Clinical trials: Ovary Disease
Ovarian Cancer
Hydralazine Valproate for Ovarian Cancer
The current standard for recurrent, persistent or metastatic cisplatin-resistant ovarian cancer is palliative chemotherapy with either topotecan, liposomal doxorubicin or gemcitabine, however, the results need to be improved.
- Trial name
- NCT00533299
- Testing
- Hydralazine and magnesium valproate
- Where
- Mexico
- Volunteers
- 211 people
- Sponsor
- National Institute of Cancerología
Ovarian Neoplasms
Comparison of Nexavar/Placebo as Maintenance Therapy for Patients With Advanced Ovarian or Primary Peritoneal Cancer
Comparison of Nexavar with a placebo as maintenance therapy for patients with advanced Ovarian or primary Peritoneal cancers in complete remission following surgery and one regimen of chemotherapy.
- Trial name
- NCT00791778
- Testing
- Sorafenib (Nexavar, BAY43-9006)
- Where
- 59 sites in United States, Belgium and 12 more
- Volunteers
- 246 people
- Sponsor
- Bayer
Primary Peritoneal Cavity Cancer, Recurrent Ovarian Epithelial Cancer
Ixabepilone in Treating Patients With Ovarian Epithelial or Primary Peritoneal Cancer That Has Not Responded to Previous Chemotherapy
Phase II trial to study the effectiveness of ixabepilone in treating patients who have recurrent or persistent ovarian epithelial or primary peritoneal cancer that has not responded to previous chemotherapy.
- Trial name
- NCT00025155
- Testing
- ixabepilone
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- National Cancer Institute (NCI)
Disorder of Endocrine Ovary, Hypersecretion; Cortisol
Pathogenesis of Functional Hypothalamic Amenorrhea
This is a randomized pilot study of the use of cognitive behavior therapy versus observation to treat functional hypothalamic amenorrhea, often termed stress-induced anovulation.
- Conditions
- Disorder of Endocrine Ovary, Hypersecretion; Cortisol, Metabolic Disturbance, Stress, Psychological
- Trial name
- NCT01674426
- Testing
- Cognitive behavior therapy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Pittsburgh
Polycystic Ovarian Syndrome (PCOS)
Effects of Wet-Cupping on Polycystic Ovary Syndrome Patients
The goal of this clinical trial is to evaluate whether wet cupping therapy (Hijama) can improve reproductive and metabolic outcomes in women diagnosed with Polycystic Ovary Syndrome (PCOS).
- Trial name
- NCT07169292
- Testing
- Wet-cupping
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- Princess Nourah Bint Abdulrahman University
Ovarian Cancer
Clinical Impact of Dedicated MR Staging of Ovarian Cancer
The only chance of cure for patients with advanced stage ovarian cancer is complete cytoreductive surgery (CRS). The only way to determine whether complete CRS can be achieved is by a laparoscopy.
- Trial name
- MRStagingOC (NCT03399344)
- Testing
- MRI
- Where
- Netherlands
- Volunteers
- 270 people
- Sponsor
- The Netherlands Cancer Institute
Polycystic Ovarian Syndrome
In Vitro Maturation (IVM) for Polycystic Ovary Syndrome (PCOS)
This pilot study will be a prospective investigation to study the efficacy and safety of In-Vitro Maturation (IVM) for women with Polycystic Ovarian Syndrome (PCOS). There will be 10 subjects total in this Study.
- Trial name
- NCT01237106
- Testing
- IVM
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Reproductive Associates
Indocyanine Green (ICG), Robotic Surgical Procedure
Assessing the Efficacy of Indocyanine Green for Ureter Identification During Robot-Assisted Surgery in Advanced-Stage Endometriosis
The goal of this side-randomized, self-controlled trial, 1-site study is to explore the efficacy of Indocyanine Green Fluorescence (ICG) for Intraoperative Ureter Identification During Robot-Assisted Single-Site Surgery in…
- Conditions
- Indocyanine Green (ICG), Robotic Surgical Procedure, Deep Infiltrating Endometriosis (DIE), Endometriosis Pelvic
- Trial name
- NCT07144904
- Testing
- Indocyanine Green (ICG)-Assisted Ureteral Identification, Standard Ureteral Identification without ICG
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Baylor College of Medicine
Polycystic Ovary Syndrome
Sub-therapeutic GnRH- Antagonist Treatment to Rectify LH Pulsatility in Lean Women With PCOS.
The clinical study using a sub-therapeutic dose of a GnRH antagonist to reduce overactive LH pulsatility in women with PCOS. With the intervention and lowered LH action we anticipate to decrease androgen levels in women with…
- Trial name
- SOPKGANI (NCT05751252)
- Testing
- Ganirelix
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Lille
Solid Tumors
Avelumab in Metastatic or Locally Advanced Solid Tumors (JAVELIN Solid Tumor)
This is a Phase 1, open-label, dose-escalation trial of avelumab [antibody targeting programmed death ligand 1 (anti PD-L1)] with consecutive parallel group expansion in participants with selected tumor indications.
- Trial name
- NCT01772004
- Testing
- Avelumab
- Where
- 74 sites in United States, Belgium and 7 more
- Volunteers
- 1,756 people
- Sponsor
- EMD Serono Research & Development Institute, Inc.
Ovarian Cancer, Fallopian Tube Cancer
Dendritic Cell Vaccine for High Risk Ovarian Cancer Patients
This is a randomized Phase I/II study designed to assess the induction of an anti-tumor immune response; the effect of cyclophosphamide on the vaccine; and to assess safety in subjects with advanced ovarian cancer or primary…
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Carcinoma
- Trial name
- DC-Ova (NCT00478452)
- Testing
- DC-Ova, DC Ova with Cyclophosphamide
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Pennsylvania
Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor
Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Germ Cell Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow patients to tolerate higher doses…
- Conditions
- Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Ovarian Cancer, Testicular Germ Cell Tumor
- Trial name
- NCT00003852
- Testing
- filgrastim, carboplatin, cyclophosphamide
- Where
- 18 sites in France
- Volunteers
- 45 people
- Sponsor
- UNICANCER
Epithelial Ovarian Cancer
Association of Ex Vivo Drug Response (EVDR) and Clinical Outcome in Ovarian Cancer
EXCYTE-1 is a multicentre, prospective observational study to investigate the relationship between ex vivo drug response (EVDR), measured in ovarian tumour-derived samples using high content imaging, and actual patient clinical…
- Trial name
- EXCYTE-1 (NCT06068738)
- Testing
- Biological sample collection
- Where
- 4 sites in Austria, Germany
- Volunteers
- 13 people
- Sponsor
- Exscientia AI Limited
Cancer, Ovarian Cancer
Efficacy Study of Maintenance IT-101 Therapy for Ovarian Cancer Patients.
This study will assess the effect of IT-101 on delaying cancer progression in patients with platinum sensitive ovarian cancer.
- Conditions
- Cancer, Ovarian Cancer, Solid Tumor
- Trial name
- NCT00753740
- Testing
- IT-101 (12mg/m2/dose), IT-101 (15mg/m2/dose)
- Where
- 7 sites in United States
- Sponsor
- NewLink Genetics Corporation
Hereditary Breast and Ovarian Cancer
Testing an Intelligent Tutoring System to Enhance Genetic Risk Assessment
Participating in genetic cancer risk assessments (GCRA) for hereditary breast and ovarian cancer can inform treatment and risk management decisions and improve breast cancer outcomes.
- Trial name
- NCT03511690
- Testing
- BRCA-Gist
- Where
- 4 sites in United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Cervical Carcinoma, Endometrioid Adenocarcinoma
Testing AZD1775 inC Combination With Radiotherapy and Chemotherapy in Cervical, Upper Vaginal and Uterine Cancers
This phase I trial studies the side effects and best dose of adavosertib when given together with external beam radiation therapy and cisplatin in treating patients with cervical, vaginal, or uterine cancer.
- Conditions
- Cervical Carcinoma, Endometrioid Adenocarcinoma, Malignant Female Reproductive System Neoplasm, Recurrent Cervical Carcinoma
- Trial name
- NCT03345784
- Testing
- Adavosertib, Cisplatin, External Beam Radiation Therapy
- Where
- 8 sites in United States, Canada
- Volunteers
- 10 people
- Sponsor
- National Cancer Institute (NCI)
Ovarian Cysts, Ovarian Cancer
Diagnosing Ovarian Cysts - the DOC Study
Background: Ovarian cysts are common in women. The vast majority is benign; yet, ovarian cancer (OC) is seen in 500 women every year in Denmark.
- Conditions
- Ovarian Cysts, Ovarian Cancer, Ovarian Neoplasms, Ovarian Cancer Stage
- Trial name
- NCT04188652
- Testing
- Detailed symptomregistration
- Where
- Denmark
- Volunteers
- 1,123 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cancer, Solid Tumor Cancer
Phase I Study of SYS6043 in Patients With Advanced/Metastatic Solid Tumors
The goal of this clinical trial is to learn if investigational drug called SYS6043 works in adults with advanced or metastatic solid tumors that have spread or cannot be treated with standard therapies.
- Conditions
- Cancer, Solid Tumor Cancer, Advanced Metastatic Cancer, Prostate
- Trial name
- NCT07424547
- Testing
- SYS6043
- Where
- 5 sites in United States
- Volunteers
- 386 people
- Sponsor
- Conjupro Biotherapeutics, Inc.
Mixed Mesodermal (Mullerian) Tumor, Ovarian Carcinosarcoma
Paclitaxel and Carboplatin or Ifosfamide in Treating Patients With Newly Diagnosed, Persistent or Recurrent Uterine, Ovarian, Fallopian Tube, or Peritoneal Cavity Cancer
This randomized phase III trial studies paclitaxel and carboplatin see how well they work compared with paclitaxel and ifosfamide in treating patients with fallopian tube, or peritoneal cavity cancer that is newly diagnosed…
- Conditions
- Mixed Mesodermal (Mullerian) Tumor, Ovarian Carcinosarcoma, Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma
- Trial name
- NCT00954174
- Testing
- Carboplatin, Ifosfamide, Paclitaxel
- Where
- 538 sites in United States, South Korea
- Volunteers
- 637 people
- Sponsor
- GOG Foundation
Polycystic Ovary Syndrome (PCOS)
Amelioration of Polycystic Ovary Syndrome Related Disorders by Supplementation of Thymoquinone and Metformin
Objective: To investigate the potential benefit of adding Thymoquinone to Metformin in alleviating symptoms of polycystic ovarian syndrome. Methods: 207 overweight and obese PCOS Patients were divided into two groups.
- Trial name
- NCT04852510
- Testing
- Metformin Versus a combination of Metformin and Thymoquinone (TQ)
- Where
- Saudi Arabia
- Volunteers
- 253 people, healthy volunteers welcome
- Sponsor
- Saudi German Hospital - Madinah
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