Clinical trials: Overactive Bladder (OAB), open to volunteers
Urinary Incontinence, Urge Incontinence
UCon Treatment of Overactive Bladder (OAB) in Males
UCon is a medical device for treatment of the symptoms of OAB and fecal incontinence (FI). It electrically stimulates the DGN through the skin to obtain modulated behaviour of the bladder musculature e.g., suppress undesired…
- Conditions
- Urinary Incontinence, Urge Incontinence, Nocturia, Urinary Frequency More Than Once at Night
- Trial name
- NCT05874375
- Testing
- Urge stimulation, Time limited stimulation
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- InnoCon Medical
Overactive Bladder (OAB), Urgency Urinary Incontinence
Long-Term Effectiveness and Safety of Sacral Neuromodulation With InterStim for Lower Urinary Tract Dysfunction
This observational study will evaluate the long-term effectiveness, safety, and patient satisfaction associated with sacral neuromodulation using the InterStim™ system in adults treated for lower urinary tract dysfunction at…
- Conditions
- Overactive Bladder (OAB), Urgency Urinary Incontinence, Non-obstructive Urinary Retention, Non-obstructive Acontractile Detrusor
- Trial name
- NCT07856238
- Testing
- InterStim™ Sacral Neuromodulation System II - X
- Where
- Colombia
- Volunteers
- 1,700 people
- Sponsor
- Fundación Santa Fe de Bogota
Urinary Bladder, Overactive, Urinary Incontinence, Urge
Treatment Efficacy for Overactive Bladder: Comparing Education, Biofeedback, and Nerve Stimulation
The purpose of this clinical trial is to evaluate the effectiveness of different behavioral therapies and neuromodulation for treating women with idiopathic Overactive Bladder (OAB).
- Trial name
- NCT07744620
- Testing
- Behavioral, Enraf-Nonius EMG-Biofeedback Unit (Biofeedback only), Enraf-Nonius EMG-Biofeedback Unit (Biofeedback + Electrical Stimulation)
- Where
- Taiwan
- Volunteers
- 201 people
- Sponsor
- Far Eastern Memorial Hospital
Urinary Incontinence, Urinary Incontinence, Urge
Safety and Performance of UCon Bar Electrode for the Treatment of Overactive Bladder (OAB) and Bowel Dysfunction (BD)
UCon is a medical device for treatment of the symptoms of overactive bladder (OAB) and bowel dysfunction (BD). It electrically stimulates the DGN through the skin to obtain modulated behaviour of the bladder/bowel musculature…
- Conditions
- Urinary Incontinence, Urinary Incontinence, Urge, Fecal Incontinence, Fecal Incontinence With Fecal Urgency
- Trial name
- NCT06091566
- Testing
- UCon-Bar
- Where
- 3 sites in Denmark
- Volunteers
- 20 people
- Sponsor
- InnoCon Medical
Overactive Bladder (OAB)
Predictive Value of Inflammatory Biomarkers for Mirabegron Response in Women With Overactive Bladder
Overactive bladder (OAB) is associated with systemic chronic inflammation. Indices derived from complete blood count (such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic…
- Trial name
- NCT07773532
- Testing
- Mirabegron (beta3-adrenoceptor agonist)
- Where
- Turkey (Türkiye)
- Volunteers
- 115 people
- Sponsor
- Bagcilar Training and Research Hospital
Overactive Bladder (OAB)
Non-invasive Saphenous Nerve Stimulation Therapy for Overactive Bladder
The goal of this clinical trial is to study the NiNA System and how it works to treat overactive bladder. Up to 290 participants will be enrolled in the study in the USA and Australia.
- Trial name
- NOVASTIM (NCT07780786)
- Testing
- Wearable neurostimulation system for saphenous nerve stimulation, tolterodine tartrate 4 mg extended release
- Where
- 2 sites in United States, Australia
- Volunteers
- 290 people
- Sponsor
- NinaMED Pty Ltd
Overactive Bladder (OAB), Urinary Urgency
Effectiveness of Ambulatory Transcutaneous Tibial Nerve Stimulation for Overactive Bladder
The goal of this clinical trial is to learn if using a portable nerve stimulation (TENS) device during daily life works to reduce overactive bladder (OAB) symptoms in adults aged 18 to 65.
- Trial name
- NCT07540273
- Testing
- Ambulatory Transcutaneous Tibial Nerve Stimulation, Conventional Clinic-Based Transcutaneous Tibial Nerve Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- SEZGIN
Overactive Bladder (OAB)
Comparing Treatments for Overactive Bladder in Taiwan: A Study of Outcomes
Overactive bladder (OAB) syndrome is a prevalent condition that significantly impairs patients' quality of life. Standard therapeutic strategies include oral antimuscarinics (e.g., solifenacin), beta-3 adrenergic agonists (e.g.…
- Trial name
- NCT07025642
- Testing
- Urodynamic evaluation before and after solifenacin treatment., Urodynamic evaluation before and after mirabegron treatment., Urodynamic evaluation before and after combined treatment with solifenacin and mirabegron.
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Mackay Medical College
Overactive Bladder (OAB)
INOPASE - Performance and Safety Study of a Personalised SNM System
The goal of this clinical trial is to learn whether a new sacral neuromodulation (SNM) system (INO-SNM-01) can safely and effectively sense bladder nerve activity and provide stimulation to help manage symptoms of refractory…
- Trial name
- NCT07193407
- Testing
- Sacral Neuromodulation System
- Where
- 2 sites in Australia
- Volunteers
- 10 people
- Sponsor
- INOPASE Pty Ltd
Overactive Bladder (OAB), Urge Incontinence
Low-intensity Shockwave Therapy Versus Solifenacin for the Treatment of Overactive Bladder in Women
The goal of this clinical trial is to evaluate the effectiveness and safety of low-intensity shockwave therapy (Li-SWT) for the treatment of overactive bladder (OAB) in adult women.
- Trial name
- NCT07473310
- Testing
- Low intensity shockwave therapy, Oral Solifenacin succinate 5 mg
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Mansoura University
Overactive Bladder (OAB)
Evaluate the Safety and Efficacy of TRG-200 KIT in Patients With Refractory Overactive Bladder.
This is an open-label, single-center pilot study designed to evaluate the safety, tolerability, and preliminary efficacy of TRG-200 KIT, an intravesical sustained-release oxybutynin formulation, in adult patients with refractory…
- Trial name
- NCT07391878
- Testing
- TRG-200 KIT
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Trigone Pharma Ltd.
Overactive Bladder (OAB)
Efficacy of Probiotics for OAB Patients With Anxiety
The goal of this clinical trial is to learn if probiotics can help improve symptoms in adults with overactive bladder (OAB) and anxiety. The main questions it aims to answer are: 1.
- Trial name
- NCT07635212
- Testing
- Multi-strain Probiotic Compound
- Where
- China
- Volunteers
- 218 people
- Sponsor
- Qilu Hospital of Shandong University
Overactive Bladder (OAB), Nocturia
A Novel Wearable Transcutaneous Tibial Nerve Stimulation (TTNS) Device in the Treatment of Patients With Overactive Bladder (OAB) and Nocturia
Overactive bladder (OAB) is a syndrome with urgency as the main symptom, usually accompanied by frequent urination, nocturia, and sometimes urge urinary incontinence.
- Trial name
- NCT07635251
- Testing
- A new wearable transcutaneous tibial nerve stimulation (TTNS) device, behavioral therapy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Qilu Hospital of Shandong University
Overactive Bladder (OAB)
RELIEVE Study: NT 201 Intravesical Administration Using Vibe System (ViXe Combination Product) for the Treatment of Idiopathic Overactive Bladder
This Phase 2b study is a prospective, multicenter, double blind, randomized, placebo and sham controlled trial to assess the safety, efficacy and dose response of NT 201 delivered by the Vibe System in participants with…
- Trial name
- RELIEVE (NCT07553065)
- Testing
- NT 201 200U and Vibe System, NT 201 300U and Vibe System
- Where
- 3 sites in United States
- Volunteers
- 210 people
- Sponsor
- Vensica Therapeutics Ltd.
Overactive Bladder (OAB), Transcutaneous Neurostimulation
Comparative Study of the Efficacy of Treatment of Idiopathic Overactive Bladder (OAB) in Children: Oxybutynine vs. Transcutaneous Neurostimulation
The absence of infectious, urological and neurological causes defines the idiopathic character of overactive bladder (OAB). Although a progressive approach starting with behavioural therapy (urotherapy) is recommended…
- Conditions
- Overactive Bladder (OAB), Transcutaneous Neurostimulation, Posterior Tibial Nerve Stimulation
- Trial name
- HAV-O-TENS (NCT07030803)
- Testing
- Oxybutynin, medical device Urostim
- Where
- France
- Volunteers
- 124 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Overactive Bladder (OAB)
Evaluation of a Non-Implanted Electrical Stimulation Device for Overactive Bladder (OAB)
A study to evaluate the safety and effectiveness of FemPulse System
- Trial name
- EVANESCE-II (NCT07195656)
- Testing
- Device Group, Medication Group
- Where
- 15 sites in United States
- Volunteers
- 151 people
- Sponsor
- FemPulse Corporation
Overactive Bladder (OAB), Overactive Bladder Syndrome
Real-world Experiences and Voices Exploring the Actual Lived Burden of OAB: A Mixed-methods Multi-country PROMs Study on OAB Patients' Quality of Life
The main goal is to understand what it is truly like to live with OAB from the patient's perspective, including how it affects: daily activities, emotional wellbeing and mental health, social life and relationships, work and…
- Trial name
- REVEAL-OAB (NCT07545148)
- Volunteers
- 2,000 people
- Sponsor
- European Association of Urology Research Foundation
Overactive Bladder (OAB), Refractory Overactive Bladder
Cefar URO - Symptomatic Treatment of Overactive Bladder
A Post-Market Prospective Clinical Investigation to collect PMCF data on the safety and performance of the Cefar URO device when using the preset program P4 (parameter setting: frequency 20Hz, pulse width 200μs) for the…
- Conditions
- Overactive Bladder (OAB), Refractory Overactive Bladder, Urinary Urgency and Frequency
- Trial name
- NCT06659536
- Testing
- Transcutaneous Tibial Nerve Stimulation (TTNS) with the Cefar Uro Device
- Where
- France
- Volunteers
- 53 people
- Sponsor
- DJO UK Ltd
Overactive Bladder (OAB), Urinary Tract Infection (Diagnosis)
Methenamine Hippurate Following Intradetrusor OnabotulinumtoxinA Injection
The goal of this clinical trial is to compare methenamine hippurate prophylaxis to routine antibiotic prophylaxis following onabotulinumtoxinA (BOTOX-A) injections in women with overactive bladder (OAB).
- Trial name
- META (NCT06953271)
- Testing
- Methenamine Hippurate, Typically prescribed oral antibiotic prophylaxis
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Women and Infants Hospital of Rhode Island