Clinical trials: Over Cancer
Acute Myeloblastic Leukaemia
Treatment of the Acute Myeloblastic Leukaemia in Patients Over 65 Years
To reproduce or to improve the index of complete responses of protocol LMA-91 with a similar protocol, decreasing the dose of Idarubicin to try to reduce the deaths in induction
- Trial name
- NCT00464217
- Testing
- ARA-C, Idarubicin, Leucomax
- Where
- 24 sites in Spain
- Volunteers
- 100 people
- Sponsor
- PETHEMA Foundation
Breast Neoplasms
GETNA2 Neoadj. TAX+Femara vs Femara in g I/II Breast Cancer
Primarily to evaluate the rates of clinical and radiological response in the 2 groups. Secondarily rate of histological response.
- Trial name
- NCT00617968
- Testing
- DOCETAXEL
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Sanofi
Squamous Cell Tumors
A Study of ABT-414 in Subjects With Solid Tumors
A study of ABT-414 in subjects with solid tumors.
- Trial name
- NCT01741727
- Testing
- ABT-414
- Where
- 6 sites in United States, Canada
- Volunteers
- 57 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Metastatic Breast Cancer, 70 Years Old Patients and Over
Evaluating Lapatinib + Capecitabine in Patients Aged 70 and Over With HER2 Metastatic Breast Cancer.
GERICO 09/0907 is a Phase II multicentric trial evaluating the toxicity and activity of the combination of lapatinib and capecitabine in locally advanced or metastatic breast cancer over expressing HER2 for patients aged ≥ 70 who…
- Conditions
- Metastatic Breast Cancer, 70 Years Old Patients and Over, After One Line of Chemotherapy With Trastuzumab
- Trial name
- GERICO09 (NCT01262469)
- Testing
- lapatinib + capecitabine
- Where
- 20 sites in France
- Volunteers
- 4 people
- Sponsor
- UNICANCER
Colorectal Cancer
Trial to Evaluate Laparoscopic Versus Open Surgery in Elderly Colorectal Cancer Patients
Elderly patients have poorer preoperative conditions than younger patients. Therefore, minimally invasive surgery should be an effective treatment method for elderly patients.
- Trial name
- NCT01862562
- Testing
- Open surgery, Laparoscopic surgery
- Where
- Japan
- Volunteers
- 200 people
- Sponsor
- Shoichi Fujii, MD, PhD
Breast Cancer, Hot Flash Due to Medication
REDucing Hot FLASHes in Women Using Endocrine Therapy.
The goal of this randomized intrapatient cross-over study is to assess the efficacy of oxybutynin versus venlafaxine in reducing hot flashes in women using endocrine therapy after breast cancer.
- Trial name
- REDFLASH (NCT06106529)
- Testing
- Oxybutynin, Venlafaxine
- Where
- Netherlands
- Volunteers
- 260 people
- Sponsor
- Reinier de Graaf Groep
Leukemia
Gemtuzumab Ozogamicin and Cyclosporine in Treating Older Patients With Relapsed Acute Myeloid Leukemia
RATIONALE: Monoclonal antibodies such as gemtuzumab ozogamicin can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells.
- Trial name
- NCT00089050
- Testing
- cyclosporine, gemtuzumab ozogamicin
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center
Crohn Disease
Immune Modulation by Parenteral Fish Oil in Patients With Crohn's Disease
To evaluate the effects of infusion of a Fish oil-based lipid emulsion on TNF-α production and other relevant immune functions. A soybean oil emulsion, rich in the omega-6 polyunsaturated fatty acid linoleic acid, will serve as…
- Trial name
- NCT02349594
- Testing
- Omegaven 10%, Intralipid 20%
- Where
- Netherlands
- Volunteers
- 6 people
- Sponsor
- Radboud University Medical Center
Postoperative Complication
Keratinocyte Skin Cancer Surgery in the Elderly, Aged 80 Years and Over, is Effective and Safe
As a result of a longer life expectancy and a change in UV exposure, physicians will be facing a growing number of elderly patients with keratinocyte cancer (KC) in fair-skinned populations.
- Trial name
- NCT06665581
- Where
- 2 sites in Switzerland
- Volunteers
- 345 people
- Sponsor
- Juerg Hafner
HER2/Neu Over-expressing Locally Advanced Breast Cancer, Metastatic Breast Cancer
Daily Everolimus in Combination With Trastuzumab and Vinorelbine in HER2/Neu Positive Women With Locally Advanced or Metastatic Breast Cancer
This phase III, double-blind, placebo-controlled multinational study will assess the combination everolimus, vinorelbine, and trastuzumab compared to the combination vinorelbine and trastuzumab with respect to progressive-free…
- Trial name
- BOLERO-3 (NCT01007942)
- Testing
- everolimus, vinorelbine, trastuzumab
- Where
- 161 sites in United States, Argentina and 19 more
- Volunteers
- 569 people
- Sponsor
- Novartis Pharmaceuticals
Metastatic Breast Cancer
Roll-over Study to Allow Continued Access to Ribociclib
The purpose of this study is to assess the long-term safety of ribociclib (LEE011) in combination with other drugs and provide post-trial access (PTA) to participants who are currently receiving treatment with ribociclib in…
- Trial name
- NCT05161195
- Testing
- Ribociclib, Letrozole, Anastrozole
- Where
- 73 sites in United States, Argentina and 20 more
- Volunteers
- 134 people
- Sponsor
- Novartis Pharmaceuticals
Colorectal Cancer
1st Line Chemotherapy Alone or With Bevacizumab in Treating Older Patients With Metastatic Colorectal Cancer
RATIONALE: Drugs used in chemotherapy, such as leucovorin calcium, fluorouracil, irinotecan hydrochloride, and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them…
- Trial name
- NCT01417494
- Testing
- Chemotherapy ( FOLFIRI regimen, FOLFOX regimen or LV5FU2 regimen), Chemotherapy ( FOLFIRI regimen, FOLFOX regimen or LV5FU2 regimen) + bevacizumab
- Where
- France
- Volunteers
- 102 people
- Sponsor
- Federation Francophone de Cancerologie Digestive
Malignant Pain, Non-malignant Pain
To Demonstrate Equivalence in Analgesic Efficacy & Bowel Function Between OXN PR Higher Dose & Lower Dose Tablet Strengths in Subjects With Non-cancer or Cancer Pain
This study is aimed to demonstrate equivalence between combinations of lower strength OXN PR tablets (OXN PR LST) and single higher strength OXN PR tablets (OXN PR HST) taken at the same overall daily dose.
- Trial name
- NCT02321397
- Testing
- Oxycodone, Naloxone
- Where
- Germany
- Volunteers
- 155 people
- Sponsor
- Mundipharma Research GmbH & Co KG
PIK3CA-Related Overgrowth Spectrum (PROS), Breast Neoplasms (Including Advanced or Metastatic Breast Cancer With PIK3CA Mutation)
Roll-Over Study of Alpelisib (BYL719) for Continued Access and Long-Term Safety.
The purpose of this study is to provide post-trial access to alpelisib and to assess its long-term safety when administered as a single agent or in combination with other drugs.
- Trial name
- EPIK-RO (NCT07679269)
- Testing
- Alpelisib, Fulvestrant, Trastuzumab
- Volunteers
- 51 people
- Sponsor
- Novartis Pharmaceuticals
Neoplasms
Study to Collect and Assess Long-term Safety of Everolimus in Patients Who Are on Everolimus Treatment in a Novartis-sponsored Study and Are Benefiting From the Treatment as Judged by the Investigator.
The purpose of this study was to collect and assess long-term safety of everolimus in patients who were currently receiving everolimus treatment in a Novartis-sponsored, Oncology CD\&MA study that had reached its study…
- Trial name
- NCT02017860
- Testing
- Everolimus
- Where
- 4 sites in Japan
- Volunteers
- 4 people
- Sponsor
- Novartis Pharmaceuticals
Breast Cancer, Colorectal Cancer
Assessment of Outpatient Digital Follow-up of Patients Over 70 Years of Age Undergoing Chemotherapy Treatment
adherence of digital follow-up in a population of elderly patients.
- Conditions
- Breast Cancer, Colorectal Cancer, Lung Cancer
- Trial name
- E-SN@P PROJECT (NCT03959774)
- Testing
- IPC NET
- Where
- 4 sites in France
- Volunteers
- 119 people
- Sponsor
- Institut Paoli-Calmettes
Breast Cancer, Joint Pain
Trial of Blue Citrus Compared to Placebo in Patients Receiving Aromatase Inhibitor Therapy for Estrogen Receptor Positive Post-Menopausal Breast Cancer
This purpose of this study is to determine if the herbal compound, Blue Citrus, decreases joint and bone pain associated with Aromotase Inhibitor therapy (AIT).
- Trial name
- NCT00702858
- Testing
- Blue Citrus
- Volunteers
- 30 people
- Sponsor
- Legacy Health System
Cancer, Breast Cancer
Mind Over Matter for Black and African American Women: A Single Arm Trial Examining Feasibility and Acceptability of a Supportive Intervention
The goal of this study is to learn if the Mind Over Matter (MOM) Intervention, a 5-week group program, can help Black and African American women deal with the fears, worries and sadness that often accompany cancer diagnosis and…
- Conditions
- Cancer, Breast Cancer, Brain Cancer, Central Nervous System Cancer
- Trial name
- MOM (NCT06168825)
- Testing
- Mind Over Matter (MOM)
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Inova Health Care Services
Metastatic, Cerebral Primitive Neuroectodermal Tumors
Treatment of High-Risk Cerebral Primitive Neuroectodermal Tumors in Children Aged Over 5 Years
Primary objective : To increase the 3 year progression-free survival from 40% to 60%. Patients included : metastatic, cerebral primitive neuroectodermal tumors in children aged over 5 years.
- Trial name
- NCT00936156
- Testing
- Chemotherapy (carboplatin, etoposide, thiotepa)
- Where
- France
- Volunteers
- 68 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Sarcoma
Registry of Sarcoma Patients Treated With Permanently Implantable LDR CivaSheet®
This patient study will determine the safety and toxicity of a permanently implantable brachytherapy source - CivaSheet® - which is designed to deliver a therapeutic dose of low dose rate (LDR) radiation with polymer encased…
- Trial name
- NCT04033081
- Testing
- CivaSheet
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- CivaTech Oncology