Clinical trials: Ovary Cyst
Polycystic Ovary Syndrome
Letrozole or Combined Metformin Clomiphene Citrate (CC) for Women With CC Resistant Polycystic Ovary Syndrome
The purpose of this study is to compare and determine the efficacy of letrozole administration to that of combined metformin and Clomiphene in infertile women with polycystic ovary syndrome (PCOS) not responding to treatment with…
- Trial name
- NCT00911313
- Testing
- Letrozole tablets (Femara; Novartis Pharma, Switzerland), metformin HCl (Cidophage®; CID,Cairo, Egypt), CC (Clomid®; Global Napi Pharmaceuticals, Cairo, Egypt)
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Mansoura University
Polycystic Ovary Syndrome
Clomiphene Stair-Step Protocol for Ovulation Induction in Women With Polycystic Ovarian Syndrome
The objective of our study is to evaluate the efficacy of the clomiphene stair-step protocol to induce ovulation in women with polycystic ovarian syndrome (PCOS) compared to traditional protocol.
- Trial name
- PCOSCCTvUSS (NCT01953796)
- Testing
- clomiphene
- Where
- Iraq
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Kufa University
Polycystic Ovary Syndrome, Infertility
Inositol in Letrozol Resistant PCOS Women
Polycystic ovary syndrome (PCOS),is a complex neuro-endocrine disorder affecting approximately 5% to 10% of women in reproductive age.Inositols are considered insulin sensitizers, as they modulate the members of insulin signaling…
- Trial name
- NCT07585396
- Testing
- Myoinositol, Metformin
- Where
- Egypt
- Volunteers
- 136 people
- Sponsor
- Kafrelsheikh University
Polycystic Ovary Syndrome
A Study to Explore Correlation Between Symptoms and Signs of Polycystic Ovarian Syndrome (PCOS) and Risk of Over-response to Ovarian Stimulation
This is a Phase IV, prospective, observational, single arm, multicenter trial to identify the population at high risk of overstimulation associated with signs and symptoms of PCOS and examines the utility of 12.5 international…
- Trial name
- ARTIST (NCT02607293)
- Testing
- Gonal-f®, Long GnRH agonist, GnRH antagonist
- Where
- Germany
- Volunteers
- 1,064 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Polycystic Ovary Syndrome, Normal Volunteers
Proteomics & Glyco-Proteomic Analysis of Follicular Fluid
To the best of the investigators knowledge, exhaustive characterization of the low and high abundant proteins and glyco-proteins of the Follicular Fluid (FF) has not yet been achieved.
- Trial name
- NCT01487486
- Testing
- IVF Antagonist Protocol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Cincinnati
Polycystic Ovarian Syndrome
Effects of Fasting Mimicking Diet (FMD) in Women With Polycystic Ovary Syndrome (PCOS)
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in reproductive-aged women, affecting 6-21% (depending on the applied diagnostic criteria) of this population worldwide.
- Trial name
- NCT05196568
- Testing
- Fasting mimicking diet
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Salento
Polycystic Ovary Syndrome, Healthy
Ovarian Response to Recombinant Follicle Stimulating Hormone in Women With PCOS
Women with PCOS suffer from anovulation and, as a result, infertility. Efforts to clinically induce ovulation in these women using follicle stimulating hormone (FSH) administered subcutaneously seemingly requires prolonged…
- Conditions
- Polycystic Ovary Syndrome, Healthy, Anovulation, Hyperandrogenism
- Trial name
- NCT03252223
- Testing
- Recombinant Follicle Stimulating Hormone
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Infertility, Polycystic Ovary Syndrome
Treatment of Anovulatory Infertility in PCOS Patients
Clomiphene citrate (CC) and metformin are two effective drugs used to induce ovulation in patients with polycystic ovary syndrome (PCOS), even if it is still unclear which compound between them should be initially administered.
- Conditions
- Infertility, Polycystic Ovary Syndrome, Anovulation
- Trial name
- NCT00471523
- Testing
- Clomiphene citrate, Metformin
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- University Magna Graecia
Ovarian Carcinoma, Ovarian Cancer
Study Into a New Diagnostic Tool (Simple Ultrasound-based Rules) in Patients With Adnexal Masses
This study is performed to compare the diagnostic performance and cost-effectiveness of different diagnostic methods for differentiating benign from malignant adnexal (ovary or Fallopian tube) masses: the Risk of Malignancy Index…
- Conditions
- Ovarian Carcinoma, Ovarian Cancer, Ovarian Mass, Ovarian Cyst
- Trial name
- SUBSONiC (NCT02218502)
- Testing
- Ultrasound by general gynaecologist, Ultrasound by an expert ultrasonographist, DW-MRI
- Where
- 5 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- Maastricht University Medical Center
Polycystic Ovary Syndrome, Obstructive Sleep Apnea
The Impact of Obstructive Sleep Apnoea in Women With Polycystic Ovary Syndrome.
Women with PCOS and OSA, compared to women with PCOS only, have more severe clinical and biochemical features of PCOS and impaired QoL.
- Trial name
- NCT03065322
- Testing
- To assess risk of OSA
- Where
- United Kingdom
- Volunteers
- 38 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Polycystic Ovary Syndrome
The Effect of Lifestyle Program Women With PCOS
Polycystic Ovary Syndrome (PCOS) is a common hormonal condition affecting women of reproductive age. In addition to physical symptoms such as irregular menstruation, hormonal changes, and changes in body weight, women with PCOS…
- Trial name
- PCOS (NCT07880366)
- Testing
- Lifestyle Modification Program (LMP)
- Where
- Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Government College University Faisalabad
Polycystic Ovarian Syndrome, Insulin Sensitivity
PED/PEA-15 Protein, PCOS, Obesity, Insulin Sensitivity Indexes, Metformin, Oral Contraceptives
Insulin-resistance plays an important role in polycystic ovary syndrome (PCOS) physiopathology. The phosphoprotein enriched in the diabetes (PED/PEA-15), a 15 kDa protein related to insulin sensitivity, is over-expressed in type…
- Trial name
- NCT00948402
- Testing
- Metformin, oral contraceptive
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federico II University
Polycystic Ovary Syndrome
AMH for the Identification of PCOM in PCOS Diagnosis
The purpose of this study is to validate the anti-müllerian hormone (AMH) cut-off established and validated in the APHRODITE study, for the determination of PCOM as part of the diagnosis of PCOS, using the Elecsys AMH Plus…
- Trial name
- HARMONIA (NCT05527353)
- Where
- Finland
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital
Hyperandrogenism, Metabolic Cardiovascular Syndrome
Phlebotomy and Polycystic Ovary Syndrome
AIMS To study the effects of the decrease in iron tissue depots after scheduled bloodletting on insulin sensitivity, carbohydrate metabolism, classic and non-classic cardiovascular risk factors in patients with functional…
- Trial name
- NCT02460445
- Testing
- Phlebotomy, ethinylestradiol, Cyproterone Acetate
- Where
- Spain
- Volunteers
- 37 people
- Sponsor
- Manuel Luque Ramírez
Polycystic Ovarian Syndrome, Infertility, Female
Spontaneous Reproductive Outcomes After Oral Inositol Supplementation in Infertile Polycystic Ovarian Syndrome Women.
Polycystic ovarian syndrome (PCOS) is a heterogeneous, multifaceted and complex disorder characterized by insulin resistance (IR), hyperinsulinemia, and hyperandrogenism leading ovarian disfunction and infertility.
- Trial name
- IROP-1 (NCT03598374)
- Testing
- Inositol + Folic acid, Folic acid, Regular intercourses
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Università degli Studi dell'Insubria
Polycystic Ovarian Syndrome (PCOS)
Assessment of the Impact of Polycystic Ovary Syndrome on Women's Sexuality
This study, titled SexOPK, aims to evaluate the impact of polycystic ovary syndrome (PCOS) on women's sexual health. PCOS is a common endocrine disorder affecting 5-20% of women of reproductive age, often leading to hormonal…
- Trial name
- SexOPK (NCT06887296)
- Testing
- women answer a questionnaire
- Where
- France
- Volunteers
- 84 people
- Sponsor
- University Hospital, Toulouse
Polycystic Ovary Syndrome
Low Dose OC Therapy in Women With Polycystic Ovary Syndrome (PCOS): Impact of BMI on Hyperandrogenism
The classic description of polycystic ovary syndrome (PCOS) is that it is a disorder characterized by menstrual irregularity, chronic anovulation, androgen excess, and abnormal gonadotropin secretion.
- Trial name
- BEYAZ-PCOS (NCT01360996)
- Testing
- 3 mg DRSP/20 μg EE
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Woman's
Polycystic Ovarian Syndrome (PCOS), Herbal Medicine
Clinical Investigation of Herbal Formulation and Its Efficacy in Polycystic Ovarian Syndrome
Polycystic Ovarian Syndrome (PCO) is a metabolic disorder that afflicts the women of childbearing age. An approximate of 5-10% women are the victim of this disorder.
- Conditions
- Polycystic Ovarian Syndrome (PCOS), Herbal Medicine, Infertility, Metabolic Disorder
- Trial name
- PCOS (NCT07399535)
- Testing
- Herbal Formulation, Metformin XR, Metformin 750 mg and herbal formulation 500 mg
- Where
- Pakistan
- Volunteers
- 116 people
- Sponsor
- Jinnah Postgraduate Medical Centre
Obesity, Hyperlipidemias
Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients
Developed nations worldwide are currently enduring a health crisis, as chronic diseases continue to decrease quality of life and promote additional disease states or even death for much of the population.
- Conditions
- Obesity, Hyperlipidemias, Polycystic Ovary Syndrome, Hypertension
- Trial name
- NCT06049420
- Testing
- Lifestyle counseling and coaching
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- West Virginia School of Osteopathic Medicine
Polycystic Ovary Syndrome, in Vitro Fertilization
Vitamin D and Pregnancy Outcome in PCOS Patients
This multicenter double-blinded placebo-controlled randomised trial aims to evaluate the effectiveness of vitamin D supplementation prior to IVF on the live birth rate in women with PCOS.
- Trial name
- NCT04082650
- Testing
- vitamin D
- Where
- 2 sites in China
- Volunteers
- 876 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
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