Clinical trials: Overweight,Obesity
Diabetes Mellitus, Diabetes Mellitus, Type 2
Determinants of Bone and Muscle Quality and Strength in Obesity With and Without Diabetes
Background: Osteoporotic fractures are a major public health issue. They cause substantial disability, loss of autonomy, morbidity and excess mortality.
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 2, Obesity, Body Weight
- Trial name
- BODI2 (NCT04093856)
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Suzanne Morin
Obesity, Physical Activity
Physical Activity: Feasibility Study
The Physical Activity Self-efficacy (PAS) intervention is a web-based behavioral intervention newly developed to promote physical activity in adults with obesity.
- Conditions
- Obesity, Physical Activity, Self-efficacy, Online Intervention
- Trial name
- NCT05935111
- Testing
- Physical Activity Self-efficacy (PAS) intervention
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Binghamton University
Obesity & Overweight
Ultra-processed Food Consumption and Health Pilot Study
The objective of this study is to explore the effects of two dietary conditions (UPF-diet and typical American diet) on a number of clinical and metabolic outcomes in order to derive sample size estimates for a larger trial and…
- Trial name
- ULTRA PIlot (NCT07318064)
- Testing
- Purple Diet, Ultra-processed diet
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Menopause, Metabolic Syndrome
Low Sexual Desire and Metabolic Syndrome
Objective: To evaluate the prevalence of hypoactive sexual desire disorder (HSDD) in postmenopausal women diagnosed with metabolic syndrome (MS) and to compare it to that of a control group without MS.
- Conditions
- Menopause, Metabolic Syndrome, Hypoactive Sexual Desire Disorder, Obesity
- Trial name
- NCT02430987
- Testing
- Female sexual function index questionnaire, Evaluation of presence of metabolic syndrome, Evaluation of the body mass index
- Where
- Brazil
- Volunteers
- 291 people, healthy volunteers welcome
- Sponsor
- Faculdade de Ciências Médicas da Santa Casa de São Paulo
Diabetes, Insulin Resistance
Physiologic and Functional Adaptations of Insulin Sensitive Tissues
The long-term goal is to understand the mechanisms of intestinal nutrient sensing and signal relays to insulin sensitive tissues (adipose, skeletal muscle, liver) in humans.
- Conditions
- Diabetes, Insulin Resistance, Obesity, Bariatric Surgery Candidate
- Trial name
- NCT03407833
- Testing
- Endoscopy biopsy, Surgical biopsy, Mixed-meal tolerance test
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Vanderbilt University Medical Center
Obesity / Overweight
A Study Comparing the Effects of BGM0504 Injection and Semaglutide Injection on Obese Subjects.
An Investigator-Initiated, Randomized, Open-Label, Active-Controlled Study Comparing the Effects of BGM0504 Injection versus Semaglutide Injection on Insulin Sensitivity and Body Weight in Obese Subjects
- Trial name
- NCT07836140
- Testing
- semaglutide, BGM0504 Administered SC
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Aging, Adults With Overweight and Obesity
Effects of Physical Exercise and a Nutritional Supplement on Body Composition, Metabolic Function, and Overall Health in Adults With a Metabolically Challenging Profile
Early-onset metabolic disturbances (such as mild hyperglycemia, subclinical dyslipidemia, excess body fat, and reduced functional capacity) represent one of the major public health challenges among middle-aged and older adults.
- Conditions
- Aging, Adults With Overweight and Obesity, Supplementation, Exercise
- Trial name
- NCT07504068
- Testing
- Group 1: Exercise + thermogenic supplement (EX-TS)
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- University of Valencia
Physical Inactivity, Mental Health Issue
Effects of Active Video Games on Chinese Overweight and Obese College Students' Physical and Mental Health
Globally, overweight and obesity have become a major health concern and are present at all ages in both developed and developing countries.
- Conditions
- Physical Inactivity, Mental Health Issue, Body Weight Changes
- Trial name
- NCT06078150
- Testing
- Active video games intervention（1-6weeks）, Active video games intervention（7-12weeks）
- Where
- China
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Obesity
Lifestyle Modification and Liraglutide
This is a 52 week, single center, open-labeled, randomized controlled trial. A total of 150 subjects with obesity, who are free of types 1 and 2 diabetes, as well as contraindications to weight loss, will be randomly assigned to…
- Trial name
- MODEL (NCT02911818)
- Testing
- CMS-recommended lifestyle counseling, Liraglutide 3.0mg, Portion-Controlled Diet
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Pennsylvania
Metabolic Syndrome, Obesity
Effect of Low Carbohydrate Versus Low Fat Diet in the Treatment of Dyslipidemia in Obese Children With Metabolic Syndrome
Two-arm, parallel design with children between the ages of 10 - 18 with obesity and metabolic syndrome randomized (15 per group) to reduced-carbohydrate diet or a reduced-fat diet for 8 weeks.
- Conditions
- Metabolic Syndrome, Obesity, Dyslipidemias
- Trial name
- NCT03937960
- Testing
- Carbohydrate restricted group, Standard low fat diet
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Body Weights and Measures, Body Weight in the Overweight and Obese Class - I Population
Machine Learning and 3D Image-Based Modeling for Real-Time Body Weight and Body Composition Estimation During Emergency Medical Care. Study 1
The goal of this observational study is to train and validate an AI-driven 3D camera system to estimate total body weight, ideal body weight and lean body weight in male and female adult volunteers of all ages.
- Trial name
- NCT06646120
- Volunteers
- healthy volunteers welcome
- Sponsor
- Florida Atlantic University
Obesity
Fear Conditioning Paradigm in Obesity
Fear processing in obesity and specifically the ability to i) learn and remember threatening stimuli, and ii) implicitly (i.e., unconsciously) and explicitly (consciously) discriminate them from neutral ones, will be investigated…
- Trial name
- GenAllertOB (NCT05768659)
- Testing
- Fear Conditioning
- Where
- Italy
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Obesity
Analysing Differences in Glycaemic Control Immediately Post Obesity SurgEry (The ADIPOSE Study)
It is well established that bariatric (weightloss) surgery affords considerable improvement in glycaemic control (control of blood sugar), and in many cases may lead to a complete resolution of type 2 diabetes.
- Trial name
- ADIPOSE (NCT01515059)
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University of Leicester
Diabete Type 2, Abdominal Obesity
Translational Study Using Human Abdominal Adipose Tissue Biopsies to Investigate the Role of Cannabinoid Receptor 1 (CB1) in Controlling Endocannabinoid and Adipokine Secretion
Abdominal obesity and type 2 diabetes are associated with the hyperactivation of the endocannabinoid system. Several animal and human studies indicate that circulating endocannabinoid (EC) levels are correlated with body fat.
- Trial name
- ENDOCATA (NCT04940962)
- Testing
- Sampling of adipose tissue
- Where
- France
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Overweight, Obesity
Cue-Reward Learning and Weight Gain in Youth
The objective of the study is to compare children at low risk for obesity (two healthy weight parents) to children at high risk for obesity (two overweight parents) in their response rate to food taste and in their rate of…
- Trial name
- ChildLearn (NCT03254576)
- Testing
- Functional MRI
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Obesity and Overweight
Efficacy and Safety of MET097 Once-Weekly in People With Overweight or Obesity
This study investigates the efficacy and safety of once weekly injectable MET097 in adult participants with obesity or overweight with weight-related comorbidities excluding T2D. This trial will last for a duration of 84 weeks.
- Trial name
- VESPER-4 (NCT07311850)
- Testing
- MET097
- Where
- 161 sites in United States, Bulgaria and 8 more
- Volunteers
- 3,578 people
- Sponsor
- Pfizer
Obesity, Pregnancy
Promoting Health in Pregnancy and Postpartum
The purpose of this study is to examine the impact of a lifestyle intervention on gestational weight gain, postpartum weight loss, and other secondary outcomes relative to a usual care control group.
- Conditions
- Obesity, Pregnancy, Overweight
- Trial name
- HIPP (NCT02260518)
- Testing
- Lifestyle Intervention, Standard Care
- Where
- United States
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Childhood Obesity, Cardiovascular Disease Prevention
Family Matters Intervention
The proposed study is a 12-month, individual randomized controlled trial (RCT). The main aim of the study is to decrease cardiovascular disease risk (BMI percentile, neck circumference) and improve child diet quality in children…
- Trial name
- NCT02669797
- Testing
- In-home Visits and Food Preparation Activities, Ecological Momentary Intervention, Feedback on Video-recorded Family Meals
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Healthy, Obesity
A Study in Healthy People or Otherwise Healthy With Overweight or Obesity to Compare 2 Formulations of Survodutide Given in Different Ways, Either as a Pre-filled Syringe or a Pen-like Injector
The goal of this study is to find out whether different formulations of survodutide given by different delivery methods is taken up in the body in a similar way. Participants visit the study site regularly.
- Trial name
- NCT07413913
- Testing
- Survodutide formulation A, Survodutide formulation B2
- Where
- Germany
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Obesity
Obesity Assessment and Education Through the Internet
The purpose of this study is to develop a web-based obesity risk assessment and counseling tool and examine its feasibility and effectiveness in improving the rate and quality of physician counseling about obesity, dietary…
- Trial name
- NCT00149682
- Testing
- 6-month educational program, 6-month standard care program
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)