Clinical trials: Overfeeding
Liver Fat, Cardiac Function
Short-term Fat Overfeeding on the Effects of Liver Metabolism
Despite work showing the overconsumption of saturated fatty acids (SFA) to be metabolically deleterious, debate continues about whether there is a link between SFA and cardiovascular disease risk.
- Conditions
- Liver Fat, Cardiac Function, Lipid Disorder, Adiposity
- Trial name
- FOS (NCT05962190)
- Testing
- Diet
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Overfed, Obesity
Experimental Overfeeding in Humans
The objective of this study is to determine the homeostatic mechanisms that counteract weight gain in response to experimental overfeeding.
- Trial name
- ExpO (NCT04065243)
- Testing
- Overfeeding diet, Isocaloric diet
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Obesity
Prevention of Overfeeding During Infancy
The overall goal of this project is to identify strategies to prevent overfeeding during infancy. One objective is to evaluate the impact on intake of allowing the infant greater control over the amount consumed when feeding from…
- Trial name
- NCT01043978
- Testing
- Use of baby bottle nipple
- Where
- United States
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Type 2 Diabetes Mellitus, Insulin Resistance
Impact of Overfeeding and Following Exercise Training in Individuals With and Without Increased Risk of Type 2 Diabetes
Low birth weight (LBW), a marker of impaired fetal growth is an independent and strong risk factor for type 2 diabetes (T2D). A western lifestyle characterized by a surplus of calories, and/or a low physical activity level…
- Conditions
- Type 2 Diabetes Mellitus, Insulin Resistance, Dyslipidemia
- Trial name
- NCT02982408
- Testing
- High carbohydrate overfeeding, Exercise, Normal physical activity
- Where
- Denmark
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Insulin Resistance, Obesity
Adipose Tissue Response to Overfeeding in Insulin Resistance-Prone vs. Insulin Sensitive Humans
Obesity has become an epidemic worldwide. Data from our laboratory and others demonstrate that most of the excess morbidity from obesity is related to insulin resistance (IR).
- Trial name
- NCT02084641
- Testing
- Over feeding
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Stanford University
Overweight and Obesity
Study of the Effects of Overfeeding on Glucocorticoids in Lean and Obese Subjects
Investigators suggest that in lean subjects cortisol increases in response to overfeeding and that this increase is blunted in obese subjects.
- Trial name
- Gluco-Food (NCT04482738)
- Testing
- High-calorie meal
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Eleonora Seelig
Obesity
Investigation of the Gut Microbiota in Regulating Nutrient Absorption in Humans
We propose to study both stool and urine energy loss in 24 individuals on two experimental diets (50% increased and 50% reduced nutrient load relative to body size) in a random cross-over design.
- Trial name
- NCT02037295
- Testing
- Vancomycin, Overfeeding diet (OF), Underfeeding diet (UF)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Over Eating
Fat Cell Size and Overfeeding and Etopic Study
It has been shown that large fat cells are associated with more risks for insulin resistance and more cardiovascular risk factors such as high cholesterol or triglycerides.
- Trial name
- EAT (NCT01672632)
- Testing
- Overfeeding
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Metabolic Disease, Appetitive Behavior
Effects of a Single Day of Mixed Macronutrient Overfeeding on Energy Balance and Metabolic Responses
Healthy male participants are recruited to observe potentially deleterious changes in appetite regulation and metabolic control.
- Trial name
- NCT03301948
- Testing
- Overfeed, Energy Balance
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Leeds Beckett University
Insulin Resistance
Can Brief High-intensity Interval Training Mitigate the Adverse Consequences of High-fat Overfeeding?
Previous research has shown that indulging in 50% more calories than required for as little as 3 days can significantly impact markers of metabolic health in lean and overweight individuals.
- Trial name
- GAINHIT (NCT02177604)
- Testing
- Wingate HIT, Modified HIT, High-fat overfeeding
- Where
- Australia
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Adelaide
Critical Illness, Starvation
Impact of Early Parenteral Nutrition Completing Enteral Nutrition in Adult Critically Ill Patients
In critically ill patients, a strategy aimed at an early delivery of full caloric support, with a combination of Enteral Nutrition (EN) and Parenteral Nutrition (PN) (in conditions preventing hyperglycemia and overfeeding)…
- Trial name
- EPaNIC (NCT00512122)
- Testing
- Withholding PN during the first week of ICU stay, Oliclinomel N71000 OR N71000E // Clinimix N17G35 OR N17G35E
- Where
- 3 sites in Belgium
- Volunteers
- 4,640 people
- Sponsor
- KU Leuven
Obesity & Overweight
Changes in Intestinal Permeability and Systemic Inflammation Following Fast Food Overfeeding.
The purpose of this study is to investigate whether lifestyle factors can alter gut barrier integrity and whether disruptions of the gut barrier can trigger systemic and tissue-specific inflammation.
- Trial name
- ChIPS (NCT07893743)
- Testing
- Fast-food overfeeding
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Overfeeding and Exercise
Effect of Exercise and Training on Fat Oxidation During Overfeeding - the FeedEX Study
Rationale: Body weight is not well regulated in all individuals. In an obesogenic environment, where overeating is common, some individuals are more prone to weight gain and therefore overweight than others.
- Trial name
- FeedEX (NCT02333916)
- Testing
- overfeeding + exercise pre-training, fitness training, overfeeding + exercise post-training
- Where
- Netherlands
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Obesity
Adaptive Responses to Overfeeding and Weight
To more effectively address the problem of weight regain following weight loss for obese individuals, this study will evaluate the underlying biology of the reduced obese state.
- Trial name
- ARrOW (NCT03857048)
- Testing
- Weight Loss, Exercise training, Overfeeding
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Overweight and Obesity, Metabolic Syndrome
Testing the Adipose Expandability Hypothesis In Vivo During Overfeeding
Adipose, or fat, tissue is a plastic organ that retains the ability to expand and store excess calories during positive energy balance in humans.
- Trial name
- EAT 2 (NCT04583514)
- Testing
- Control, Overfeeding
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Obesity, Lipid Metabolism
Metabolic Fate Modifications of Saturated Fats After an Overfeeding
The purpose of this study is to determine the partitioning of exogenous lipids in the postprandial period while a study of overfeeding.
- Conditions
- Obesity, Lipid Metabolism, Inflammation
- Trial name
- SURNUT (NCT00905892)
- Testing
- Hyperlipidic overfeeding
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche en Nutrition Humaine Rhone-Alpe
NAFLD
Effects of Overfeeding Followed by Weight Loss on Liver Fat Content and Adipose Tissue Inflammation
A. BACKGROUND Accumulation of fat in the liver due to non-alcoholic causes (NAFLD) is associated with hepatic insulin resistance, which impairs the ability of insulin to inhibit the production of glucose and VLDL .
- Trial name
- NCT02133144
- Testing
- overeating fat, overeating carbohydrate
- Where
- Finland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Obesity, Diabetes
Study of the Mechanisms of Metabolic Adaptations to Overfeeding
Obesity results from complex interactions between genetic and environmental factors, and are strongly associated with metabolic complications such as type 2 diabetes mellitus.
- Trial name
- Polynut (NCT02225457)
- Testing
- Hypercaloric diet, polyphenols
- Where
- Switzerland
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Healthy
White Adipose Tissue Clocks and High Calorie Feeding
Peripheral tissues (e.g. liver, adipose, muscle) express self-sustained circadian clocks that coordinate daily metabolic rhythms.
- Trial name
- NCT02809482
- Testing
- Eucaloric feeding, Overfeeding
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Lipid-induced Insulin Resistance
Overfeeding Induced Fat-tissue Stimulation
Type 2 diabetes is the most common metabolic disease worldwide, characterized by hyperglycemia, decreased whole body insulin sensitivity, and white adipose tissue (WAT) dysfunction.
- Trial name
- OVID_FASTI (NCT06193668)
- Testing
- High-fat overnutrition, Normocaloric macronutrient-balanced nutrition
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center