Clinical trials: Ovarian Stimulation
Infertility
Recombinant FSH Investigation in the Treatment of Infertility With Assisted Reproductive Technology (ART) (RITA-1)
This trial investigates the effects of FE 999049 compared to placebo.
- Trial name
- RITA-1 (NCT03740737)
- Testing
- Follitropin delta
- Where
- 23 sites in United States
- Volunteers
- 579 people
- Sponsor
- Ferring Pharmaceuticals
Fertility Issues
Continuous Double Ovarian Stimulation.
To evaluate the efficacy of the weekly use of corifollitropin alfa in double ovarian stimulation process and to compare it to the conventional protocol with daily medication administration.
- Trial name
- NCT05815719
- Testing
- Corifollitropin Alfa, Follitropin Alfa, Follitropin Alfa Biosimilar
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Instituto Bernabeu
Controlled Ovarian Stimulation
A Study to Assess the Efficacy and Safety of Ganirelix (Orgalutran®) Treatment in Chinese Women Undergoing Controlled Ovarian Stimulation for in Vitro Fertilization (IVF) or Intra Cytoplasmatic Sperm Injection (ICSI) (Study 38651)(P05703)
The primary purpose of this study is to assess that ganirelix is safe and well-tolerated in Chinese women and that a controlled ovarian stimulation (COS) protocol combining recombinant follicle stimulating hormone (recFSH) with…
- Trial name
- NCT00725491
- Testing
- ganirelix, triptorelin
- Volunteers
- 259 people
- Sponsor
- Organon and Co
Oocyte Donation
Immunogenicity of Repeated Follicle Stimulating Hormone (FSH) Stimulation Cycles
The purpose of the study is to evaluate immunogenic potential of FSH-IBSA in healthy volunteers undergoing controlled ovarian hyperstimulation (COH) in an oocyte donation program.
- Trial name
- NCT01785095
- Testing
- FSH (Follicle Stimulating Hormone)
- Where
- Spain
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- IBSA Institut Biochimique SA
Infertility, Ovarian Stimulation
A Prospective Study to Evaluate the Addition of Subcutaneous Recombinant Human-Luteinizing Hormone With Recombinant Human-Follicle Stimulating Hormone on Follicular Development in Women Undergoing Ovarian Stimulation for Assisted Reproductive Technologies
In-vitro fertilization (IVF) of human oocytes followed by the replacement of embryo in the uterine cavity has become a well established treatment for female infertility attributable to damaged fallopian tubes, endometriosis or…
- Trial name
- NCT01121991
- Testing
- Recombinant Human-Luteinizing Hormone (Luveris)
- Volunteers
- 55 people
- Sponsor
- EMD Serono
in Vitro Fertilization, Ovulation Induction
Trial Comparing Start Stimulation of Recombinant Follicle Stimulating Hormone (rFSH) on Cycle Day 2 Versus Cycle Day 5 in In Vitro Fertilization (IVF)
Background of the study: Milder stimulation protocols have the advantage of being less expensive and more patient-friendly. Moreover, recent evidence suggests that mild stimulation protocols lead to lower embryo aneuploidy rates…
- Trial name
- LITE (NCT00823472)
- Testing
- Mild stimulation
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Infertility
Efficacy and Safety of FE 999049 in Controlled Ovarian Stimulation in Japanese Women
To demonstrate non-inferiority of FE 999049 compared to FOLLISTIM with respect to number of oocytes retrieved in Japanese IVF/ICSI patients undergoing controlled ovarian stimulation.
- Trial name
- NCT03228680
- Testing
- Follitropin delta, Follitropin beta
- Where
- 17 sites in Japan
- Volunteers
- 373 people
- Sponsor
- Ferring Pharmaceuticals
Infertility
A Trial to Compare the Ovarian Response of REKOVELLE and GONAL-F in Conventional Dosing in Women Undergoing Controlled Ovarian Stimulation
Hormone preparations like REKOVELLE and GONAL-F are used to make the body produce multiple egg sacs, allowing more eggs to be collected from women undergoing infertility treatment.
- Trial name
- ADAPT-1 (NCT05263388)
- Testing
- REKOVELLE (Follitropin Delta), GONAL-F (Follitropin Alfa)
- Where
- 16 sites in Austria, France and 3 more
- Volunteers
- 302 people
- Sponsor
- Ferring Pharmaceuticals
In Vitro Fertilization
Follow-up Protocol on the Outcome of Frozen-thawed Embryo Transfer Cycles From Clinical Trial P05690 (P05711)
Clinical trial objective is to collect the outcome of Frozen-Thawed Embryo Transfer (FTET) cycles performed after the embryos are cryopreserved in the base study P05690 in order to estimate the cumulative pregnancy rate for each…
- Trial name
- NCT00702546
- Testing
- corifollitropin alfa, recFSH (follitropin alfa), gonadatropin releasing hormone (GnRH) antagonist ganirelix
- Volunteers
- 102 people
- Sponsor
- Organon and Co
Infertility, Controlled Ovarian Hyperstimulation
Follicular Steroid Genesis in Controlled Ovarian Stimulation
Serum concentrations of the different hormones involved in follicular steroid genesis during a cycle of controlled ovarian stimulation with recombinant FSH or HMG will be compared in this study.
- Trial name
- ESTEFOL (NCT02738580)
- Testing
- COS with GnRH antagonists and rFSH, COS with GnRH antagonists and HP-HMG
- Where
- Spain
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Infertility
Trial Comparing hCG Triggering Versus hCG Associated With GnRH Agonist
The purpose of this study is to see whether patients triggered with only human Chorion Gonadotropin (hCG) have higher number of Metaphase II oocytes (MII) and implantation rate than patients triggered with hCG combined with…
- Trial name
- NCT01607203
- Testing
- Decapeptyl Daily, pregnyl
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- AZ Jan Palfijn Gent
Pregnancy, Neonates
Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial P05787 (P05712)
The objective of this trial was to evaluate whether Corifollitropin Alfa treatment for the induction of multifollicular growth in women undergoing controlled ovarian stimulation (COS) prior to in vitro fertilization (IVF) or…
- Trial name
- NCT00703014
- Testing
- Corifollitropin Alfa 150 μg, 200 IU RecFSH/Follitropin beta (Days 1 to 7), 200 IU RecFSH/Follitropin beta (Days 8 to hCG)
- Volunteers
- 541 people
- Sponsor
- Organon and Co
Infertility, Female
Recombinant FSH Investigation in the Treatment of Infertility With Assisted Reproductive Technology (ART) (RITA-2)
This trial investigates the effects of FE 999049 compared to placebo.
- Trial name
- RITA-2 (NCT03738618)
- Testing
- Follitropin delta
- Where
- 24 sites in United States
- Volunteers
- 588 people
- Sponsor
- Ferring Pharmaceuticals
Infertility
Clinical Performance and Safety Investigation of ENDOmetrial Washing MEdical DEvice Forielle
This is a multicenter, prospective randomized controlled, interventional investigation to assess the safety and clinical performance of Forielle, a medical device for endometrial washing, in restoring favorable endometrial…
- Trial name
- ENDOMEDE (NCT03387059)
- Testing
- Forielle
- Where
- 7 sites in Italy
- Volunteers
- 9 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Infertility
A Randomised Trial Using Highly Purified Human Chorionic Gonadotropin (HP-hCG) and Recombinant Human Chorionic Gonadotropin (rhCG) in Women Undergoing Controlled Ovarian Stimulation
This trial is investigating the efficacy and safety of highly purified human chorionic gonadotropin (HP-hCG) and recombinant human chorionic gonadotropin (rhCG) for triggering of final follicular maturation in women undergoing…
- Trial name
- FASHION (NCT02449889)
- Testing
- highly purified human chorionic gonadotropin, recombinant human chorionic gonadotropin
- Where
- Brazil
- Volunteers
- 176 people
- Sponsor
- Ferring Pharmaceuticals
Primary Ovarian Insufficiency, Premature Ovarian Failure
The Impact of Granulocyte Colony Stimulating Factor on Premature Ovarian Insufficiency
The goal of this pilot study is to improve ovarian reserve markers in patients with premature ovarian insufficiency. The main question it aims to answer is: Will treatment with G-CSF allow improvement in markers of ovarian…
- Trial name
- NCT06117982
- Testing
- Neupogen
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Trio Fertility
Infertility
Predictive Factors for Ovarian Stimulation Using a Fixed Daily Dose of 200 IU Recombinant FSH (Study 142003)(P05696)
The success of assisted reproductive technologies (ART) is critically dependent on optimizing protocols for controlled ovarian stimulation to provide adequate numbers of good quality oocytes and embryos.
- Trial name
- Xpect (NCT00778999)
- Testing
- Marvelon
- Volunteers
- 442 people, healthy volunteers welcome
- Sponsor
- Organon and Co
Ovarian Stimulation
Lutropin Alfa in Women at Risk of Poor Response
Evaluate the effectiveness of adding lutropin alfa (recombinant human luteinizing hormone [r-hLH]) in the middle of the follicular phase compared to no addition, in infertile women at risk of poor response stimulated with…
- Trial name
- NCT01112358
- Testing
- r-FSH, r-hLH, Analogous GnRH antagonist
- Where
- Spain
- Volunteers
- 58 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Infertility
Rekovelle PK Trial in Chinese Women
FE 999049 is a gonadotropin preparation containing recombinant human follicle stimulating hormone (rhFSH) under development by Ferring Pharmaceuticals.
- Trial name
- NCT04150861
- Testing
- Follitropin Delta
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Infertility, Monofollicular Development
Low-dose Gonal-f® in Ovulation Induction
This is a prospective, multicenter, open-label, comparative and parallel-group study of ovulation induction evaluating tailoring of Recombinant follicle stimulating hormone (FSH) treatment using the Gonal-f® prefilled pen in…
- Trial name
- LoGo (NCT01871532)
- Testing
- Gonal-f®
- Where
- 10 sites in Ireland, United Kingdom
- Volunteers
- 24 people
- Sponsor
- Merck KGaA, Darmstadt, Germany