Clinical trials: Overweight , Obesity
Obesity, Liver Cirrhosis
Endoscopic Intragastric Balloon Placement for Weight Loss in Liver Transplant Waitlist Candidates
The purpose of this study is to determine whether the Orbera Intragastric Balloon is a safe and effective means for weight loss and improved metabolic disease in patients with cirrhosis requiring liver transplantation.
- Trial name
- NCT02556138
- Testing
- ORBERA Intragastric Balloon
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Mayo Clinic
Obesity
The Effect Of NS-0200 and NS-0300 Versus Placebo on Weight In Obesity
This is a 24-week study to evaluate the effects of two fixed-dose combinations of leucine and sildenafil or two fixed-dose combinations of leucine, sildenafil and metformin compared to placebo.
- Trial name
- NCT03364335
- Testing
- Leu Sil 1.0mg, Leu Sil 4.0mg, Leu Met Sil 1.0mg
- Where
- 15 sites in United States
- Volunteers
- 267 people
- Sponsor
- NuSirt Biopharma
Epidural Anesthesia, Spinal Ultrasound
Utility of Ultrasound in Identification of Midline and Placement of Epidural in Severely Obese Parturients
This study will address the utility of ultrasound in the placement of an epidural catheter in severely obese parturients. Identification of midline can often be difficult using the standard method of palpation in obese patients.
- Conditions
- Epidural Anesthesia, Spinal Ultrasound, Obesity
- Trial name
- NCT03100968
- Testing
- Palpation, Ultrasound
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Obesity
GLP-1 Analogue Effects on Food Cues, Stress, Motivation for Highly Palatable Foods, and Weight
To examine response to a glucagon-like peptide-1 analogue vs. placebo in patients with obesity and assess impact on craving, hunger, stress, and weight outcomes.
- Trial name
- NCT04779697
- Testing
- GLP-1 analogue - semaglutide
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Yale University
Morbid Obesity
A Study of Clinical Outcomes of the REALIZE Adjustable Gastric Band-C
The purpose of this study is to evaluate the results patients are obtaining with the Realize™ Adjustable Gastric Band-C during the first 24 months after surgery.
- Trial name
- NCT00999661
- Where
- 7 sites in United States
- Volunteers
- 231 people
- Sponsor
- Ethicon Endo-Surgery
Obesity, Oligospermia
Aromatase Inhibitors in the Treatment of Male Infertility
Obesity is associated with an increase in blood levels of estrogen. Estrogen or "female hormone" is believed to have a negative effect on sperm production.
- Trial name
- NCT00440180
- Testing
- Anastrozole
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Obesity
DVD Lifestyle Intervention
Most Veterans who receive VA healthcare have obesity (41%) or are classified as overweight (37%), putting them at higher risk for multiple serious chronic health conditions.
- Trial name
- D-ELITE (NCT03260140)
- Testing
- behavioral lifestyle intervention
- Where
- United States
- Volunteers
- 511 people
- Sponsor
- VA Office of Research and Development
Obesity
The Effects of Oxytocin in Obese Adults
This is a randomized, double blind, placebo-controlled study of the effects of intranasal oxytocin in obese adults, ages 18-45 years old.
- Trial name
- NCT03043053
- Testing
- oxytocin nasal spray
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Massachusetts General Hospital
Obesity
The Acute Effect of Propionate on Energy Homeostasis
The research project aims to examine the effect of a dietary supplement called propionate on how the human body in healthy adults aged (18- 65 years) responds to during fasting, exercise and following a liquid mixed meal test and…
- Trial name
- PROEM (NCT04093453)
- Testing
- Exercise, Sodium Propionate
- Where
- United Kingdom
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Acquired Hypogonadotropic Hypogonadism, Obesity
A Multi-Center Study in Men With Acquired Hypogonadotropic Hypogonadism to Compare Changes in Body Composition and Metabolic Parameters With Diet and Exercise in Conjunction With Treatment With 12.5 mg or 25 mg Enclomiphene
The purpose of this study is to compare the effects of 12 months of treatment with enclomiphene 12.5 mg, 25 mg, or placebo capsules on body composition and metabolic parameters in overweight men with acquired hypogonadotropic…
- Trial name
- NCT02651688
- Testing
- Enclomiphene
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- Repros Therapeutics Inc.
Obesity
Improving Cardiovascular Risk Factors in Black Young Adults
The objectives of the study are to conduct a randomized controlled trial to test the efficacy of the Smartphone intervention on % weight loss and maintaining % weight loss at 6 and 12 months in a sample (N=256) of Black community…
- Trial name
- NCT04412954
- Testing
- Smartphone + Text Messaging with Health Coach
- Where
- United States
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Insulin Resistance, Obesity
Metabolic Effects of Sleep Extension in People With Obesity
This study is designed to determine the impact of extending sleep duration on glucose metabolism in people with obesity. Half of the participants will be instructed to increase their time-in-bed in order to achieve >7h…
- Trial name
- NCT03594994
- Testing
- Sleep extension
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Weight Loss, Obesity
Noom Health for Weight Management
The goals of the study are to use the Noom mobile app to help individuals with weight loss and weight loss maintenance. This project will test the comparative efficacy of Noom Health vs.
- Trial name
- NCT04797169
- Testing
- Noom Health, Noom Digital Health
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Metabolism and Nutrition Disorder, Obesity
Effect of Liraglutide in Obese Subjects With Moderate or Severe Obstructive Sleep Apnoea: SCALE™ - Sleep Apnoea
This trial is conducted in North America. The aim of the trial is to investigate the effect of liraglutide in obese subjects with sleep apnoea.
- Conditions
- Metabolism and Nutrition Disorder, Obesity, Obstructive Sleep Apnoea
- Trial name
- NCT01557166
- Testing
- liraglutide
- Where
- 42 sites in United States, Canada
- Volunteers
- 359 people
- Sponsor
- Novo Nordisk A/S
Psychotic Disorders, Obesity
Web-Based Delivery of MOVE! to Veterans With Serious Mental Illness (SMI)
Obesity and physical inactivity have reached epidemic proportions, resulting in increased rates of a variety of chronic diseases, increased risk of death, and substantial health care costs.
- Conditions
- Psychotic Disorders, Obesity, Health Behaviors
- Trial name
- Web-MOVE! (NCT00983476)
- Testing
- in-person MOVE! SMI, web-based MOVE! SMI
- Where
- United States
- Volunteers
- 276 people
- Sponsor
- VA Office of Research and Development
Pain, Obesity
Ketamine Effect After Laparoscopic Gastric Reduction: A Randomized, Double-Blinded, Placebo Controlled Study
Laparoscopic surgery for gastric reduction is frequently associated with high levels of postoperative pain. Postoperative pain is very often treated with opioids.
- Conditions
- Pain, Obesity, Hypoxia
- Trial name
- NCT01997515
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Northwestern University
Childhood Obesity
Testing Digital Technologies to Help Families Build Healthy Habits
The current study is a randomized pilot trial to test the feasibility of a psychoeducational virtual reality experience to increase motivation for behavior change among children with overweight or obesity.
- Trial name
- NCT04845568
- Testing
- Virtual Reality Experience
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Washington University School of Medicine
Type 2 Diabetes, Obesity
Post Marketing Study in Subjects Who Have Type 2 Diabetes Using the EndoBarrier™ Gastrointestinal Liner
The purpose of this study is to evaluate EndoBarrier Gastrointestinal Liner in the post marketing environment in subjects who are obese and have Type 2 Diabetes.
- Trial name
- NCT01114438
- Testing
- EndoBarrier Gastrointestinal Liner
- Where
- 3 sites in United Kingdom
- Volunteers
- 45 people
- Sponsor
- Morphic Medical Inc.
Obesity
Childcare Healthy Beverage Access, Food and Beverage Intake, and Obesity
Interventions that promote water consumption in place of sugar-sweetened beverages have shown promise for preventing childhood obesity in schoolchildren.
- Trial name
- NCT05112185
- Testing
- Healthy Drinks, Healthy Futures
- Where
- United States
- Volunteers
- 1,034 people
- Sponsor
- Stanford University
Heart Failure, Coronary Artery Disease
COVID-19 Testing in Underserved and Vulnerable Populations
As part of National Institutes of Health Rapid Acceleration of Diagnostics-Underserved Populations (RADx-UP) program, the goal of the RADxUP study is to develop, test, and evaluate a rapid, scalable capacity building project to…
- Conditions
- Heart Failure, Coronary Artery Disease, Cancer, Chronic Kidney Diseases
- Trial name
- NCT05315908
- Testing
- Community outreach method
- Where
- United States
- Volunteers
- 9,120 people
- Sponsor
- Jesse Nodora
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