnRH antagonist protocol in women with polycystic ovarian syndrome (PCOS) regarding the number of oocytes retrieved…
- Trial name
- NCT06812559
- Testing
- Progesterone, GnRH antagonist (Cetrorelix)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- El Shatby University Hospital for Obstetrics and Gynecology
Infertility, Polycystic Ovary Syndrome
GnRH Antagonist Versus GnRH Agonist in Polycystic Ovary Syndrome During in Vitro Fertilization - Embryo Transfer
GnRH (Gonadotropin-releasing hormone) antagonists in IVF (in vitro fertilization) has been accomplished by several randomized controlled trials compared with conventional GnRH agonist long protocol in polycystic ovary syndrome…
- Trial name
- NCT01402336
- Testing
- GnRH antagonist (Cetrorelix), Conventional GnRH agonist (Triptorelin)
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- Seoul National University Hospital
Ultrasonography
The Effect of Preoperative Anxiety, on Gastric Antrum Size in Women Undergoing in Vitro Fertilization
Pulmonary aspiration is one of the most serious risks of general anesthesia and has been reported to occur in as many as 1 in 4000 cases of general anesthesia.
- Trial name
- NCT04833530
- Testing
- Gastric Ultrasound
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Rabin Medical Center
Infertility
Pharmacogenetic Algorithm for Individualized Controlled Ovarian Stimulation
In this study, the investigators will evaluate genetic variation or polymorphisms between individuals submitted to IVF/ICSI cycles, and how these variations influence response to COS and pregnancy outcomes.
- Trial name
- NCT03149536
- Testing
- Pharmacogenetic test
- Volunteers
- 1,350 people
- Sponsor
- Clínica Origen
Infertility
Gonadotropin Type in Ovarian Stimulation
A key challenge facing reproductive biologists is the integration of the knowledge about oocyte-secreted factors into coherent physiological mechanisms of how oocytes govern folliculogenesis, cumulus cell function, and oocyte and…
- Trial name
- NCT02437032
- Testing
- recombinant FSH, Urinary FSH, hMG
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
IVF, GnRH Antagonist
Live Birth Rate Between PPOS and GnRH Antagonist Protocol in Patients With Anticipated High Ovarian Response
Progestin can inhibit the pituitary LH surge during ovarian stimulation and various studies show progestin-primed ovarian stimulation (PPOS) is effective in blocking the LH surge in IVF.
- Conditions
- IVF, GnRH Antagonist, PPOS
- Trial name
- NCT04414761
- Testing
- Progesterone, GnRH Antagonist
- Where
- China
- Volunteers
- 784 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Infertility, Controlled Ovarian Hyperstimulation
Follicular Steroid Genesis in Controlled Ovarian Stimulation
Serum concentrations of the different hormones involved in follicular steroid genesis during a cycle of controlled ovarian stimulation with recombinant FSH or HMG will be compared in this study.
- Trial name
- ESTEFOL (NCT02738580)
- Testing
- COS with GnRH antagonists and rFSH, COS with GnRH antagonists and HP-HMG
- Where
- Spain
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Polycystic Ovary Syndrome, Infertility
Progesterone Primed Ovarian Stimulation Protocol Versus Antagonist Protocol for PCO Patient
this study is designed to compare the Progesterone primed ovarian stimulation protocol versus the antagonist protocol as a method to stimulate PCO patients in ICSI cycles to decrease cost and decrease OHSS.
- Conditions
- Polycystic Ovary Syndrome, Infertility, IVF
- Trial name
- NCT05847660
- Testing
- Progesterone antagonist, conventional antagonist protocol
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Female Infertility Due to Diminished Ovarian Reserve
Use of Dehydroepiandrosterone (DHEA) in Women With Normal and Poor Ovarian Reserve Undergoing IVF
The aim of the study is to evaluate the effect of DHEA supplement on ovarian reserve markers, ovarian response to gonadotrophins and cycle outcomes in patients with normal and poor ovarian reserve. Study Hypotheses: 1.
- Trial name
- NCT01915186
- Testing
- Dihydroepiandrosterone (DHEA)
- Where
- Hong Kong
- Volunteers
- 104 people
- Sponsor
- The University of Hong Kong