Clinical trials: Overdose
Hepatitis C
Hepatitis C Pharmacy-based Strategy for Injectors
The aim of this study is evaluate the acceptability/usage of a newly implemented model of delivery of care, namely a community-pharmacy program, to provide access to medications to treat hepatitis C (HCV), and prevent overdose…
- Trial name
- HepPSI (NCT04698629)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Washington
Opioid Use Disorder, Pregnancy Related
Personally-Tailored Opioid-overdose and Medication for Opioid Use Disorder (MOUD) Education (TOME) for Pregnant and Postpartum Persons in MOUD
The primary objective of this study is to evaluate the ability of TOME to increase Medication for Opioid Use Disorder (MOUD) and opioid-overdose knowledge in pregnant and postpartum persons.
- Conditions
- Opioid Use Disorder, Pregnancy Related, Substance Use, Drug Abuse
- Trial name
- TOME (NCT06262347)
- Testing
- Personally-Tailored Opioid-overdose and Medication for opioid use disorder (MOUD) Education (TOME), Control
- Where
- 6 sites in United States
- Volunteers
- 131 people
- Sponsor
- T. John Winhusen, PhD
Opioid-use Disorder
Buprenorphine Treatment Engagement and Overdose Prevention
Office-based buprenorphine could be expanded to treat many of the opioid users who are not in treatment and who are at great risk for opioid overdose, but effective approaches are needed to help individuals with opioid use…
- Trial name
- NCT03677986
- Testing
- Video DOT+
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Johns Hopkins University
Opioid Use, Stimulant Use
THRIVE: Culturally AdapTed Harm Reduction Intervention
The goal of this study is to develop and test a culturally adapted harm reduction intervention among Black adults who misuse opioids and/or stimulants.
- Trial name
- NCT06609278
- Testing
- harm reduction intervention
- Where
- 3 sites in United States
- Volunteers
- 63 people
- Sponsor
- Brittany Miller-Roenigk
Opioid Use Disorder, Opioid Overdose
A Bundled Intervention
Opioid overdose deaths have reached historically high records in the United States and are particularly concentrated among patients after emergency department (ED) discharge.
- Trial name
- B-CARE (NCT06593093)
- Testing
- a bundled intervention, including peer support specialist, buprenorphine, physician care, and telehealth
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Opioid-Related Disorders, Drug Overdose
Repeated-dose Behavioral Intervention to Reduce Opioid Overdose
REBOOT is a randomized trial of a repeated-dose brief intervention to reduce overdose and risk behaviors among naloxone recipients with opioid use disorder.
- Trial name
- REBOOT (NCT03838510)
- Testing
- REBOOT
- Where
- 2 sites in United States
- Volunteers
- 268 people
- Sponsor
- San Francisco Department of Public Health
Opioid Overdose
Pharmacodynamic Evaluation of Intramuscular Nalmefene Autoinjector 1.5 mg Compared to Intranasal Narcan 4 mg
The purpose of this study is to determine the pharmacodynamics (change in minute ventilation) of nalmefene when given as an autoinjector intramuscularly (IM; into the thigh) compared to naloxone when given intranasally (IN; into…
- Trial name
- NCT06719986
- Testing
- Nalmefene HCl injection, Naloxone HCl intranasal
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Purdue Pharma LP
Acute Myeloid Leukemia
Study of Milademetan in Japanese Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML)
This is a Phase 1, multicenter, open-label study to evaluate safety, tolerability and pharmacokinetics of milademetan in Japanese patients with relapsed or refractory acute myeloid leukemia.
- Trial name
- NCT03671564
- Testing
- Milademetan
- Where
- 8 sites in Japan
- Volunteers
- 14 people
- Sponsor
- Daiichi Sankyo Co., Ltd.
Acetaminophen Overdose
Safety and Efficacy Study of a New Formulation of Acetylcysteine Injection
The primary purpose of this study is determine if a new formulation of Acetadote is at least as effective as the current formulation in the prevention and treatment of acetaminophen overdose related liver injury.
- Trial name
- NCT01118663
- Testing
- Acetadote EF (Ethylenediaminetetraacetic Acid (EDTA) - Free), Acetadote
- Where
- 14 sites in United States
- Volunteers
- 17 people
- Sponsor
- Cumberland Pharmaceuticals
Naloxone
Increasing Naloxone Access for Persons Who Use Opioids
Deaths relating to opioid overdose have rapidly increased over the past two decades. Due to the serious public health concern of the opioid epidemic, federal agencies recommend employing various harm reduction interventions.
- Trial name
- NCT04303000
- Testing
- Opioid Overdose Education with Naloxone Distribution, Opioid Overdose Education
- Where
- 4 sites in United States
- Volunteers
- 111 people
- Sponsor
- University of Alabama at Birmingham
Vitiligo, Depressive Episode
Mental Health Associations With Vitiligo
This cohort study is a large population-based study in the UK to determine the risks of comorbid mental health conditions (including depression, anxiety and other potential psychological complications of vitiligo) in adults with…
- Conditions
- Vitiligo, Depressive Episode, Recurrent Depressive Disorder, Anxiety Disorders
- Trial name
- NCT04953338
- Testing
- Exposure of mental health condtion of interest
- Where
- United Kingdom
- Volunteers
- 36,104 people, healthy volunteers welcome
- Sponsor
- Momentum Data
Opioid Overdose
Vaped Marijuana to Attenuate Naloxone-Precipitated Withdrawal
The goal of the proposed, proof-of-concept study is to test the combined effects of vaporized marijuana [Delta-9-tetrahydracannabinol (THC)] with NLX as a proof of concept towards the possible development of a combined overdose…
- Trial name
- NCT05114460
- Testing
- Naloxone, Marijuana
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- New York State Psychiatric Institute
Opioid Overdose
Project OOPEN: Opioid Overdose Prevention, Education and Intervention
This prospective, randomized emergency department trial will study the effectiveness of an intervention that combines opioid overdose prevention, education and intervention that includes take home naloxone with brief behavioral…
- Trial name
- OOPEN (NCT01788306)
- Testing
- OOPEN+BBCC
- Where
- 3 sites in United States
- Volunteers
- 256 people
- Sponsor
- University of Washington
Opioid Overdose
Preventing Opioid Overdose Mortality in the United States
This study aims to conduct a randomized controlled trial of 105 syringe services programs (SSPs) throughout the United States to understand the effectiveness of a multifaceted, facilitation-based strategy at advancing naloxone…
- Trial name
- NCT03924505
- Testing
- Organize and Mobilize for Implementation Effectiveness, Dissemination
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- RTI International
Opioid Use Disorder (OUD)
HEALing Communities Study
This study will test the impact of implementing the Communities That Helping to End Addiction Long-term (HEAL) intervention on opioid overdose deaths within 67 highly affected communities with the goal of reducing opioid overdose…
- Trial name
- NCT04111939
- Testing
- Communities That HEAL, Wait-list control
- Where
- 4 sites in United States
- Volunteers
- 67 people
- Sponsor
- RTI International
Suicide, Overdose Accidental
Pilot of Training on 988 and Narcan
This pilot study evaluates the acceptability, appropriateness, and feasibility of a new crisis response training called Crisis Ready.
- Conditions
- Suicide, Overdose Accidental, Overdose Antidote, Crisis Response Plan
- Trial name
- NCT07072819
- Testing
- Crisis Ready Training
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- RAND
Substance Use Disorders, Overdose
Project POINT: Effectiveness and Scalability of an Overdose Survivor Intervention
The investigators seek to assess the effectiveness of Project POINT (Planned Outreach, Intervention, Naloxone, and Treatment). As originated in Indianapolis, Project POINT is a collaboration between Indianapolis Emergency Medical…
- Trial name
- POINT (NCT03336268)
- Testing
- POINT
- Where
- 2 sites in United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Indiana University
Methamphetamine Intoxication (Disorder)
Meth-OD: A Study of IXT-m200 in Patients With Toxicity From Methamphetamine Overdose
The hypothesis of this multisite Phase 2a study is that IXT-m200 will be well-tolerated in patients with acute mild to moderate METH toxicity.
- Trial name
- Meth-OD (NCT04715230)
- Testing
- IXT-m200, Lorazepam, Haloperidol
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- InterveXion Therapeutics, LLC
Intravenous Anesthetic Agent Overdose
Propofol Pharmacokinetics and Pharmacodynamics Modelling
The main purpose of this research is to develop a population pharmacokinetic and pharmacodynamic model of Propofol when used for induction and maintenance of anaesthesia, using BIS as a pharmacodynamic endpoint.
- Trial name
- NCT02713698
- Testing
- Propofol
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- Centro Hospitalar do Porto
Occupational Health
Adaptation of SFA for HRW
The aim of this study is to pilot and test the feasibility, acceptability, and effectiveness of a Stress First Aid (SFA) intervention adapted for Harm Reduction Workers (HRWs) serving Persons Who Use Drugs.
- Trial name
- NCT07149155
- Testing
- Stress First Aid for Harm Reduction Workers
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Suzannah Creech