Clinical trials: Overdose, Drug, open to volunteers
Opioid Use Disorder
Identifying Optimal Buprenorphine Dosing for Opioid Use Disorder Treatment and Prevention of Overdose
The investigators aim to test the effectiveness of a high maintenance daily dose of buprenorphine (24 mg) for improving outcomes among patients who used fentanyl compared to the standard daily dose (16 mg).
- Trial name
- Optimal Bup (NCT06316830)
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Rhode Island Hospital
Substance Use Disorder (SUD)
Preventing Overdose and Promoting Recovery Through Court Navigation
This project is a hybrid type I clinical trial to assess the effectiveness and implementation determinants of a peer-led court navigation program for people who use drugs and are passing through county courthouses.
- Trial name
- POPCORN (NCT07700407)
- Testing
- CourtConnect, Information Only
- Where
- 2 sites in United States
- Volunteers
- 600 people
- Sponsor
- RTI International
HIV Testing, STI
HIV/STI/HCV Testing and Overdose Prevention Among Survivors of Sex Trafficking
This project will assess whether a digital survivor crowdsourced intervention can increase HIV/STI/HCV testing and overdose prevention kit utilization among survivors of sex trafficking living in New York City.
- Conditions
- HIV Testing, STI, HCV, Overdose, Drug
- Trial name
- NCT07264582
- Testing
- Sex Trafficking Survivor-Developed Digital Crowdsourced Intervention
- Where
- United States
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- Columbia University
Substance Abuse, Decision Making, Shared
Data2Action Oregon Project: Supporting Data-driven Decision-Making for Substance Use Services, Policy, and Overdose Prevention
Oregon's decision makers (e.g., community service providers, public health, justice, advocacy groups, payers) are calling for comprehensive, current, and trusted data to inform how they allocate resources to improve substance use…
- Conditions
- Substance Abuse, Decision Making, Shared, Implementation Science, Decision Making
- Trial name
- D2A Oregon (NCT06852170)
- Testing
- Co-Design Sessions (CDS), Data products
- Where
- United States
- Volunteers
- 341 people, healthy volunteers welcome
- Sponsor
- Chestnut Health Systems
Occupational Health
Impact of Stress First Aid for Workers in Substance Misuse Settings
Test the effectiveness of SFA adapted for the substance use outreach workforce compared to a no treatment control condition on social-support and burnout of HRWs in a cluster-randomized hybrid type I trial.
- Trial name
- SFA-Impact (NCT07177014)
- Testing
- Stress First Aid (SFA)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Texas at Austin
Opioid Overdose
UnityPhilly Response App for Overdose Reversal
The goal of this clinical trial is to discover if an overdose prevention app (UnityPhilly) can encourage citizen responders to respond and prevent opioid overdoses using the UnityPhilly app.
- Trial name
- NCT06466005
- Testing
- UnityPhilly app
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Drexel University
Substance-Related Disorders, Opioid-Related Disorders
Fatal Overdose Review Teams - Research to Enhance Surveillance Systems
This project seeks to address the overdose epidemic by working with overdose fatality review (OFR) teams. Current OFR practices rely on a case review model where OFR teams assess one or two overdose cases to make policy and…
- Trial name
- FORTRESS (NCT06084221)
- Testing
- Data-Driven Decision Making (DDDM), Overdose-prevention strategies inventory
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Indiana University
Overdose Accidental
Naltrexone for Overdose Prevention
The goal of this clinical trial is to see if an injectable medicine called naltrexone can prevent fentanyl overdose deaths in people who use other drugs (cocaine, methamphetamine).
- Trial name
- NOD (NCT06633900)
- Testing
- IM naltrexone, Usual Care
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Acute Liver Failure, Sepsis
Transcriptional Analysis of Mechanisms in Liver Failure and Sepsis
Context Acute liver failure (ALF) is a life-threatening condition that occurs on the background of a healthy liver. The most common cause of acute liver failure in the UK is paracetamol overdose.
- Trial name
- MAP-ALF (NCT07131969)
- Testing
- blood draw
- Where
- 7 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Cambridge
Opioid Use Disorder
Addressing Racial Disparities in Opioid Overdose Using Peer Recovery Coach Training and mHealth Platform
The study aims to adapt an existing Cultural Structural Humility (CSH) training into a video format for peer recovery coaches (PRCs) and refine an AI-driven texting tool to reinforce the training.
- Trial name
- NCT06573476
- Testing
- PRC supported text + AI driven CSDH-enhanced text, AI driven CSDH-enhanced text only, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Friends Research Institute, Inc.
Healthy Adult, Overdose Antidote
Safety and Pharmacokinetics of Rescue Liposome in Healthy Adults
This is a Phase 1 study to assess the safety and tolerability of the liposomal product in healthy participants.
- Trial name
- NCT07375498
- Testing
- liposome dispersion
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cristália Produtos Químicos Farmacêuticos Ltda.
Substance Use Disorder (SUD), Opioid Use Disorder
Disease Intervention Specialist (DIS) for SUD
This prospective observational study evaluates three Disease Intervention Specialist service models designed to proactively identify and support adults at risk for substance use disorder.
- Conditions
- Substance Use Disorder (SUD), Opioid Use Disorder, Alcohol Use Disorder (AUD), Drug Use
- Trial name
- DIS-SUD (NCT07875361)
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Ohio State University
Cerebral Palsy, Magnesium Sulfate Overdose
Antenatal Magnesium Sulphate in High-Risk Preterm Patients
The goal of this clinical trial is to evaluate whether antenatal magnesium sulphate reduces the risk of cerebral palsy in infants born to women at high risk of preterm birth.
- Trial name
- NCT07524972
- Testing
- Magnesium sulfate
- Where
- Egypt
- Volunteers
- 138 people
- Sponsor
- Cairo University
Substance Use Disorder (SUD), Drug Overdose
Justice Community Overdose Innovation Network II TCU Hub
The current study proposes to use a Hybrid Type 3 implementation research strategy to: 1) Significantly enhance our understanding of public health outcomes [e.g., overdose incidents and substance-use (SU)-related Emergency…
- Conditions
- Substance Use Disorder (SUD), Drug Overdose, Criminal Behavior
- Trial name
- JCOIN II TCU (NCT07528846)
- Testing
- Core-interagency community engagement approach, Enhanced-Core plus community engagement specialist
- Where
- United States
- Volunteers
- 1,620 people, healthy volunteers welcome
- Sponsor
- Texas Christian University
Opioid Use Disorder, Overdose, Drug
The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services Study
The goal of this clinical trial is to develop and test the CROSSROADS intervention. CROSSROADS is designed for people who have recently survived an opioid and/or stimulant-related non-fatal overdose and had contact with staff…
- Conditions
- Opioid Use Disorder, Overdose, Drug, Overdose, Substance Use (Drugs, Alcohol)
- Trial name
- CROSSROADS (NCT07216963)
- Testing
- Community Paramedic Standard of Care (CP SOC), CROSSROADS
- Where
- 4 sites in United States
- Volunteers
- 400 people
- Sponsor
- Duke University
Methadone Toxicity, Methadone Overdose
Assessment of Methadone Dose Taken
Proof of concept: Pilot Study A Pilot, proof of concept, observational study with a long-term goal to develop a minimally invasive wearable Remote Medication Monitor (RMM) that provides continuous, real-time data on methadone…
- Conditions
- Methadone Toxicity, Methadone Overdose, Pain, Chronic, Drug Metabolism, Poor, CYP2D6-Related
- Trial name
- NCT05981573
- Testing
- Measurement of Methadone in the Interstitial Fluid (ISF) before and after prescribed dose taken ex vivo, Measurement of Methadone in the Interstitial Fluid before and after prescribed dose taken in vivo, ISF Extraction Device 2
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Cari Health Inc.
Opioid Use Disorder, Opioid Use Disorder, Moderate
TRTME: Improving Outpatient Initiation of Medication for Opioid Use Disorder Following Hospitalization
The primary objective of this study is to evaluate the ability of TRTME to increase initiation of MOUD outpatient treatment and MOUD knowledge in hospitalized patients with OUD deemed to be good candidates for MOUD by the UCMC…
- Conditions
- Opioid Use Disorder, Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe
- Trial name
- TRTME (NCT07780097)
- Testing
- TRTME
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- T. John Winhusen, PhD
Opioid Use Disorder, Opioid Use Disorder, Severe
Buprenorphine Implementation at Syringe Service Programs to Reduce Overdoses
This study is testing whether offering buprenorphine treatment directly at syringe service programs (SSPs) helps more people start and stay in treatment for opioid use disorder (OUD) than referring them to community buprenorphine…
- Conditions
- Opioid Use Disorder, Opioid Use Disorder, Severe, Opioid Use Disorder, Moderate
- Trial name
- BISTRO (NCT07631598)
- Testing
- Standard of Care Referral, Low Threshold Buprenorphine
- Where
- 8 sites in United States
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Substance Use, Substance-Related Disorders
Clinician Practice Companion to Address Youth Substance Use
Substance use, including the use of opioids, cannabis, and other drugs, is common among adolescents and young adults, and overdose has become a leading cause of death among youth in Canada and the United States.
- Conditions
- Substance Use, Substance-Related Disorders, Adolescent Substance Use, Cannabis Use
- Trial name
- NCT07725289
- Testing
- Practice Companion
- Where
- 5 sites in United States, Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Overdose, Substance Use
Permanent Supportive Housing Overdose Prevention+ Study
This community-partnered study examines a technical assistance intervention designed to help permanent supportive housing agencies implement evidence-based practices to prevent tenant overdose and improve tenant health.
- Trial name
- POP+ (NCT07214519)
- Testing
- TA Intervention
- Where
- United States
- Volunteers
- 2,940 people
- Sponsor
- NYU Langone Health