Clinical trials: Overdose, open to volunteers
Anabolic Steroid Overdose, Infertility
Prospective, Longitudinal Study on FItness DOping in DenmarK
The aim of this prospective longitudinal study is to investigate the risks associated with use of anabolic steroids in fitness circles in Denmark in order to assess the scope of therapeutic need existing as a consequence of use.
- Conditions
- Anabolic Steroid Overdose, Infertility, Cardiovascular Complication, Illicit Drug Use
- Trial name
- FIDO-DK/RH (NCT05599438)
- Testing
- No intervention
- Where
- Denmark
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Caroline Michaela Kistorp
Substance Use Disorder (SUD), Drug Overdose
Justice Community Overdose Innovation Network II TCU Hub
The current study proposes to use a Hybrid Type 3 implementation research strategy to: 1) Significantly enhance our understanding of public health outcomes [e.g., overdose incidents and substance-use (SU)-related Emergency…
- Conditions
- Substance Use Disorder (SUD), Drug Overdose, Criminal Behavior
- Trial name
- JCOIN II TCU (NCT07528846)
- Testing
- Core-interagency community engagement approach, Enhanced-Core plus community engagement specialist
- Where
- United States
- Volunteers
- 1,620 people, healthy volunteers welcome
- Sponsor
- Texas Christian University
Opioid Overdose Prevention, People Who Use Opioids/People With Opioid Use Disorder (OUD)
Reducing Overdose and Substance Use-related Stigma by Training Non-substance-using Friends and Family Members of People Who Use Opioids to Be Harm Reduction Champions
Fatal opioid overdoses are more frequent among populations with low access to harm reduction (HR) services and with high substance use-related stigma (which is a major barrier to accessing HR services).
- Conditions
- Opioid Overdose Prevention, People Who Use Opioids/People With Opioid Use Disorder (OUD), Reduction of Substance Use-related Stigma, Non-substance-using People With a Friend or Family Member Who Uses Opioids
- Trial name
- NCT06823453
- Testing
- Peer Harm Reduction Support Champion Intervention
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
HIV Infections, HCV
A Setting Focus Overdose Prevention Intervention
A pilot injection-setting targeted peer-driven intervention to reduce HIV and hepatitis C virus transmission and overdose risk behaviors among people who inject drugs (PWID).
- Conditions
- HIV Infections, HCV, Drug Overdose
- Trial name
- Oasis (NCT05320835)
- Testing
- HIV, HCV and overdose prevention
- Where
- United States
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Drug Overdose, Drug Overdose Accidental
Behavioral Safety and Fentanyl Education: BSAFE
BSAFE is a randomized trial of a repeated-dose brief intervention to reduce overdose and risk behaviors among people who use stimulants who may have unintentional fentanyl use (UFU).
- Trial name
- BSAFE (NCT07219082)
- Testing
- BSAFE Intervention, Attention control
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- San Francisco Department of Public Health
Remote vs. In-Person, Remote Visits
Remote vs. In-Person Study Evaluation (RISE) Trials: RISE Above Opioid Overdose (Trial 3 of 3)
The study will employ a randomized, parallel-group design with two-stage randomization. After an initial brief screen for basic eligibility, participants will be randomized (within site) to either Remote (R) or In-Person (IP)…
- Conditions
- Remote vs. In-Person, Remote Visits, In-person Visits
- Trial name
- NCT07875569
- Testing
- Opioid Overdose Prevention Training
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Fentanyl Overdose, Fentanyl Poisoning
A Phase 2 Safety, Tolerability, PK, and Efficacy Study of CS-1103 Following Fentanyl Challenge With Naloxone Blockade
The purpose of the study is to evaluate the safety, tolerability, pharmacokinetics, and efficacy of CS-1103 (1,000 mg), given by intravenous (IV) infusion in healthy participants in the presence of a clinically relevant dose of…
- Trial name
- NCT07459166
- Testing
- Naloxone Hydrochloride, Fentanyl, Sterile Saline
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Clear Scientific, Inc.
Opioid Abuse (Disorder)
Improving Jail Response to the Overdose Crisis: A Hybrid Trial of Jail ECHO to Improve MOUD Implementation and Public Health Outcomes
This project tests a training strategy to help rural jails start or increase their use of medications to treat opioid use disorder (MOUD - methadone, buprenorphine, naltrexone).
- Trial name
- J-ECHO OPS (NCT07637994)
- Testing
- Project ECHO
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Fever, Anxiety
LázBarát™ (FeverFriend™) Projekt: Attitude Toward Fever and Its Change in the Healthcare System
The positive effects of fever are supported by a number of physiological, pathophysiological and clinical evidence. However, the negative attitude toward fever is widespread and have become persistent.
- Conditions
- Fever, Anxiety, Help-Seeking Behavior, Virus Diseases
- Trial name
- NCT04633603
- Testing
- FeverFriend mobile application
- Where
- Hungary
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- University of Pecs
Substance Use Disorder (SUD)
Trauma-informed Intervention to Reduce Substance Use and to Support Community Transition
The overall aim of this study is to reduce overdose risk for criminal legal system (CLS) involved women during community re-entry through the adaptation and testing of an innovative, trauma-informed, relational intervention…
- Trial name
- TRUST (NCT06651528)
- Testing
- TAU + TRUST, TAU + TRUST + Re-entry Recovery Support, Treatment as Usual (TAU)
- Where
- 4 sites in United States
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Michele Staton
Substance Use, Substance-Related Disorders
Clinician Practice Companion to Address Youth Substance Use
Substance use, including the use of opioids, cannabis, and other drugs, is common among adolescents and young adults, and overdose has become a leading cause of death among youth in Canada and the United States.
- Conditions
- Substance Use, Substance-Related Disorders, Adolescent Substance Use, Cannabis Use
- Trial name
- NCT07725289
- Testing
- Practice Companion
- Where
- 5 sites in United States, Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Opioid Overdose
UnityPhilly Response App for Overdose Reversal
The goal of this clinical trial is to discover if an overdose prevention app (UnityPhilly) can encourage citizen responders to respond and prevent opioid overdoses using the UnityPhilly app.
- Trial name
- NCT06466005
- Testing
- UnityPhilly app
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Drexel University
HIV Testing, STI
HIV/STI/HCV Testing and Overdose Prevention Among Survivors of Sex Trafficking
This project will assess whether a digital survivor crowdsourced intervention can increase HIV/STI/HCV testing and overdose prevention kit utilization among survivors of sex trafficking living in New York City.
- Conditions
- HIV Testing, STI, HCV, Overdose, Drug
- Trial name
- NCT07264582
- Testing
- Sex Trafficking Survivor-Developed Digital Crowdsourced Intervention
- Where
- United States
- Volunteers
- 368 people, healthy volunteers welcome
- Sponsor
- Columbia University
Opioid Overdose Prevention, HIV Prevention and Care
Prevention and Rapid Outreach for Treatment, Engagement, and Care Transition From the Emergency Department
The Prevention and Rapid Outreach for Treatment, Engagement, and Care Transition from the Emergency Department (PROTECT-ED) study evaluates an emergency department-based implementation strategy designed to improve delivery of…
- Conditions
- Opioid Overdose Prevention, HIV Prevention and Care, Harm Reduction
- Trial name
- PROTECT-ED (NCT07868393)
- Testing
- PROTECT-ED Care Coordination
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Gender Incongruence, Gender Dysphoria
Sex Hormone Overdose and Misuse in Chinese Transgender and Gender Non-conforming Population
The investigators propose to investigate the definition of hormone overdose and misuse (HODM) in Chinese transgender and gender nonconforming population (TGNCs), address the incidence of HODM in Chinese TGNC population, related…
- Trial name
- HODMChina (NCT05583058)
- Testing
- Hormone Overdose and Misuse
- Where
- China
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Xiamen University
Substance-Related Disorders, Opioid-Related Disorders
Fatal Overdose Review Teams - Research to Enhance Surveillance Systems
This project seeks to address the overdose epidemic by working with overdose fatality review (OFR) teams. Current OFR practices rely on a case review model where OFR teams assess one or two overdose cases to make policy and…
- Trial name
- FORTRESS (NCT06084221)
- Testing
- Data-Driven Decision Making (DDDM), Overdose-prevention strategies inventory
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Indiana University
Substance Use Disorders, Overdose
Emergency Medicine Peer Outreach Worker Engagement for Recovery
This is an observational, prospective case-control study evaluating the effects of an emergency department community health worker-peer recovery specialist program (PCHW), the Substance Misuse Assistance Response Team (SMART).
- Conditions
- Substance Use Disorders, Overdose, Opioid Use Disorder, Alcohol Use Disorder
- Trial name
- EMPOWER (NCT06320015)
- Testing
- Substance Misuse Assistance Response Team (SMART), Usual Care Group
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Pharmacokinetics, Healthy Volunteer
Single Dose Study, Pharmacokinetics of Oxycodone and PF614 Co-Administered With Nafamostat (PF614-MPAR-102)
A single dose dose study to assess the pharmacokinetics (PK) of oxycodone, when PF614 is administered alone and with nafamostat as an immediate-release (IR) solution and/or extended-release(ER) capsule prototypes.
- Trial name
- NCT06500793
- Testing
- PF614 capsule, Nafamostat Mesylate
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ensysce Biosciences
Substance Abuse, Decision Making, Shared
Data2Action Oregon Project: Supporting Data-driven Decision-Making for Substance Use Services, Policy, and Overdose Prevention
Oregon's decision makers (e.g., community service providers, public health, justice, advocacy groups, payers) are calling for comprehensive, current, and trusted data to inform how they allocate resources to improve substance use…
- Conditions
- Substance Abuse, Decision Making, Shared, Implementation Science, Decision Making
- Trial name
- D2A Oregon (NCT06852170)
- Testing
- Co-Design Sessions (CDS), Data products
- Where
- United States
- Volunteers
- 341 people, healthy volunteers welcome
- Sponsor
- Chestnut Health Systems
Healthy Adult, Overdose Antidote
Safety and Pharmacokinetics of Rescue Liposome in Healthy Adults
This is a Phase 1 study to assess the safety and tolerability of the liposomal product in healthy participants.
- Trial name
- NCT07375498
- Testing
- liposome dispersion
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cristália Produtos Químicos Farmacêuticos Ltda.