Clinical trials: Ovary Disease
Polycystic Ovary Syndrome
Intermittent Fasting Diet Versus Resistive Exercise Program on Insulin Resistance in Obese Women With P.C.O.S
This study will be carried out in an attempt to know which is more effective, Intermittent fasting diet or resistive exercise program on insulin resistance in obese woman with polycystic ovarian syndrome.
- Trial name
- NCT06882291
- Testing
- Intermittent fasting diet, Resistive exercise program, Medical treatment
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Cairo University
Ovarian Cancer
Thalidomide in Treating Patients With Refractory or Resistant Epithelial Ovarian Cancer
RATIONALE: Drugs such as thalidomide may stop the growth of cancer cells by stopping blood flow to the tumor. PURPOSE: Phase II trial to study the effectiveness of thalidomide in treating women who have epithelial ovarian cancer…
- Trial name
- NCT00016224
- Testing
- thalidomide
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Ovarian Cancer
Interval Cytoreductive Surgery With or Without HIPEC for Ovarian Cancer (FOCUS / KOV-HIPEC-04)
Primary stage III-IV epithelial ovarian cancer randomizing between interval cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy (HIPEC)
- Trial name
- FOCUS / KOV-04 (NCT05827523)
- Testing
- Cisplatin
- Where
- 10 sites in South Korea
- Volunteers
- 520 people
- Sponsor
- National Cancer Center, Korea
Solid Tumors
Investigator Initiated Phase 1 Study of TBI-1301
Following pre-treatment with cyclophosphamide and/or fludarabine, NY-ESO-1-specific TCR gene transduced T lymphocytes are transferred to the patients with NY-ESO-1-expressing solid tumors.
- Trial name
- NCT02366546
- Testing
- TBI-1301, Cyclophosphamide, Fludarabine
- Where
- Japan
- Volunteers
- 9 people
- Sponsor
- Mie University
Gynecologic Cancer, Ovarian Cancer
Gyn Onc Prehab Study
Patients will be randomized to a unimodal or trimodal prehabilitation program prior to surgery for known or suspected gynecologic cancer.
- Conditions
- Gynecologic Cancer, Ovarian Cancer, Endometrial Cancer, Cervical Cancer
- Trial name
- NCT04298827
- Testing
- Unimodal, Trimodal
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- St. Louis University
PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Depression, Anxiety
Online Brief CBT Intervention for Women With PCOS
Primary Objective: -To study if an online individual brief CBT (group A) intervention is effective for psychological distress (anxiety and depression) compared to a CAU group in patients with PCOS at 3 and 6 months relative to…
- Conditions
- PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Depression, Anxiety, Self Esteem
- Trial name
- How2deal (NCT05679362)
- Testing
- online brief CBT intervention
- Where
- Netherlands
- Volunteers
- 222 people
- Sponsor
- Erasmus Medical Center
Ovarian Cancer
Paclitaxel/Pazopanib for Platinum Resistant/Refractory Ovarian Cancer
Study of Pazopanib and weekly Paclitaxel in patients with platinum resistant/refractory ovarian cancer who relapse during bevacizumab maintenance.
- Trial name
- TAPAZ (NCT02383251)
- Testing
- Pazopanib, Paclitaxel
- Where
- 36 sites in France
- Volunteers
- 118 people
- Sponsor
- ARCAGY/ GINECO GROUP
Fallopian Tube Cancer, Peritoneal Cavity Cancer
Cyclophosphamide With or Without Celecoxib in Treating Patients With Recurrent or Persistent Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cancer
RATIONALE: Drugs used in chemotherapy, such as cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Fallopian Tube Cancer, Peritoneal Cavity Cancer, Recurrent Ovarian Epithelial Cancer
- Trial name
- NCT00538031
- Testing
- cyclophosphamide, celecoxib
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- City of Hope Medical Center
Advanced Solid Tumor, Ovarian Cancer
Niraparib and Neratinib in Advanced Solid Tumors With Expansion Cohort in Advanced Ovarian Cancer
To determine the recommended phase 2 dose (RP2D) of niraparib and neratinib in combination in patients with advanced solid tumors during Phase 1.
- Trial name
- iNNOVATE (NCT04502602)
- Testing
- Neratinib 160 mg, Neratinib 200 mg, Neratinib 240 mg
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Virginia Commonwealth University
Type2 Diabetes, Polycystic Ovary Syndrome
Myocardial Pathological Changes in Patients of Type 2 Diabetes With or Without PCOS Using Cardiac Magnetic Resonance
The study is prepared to use CMR technology for early screening of myocardial lesions in 561 age-matched women with type 2 diabetes without PCOS, with PCOS without type 2 diabetes and with type 2 diabetes combined with PCOS…
- Trial name
- NCT04805853
- Where
- China
- Volunteers
- 561 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Polycystic Ovary Syndrome
Cinnamon and COH in PCOS Women Underdoing IVF/ICSI Cycles
In patients with polycystic ovary syndrome, insulin resistance increases, and since the extracts from cinnamon reduces insulin resistance by two mechanisms (1- increasing activation of the IRS/PI-3 kinase insulin signaling…
- Trial name
- NCT06199024
- Testing
- Oral cinnamon supplementation
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Royan Institute
Fallopian Tube Cancer, Ovarian Cancer
Combination Chemotherapy in Treating Patients With Ovarian Epithelial, Fallopian Tube, or Peritoneal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Conditions
- Fallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer
- Trial name
- NCT00031954
- Testing
- carboplatin, gemcitabine hydrochloride, paclitaxel
- Where
- 18 sites in Germany
- Volunteers
- 105 people
- Sponsor
- AGO Study Group
Polycystic Ovary Syndrome, Metformin
Metabolic Responses of Metformin and Genetic Polymorphisms of SLC22A1 Gene in PCOS
The aim of this study is to see the associations of metabolic responses of metformin with single nucleotide polymorphisms (SNPs) (rs628031 and rs2282143) of solute carrier family 22 member 1 (SLC22A1) gene in women with…
- Trial name
- NCT05680805
- Testing
- Metformin Hydrochloride
- Where
- Bangladesh
- Volunteers
- 150 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Polycystic Ovary Syndrome, Metabolic Syndrome
A Comparison of a PULSE Diet and the TLC Diet on Reproductive, Metabolic Parameters in Women with PCOS
The main objective of the study is to evaluate the effectiveness of a lifestyle program for women with Polycystic Ovary Syndrome (PCOS). The investigators want to assess the efficacy of a pulse-based diet (i.e.
- Trial name
- NCT05428566
- Testing
- Pulse-based diet, TLC diet
- Where
- 2 sites in Jordan
- Volunteers
- 144 people
- Sponsor
- University of Jordan
Polycystic Ovary Syndrome, Infertility
Ovulation Induction in Clomiphene Citrate Resistant PCO Women
Polycystic ovary syndrome (PCOS) affects 5-10% of women in childbearing age. Hyperinsulinemia contributes to chronic anovulation commonly encountered in women with PCOS. The first choice therapy is clomiphene citrate (CC).
- Trial name
- NCT02341703
- Testing
- letrozole-metformin, letrozole-metformin-pioglitazone, transvaginal ultrasound
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Polycystic Ovary Syndrome, Overweight and Obesity
Weight Loss Intervention in Women With PCOS
The proposed single arm 6 mo. trial will assess the impact of weight loss and fat loss due to a multicomponent remotely-delivered lifestyle intervention on ovulation rates and time-to-ovulation in overweight and obese women with…
- Trial name
- NCT03677362
- Testing
- Weight loss intervention
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Kansas Medical Center
Infertility Drugs, Infertility Involuntary
Letrozole vs. Clomiphene Citrate Plus Tamoxifen for Ovulation Induction and Pregnancy Outcomes.
Infertility is a common reproductive health problem. Ovulation induction is a key treatment for women with anovulatory infertility. Letrozole and clomiphene citrate are widely used medications for ovulation induction.
- Trial name
- LET-CC-TAM (NCT07616973)
- Testing
- Letrozole, Clomiphene Citrate + Tamoxifen
- Where
- Yemen
- Volunteers
- 240 people
- Sponsor
- Sana'a University
in Vitro Activation, Dormant Follicle
In Vitro Activation of Dormant Follicles for Patients With Primary Ovarian Insufficiency
In this study, the investigators used the newly developed technique i.e. in vitro activation of dormant follicles (IVA) to promote ovarian follicle growth much more efficiently than natural, in vivo process for women with Primary…
- Conditions
- in Vitro Activation, Dormant Follicle, Primary Ovarian Insufficiency, Ovarian Resistance Syndrome
- Trial name
- IVADFPOI (NCT02322060)
- Testing
- Ovariotomy, Activate dormant follicles, Ovary tissue transplantation
- Where
- China
- Volunteers
- 35 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Ovarian Cancer
Apatinib Combined With Abraxane and Carboplatin or Cisplatinum as First-line Treatment for Epithelial Ovarian Cancer
This monocentric, prospective, observational study will evaluate the safety and efficacy of apatinib in combination with albumin binds paclitaxel and carboplatin or cisplatinum as first-line treatment for stage II-IV epithelial…
- Trial name
- NCT04590625
- Testing
- Apatinib Mesylate, Abraxane, Cis Platinum
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Zhongshan Hospital Xiamen University
PCOS (Polycystic Ovary Syndrome), Infertility
Letrozole Extended vs Traditional Therapy for Ovulation Induction in Women With PCOS (PROLEx-PCOS)
This randomized clinical trial aims to compare the efficacy and safety of extended letrozole therapy (5 mg/day for 10 days) versus standard letrozole therapy (5 mg/day for 5 days) for ovulation induction in women with polycystic…
- Conditions
- PCOS (Polycystic Ovary Syndrome), Infertility, Anovulation
- Trial name
- PROLEx-PCOS (NCT07159880)
- Testing
- Traditional Letrozole Therapy, Extended Letrozole Therapy
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GABRIEL MONTEIRO PINHEIRO
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